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  • Nakeva von Mentzer, Cecilia
    The Listen-Say Test -: Assessment of speech processing in children 20152015Conference paper (Other academic)
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  • Nakeva von Mentzer, Cecilia
    et al.
    Hua, H
    Sundström, M
    Enqvist, K
    Hällgren, M
    Assessing Children’s Speech Processing Ability using a New Analytical Method: The Listen-Say Test2015In: Assessing Children’s Speech Processing Ability using a New Analytical Method: The Listen-Say Test., Uppsala, 2015Conference paper (Other academic)
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  • Nakeva von Mentzer, Cecilia
    et al.
    Sundström, M
    Enkvist, K
    Hällgren, M
    Talperception hos svenska normalhörande skolbarn i tyst och störande tal: effekt av fonetiska kontraster, ljudbakgrund och kön2015In: Audionomen : medlemstidning för Audionomföreningen, ISSN 1403-1272, no 3Article in journal (Other (popular science, discussion, etc.))
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  • Nakeva von Mentzer, Cecilia
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, The Swedish Institute for Disability Research.
    Lyxell, Björn
    Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, The Swedish Institute for Disability Research. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Department of Otorhinolaryngology in Linköping.
    Sahlén, Birgitta
    Linneaus Centre: Cognition, Communication & Learning, Lund University, Sweden.
    Dahlström, Örjan
    Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, The Swedish Institute for Disability Research.
    Lindgren, Magnus
    Linneaus Centre: Cognition, Communication & Learning, Lund University, Sweden.
    Ors, Marianne
    Linneaus Centre: Cognition, Communication & Learning, Lund University, Sweden.
    Kallioinen, Petter
    Stockholms universitet, Avdelningen för fonetik.
    Uhlén, Inger
    Karolinska University Hospital and Karolinska Institutet, Rosenlunds sjukhus, Stockholm, Sweden.
    The Phonics Approach in Swedish Children using Cochlear Implants or Hearing Aids: Inspecting Phonological Gain2014In: Journal of Communication Disorders, Deaf Studies & Hearing Aids, ISSN 2375-4427, Vol. 2, no 3, p. 117-Article in journal (Refereed)
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  • Kallioinen, Petter
    et al.
    Olofsson, Jonas
    Nakeva von Mentzer, Cecilia
    Department of Behavioral Sciences and Learning, Swedish Institute for Disability Research, Linkoping University, Linkoping, Sweden.
    Lindgren, Magnus
    Ors, Marianne
    Sahlén, Birgitta
    Lyxell, Björn
    Engström, Elisabet
    Uhlén, Inger
    Semantic Processing in Deaf and Hard-of-Hearing Children: Large N400 Mismatch Effects in Brain Responses, Despite Poor Semantic Ability2016In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 7, article id 1146Article in journal (Refereed)
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  • Eliasson, Ann-Christin
    et al.
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Holmström, Linda
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Aarne, Päivikki
    Karolinska Inst, Div Speech & Language Pathol, Dept CLINTEC, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Speech & Language Pathol, Stockholm, Sweden..
    Nakeva von Mentzer, Cecilia
    Uppsala universitet, Logopedi.
    Weiland, Ann-Louise
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Sjöstrand, Lena
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Forssberg, Hans
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Tedroff, Kristina
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Löwing, Kristina
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Efficacy of the small step program in a randomised controlled trial for infants below age 12 months with clinical signs of CP; a study protocol2016In: BMC Pediatrics, ISSN 1471-2431, E-ISSN 1471-2431, Vol. 16, article id 175Article in journal (Refereed)
    Abstract [en]

    Background: Children with cerebral palsy (CP) have life-long motor disorders, and they are typically subjected to extensive treatment throughout their childhood. Despite this, there is a lack of evidence supporting the effectiveness of early interventions aiming at improving motor function, activity, and participation in daily life. The study will evaluate the effectiveness of the newly developed Small Step Program, which is introduced to children at risk of developing CP during their first year of life. The intervention is based upon theories of early learning-induced brain plasticity and comprises important components of evidence-based intervention approaches used with older children with CP.

    Method and design: A two-group randomised control trial will be conducted. Invited infants at risk of developing CP due to a neonatal event affecting the brain will be randomised to either the Small Step Program or to usual care. They will be recruited from Astrid Lindgren Children's Hospital at regular check-up and included at age 3-8 months. The Small Step Program was designed to provide individualized, goal directed, and intensive intervention focusing on hand use, mobility, and communication in the child's own home environment and carried out by their parents who have been trained and coached by therapists. The primary endpoint will be approximately 35 weeks after the start of the intervention, and the secondary endpoint will be at 2 years of age. The primary outcome measure will be the Peabody Developmental Motor Scale (second edition). Secondary assessments will measure and describe the children's general and specific development and brain pathology. In addition, the parents' perspective of the program will be evaluated. General linear models will be used to compare outcomes between groups.

    Discussion: This paper presents the background and rationale for developing the Small-Step Program and the design and protocol of a randomized controlled trial. The aim of the Small Step Program is to influence development by enabling children to function on a higher level than if not treated by the program and to evaluate whether the program will affect parent's ability to cope with stress and anxiety related to having a child at risk of developing CP.

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  • Järnberg, Ulf
    et al.
    Department of Applied Environmental Science, ITM, Stockholm University.
    Holmström, Katrin
    Department of Applied Environmental Science, ITM, Stockholm University.
    van Bavel, Bert
    Örebro University, School of Science and Technology.
    Kärrman, Anna
    Örebro University, School of Science and Technology.
    Perfluoroalkylated acids and related compounds (PFAS) in the Swedish environment2007Report (Other academic)
    Abstract [sv]

    The perfluoroalkylated substances have gained increased attention among scientists and regulators during the last few years. In particular, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and similar perfluorinated alkylated acids are regarded as the most stable end products of various perfluoroalkylated substances and have been shown to be extremely stable, bioconcentrate and biomagnify and have several toxicological effects. The industrial chemistry of perfluoroalkylated substances is extremely diverse and includes almost all chemical functionalities from simple pure alkanes to complex co-polymers. Major usage of perfluoroalkylated products is related to polymeric compounds and the dominant release to the environment is from primary and secondary production plants which are lacking in the Nordic countries. The occurrence of elevated concentrations of perfluoroalkylated acids in Sweden is strongly related to urbanized areas and the most likely path into the aquatic environment is through sewage water, although atmospheric input is also possible via more volatile precursor compounds. Up to 40 times elevated concentrations were found in biota from urban areas compared to unpolluted areas. Lake Mälaren and lower parts of the river Helge å are examples of aqueous environments clearly contaminated by PFOS. One of several potential point sources in Sweden has been screened for PFOS. A firefighting training site was found to release PFOS to the local aqueous environment (wetland) where μg/l concentrations where found. Long chain (more than 8 C for sulfonates and 10 C or more for carboxylates) perfluoroalkylated acids are readily taken up by biota in aqueous environments and reach very high concentrations in predators at high trophic levels of aquatic food webs. Baltic guillemot egg showed an increasing trend in PFOS concentration from 20-30 ng/g by the end of sixties to more than 600 ng/g at present. Freshwater otter from various locations in Sweden showed concentrations similar to guillemot eggs and Baltic grey seal has extreme values up to ten times higher (21 μg/g sum of all acids 6-14 C, PFOS alone:11μg/g). Human exposure, as described by Swedish human blood levels, appears to be similar to most other countries. No extreme values were encountered which would indicate occupational exposure. An excessive consumption of freshwater fish may contribute to an increased exposure, but this could not be clearly verified. Occupational settings where exposure to precursor compounds can take place are present in Sweden and should be included in future studies. Industrial use of textile and leather impregnating formulations result in elevated concentrations of perfluorocarboylates in effluent water from sewage treatment plants. The relation between effluent and biota concentrations for an aquatic environment with this type of activity needs to be further described in particular for perfluoroalkyl carboxylates which are currently being discharged in Sweden. Exposure routes and distribution behavior are yet not completely described for many PFAS, in particular their precursors. Environmental levels, human levels and human exposure data are lacking for a wide variety of PFAS discussed in this report

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    Perfluoroalkylated acids and related compounds (PFAS) in the Swedish environment
  • Eriksson, Ulrika
    et al.
    Örebro University, School of Science and Technology.
    Haglund, Peter
    Umeå universitet, Kemiska institutionen.
    Kärrman, Anna
    Örebro University, School of Science and Technology.
    Screening of PFASs in sludge and water from waste water treatment plants2017Report (Other academic)
    Abstract [en]

    The purpose of this study was to assess the contribution from precursor compounds to the total amount of selected PFASs in water and sludge from Swedish waste water treatment plants, as a supplemental to previous studies of two persistent PFAS-classes; perfluorocarboxylic acids (PFCAs) and perfluorosulfonic acids (PFSAs). Compound classes added in this study were fluorotelomer sulfonic acids (FTSAs), polyfluoroalkyl phosphoric acid esters (PAPs), perfluoroalkyl phosphonic and phosphinic acids (PFPAs, PFPiAs), perfluoralkane sulfonamides (FOSAs), and sulfonamido ethanols (FOSEs), and also the intermediates fluorotelomer unsaturated carboxylic acids (FTUCAs) and the stable transformation products fluorotelomer carboxylic acids (FTCAs). Three waste water treatment plants were included; Gässlösa (Borås), Henriksdal (Stockholm) and Umeå. PFAS levels in sludge from 2012. 2014, and 2015, and in filtered effluent and influent water from 2015 are reported. Precursor compounds were detected in sludge and influent water from all three WWTPs. Levels of precursor compounds in sludge samples exceeded those of persistent PFASs. Increasing PFCA levels in the effluent water compared to the influent water was observed, especially for the short-chained PFCAs. Occurrence of precursor compounds in influent water and sludge indicate degradation of precursor compounds to persistent PFASs.

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    Screening of PFASs in sludge and water from waste water treatment plants
  • Karlsson, Therese
    et al.
    Kristinebergs marina forskningsstation, Institutionen för marina vetenskaper, Göteborgs universitet.
    Kärrman, Anna
    Örebro University, School of Science and Technology.
    Rotander, Anna
    Örebro University, School of Science and Technology.
    Hassellöv, Martin
    Kristinebergs marina forskningsstation, Institutionen för marina vetenskaper, Göteborgs universitet.
    Provtagningsmetoder för mikroplast >300 μm i ytvatten: En jämförelsestudie mellan pump och trål2018Report (Other academic)
    Abstract [en]

    Sampling and analyzing microplastics (MPs) comes with a unique set of challenges and currently a wide variety of methods are developed and applied. In order to facilitate future environmental monitoring we compared two methods that are often used for sampling MPs >300 μm; a manta trawl and a filtering pump. Six replicates per method were taken during calm weather conditions in the same location on the same day. The volume per replicate was 20 m3 for the pump and approximately 60 m3 for the trawl. Following analysis was done with visual sorting in a stereo microscope. The same person analyzed all samples and the anthropogenic particles were divided into eleven classification categories.

    In the pump samples zero to eight MPs were found per sample, rendering an arithmetic mean of 0.17 MPs/m3. In the trawl samples the numbers varied between 9 and 33 MPs, which corresponded to a significantly higher concentration per volume than the pump with an arithmetic mean of 0.32 MPs/m3. The results also indicated that in order to reach a statistical power of 60%, ten pump replicates would be needed to measure a difference between the examined area and an uncontaminated area. For the trawl a corresponding number of two replicates would be required. Alternatively a higher sample volume can be applied, which would render a higher certainty as the distribution data would approach a Gaussian distribution. A higher sampling volume would also lower the measurement uncertainty as it would decrease fluctuations in the counting statistics. Variations in measurement uncertainty between the methods was hypothesized to be primarily related to the differences in sample volume and could also be compensated through increasing the volume sampled, which would be somewhat faster than increasing the amount of replicates.

    The composition of MPs in the study varied between the replicates but mainly consisted of expanded cellular plastics, films, filaments and fragments. Each pump sample had on average 1.3 films and 0.33 expanded cellular plastics whereas each trawl sample had on average 2.5 films and 9.2 expanded cellular plastics. Per unit of volume the majority of the particles in the pump samples (40%) consisted of films, whereas the particles in the trawl predominantly consisted of expanded cellular plastics (46%). Expanded cellular plastics therefore seem to be sampled more efficiently by trawls, which could be because they float on top of the surface, the pump samples a bit lower in the surface water and the results in this study show that the sample compositions were more comparable for particles with more neutral buoyancy. Not enough particles were however obtained to allow for a more in-depth analysis of the compositional differences.

    The probability of false null-values increase with a lower true value of numbers of particles per sample and this starts to have a significantly negative effect below five particles per sample. Regardless of which method that is used it is therefore crucial to sample a sufficient number of particles (volume times concentration) suitable for comparing spatial, temporal or compositional differences.

    Background and purpose of the report

    Even if methods for sampling, extraction and identification of microplastics have developed rapidly during recent years several challenges remain. One of the challenges that remain is how to sample a group of contaminants that is as heterogeneous, both concerning shape and distribution, as microplastics. Additionally it is important to know to what extent results from different types of sampling devices can be compared. Here we compare two methods that are often used to sample microplastics above 300 μm in surface waters; a manta trawl and a pump. During one day (10th of October 2017) six replicates per sampling method was taken in the same spot in Gullmarsfjorden outside Lysekil. Through counting microplastics and other types of microlitter in the samples the aim was to compare differences between replicates and methods.

    This study was commissioned by the Swedish Environmental Protection Agency and the Swedish Agency for Marine and Water Management, as a step in the work to develop monitoring of microlitter.

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    Provtagningsmetoder för mikroplast
  • Rotander, Anna
    et al.
    Örebro University, School of Science and Technology.
    Kärrman, Anna
    Örebro University, School of Science and Technology.
    Microplastics in Södertälje: From Lake Mälaren to the Baltic Sea2019Report (Other academic)
    Abstract [en]

    Although an increasing number of studies in recent years have established that a significant amount of microplastics is continuously released into the marine environment, there is a lack of knowledge as to which sources contribute the most. Several studies suggest that the major sources are land-based and that the pollution is spread by fresh water systems before reaching the ocean [1-3]. Although the number of published articles on microplastics in the environment has increased dramatically in recent years, studies on fresh water environments are still scarce and reported to compose of less than 4% of all published studies associated with microplastics [4]. The purpose of this study was to evaluate how urban areas influence the emission of microplastics to the sea and if possible characterize sources of microplastics. The study was conducted in Södertälje and samples have been taken upstream from Södertälje in lake Mälaren, and downstream into the Baltic Sea. In addition to the human population,the area is affected by different types of industries. The Södertälje strait is well-defined and has few influents except from run-off from the city and industrial areas. Surface water was sampled on nine locations in the Södertälje strait, including two influents, on two occasions during the autumn of 2017. At six of these locations and during one occasion, sediment cores were also taken. Surface water was processed with a pump that sorted the particles into two fractions:>300 μm and 50-300 μm. The concentrations of anthropogenic particles (microplastics, fibers and other anthropogenic particles) were higher in all the surface water samples in the 50-300 μm fraction with a difference that varied between about a factor of 5 and a factor of 160. The levels of microplastics>300 μm in surface water varied between 0.1 and 1 particles / m3. The relatively low number of microplastics, in combination with variations in levels between the two replicate samples, make the study of point sources more difficult. The most common polymers were polyethylene and polypropylene based on infrared spectroscopy analysis. However, half of the particles tested could not be attributed to a polymer type and ended up in the category "unidentified polymer". A characteristically shaped red fragment was found in several of the surface water samples and the sediment samples,and was probably paint chips from for example antifouling paints. The microplastic concentrations in surface water were comparable with studies from the Baltic Sea, the Gullmar fjord and rivers in Nyköping and Trosa (Nyköpingsån, Kilaån, Sväraån and Trosaån), but lower compared to surface water in Gothenburg (Mölndalsån, Kvillebäcken, Säveån, Lärjeån and Stora ån). The occurrence of microplastics did not increase notably from the background level at the reference point Björkfjärden in Lake Mälaren to the beginning of the Södertälje strait (Snäckviken) with industries, boat traffic etc. and to central Södertälje (Maren) where Mälaren meets the Baltic Sea. Downstream the city center, a certain increase in occurrence could be distinguished in Igelstaviken with its larger industries and Södertälje harbor. The levels of microplastic then decreased further downstream out into the Baltic Sea. This was also seen 6 in the sediment samples, but in sediment one can see an increase in concentrations already in Snäckviken. The results indicate that there are point sources connected to Igelstaviken and Torpaviken, but their importance for the total emission of microplastics from land is not established. Both boat traffic, industries, and heating plants are connected to these locations. There are no known plastic manufacturers in these areas and it should therefore be investigated how much microplastics are released from other manufacturing industries. The sediment results show gradients with increasing levels in Södertäljeviken down to Igelsta, and then a gradually decreasing level downstream. The level of microplastic in sediment is higher in Oaxen representing the background level in the Baltic Sea compared to Björkfjärden representing the background level in lake Mälaren. This indicates an influence from Södertälje. More sediment samples need to be analyzed to ensure the difference since the variation of microplastic occurrence in sediment is not known.

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    Microplastics in Södertälje From Lake Mälaren to the Baltic Sea
  • Malmström, Joakim
    et al.
    Uppsala universitet, Historiska institutionen.
    Winton, Patrik
    Uppsala universitet, Historiska institutionen.
    Eliter i historien: en inledning2003In: Med börd, svärd och pengar: Eliters manifestation, maktutövning och reproduktion 1650-1900 / [ed] Gudrun Andersson, Esbjörn Larsson och Patrik Winton, Uppsala: Historiska institutionen, Uppsala universitet , 2003, p. 5-16Chapter in book (Other academic)
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  • Winton, Patrik
    Uppsala universitet, Historiska institutionen.
    Det sakrala nätverket: Biskop Andreas Rhyzelius väg till makten2003In: Med börd, svärd och pengar: Eliters manifestation, maktutövning och reproduktion 1650-1900 / [ed] Gudrun Andersson, Esbjörn Larsson och Patrik Winton, Uppsala: Historiska institutionen, Uppsala universitet , 2003, p. 83-104Chapter in book (Other academic)
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  • Fredriksson, Felicia
    et al.
    Örebro University, School of Science and Technology.
    Eriksson, Ulrika
    Örebro University, School of Science and Technology.
    Kärrman, Anna
    Örebro University, School of Science and Technology.
    Yeung, Leo
    Örebro University, School of Science and Technology.
    A Pilot Study of the Fluorinated Ingredient of Scotchgard Products and Their Levels in WWTP Sludge and Landfill Leachate from Sweden2020Report (Other academic)
    Abstract [en]

    This study performed by Örebro University on behalf of the Swedish Environmental Agency aims at assessing the occurrence and levels of the newly identified side-chain fluorinated polymers from an environmental perspective. The aims of present study are 1) to develop instrumental and extraction methods to measure the active ingredient of two Scotchgard products (two side-chain fluorinated polymers, hereafter referred to as Pre-2002 and Post-2002) in sludge and leachate samples from Swedish wastewater treatment plants and landfills; 2) to evaluate if Pre-2002 and Post-2002 may be responsible for the unidentified organofluorine in the sludge samples from our previous screening study reporting extractable organofluorine (EOF); and 3) to conduct a mass balance analysis on EOF and sum of 93 per- and polyfluoroalkyl substances (PFAS) including Pre-2002 and Post-2002 in the sludge and landfill leachate samples to assess the levels of unidentified EOF that potentially are other polymeric or non-polymeric PFAS.

    Levels of Pre-2002 and Post-2002 and EOF are reported for sludge samples from four wastewater treatment plants (Bergkvara in Torsås, Gässlösa in Borås, Henriksdal in Stockholm, and Öhn in Umeå) collected in 2015, and leachate samples from three different landfills (Atleverket in Örebro, Hässleholm Kretsloppscenter in Hässleholm, and Flishult in Vetlanda). Sludge samples from Gässlösa wastewater treatment plant collected between 2004 and 2016 (excluding 2005 and 2006) were analyzed to assess any temporal trends of the two side-chain fluorinated polymers (Pre-2002 and Post-2002). The present investigation reported levels of both Pre-2002 and Post-2002 in all sludge samples (158-2618 ng/g d.w.). Levels of Pre-2002 were always higher than those of Post-2002 in the same samples. A declining trend was observed for Pre-2002 in sludge samples from Gässlösa but no clear trend was noted for Post-2002. The concentrations of the Pre-2002 and Post-2002 in sludge were higher than the sum of 83 PFAS analyzed in the previous screening study. No relationship between number of people that the wastewater treatment plants served and the concentrations of EOF and Pre-2002 and Post-2002 could be observed. The concentrations of both EOF and Pre-2002 and Post-2002 seem to be more related to the types of industry located in that area. Only three of the five leachate samples showed detectable levels of Pre-2002. Post-2002 was not detected in any of the landfill leachates. The low levels could be due to that both compounds are strongly sorbed to particles, which indicates the fate and distribution of these compounds. For both the sludge and leachate samples, the quantified levels of Pre-2002 and Post-2002 only contributed to a minor part of the EOF. A high proportion of unknown EOF still remains and may be related to other polymeric or non-polar PFAS.

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    A Pilot Study of the Fluorinated Ingredient of Scotchgard Products and Their Levels in WWTP Sludge and Landfill Leachate from Sweden
  • Winton, Patrik
    Uppsala universitet, Historiska institutionen.
    Den politiserade predikstolen: debatten om krig mot Ryssland 1740-412007In: Gud, konung och undersåtar: Politisk predikan i Sverige under tidigmodern tid / [ed] Peter Ericsson, Uppsala: Historiska institutionen, Uppsala universitet , 2007, p. 195-230Chapter in book (Other academic)
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  • Winton, Patrik
    Uppsala universitet, Historiska institutionen.
    Den högsta maktens verkningskraft: statsskuld och politik i Sverige 1800-18152009In: Ett nödvändigt ont: Statsskuld och politik i Förenta Staterna och Sverige 1780-1870 / [ed] Max Edling & Patrik Winton, Uppsala: Historiska institutionen, Uppsala universitet , 2009, p. 71-127Chapter in book (Other academic)
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  • Winton, Patrik
    et al.
    Uppsala universitet, Historiska institutionen.
    Edling, Max
    Uppsala universitet, Historiska institutionen.
    Ett nödvändigt ont: statsskulden som historiskt fenomen2009In: Ett nödvändigt ont: Statsskuld och politik i Förenta Staterna och Sverige 1780-1870 / [ed] Max Edling & Patrik Winton, Uppsala: Historiska institutionen, Uppsala universitet , 2009, p. 9-28Chapter in book (Other academic)
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  • Winton, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Denmark and Sweden in the European Great Power System: 1720-17652012In: Revue d'histoire Nordique, ISSN 1778-9605, Vol. 14, p. 39-62Article in journal (Refereed)
    Abstract [en]

    This article compares the strategies the two Scandinavian states adopted in the European state system during the period 1720–65. Previous research has emphasized the difference in policies: Denmark sought neutrality and avoided war, while Sweden was involved in two wars. Inability of the Swedish political elite to adapt to a new position in the international state system has been presented as one major reason for the Swedish participation in wars. This article argues instead that the difference should be seen as a consequence of the assets the two states could offer the major powers. The Danish state’s resources were highly sought after, which meant that the government could gain advantages such as subsidies and territory without fighting wars, while the Swedish state had less to offer the major powers and was thus forced to commit to one major power and war in order to try and gain the same types of benefits as the Danish state.

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  • Winton, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    The political economy of Swedish absolutism: 1789–18092012In: European Review of Economic History, ISSN 1361-4916, E-ISSN 1474-0044, Vol. 16, no 4, p. 430-448Article in journal (Refereed)
    Abstract [en]

    This article examines the connections between struggles over fiscal institutions and political change in Sweden during the period 17891809. The political situation was characterized by a divided fiscal authority: the absolute king controlled how resources were spent while the Diet controlled the operations of the Bank of Sweden and the National Debt Office. This division affected fiscal policies and how the country financed its wars. During the Napoleonic Wars, the king was unwilling to negotiate a deal with the Diet that relinquished his spending control in exchange for greater revenues to fight the war. As a consequence, he was unable to mobilize the necessary resources, which led to the loss of Finland and to his dethronement through a coup dtat organized by the elite in 1809.

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  • Klein, Gunnar O.
    et al.
    Örebro University, Örebro University School of Business.
    Rosén, Anders
    Linköpings universitet.
    Det är dags för seriös diskussion och samverkan om antikroppstester vid Covid-192020Manuscript (preprint) (Other academic)
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    Det är dags för seriös diskussion och samverkan om antikroppstester vid Covid-19
  • Klein, Gunnar O.
    Örebro University, Örebro University School of Business.
    Om immunitetsintyg för Covid-19Manuscript (preprint) (Other (popular science, discussion, etc.))
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    Om immunitetsintyg för Covid-19
  • Amnå, Erik
    Örebro University, School of Humanities, Education and Social Sciences.
    När tilliten prövas: sex dygder2020In: Kurage, ISSN 2001-175X, no 35Article, review/survey (Other (popular science, discussion, etc.))
    Abstract [sv]

    Ökande populism och krympande utrymme för civilsamhället är frågor som idag står på fler och fler organisationers dagordningar. Nu är hög tid att reflektera över civilsamhällets roll för att bevara och utveckla demokratin. Här återger vi Erik Amnås anförande från Ledarskapsarenan, som arrangeras av Ideel Arena, i Sånga Säby, 30 januari 2020.

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    När tilliten prövas - sex dygder
  • Baianstovu, Rúna Í
    Örebro University, School of Law, Psychology and Social Work.
    Diversity as the Challenge of Democracy: A study of how the social welfare services, as a welfare bureaucracy and moral institution in society, understands and handles cultural diversity2012Other (Refereed)
    Abstract [en]

    Abstract Dissertation

     

    This dissertation deals with the how Swedish society is confronting the democratic challenge of fining ways to integrate individuals and groups with a diversity of cultural and religious beliefs and social practices. The ide that democracy must include all members of society is central in contemporary welfare states. In Sweden, this idea is closely related to a concept of social justice and equality. This means that this study deals with aspects of integration processes. Social service is one of the  societal institutions that institutionalises the moral conceptions of how life should be lived. Therefore, its function in the integrations processes mirrors the ethos of society as a whole. The chief characteristics of a democratic state is that it represents every member of society and that it is transparent, communicative, and reflexive. But this is not easily performed. The state may exercise oppression in the form of forced assimilation through the culturally detached design of law and policy, and with the politics of diversity, minority groups may exert internal oppression of vulnerable elements within the group. In this thesis, this tension expresses The Paradox of Democracy. Social workers deal with the paradox while handling society’s moral panic regarding “other’s” traditions that are perceived as difficult to comprehend. Therefore, there investigative work is of great importance in a society that aspires to treat all citizens as equals. But the framework for such investigations is narrow and tightly controlled. A qualitative change in the scope of social workers’ ability to work in the service of communicative action within the complex areas discussed in this study could be a step towards broadening and deepening democratic practices. When the public institutions take their clients’ wishes and needs seriously and treat them as indicators of the actual needs seriously, the public institutions can build a foundation for reciprocal and communicatively anchored integration work.

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    Diversity as a Challenge for Democracy - English Summary
  • Arunachalam, Ajay
    et al.
    Department of Computer Science, National Institute of Development Administration (NIDA), Bangkok, Thailand.
    Sornil, Ohm
    Department of Computer Science, National Institute of Development Administration (NIDA), Bangkok, Thailand.
    Issues of Implementing Random Walk and Gossip Based Resource Discovery Protocols in P2P MANETs & Suggestions for Improvement2015In: Procedia Computer Science, ISSN 1877-0509, E-ISSN 1877-0509, Vol. 57, p. 509-518Article in journal (Refereed)
    Abstract [en]

    Wireless multi-hop networks attracted much attention in recent years. Mobile Ad-hoc Network (MANET) being one of such networks has its own limitations in terms of resource discovery with unstable topology and paths through the networks. So eventually traditional searching techniques are still widely used. Peer-to-Peer (P2P) model is the major candidate for the internet traffic mainly due to its decentralized nature. This article evaluates classic flooding, random walk and gossip based resource discovery algorithms under mobile peer-to-peer (MP2P) networks and studied their performance. Further we suggest way to improve these algorithms to suit and work better under MANET. We compare the performance in terms of success rate, query response time, network overhead, battery power consumed, overall dropped packets, MAC load, network bandwidth, packet delivery ratio, network routing load and end to end delay. The experiments are validated through NS-2 simulations.

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    Issues of Implementing Random Walk and Gossip Based Resource Discovery Protocols in P2P MANETs & Suggestions for Improvement
  • Richter, Hans O.
    et al.
    Department of Occupational and Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Forsman, M.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Elcadi, G.H.
    Department of Health and Caring Sciences, Faculty of Health and Occupational Studies, University of Gävle, Gävle, Sweden.
    Brautaset, R.
    School of Optometry, Karolinska Institutet, Stockholm, Sweden.
    Marsh, John E.
    Environmental Psychology, Department of Building, Energy, and Environmental Engineering, University of Gävle, Gävle, Sweden; School of Psychology, University of Central Lancashire, Preston, United Kingdom.
    Zetterberg, C.
    Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Section of Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS2018In: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 12, article id 298Article in journal (Refereed)
    Abstract [en]

    Purpose: To extend our knowledge of the functional linkages between visual fatigue and regional cerebral prefrontal cortex (PFC) oxygenation, we measured time related hemodynamic changes over the right dorsolateral prefrontal cortex (dIPFC) during convergence load under conflicting stimulus-to-accommodation and stimulus-to-vergence eye movements with and without concurrent mental load.

    Methods: Twenty healthy participants with a median age of 28 years (range: 18-44 years) fixated upon a vertical bar presented separately to the left and right eyes, using polarized filters, during four counterbalanced 10-min periods: (i) no accommodation/vergence conflict (Control, Ctrl): (ii) added convergence load and accommodation/vergence conflict (Conv); (iii) added cognitive load only (Cog) and; (iv) a combination of added cognitive and convergence load and accommodation/vergence conflict (Cc). Viewing distance was 65 cm. Non-invasive measurements of hemodynamic activity over the dIPFC were quantified by functional near-infrared spectroscopy (fNIRS). During the two-convergence load conditions, the horizontal disparity of the two bars varied dynamically from no disparity to a disparity set 20% below the individual threshold for diplopia. Cognitive load was induced by the n-back-2 test which required the subject to memorize and recall the changing colors of the horizontal bars and decide when a given color was the same as that occurring two colors previously. fNIRS data were averaged over 10-s windows centered at 0, 2, 4, 6, 8, and 10 min of each task, subtracted from a 20-s baseline window immediately preceding the visual task, and then represented as changes in oxygenated hemoglobin (Delta HbO(2)), deoxygenated hemoglobin (Delta HHb) and total hemoglobin (Delta tHb).

    Results: Linear mixed model analyses showed that hemodynamic activity was systematically influenced by time (p < 0.001). The group-averaged time-related level of change across the viewing conditions did not differ when compared with one another (p > 0.05). Larger convergence eye-movement responses under conflicting stimulus-to-accommodation, and stimulus-to-vergence over time, increased Delta HbCO(2) and Delta tHb only in condition Cc and after 8 min of task time (p < 0.10 for min(-6) and min(-8): p < 0.05 for min(-10)).

    Discussion: Collectively, our data suggest that HbCO(2), HHb, and tHb, recorded over the dIPFC with fNIRS, can be used to assay the degree to which supervisory oculomotor control processes are activated during visually deficient near work.

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    Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS
  • Richter, Hans O.
    et al.
    Department of Occupational and Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Forsman, M.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Elcadi, G.H.
    Department of Health and Caring Sciences, Faculty of Health and Occupational Studies, University of Gävle, Gävle, Sweden.
    Brautaset, R.
    School of Optometry, Karolinska Institutet, Stockholm, Sweden.
    Marsh, John E.
    Environmental Psychology, Department of Building, Energy and Environmental Engineering, University of Gävle, Gävle; School of Psychology, University of Central Lancashire, Preston, United Kingdom.
    Zetterberg, C.
    Department of Occupational and Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Section of Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Corrigendum: Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS2018In: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 12, article id 384Article in journal (Other academic)
    Abstract [en]

    A Corrigendum on

    Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS

    by Richter, H. O., Forsman, M., Elcadi, G. H., Brautaset, R., Marsh, J. E., and Zetterberg, C. (2018). Front. Hum. Neurosci. 12:298. doi: 10.3389/fnhum.2018.00298

    In the original article, there was a mistake in Figure 5A (left panel) as published.

    Figure 5A (left panel) should show Ctrl Low convergence group, not Conv Low convergence group. The corrected Figure 5A (left panel) appears below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.

    The original article has been updated.

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    Corrigendum: Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS
  • Elcadi, Guilherme H.
    et al.
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Department of Community Medicine and Rehabilitation, Rehabilitation medicine, Umeå University, Umeå, Sweden.
    Forsman, Mikael
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Hallman, David M.
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Aasa, Ulrika
    Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
    Fahlstrom, Martin
    Department of Community Medicine and Rehabilitation, Rehabilitation medicine, Umeå University, Umeå, Sweden; Department of Clinical Sciences, Professional Development, Umeå University, Umeå, Sweden.
    Crenshaw, Albert G.
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Oxygenation and Hemodynamics Do Not Underlie Early Muscle Fatigue for Patients with Work-Related Muscle Pain2014In: PLoS ONE, E-ISSN 1932-6203, Vol. 9, no 4, article id e95582Article in journal (Refereed)
    Abstract [en]

    Patients suffering from work-related muscle pain (WRMP) fatigue earlier during exercise than healthy controls. Inadequate oxygen consumption and/ or inadequate blood supply can influence the ability of the muscles to withstand fatigue. However, it remains unknown if oxygenation and hemodynamics are associated with early fatigue in muscles of WRMP patients. In the present study we applied near-infrared spectroscopy (NIRS) on the extensor carpi radialis (ECR) and trapezius (TD) muscles of patients with WRMP (n = 18) and healthy controls (n = 17). Our objective was to determine if there were group differences in endurance times for a low-level contraction of 15% maximal voluntary contraction (MVC) -sustained for 12-13 min, and to see if these differences were associated with differences in muscle oxygenation and hemodynamics. At baseline, oxygen saturation (StO(2)%) was similar between groups for the ECR, but StO2% was significantly lower for TD for the WRMP patients (76%) compared to controls (85%) (P < 0.01). Also, baseline ECR blood flow was similar in the two groups. For both muscles there were a larger number of patients, compared to controls, that did not maintain the 15% MVC for the allotted time. Consequently, the endurance times were significantly shorter for the WRMP patients than controls (medians, ECR: 347 s vs. 582 s; TD: 430 s vs. 723 s respectively). Responses in StO(2)% during the contractions were not significantly different between groups for either muscle, i.e. no apparent difference in oxygen consumption. Overall, we interpret our findings to indicate that the early fatigue for our WRMP patients was not associated with muscle oxygenation and hemodynamics.

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    Oxygenation and Hemodynamics Do Not Underlie Early Muscle Fatigue for Patients with Work-Related Muscle Pain
  • Rasmussen, Joel
    et al.
    Örebro University, School of Humanities, Education and Social Sciences.
    Ewald, Jens
    Department of Economics, School of Business, Economics and Law, Gothenburg University, Gothenburg, Sweden.
    Sterner, Thomas
    Department of Economics, School of Business, Economics and Law, Gothenburg University, Gothenburg, Sweden.
    Gender and life-stage dependent reactions to the risk of radioactive contamination: A survey experiment in Sweden2020In: PLoS ONE, E-ISSN 1932-6203, Vol. 15, no 4, article id e0232259Article in journal (Refereed)
    Abstract [en]

    This article proposes and examines gender and life-stage factors as determinants of public worry and risk avoidance in a nuclear fallout scenario. Drawing on a survey (N 2,291) conducted in Sweden, the article demonstrates statistically significant results that women as well as parents with children at home are more likely to express high levels of worry for radiation exposure and have a preference to move away from a fallout area despite assurance of successful remediation. Moreover, a negative relationship is shown between age and both worry for radiation exposure and preference to move. These novel results from Northern Europe thus support a life-stage framing of public risk attitudes. As radiation physicists develop new methods showing that women and children are at higher risk of cancer than other groups at the same radiation exposure, we may actually see the precaution among women and parents as a regulating mechanism for the higher objective risk they face. The results are moreover in agreement with studies of public risk reactions in Japan, creating a strong knowledge base that human-induced radiation pollution is largely an intolerable risk to the public. Considering the public opinion, managing an intolerable risk through risk mitigation by remediation alone is likely insufficient in many cases. A viable strategy would offer a range of social support options that enable individual decision-making and the protection of risk groups.

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    Gender and life-stage dependent reactions to the risk of radioactive contamination: A survey experiment in Sweden
  • Kärrman, Anna
    et al.
    Örebro University, School of Science and Technology.
    Wang, Thanh
    Örebro University, School of Science and Technology.
    Kallenborn, Roland
    Langseter, Anne Marie
    Grønhovd, Siri Merete
    Ræder, Erik Magnus
    Lyche, Jan Ludvig
    Yeung, Leo W. Y.
    Örebro University, School of Science and Technology.
    Chen, Fangfang
    Eriksson, Ulrika
    Örebro University, School of Science and Technology.
    Aro, Rudolf
    Örebro University, School of Science and Technology.
    Fredriksson, Felicia
    PFASs in the Nordic environment: Screening of Poly- and Perfluoroalkyl Substances (PFASs) and Extractable Organic Fluorine (EOF) in the Nordic Environment2019Report (Refereed)
    Abstract [en]

    This report describes a screening study of in all ninety-nine conventional and emerging per- and polyfluoroalkyl substances (PFASs) in the Nordic environment. In addition, extractable organic fluorine (EOF) was analysed. The latter can provide the amount, but not identity, of organofluorine in the samples, which in turn can be used to assess the mass balance between known and unknown PFASs. The study was initiated by the Nordic Screening Group and funded by these and the Nordic Council of Ministers through the Chemicals Group. A total of 102 samples were analyzed in this study, including bird eggs, fish, marine mammals, terrestrial mammals, surface water, WWTP effluents and sludge, and air. Samples were collected by institutes from the participating countries and self-governing areas; Denmark, Faroe Islands, Finland, Greenland, Iceland, Norway, and Sweden.

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    PFASs in the Nordic environment
  • Public defence: 2020-06-11 09:00 Örebro universitet, Campus USÖ, hörsal C1, Örebro
    Zhang, Xueli
    Örebro University, School of Medical Sciences.
    Biomarkers for Diagnosis, Therapy and Prognosis in Colorectal Cancer: a study from databases, machine learning predictions to laboratory confirmations2020Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Early diagnosis and better therapy response have been believed to be associated with better prognosis. CRC biomarkers are considered as precise indicators for the early diagnosis and better therapy response. It is, therefore, of importance to find out, analyze and evaluate the CRC biomarkers to further provide the more precis evidence for predicting novel potential biomarkers and eventually to improve early diagnosis, personalized therapy and prognosis for CRC.

    In this study, we started with creating and establishing a CRC biomarker database. (CBD: http://sysbio.suda.edu.cn/CBD/index.html) In the CBD database, there were 870 reported CRC biomarkers collected from the published articles in PubMed. In this version of the CBD, CRC biomarker data was carefully collected, sorted, displayed, and analyzed. The major applications of the CBD are to provide 1) the records of CRC biomarkers (DNA, RNA, protein and others) concerning diagnosis, treatment and prognosis; 2) the basic and clinical research information concerning the CRC biomarkers; 3) the primary results for bioinformatics and biostatics analysis of the CRC biomarkers; 4) downloading/uploading the biomedicine information for CRC biomarkers.

    Based on our CBD and other public databases, we further analyzed the presented CRC biomarkers (DNAs, RNAs, proteins) and predicted novel potential multiple biomarkers (the combination of single biomarkers) with biological networks and pathways analysis for diagnosis, therapy response and prognosis in CRC. We found several hub biomarkers and key pathways for the diagnosis, treatment and prognosis in CRC. Receiver operating characteristic (ROC) test and survival analysis by microarray data revealed that multiple biomarkers could be better biomarkers than the single biomarkers for the diagnosis and prognosis of CRC.

    There are 62 diagnosis biomarkers for colon cancer in our CBD. In the previous studies, we found these present biomarkers were not enough to improve significantly the diagnosis of colon cancer. In order to find out novel biomarkers for the colon cancer diagnosis, we have performed /machine learning (ML) techniques such as support vector machine (SVM) and regression tree to predict candidate to discover diagnostic biomarkers for colon cancer. Based on the protein-protein interaction (PPI) network topology features of the identified biomarkers, we found 12 protein biomarkers which were considered as the candidate colon cancer diagnosis biomarkers. Among these protein biomarkers Chromogranin-A (CHGA)  was the most powerful biomarker, which showed good performance in bioinformatics test and Immunohistochemistry(IHC). We are now expanding this study to CRC.

    Expression of CHGA protein in colon cancer was further verified with a novel logistic regressionbased meta-analysis, and convinced as a valuable diagnostic biomarker as compared with the typical diagnostic biomarkers, such as TP53, KRAS and MKI67.

    microRNAs (miRNAs/miRs) have been considered as potential biomarkers. A novel miRNA-mRNA interaction network-based model was used to predict miRNA biomarkers for CRC and found that miRNA-186-5p, miRNA-10b-5p and miRNA-30e-5p might be the novel biomarkers for CRC diagnosis. In conclusion, we have created a useful CBD database for CRC biomarkers and provided detailed information for how to use the CBD in CRC biomarker investigations. Our studies have been focusing on the biomarkers in diagnosis, therapy and prognosis. Based on our CBD and other powerful cancer associated databases, ML has been used to analyze the characteristics of the CRC biomarkers and predict novel potential CRC biomarkers. The predicted potential biomarkers were further confirmed at biomedical laboratory.

    List of papers
    1. CBD: a biomarker database for colorectal cancer
    Open this publication in new window or tab >>CBD: a biomarker database for colorectal cancer
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    2018 (English)In: Database: The Journal of Biological Databases and Curation, ISSN 1758-0463, E-ISSN 1758-0463, article id bay046Article in journal (Refereed) Published
    Abstract [en]

    Colorectal cancer (CRC) biomarker database (CBD) was established based on 870 identified CRC biomarkers and their relevant information from 1115 original articles in PubMed published from 1986 to 2017. In this version of the CBD, CRC biomarker data were collected, sorted, displayed and analysed. The CBD with the credible contents as a powerful and time-saving tool provide more comprehensive and accurate information for further CRC biomarker research. The CBD was constructed under MySQL server. HTML, PHP and JavaScript languages have been used to implement the web interface. The Apache was selected as HTTP server. All of these web operations were implemented under the Windows system. The CBD could provide to users the multiple individual biomarker information and categorized into the biological category, source and application of biomarkers; the experiment methods, results, authors and publication resources; the research region, the average age of cohort, gender, race, the number of tumours, tumour location and stage. We only collect data from the articles with clear and credible results to prove the biomarkers are useful in the diagnosis, treatment or prognosis of CRC. The CBD can also provide a professional platform to researchers who are interested in CRC research to communicate, exchange their research ideas and further design high-quality research in CRC. They can submit their new findings to our database via the submission page and communicate with us in the CBD.

    Place, publisher, year, edition, pages
    Oxford University Press, 2018
    National Category
    Bioinformatics (Computational Biology) Cancer and Oncology
    Identifiers
    urn:nbn:se:oru:diva-68074 (URN)10.1093/database/bay046 (DOI)000436293800001 ()29846545 (PubMedID)
    Funder
    Swedish Cancer SocietySwedish Research Council
    Available from: 2018-07-25 Created: 2018-07-25 Last updated: 2020-05-18Bibliographically approved
    2. Potential Applications of DNA, RNA and Protein Biomarkers in Diagnosis, Therapy and Prognosis for Colorectal Cancer: A Study from Databases to AI-Assisted Verification
    Open this publication in new window or tab >>Potential Applications of DNA, RNA and Protein Biomarkers in Diagnosis, Therapy and Prognosis for Colorectal Cancer: A Study from Databases to AI-Assisted Verification
    2019 (English)In: Cancers, ISSN 2072-6694, Vol. 11, no 2, article id 172Article in journal (Refereed) Published
    Abstract [en]

    In order to find out the most valuable biomarkers and pathways for diagnosis, therapy and prognosis in colorectal cancer (CRC) we have collected the published CRC biomarkers and established a CRC biomarker database (CBD: http://sysbio.suda.edu.cn/CBD/index.html). In this study, we analysed the single and multiple DNA, RNA and protein biomarkers as well as their positions in cancer related pathways and protein-protein interaction (PPI) networks to describe their potential applications in diagnosis, therapy and prognosis. CRC biomarkers were collected from the CBD. The RNA and protein biomarkers were matched to their corresponding DNAs by the miRDB database and the PubMed Gene database, respectively. The PPI networks were used to investigate the relationships between protein biomarkers and further detect the multiple biomarkers. The Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Ontology (GO) annotation were used to analyse biological functions of the biomarkers. AI classification techniques were utilized to further verify the significances of the multiple biomarkers in diagnosis and prognosis for CRC. We showed that a large number of the DNA, RNA and protein biomarkers were associated with the diagnosis, therapy and prognosis in various degrees in the CRC biomarker networks. The CRC biomarkers were closely related to the CRC initiation and progression. Moreover, the biomarkers played critical roles in cellular proliferation, apoptosis and angiogenesis and they were involved in Ras, p53 and PI3K pathways. There were overlaps among the DNA, RNA and protein biomarkers. AI classification verifications showed that the combined multiple protein biomarkers played important roles to accurate early diagnosis and predict outcome for CRC. There were several single and multiple CRC protein biomarkers which were associated with diagnosis, therapy and prognosis in CRC. Further, AI-assisted analysis revealed that multiple biomarkers had potential applications for diagnosis and prognosis in CRC.

    Place, publisher, year, edition, pages
    MDPI, 2019
    Keywords
    DNA, RNA, protein, single-biomarkers, multiple-biomarkers, cancer-related pathways, colorectal cancer
    National Category
    Cancer and Oncology
    Identifiers
    urn:nbn:se:oru:diva-73340 (URN)10.3390/cancers11020172 (DOI)000460747200046 ()30717315 (PubMedID)2-s2.0-85062386858 (Scopus ID)
    Funder
    Swedish Cancer SocietySwedish Research Council
    Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2020-05-18Bibliographically approved
    3. Loss of CHGA protein as a potential biomarker for colon cancer diagnosis: a study on biomarker discovery by machine learning and confirmation by immunohistochemistry in colorectal cancer tissue microarrays
    Open this publication in new window or tab >>Loss of CHGA protein as a potential biomarker for colon cancer diagnosis: a study on biomarker discovery by machine learning and confirmation by immunohistochemistry in colorectal cancer tissue microarrays
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    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Basic Medicine
    Identifiers
    urn:nbn:se:oru:diva-81935 (URN)
    Available from: 2020-05-18 Created: 2020-05-18 Last updated: 2020-05-18Bibliographically approved
    4. Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients
    Open this publication in new window or tab >>Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients
    2019 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, no 12, article id 2919Article in journal (Refereed) Published
    Abstract [en]

    Colon cancer is one of the major causes of cancer death worldwide. The five-year survival rate for the early-stage patients is more than 90%, and only around 10% for the later stages. Moreover, half of the colon cancer patients have been clinically diagnosed at the later stages. It is; therefore, of importance to enhance the ability for the early diagnosis of colon cancer. Taking advantages from our previous studies, there are several potential biomarkers which have been associated with the early diagnosis of the colon cancer. In order to investigate these early diagnostic biomarkers for colon cancer, human chromogranin-A (CHGA) was further analyzed among the most powerful diagnostic biomarkers. In this study, we used a logistic regression-based meta-analysis to clarify associations of CHGA expression with colon cancer diagnosis. Both healthy populations and the normal mucosa from the colon cancer patients were selected as the double normal controls. The results showed decreased expression of CHGA in the early stages of colon cancer as compared to the normal controls. The decline of CHGA expression in the early stages of colon cancer is probably a new diagnostic biomarker for colon cancer diagnosis with high predicting possibility and verification performance. We have also compared the diagnostic powers of CHGA expression with the typical oncogene KRAS, classic tumor suppressor TP53, and well-known cellular proliferation index MKI67, and the CHGA showed stronger ability to predict early diagnosis for colon cancer than these other cancer biomarkers. In the protein-protein interaction (PPI) network, CHGA was revealed to share some common pathways with KRAS and TP53. CHGA might be considered as a novel, promising, and powerful biomarker for early diagnosis of colon cancer.

    Place, publisher, year, edition, pages
    MDPI, 2019
    Keywords
    CHGA, colon cancer, biomarker, early diagnosis, logistic regression, meta-analysis, PPI
    National Category
    Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
    Identifiers
    urn:nbn:se:oru:diva-75234 (URN)10.3390/ijms20122919 (DOI)000473756000069 ()31207989 (PubMedID)2-s2.0-85068403124 (Scopus ID)
    Funder
    Swedish Cancer SocietySwedish Research Council
    Available from: 2019-07-25 Created: 2019-07-25 Last updated: 2020-05-18Bibliographically approved
    5. Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications
    Open this publication in new window or tab >>Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications
    2020 (English)In: Cancers, ISSN 2072-6694, Vol. 12, no 2, article id E341Article in journal (Refereed) Published
    Abstract [en]

    Colorectal cancer (CRC) is one of the major causes of cancer death worldwide. In general, early diagnosis for CRC and individual therapy have led to better survival for the cancer patients. Accumulating studies concerning biomarkers have provided positive evidence to improve cancer early diagnosis and better therapy. It is, however, still necessary to further investigate the precise biomarkers for cancer early diagnosis and precision therapy and predicting prognosis. In this study, AI-assisted systems with bioinformatics algorithm integrated with microarray and RNA sequencing (RNA-seq) gene expression (GE) data has been approached to predict microRNA (miRNA) biomarkers for early diagnosis of CRC based on the miRNA-messenger RNA (mRNA) interaction network. The relationships between the predicted miRNA biomarkers and other biological components were further analyzed on biological networks. Bayesian meta-analysis of diagnostic test was utilized to verify the diagnostic value of the miRNA candidate biomarkers and the combined multiple biomarkers. Biological function analysis was performed to detect the relationship of candidate miRNA biomarkers and identified biomarkers in pathways. Text mining was used to analyze the relationships of predicted miRNAs and their target genes with 5-fluorouracil (5-FU). Survival analyses were conducted to evaluate the prognostic values of these miRNAs in CRC. According to the number of miRNAs single regulated mRNAs (NSR) and the number of their regulated transcription factor gene percentage (TFP) on the miRNA-mRNA network, there were 12 promising miRNA biomarkers were selected. There were five potential candidate miRNAs (miRNA-186-5p, miRNA-10b-5, miRNA-30e-5p, miRNA-21 and miRNA-30e) were confirmed as CRC diagnostic biomarkers, and two of them (miRNA-21 and miRNA-30e) were previously reported. Furthermore, the combinations of the five candidate miRNAs biomarkers showed better prediction accuracy for CRC early diagnosis than the single miRNA biomarkers. miRNA-10b-5p and miRNA-30e-5p were associated with the 5-FU therapy resistance by targeting the related genes. These miRNAs biomarkers were not statistically associated with CRC prognosis.

    Place, publisher, year, edition, pages
    MDPI, 2020
    Keywords
    CRC, biomarkers, diagnosis, miRNA, network models
    National Category
    Cancer and Oncology
    Identifiers
    urn:nbn:se:oru:diva-79936 (URN)10.3390/cancers12020341 (DOI)000522477300087 ()32028703 (PubMedID)2-s2.0-85079242365 (Scopus ID)
    Funder
    Swedish Cancer Society, CAN 2016/341Swedish Research Council Formas, 2016-01098
    Available from: 2020-02-20 Created: 2020-02-20 Last updated: 2020-05-18Bibliographically approved
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    Biomarkers for Diagnosis, Therapy and Prognosis in Colorectal Cancer: a study from databases, machine learning predictions to laboratory confirmations
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  • Wide, Sverre
    Sociologisk Forskning 2014:22014Collection (editor) (Refereed)
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    Sociologisk Forskning 2014:2
  • Wide, Sverre
    Sociologisk Forskning 2015:12015Collection (editor) (Refereed)
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    Sociologisk Forskning 2015:1
  • Wide, Sverre
    Sociologisk Forskning 2015:22015Collection (editor) (Refereed)
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    Sociologisk Forskning 2015:2
  • Wide, Sverre
    Sociologisk Forskning 2016:12016Collection (editor) (Refereed)
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    Sociologisk Forskning 2016:1
  • Wide, Sverre
    Sociologisk Forskning 2015:42015Collection (editor) (Refereed)
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    Sociologisk Forskning 2015:4
  • Wide, Sverre
    Sociologisk Forskning 2015:32015Collection (editor) (Refereed)
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    Sociologisk Forskning 2015:3
  • Wide, Sverre
    Sociologisk Forskning 2016:22016Collection (editor) (Refereed)
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    Sociologisk Forskning 2016:2
  • Wide, Sverre
    Sociologisk Forskning 2016:32016Collection (editor) (Refereed)
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    Sociologisk Forskning 2016:3
  • Wide, Sverre
    Sociologisk Forskning 2016:42016Collection (editor) (Refereed)
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    Sociologisk Forskning 2016:4
  • Mjöberg, Jessica
    et al.
    Dalarna University, Falun, Sweden.
    Wide, Sverre
    Örebro University, School of Humanities, Education and Social Sciences.
    Aktörer, observatörer, deltagare: Om experiment, självkunskap och det socialas in- och utsida2012In: En gestalt, många berättelser: En vänbok till Lars-Erik Berg / [ed] Jessica Mjöberg och Anette Lundin, Skövde: Institutionen för teknik och samhälle, Högskolan i Skövde , 2012, p. 160-187Chapter in book (Refereed)
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    Aktörer, observatörer, deltagare: Om experiment, självkunskap och det socialas in- och utsida
  • Wide, Sverre
    School of Education, Health and Social Studies, Dalarna University, Swe.
    Causation and reason: R.G. Collingwood and causal analysis as the essence of social thinking2017In: Distinktion Scandinavian Journal of Social Theory, ISSN 1600-910X, E-ISSN 2159-9149, Vol. 18, no 2, p. 173-195Article in journal (Refereed)
    Abstract [en]

    How are we to understand causal relations and analysis in social science? This paper takes R. G. Collingwood’s writing about causation as its point of departure for the answering of this question. Two different kinds of causal relations are distinguished from pseudo-causality; of the former, one is directly connected to reason, the other to our ability to manipulate the world. Their interconnection and significance are discussed and th econclusions are drawn that (a) causality belongs to the realm of human praxis and that (b) causal analysis proper is well suited forthe social sciences. It is further showed that some important explanations are not causal in any of the above-mentioned senses. These explanations could conceivably be called interpretative descriptions, but it is suggested that perhaps they can be understood as examples of causa sui, of something selfcaused.

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    Causation and reason: R. G. Collingwood and causal analysis as the essence of social thinking
  • Wide, Sverre
    En Kaj Håkanson-bibliografi till år 20082008In: n()n()a()g()e()n()t() : om kunskap, kärlek och ingenting särskiljt: en vänbok till Kaj Håkanson / [ed] Palm, Fredirk; Misheva, Vessela; Wide, Sverre, Uppsala, Sweden: Uppsala University, 2008, p. 26-40Chapter in book (Refereed)
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    En Kaj Håkanson-bibliografi till år 2008
  • Wide, Sverre
    Inledning2008In: n()n()a()g()e()n()t(): om kunskap, kärlek och ingenting särskiljt: En vänbok till Kaj Håkanson / [ed] Wide, Sverre; Palm, Fredrik; Misheva, Vessela, Uppsala, Sweden: Uppsala University, 2008, p. 7-10Chapter in book (Other academic)
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    Inledning
  • Wide, Sverre
    Dalarna University, Sweden.
    Max Scheler på norska?: Om ursprunget till "Deltakar og tilskodar"2017In: Norsk sosiologisk tidsskrift, ISSN 1590-7929, E-ISSN 1936-4660, Vol. 1, no 5, p. 365-379, article id 05-02Article in journal (Refereed)
    Abstract [en]

    Hans Skjervheim was one of the most influential philosophers of social science in the Scandinavian countries during the twentieth century. This paper contributes to the understanding of one of his central meta-scientific distinctions – between the participant and the spectator – by relating him to surprisingly similar distinctions found in the works of Max Scheler. It is well-known that Skjervheim studied Scheler, but the latter’s direct (and partly unacknowledged) influence on Skjervheim’s central distinction has not been noticed. Through an examination of similarities between Skjervheim and Scheler, an interpretation of Skjervheim is reached, which renders, so the paper additionally argues, some contemporary criticism of his work less valid than might be thought.

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    Max Scheler på norska?: Om ursprunget till "Deltakar og tilskodar"
  • Wide, Sverre
    Dalarna University, Sweden.
    Recension av: Sociologi genom litteratur: Skönlitteraturens begränsningar och samhällsvetenskapernas förutsättningar. Christofer Edling & Jens Rydgren (red.)2016In: Sociologisk forskning, ISSN 0038-0342, Vol. 53, no 1, p. 92-94Article, book review (Refereed)
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    Sociologi genom litteratur: Skönlitteraturens möjligheter och samhällsvetenskapernas begränsningar. Christofer Edling & Jens Rydgren (red.). Lund: Arkiv, 2015 [Recension]
  • Wide, Sverre
    Redaktören har ordet2016In: Sociologisk forskning, ISSN 0038-0342, Vol. 53, no 4, p. 343-343Article in journal (Other academic)
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    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2016In: Sociologisk forskning, ISSN 0038-0342, Vol. 53, no 3, p. 225-225Article in journal (Other academic)
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    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2016In: Sociologisk forskning, ISSN 0038-0342, Vol. 53, no 2, p. 99-99Article in journal (Other academic)
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    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2015In: Sociologisk forskning, ISSN 0038-0342, Vol. 52, no 4, p. 319-319Article in journal (Other academic)
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    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2015In: Sociologisk forskning, ISSN 0038-0342, Vol. 52, no 2, p. 107-108Article in journal (Other academic)
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    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2015In: Sociologisk forskning, ISSN 0038-0342, Vol. 52, no 1, p. 3-4Article in journal (Other academic)
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    Redaktören har ordet