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  • Public defence: 2017-01-27 09:00 Campus USÖ, hörsal C1, Örebro
    Paramel Varghese, Geena
    Örebro University, School of Medical Sciences.
    Paramel Varghese, Geena
    Örebro University, School of Medical Sciences.
    Innate immunity in human atherosclerosis and myocardial infarction: Role of CARD8 and NLRP32017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Atherosclerosis is complex inflammatory disease of the arterial wall with progressive accumulation of lipids and narrowing of the vessel. Increasing evidence suggest that inflammation plays an important role in plaque stability and often accelerate cardiovascular events such as myocardial infarction (MI). Among the vast number of inflammatory cytokines, IL-1β is known to be a key modulator in vessel wall inflammation and acceleration of the atherosclerotic process. The biologically active IL-1β is regulated by a multiprotein complex known as the NLRP3 inflammasome complex. In this thesis, we have focused on polymorphisms in the NLRP3 and CARD8 genes and their possible association to atherosclerosis and/or MI. We have also investigated the expression of inflammasome components NLRP3 and CARD8 in atherosclerosis and the role of genetic variants for the expression of these genes. The expression of NLRP3, CARD8, ASC, caspase-1, IL-1β, and IL-18 were found significantly upregulated in atherosclerotic lesions compared to normal arteries. Human carotid plaques not only express the NLRP3 inflammasome, but also release IL-1β upon exposure to lipopolysaccharide (LPS), adenosine triphosphate (ATP) and cholesterol crystals, which suggest NLRP3 inflammasome activation in human atherosclerotic lesions. Also, CARD8 was found to be important in the regulation of several inflammatory markers in endothelial cells, like RANTES, IP10 and ICAM-1. We further assessed the potential association of a CARD8 polymorphism and polymorphisms located downstream of the NLRP3 gene to the risk of MI in two independent Swedish cohorts. The CARD8 variant exhibited no association to risk of MI in either of the two cohorts. Some of the minor alleles of NLRP3 variants were associated with increased IL-1β levels and to NLRP3 mRNA levels in peripheral blood monocytic cells (PBMC). Taken together, the present thesis shows that NLRP3 inflammasome activation and increased expression of CARD8 in the atherosclerotic plaque might be possible contributors to the enhanced inflammatory response and leukocyte infiltration in the pathophysiology of atherosclerosis.

    List of papers
    1. NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
    Open this publication in new window or tab >>NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
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    2016 (English)In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 5, no 5, e003031Article in journal (Refereed) Published
    Abstract [en]

    Background: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)-1β and IL-18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood.

    Methods and Results: Atherosclerotic plaques were analyzed for transcripts of the NLRP3 inflammasome, and for IL-1β release. The Swedish First-ever myocardial Infarction study in Ac-county (FIA) cohort consisting of DNA from 555 myocardial infarction patients and 1016 healthy individuals was used to determine the frequency of 4 single nucleotide polymorphisms (SNPs) from the downstream regulatory region of NLRP3. Expression of NLRP3, Apoptosis-associated speck-like protein containing a CARD (ASC), caspase-1 (CASP1), IL1B, and IL18 mRNA was significantly increased in atherosclerotic plaques compared to normal arteries. The expression of NLRP3 mRNA was significantly higher in plaques of symptomatic patients when compared to asymptomatic ones. CD68-positive macrophages were observed in the same areas of atherosclerotic lesions as NLRP3 and ASC expression. Occasionally, expression of NLRP3 and ASC was also present in smooth muscle cells. Cholesterol crystals and ATP induced IL-1β release from lipopolysaccharide-primed human atherosclerotic lesion plaques. The minor alleles of the variants rs4266924, rs6672995, and rs10733113 were associated with NLRP3 mRNA levels in peripheral blood mononuclear cells but not with the risk of myocardial infarction.

    Conclusions: Our results indicate a possible role of the NLRP3 inflammasome and its genetic variants in the pathogenesis of atherosclerosis.

    Place, publisher, year, edition, pages
    Hoboken, USA: Wiley-Blackwell Publishing Inc., 2016
    Keyword
    Inflammasome, interleukin-1b, myocardial infarction, NLRP3, polymorphism
    National Category
    Cardiac and Cardiovascular Systems
    Research subject
    Cardiology
    Identifiers
    urn:nbn:se:oru:diva-50441 (URN)10.1161/JAHA.115.003031 (DOI)000386711200020 ()27207962 (PubMedID)
    Funder
    Swedish Research Council, 6816 K2012-64X-12233-13-3Swedish Heart Lung Foundation, 20110359Magnus Bergvall Foundation
    Note

    Funding Agencies:

    Center of Excellence for Research on Inflammation and Cardiovascular Disease (CERIC) Linnaeus Center8703

    Foundation for Strategic Research, Uppdrag Besegra Stroke P581/2011-123

    Strategic Cardiovascular Programs of Karolinska Institutet, Stockholm County Council ALF 20110279

    Örebro University

    Sigurd and Elsa Goljes Foundation

    Available from: 2016-05-26 Created: 2016-05-26 Last updated: 2016-12-20Bibliographically approved
    2. Q705Kvariant in NLRP3 gene confers protection against myocardial infarction infemale individuals
    Open this publication in new window or tab >>Q705Kvariant in NLRP3 gene confers protection against myocardial infarction infemale individuals
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    2013 (English)In: Biomedical Reports, ISSN 2049-9434, Vol. 1, no 6, 879-882 p.Article in journal (Refereed) Published
    Abstract [en]

    Inflammation is a multifaceted process that underlies the pathophysiology of acute myocardial infarction (MI). Variations in the inflammasome‑related NLRP3 gene have been associated with risk for a number of different inflammatory diseases. Therefore, Q705K polymorphism in NLRP3 gene likely confers susceptibility to risk for MI. A First‑ever myocardial Infarction study in Ac‑county (FIA) cohort comprising 555 MI patients and 1,016 controls was used to genotype rs35829419 in the NLRP3 gene by TaqMan single‑nucleotide polymorphism assay. C‑reactive protein (CRP) was measured in the study participants by ELISA. The results showed no significant association between the variant rs35829419 and MI. However, the minor A allele of the rs35829419 polymorphism conferred a protective effect against the risk of developing MI in females. The minor A allele of rs35829419 polymorphism was also associated with increased CRP levels in males. Results of the study suggested a gender‑specific deregulation of NLRP3 gene mediated by rs35829419 polymorphism that confers protection against MI in females but has no effect on MI susceptibility in males. However, the rs35829419 polymorphism was associated with increased CRP levels among the male subjects, thereby demonstrating the possible effect of the Q705K polymorphism in elevating the basal active state of innate immune response.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:oru:diva-35448 (URN)10.3892/br.2013.155 (DOI)
    Available from: 2014-06-19 Created: 2014-06-19 Last updated: 2016-12-20Bibliographically approved
    3. CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation
    Open this publication in new window or tab >>CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation
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    2013 (English)In: Clinical Science, ISSN 0143-5221, E-ISSN 1470-8736, Vol. 125, no 8, 401-407 p.Article in journal (Refereed) Published
    Abstract [en]

    Inflammation is a key factor in the development of atherosclerotic coronary artery disease. It is promoted through the inflammasome, a molecular machine that produces IL (interleukin)-1 beta in response to cholesterol crystal accumulation in macrophages. The CARD8 (caspase recruitment domain 8) protein modulates this process by suppressing caspase 1 and the transcription factor NF-kappa B (nuclear factor kappa B). The expression of CARD8 mRNA was examined in atherosclerotic vascular tissue and the impact on MI (myocardial infarction) of a polymorphism in the CARD8 gene determined. CARD8 mRNA was analysed by microarray of human atherosclerotic tissue and compared with transplant donor arterial tissue. Microarray analysis was performed for proximal genes associated with the rs2043211 locus in plaque. The CARD8 rs2043211 polymorphism was analysed by genotyping of two Swedish MI cohorts, FIA (First Myocardial Infarction in Northern Sweden) and SCARF (Stockholm Coronary Atherosclerosis Risk Factor). The CRP (C-reactive protein) level was measured in both cohorts, but the levels of the pro-inflammatory cytokines IL-1 beta, IL-18, TNF (tumour necrosis factor) and MCP-1 (monocyte chemoattractant protein) were measured in sera available from the SCARF cohort. CARD8 mRNA was highly expressed in atherosclerotic plaques compared with the expression in transplant donor vessel (P < 0.00001). The minor allele was associated with lower expression of CARD8 in the plaques, suggesting that CARD8 may promote inflammation. Carriers of the minor allele of the rs2043211 polymorphism also displayed lower circulating CRP and lower levels of the pro-atherosclerotic chemokine MCP-1. However, no significant association could be detected between this polymorphism and MI in the two cohorts. Genetic alterations in the CARD8 gene therefore seem to be of limited importance for the development of MI.

    Place, publisher, year, edition, pages
    London, United Kingdom: Portland Press, 2013
    Keyword
    Caspase activation and recruitment domain 8 (CARD8), cytokines, gene polymorphism, inflammasome, myocardial infarction, rs2043211
    National Category
    Medical and Health Sciences Genetics
    Research subject
    Medicine
    Identifiers
    urn:nbn:se:oru:diva-30985 (URN)10.1042/CS20120572 (DOI)000323852600009 ()23611467 (PubMedID)2-s2.0-84880141884 (ScopusID)
    Funder
    Swedish Heart Lung FoundationSwedish Research Council, 521-2009-4203 349-2007-8703
    Note

    Funding Agencies:

    Magnus Bergvalls Foundation

    Örebro University

    Available from: 2013-09-27 Created: 2013-09-27 Last updated: 2016-12-20Bibliographically approved
    4. CARD8, a protein of innate immunity regulates the release of inflammatory cytokines in human endothelial cells
    Open this publication in new window or tab >>CARD8, a protein of innate immunity regulates the release of inflammatory cytokines in human endothelial cells
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    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Basic Medicine
    Research subject
    Biomedicine
    Identifiers
    urn:nbn:se:oru:diva-54142 (URN)
    Available from: 2016-12-20 Created: 2016-12-20 Last updated: 2016-12-20Bibliographically approved
  • Public defence: 2017-02-01 10:15 Örebro universitet, Forumhuset, Biografen, Örebro
    Yang, Yishen
    Örebro University, Orebro University School of Business, Örebro University, Sweden.
    Yang, Yishen
    Örebro University, Orebro University School of Business, Örebro University, Sweden.
    On Rank-invariant Methods for Ordinal Data2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Data from rating scale assessments have rank-invariant properties only, which means that the data represent an ordering, but lack of standardized magnitude, inter-categorical distances, and linearity. Even though the judgments often are coded by natural numbers they are not really metric. The aim of this thesis is to further develop the nonparametric rank-based Svensson methods for paired ordinal data that are based on the rank-invariant properties only.

    The thesis consists of five papers. In Paper I the asymptotic properties of the measure of systematic disagreement in paired ordinal data, the Relative Position (RP), and the difference in RP between groups were studied. Based on the findings of asymptotic normality, two tests for analyses of change within group and between groups were proposed. In Paper II the asymptotic properties of rank-based measures, e.g. the Svensson’s measures of systematic disagreement and of additional individual variability were discussed, and a numerical method for approximation was suggested. In Paper III the asymptotic properties of the measures for paired ordinal data, discussed in Paper II, were verified by simulations. Furthermore, the Spearman rank-order correlation coefficient (rs) and the Svensson’s augmented rank-order agreement coefficient (ra) were compared. By demonstrating how they differ and why they differ, it is emphasized that they measure different things. In Paper IV the proposed test in Paper I for comparing two groups of systematic changes in paired ordinal data was compared with other nonparametric tests for group changes, both regarding different approaches of categorising changes. The simulation reveals that the proposed test works better for small and unbalanced samples. Paper V demonstrates that rank invariant approaches can also be used in analysis of ordinal data from multi-item scales, which is an appealing and appropriate alternative to calculating sum scores.

    List of papers
    1. Non-parametric analyses of change within group and between two groups of paired assessments on rating scales
    Open this publication in new window or tab >>Non-parametric analyses of change within group and between two groups of paired assessments on rating scales
    (English)Manuscript (preprint) (Other academic)
    National Category
    Probability Theory and Statistics
    Identifiers
    urn:nbn:se:oru:diva-54444 (URN)
    Available from: 2017-01-11 Created: 2017-01-11 Last updated: 2017-01-11Bibliographically approved
    2. Asymptotic distribution of rank-based measures for paired ordinal data and their use in interval estimations
    Open this publication in new window or tab >>Asymptotic distribution of rank-based measures for paired ordinal data and their use in interval estimations
    (English)Manuscript (preprint) (Other academic)
    National Category
    Probability Theory and Statistics
    Identifiers
    urn:nbn:se:oru:diva-54446 (URN)
    Available from: 2017-01-11 Created: 2017-01-11 Last updated: 2017-01-11Bibliographically approved
    3. Analysing inter-rater agreement: Spearman’s rank order correlation coefficient vs. Svensson’s augmented rank order agreement correlation
    Open this publication in new window or tab >>Analysing inter-rater agreement: Spearman’s rank order correlation coefficient vs. Svensson’s augmented rank order agreement correlation
    (English)Manuscript (preprint) (Other academic)
    National Category
    Probability Theory and Statistics
    Identifiers
    urn:nbn:se:oru:diva-54448 (URN)
    Available from: 2017-01-11 Created: 2017-01-11 Last updated: 2017-01-11Bibliographically approved
    4. Comparison of methods for comparing two groups of paired ordinal data
    Open this publication in new window or tab >>Comparison of methods for comparing two groups of paired ordinal data
    (English)Manuscript (preprint) (Other academic)
    National Category
    Probability Theory and Statistics
    Identifiers
    urn:nbn:se:oru:diva-54449 (URN)
    Available from: 2017-01-11 Created: 2017-01-11 Last updated: 2017-01-11Bibliographically approved
    5. The use of rank-invariant method in analysis of change in multiitem scales
    Open this publication in new window or tab >>The use of rank-invariant method in analysis of change in multiitem scales
    (English)Manuscript (preprint) (Other academic)
    National Category
    Probability Theory and Statistics
    Identifiers
    urn:nbn:se:oru:diva-54450 (URN)
    Available from: 2017-01-11 Created: 2017-01-11 Last updated: 2017-01-11Bibliographically approved
  • Public defence: 2017-02-03 09:00 Campus USÖ, hörsal C3, Örebro
    Barzangi, Jir
    Örebro University, School of Health Sciences.
    Barzangi, Jir
    Örebro University, School of Health Sciences.
    Infant Dental Enucleation in Sweden: Perspectives on a Practice among Residents of Eastern African Origin2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Infant dental enucleation (IDE) is a practice consisting of the removal of deciduous canine tooth buds in infants. Practiced mainly in Eastern Africa, the purpose is to treat or to prevent bodily symptoms and diseases. IDE can cause both general and oral complications. The occurrence of IDE among Eastern African immigrants in a few European countries has been reported. However, knowledge surrounding the practice in Sweden was poor. The overall aim of this work was to explore IDE in the Swedish context. Four studies were conducted. Paper I presents a review of scientific publications. An overview of IDE was gained, and some knowledge gaps were identified. Paper II describes a cross-sectional study to determine the prevalence of IDE in small children. Dental records of 1133 children (mean age 4.6 years, SD 1.4) from a multi-ethnic area were studied. Missing deciduous canines without any registered reason were documented. One or more deciduous canines were missing in 21% of the children with known Eastern African origin (n=101), compared to only three children in the rest of the population (n=1032). Six adults of Somali origin were interviewed to explore their experiences and perceptions of IDE (paper III). These experiences and perceptions were categorised in four essentially different ways: an effective and necessary treatment, a disputed tradition, an option to failure and a desperate measure. Their experiences and perceptions were found to be highly influenced by contexts. In the final study (paper IV), the knowledge, experiences and attitudes among dental and health care personnel were examined. Questionnaires were sent to licensed personnel working in emergency departments, midwifery and child health centres, school health services and public dental health services in ten municipalities. Less than 20% had any knowledge of IDE, while 12.5% of the respondents encountering children had seen at least one patient subjected to IDE. Different attitudes were reported between clinical settings regarding responsibilities and possibilities concerning the management and prevention of IDE. From the findings presented in this thesis, it was concluded that there is a need for initiatives to increase awareness of and knowledge on IDE among dental and health care professionals. Legally obligated responsibilities in these professions regarding IDE need to be clarified, and initiatives should include guidelines regarding both the management of IDE and its prevention in Sweden. Educational programmes should also be produced for residents of Eastern African origin to change their perceptions of IDE, and a culturally sensitive approach should be adopted to ensure that such programmes are effective.

    List of papers
    1. Infant dental enucleation: A literature review on a traditional remedial practice in East Africa
    Open this publication in new window or tab >>Infant dental enucleation: A literature review on a traditional remedial practice in East Africa
    2014 (English)In: Acta Odontologica Scandinavica, ISSN 0001-6357, Vol. 72, no 3, 168-178 p.Article, review/survey (Refereed) Published
    Abstract [en]

    Objective. To summarize and review the literature on infant dental enucleation, a traditional remedial procedure prevalent mainly in East Africa.

    Materials and methods. Literature searches were made electronically using general and specialized search engines. The main search was performed through a systematic strategy in PubMed, comprising tabulated keywords, search codes, and translated and transliterated terms. Criteria for the selection of studies were designed to provide a general understanding of the procedure. The findings were synthesized into two sections: a summary of the population prevalence studies, and a thematic literature review.

    Results. An overview of the known prevalence and clinical specifications was established. Insight was gained into the purpose of the procedure and the factors influencing its performance. Diverging suggestions were seen with regard to the rationale for use of infant dental enucleation between different populations. Moreover, reports of complications and consequences involving the general health and the dentoalveolar structures of patients were examined.

    Conclusions. Prevalence, clinical features and risks of infant dental enucleation point to a need for greater awareness of the procedure. Further, there is a need for specific guidelines regarding management of suspected cases within dental and healthcare communities.

    Place, publisher, year, edition, pages
    London: Informa Healthcare, 2014
    Keyword
    African traditional medicine, attitude to health, cuspid, post-operative complications, tooth germ surgery
    National Category
    Dentistry
    Research subject
    Medicine
    Identifiers
    urn:nbn:se:oru:diva-34848 (URN)10.3109/00016357.2013.817603 (DOI)000333047400002 ()
    Note

    Funding Agencies:

    Public Dental Health Organizations of the county of Västmanland, Sweden

    Public Dental Health Organizations of the county of Örebro, Sweden

    Available from: 2014-04-28 Created: 2014-04-25 Last updated: 2017-01-03Bibliographically approved
    2. Infant dental enucleation in an East African population in Sweden: a cross-sectional study on dental records
    Open this publication in new window or tab >>Infant dental enucleation in an East African population in Sweden: a cross-sectional study on dental records
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    2014 (English)In: International Journal of Paediatric Dentistry, ISSN 0960-7439, E-ISSN 1365-263X, Vol. 24, no 3, 209-214 p.Article in journal (Refereed) Published
    Abstract [en]

    Aim: To examine the prevalence of infant dental enucleation (IDE) of primary canines, an East African traditional remedial procedure, in a multiethnic population of children in Sweden.

    Design: A cross-sectional study was conducted of dental records of 1133 patients (mean age 4.6years, SD +/- 1.4) attending one public dental service clinic in Sweden. The clinic was located in an area with a large multiethnic community. All were born within the years 2002-2006 and had received a check-up in one of the years 2007-2009. A registry was made of missing primary canines where no reason could be found. In documented cases, information about ethnic origin was extracted. Statistical grouping was made according to known East African ethnicities.

    Results: At least 36 ethnicities were recorded. Twenty-four (2.1%) patients were missing one or more canines according to the criteria for IDE. Significant difference was seen when comparison was made between patients of known East African ethnicities, of whom 20.8% (21/101) manifested findings consistent with the criteria, and the rest of the population (3/1032; P<0.001).

    Conclusions: Prevalence of cases suggestive of IDE among patients of East African origin points to a need for increased awareness within dental and healthcare communities.

    Place, publisher, year, edition, pages
    Hoboken: Wiley-Blackwell, 2014
    Keyword
    NORTHERN UGANDA; WEST ETHIOPIA; CHILD HEALTH; MUTILATION; MORBIDITY; MORTALITY; MAASAI; SUDAN; EBINO; JUBA
    National Category
    Dentistry
    Research subject
    Medicine
    Identifiers
    urn:nbn:se:oru:diva-34940 (URN)10.1111/ipd.12063 (DOI)000333828800007 ()
    Note

    Funding Agency:

    Public Dental Services of Västmanland and Örebro in Sweden

    Available from: 2014-05-05 Created: 2014-05-05 Last updated: 2017-01-03Bibliographically approved
    3. Experiences and perceptions of infant dental enucleation among Somali immigrants in Sweden: A phenomenographic study
    Open this publication in new window or tab >>Experiences and perceptions of infant dental enucleation among Somali immigrants in Sweden: A phenomenographic study
    (Swedish)Manuscript (preprint) (Other academic)
    National Category
    Other Health Sciences
    Identifiers
    urn:nbn:se:oru:diva-54270 (URN)
    Available from: 2017-01-03 Created: 2017-01-03 Last updated: 2017-01-03Bibliographically approved
    4. Knowledge, experiences and attitudes of dental and health care personnel in Sweden towards infant dental enucleation
    Open this publication in new window or tab >>Knowledge, experiences and attitudes of dental and health care personnel in Sweden towards infant dental enucleation
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Health Sciences
    Identifiers
    urn:nbn:se:oru:diva-54271 (URN)
    Available from: 2017-01-03 Created: 2017-01-03 Last updated: 2017-01-03Bibliographically approved
  • Public defence: 2017-02-17 10:15 Örebro universitet, Hörsalen, Musikhögskolan, Örebro
    Sjöberg, Viktor
    Örebro University, School of Science and Technology, Örebro University, Sweden.
    Sjöberg, Viktor
    Örebro University, School of Science and Technology, Örebro University, Sweden.
    Utilization of waste materials for extraction of strategic metals: a biogeochemical approach2017Doctoral thesis, comprehensive summary (Other academic)
  • Public defence: 2017-03-03 13:00 Campus USÖ, hörsal C3, Örebro
    Melinder, Carren Anyango
    Örebro University, School of Medical Sciences.
    Melinder, Carren Anyango
    Örebro University, School of Medical Sciences.
    Physical and psychological characteristics in adolescence and risk of gastrointestinal disease in adulthood2017Doctoral thesis, comprehensive summary (Other academic)
  • Public defence: 2017-03-03 13:15 Örebro universitet, Forumhuset, Hörsal F, Örebro
    Nothhaft, Camilla
    Örebro University, School of Humanities, Education and Social Sciences, Örebro University, Sweden.
    Nothhaft, Camilla
    Örebro University, School of Humanities, Education and Social Sciences, Örebro University, Sweden.
    Moments of lobbying: an ethnographic study of meetings between lobbyists and politicians2017Doctoral thesis, monograph (Other academic)
  • Public defence: 2017-03-10 09:30 Campus USÖ, hörsal C3, Örebro
    Bergh, Cecilia
    Örebro University, School of Medical Sciences.
    Bergh, Cecilia
    Örebro University, School of Medical Sciences.
    Life-course influences on occurrence and outcome for stroke and coronary heart disease2017Doctoral thesis, comprehensive summary (Other academic)
  • Public defence: 2017-03-28 13:00 Örebro universitet, rum P201, Örebro
    Asiimwe, Edgar Napoleon
    Örebro University, Orebro University School of Business, Örebro University, Sweden.
    Asiimwe, Edgar Napoleon
    Örebro University, Orebro University School of Business, Örebro University, Sweden.
    On Emerging Mobile Learning Environments2017Doctoral thesis, comprehensive summary (Other academic)
  • Public defence: 2017-03-31 09:00 Örebro universitet, Prismahuset, Hörsal 2, Örebro
    Hugelius, Karin
    Örebro University, School of Health Sciences.
    Hugelius, Karin
    Örebro University, School of Health Sciences.
    Disaster response for recovery: survivor´s experiences, health and the use of disaster radio to promote health after disasters2017Doctoral thesis, comprehensive summary (Other academic)
  • Public defence: 2017-03-31 09:00 Campus USÖ, hörsal C3, Örebro
    Rasmussen, Gunlög
    Örebro University, School of Medical Sciences.
    Rasmussen, Gunlög
    Örebro University, School of Medical Sciences.
    Staphylococcus aureus bacteremia, molecular epidemiology and host immune response2017Doctoral thesis, comprehensive summary (Other academic)
  • Public defence: 2017-04-07 09:00 Campus USÖ, hörsal C3, Örebro
    Olsson, Emma
    Örebro University, School of Medical Sciences.
    Olsson, Emma
    Örebro University, School of Medical Sciences.
    Promoting health in premature infants: with special focus on skin-to-skin contact and development of valid pain assesment2017Doctoral thesis, comprehensive summary (Other academic)