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  • Winton, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    Denmark and Sweden in the European Great Power System: 1720-17652012Inngår i: Revue d'histoire Nordique, ISSN 1778-9605, Vol. 14, s. 39-62Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article compares the strategies the two Scandinavian states adopted in the European state system during the period 1720–65. Previous research has emphasized the difference in policies: Denmark sought neutrality and avoided war, while Sweden was involved in two wars. Inability of the Swedish political elite to adapt to a new position in the international state system has been presented as one major reason for the Swedish participation in wars. This article argues instead that the difference should be seen as a consequence of the assets the two states could offer the major powers. The Danish state’s resources were highly sought after, which meant that the government could gain advantages such as subsidies and territory without fighting wars, while the Swedish state had less to offer the major powers and was thus forced to commit to one major power and war in order to try and gain the same types of benefits as the Danish state.

    Fulltekst (pdf)
    FULLTEXT01
  • Winton, Patrik
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of History.
    The political economy of Swedish absolutism: 1789–18092012Inngår i: European Review of Economic History, ISSN 1361-4916, E-ISSN 1474-0044, Vol. 16, nr 4, s. 430-448Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article examines the connections between struggles over fiscal institutions and political change in Sweden during the period 17891809. The political situation was characterized by a divided fiscal authority: the absolute king controlled how resources were spent while the Diet controlled the operations of the Bank of Sweden and the National Debt Office. This division affected fiscal policies and how the country financed its wars. During the Napoleonic Wars, the king was unwilling to negotiate a deal with the Diet that relinquished his spending control in exchange for greater revenues to fight the war. As a consequence, he was unable to mobilize the necessary resources, which led to the loss of Finland and to his dethronement through a coup dtat organized by the elite in 1809.

    Fulltekst (pdf)
    FULLTEXT01
  • Klein, Gunnar O.
    et al.
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    Rosén, Anders
    Linköpings universitet.
    Det är dags för seriös diskussion och samverkan om antikroppstester vid Covid-192020Manuskript (preprint) (Annet vitenskapelig)
    Fulltekst (pdf)
    Det är dags för seriös diskussion och samverkan om antikroppstester vid Covid-19
  • Klein, Gunnar O.
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    Om immunitetsintyg för Covid-19Manuskript (preprint) (Annet (populærvitenskap, debatt, mm))
    Fulltekst (pdf)
    Om immunitetsintyg för Covid-19
  • Arunachalam, Ajay
    et al.
    Department of Computer Science, National Institute of Development Administration (NIDA), Bangkok, Thailand.
    Sornil, Ohm
    Department of Computer Science, National Institute of Development Administration (NIDA), Bangkok, Thailand.
    Issues of Implementing Random Walk and Gossip Based Resource Discovery Protocols in P2P MANETs & Suggestions for Improvement2015Inngår i: Procedia Computer Science, ISSN 1877-0509, E-ISSN 1877-0509, Vol. 57, s. 509-518Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Wireless multi-hop networks attracted much attention in recent years. Mobile Ad-hoc Network (MANET) being one of such networks has its own limitations in terms of resource discovery with unstable topology and paths through the networks. So eventually traditional searching techniques are still widely used. Peer-to-Peer (P2P) model is the major candidate for the internet traffic mainly due to its decentralized nature. This article evaluates classic flooding, random walk and gossip based resource discovery algorithms under mobile peer-to-peer (MP2P) networks and studied their performance. Further we suggest way to improve these algorithms to suit and work better under MANET. We compare the performance in terms of success rate, query response time, network overhead, battery power consumed, overall dropped packets, MAC load, network bandwidth, packet delivery ratio, network routing load and end to end delay. The experiments are validated through NS-2 simulations.

    Fulltekst (pdf)
    Issues of Implementing Random Walk and Gossip Based Resource Discovery Protocols in P2P MANETs & Suggestions for Improvement
  • Richter, Hans O.
    et al.
    Department of Occupational and Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Forsman, M.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Elcadi, G.H.
    Department of Health and Caring Sciences, Faculty of Health and Occupational Studies, University of Gävle, Gävle, Sweden.
    Brautaset, R.
    School of Optometry, Karolinska Institutet, Stockholm, Sweden.
    Marsh, John E.
    Environmental Psychology, Department of Building, Energy, and Environmental Engineering, University of Gävle, Gävle, Sweden; School of Psychology, University of Central Lancashire, Preston, United Kingdom.
    Zetterberg, C.
    Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Section of Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS2018Inngår i: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 12, artikkel-id 298Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: To extend our knowledge of the functional linkages between visual fatigue and regional cerebral prefrontal cortex (PFC) oxygenation, we measured time related hemodynamic changes over the right dorsolateral prefrontal cortex (dIPFC) during convergence load under conflicting stimulus-to-accommodation and stimulus-to-vergence eye movements with and without concurrent mental load.

    Methods: Twenty healthy participants with a median age of 28 years (range: 18-44 years) fixated upon a vertical bar presented separately to the left and right eyes, using polarized filters, during four counterbalanced 10-min periods: (i) no accommodation/vergence conflict (Control, Ctrl): (ii) added convergence load and accommodation/vergence conflict (Conv); (iii) added cognitive load only (Cog) and; (iv) a combination of added cognitive and convergence load and accommodation/vergence conflict (Cc). Viewing distance was 65 cm. Non-invasive measurements of hemodynamic activity over the dIPFC were quantified by functional near-infrared spectroscopy (fNIRS). During the two-convergence load conditions, the horizontal disparity of the two bars varied dynamically from no disparity to a disparity set 20% below the individual threshold for diplopia. Cognitive load was induced by the n-back-2 test which required the subject to memorize and recall the changing colors of the horizontal bars and decide when a given color was the same as that occurring two colors previously. fNIRS data were averaged over 10-s windows centered at 0, 2, 4, 6, 8, and 10 min of each task, subtracted from a 20-s baseline window immediately preceding the visual task, and then represented as changes in oxygenated hemoglobin (Delta HbO(2)), deoxygenated hemoglobin (Delta HHb) and total hemoglobin (Delta tHb).

    Results: Linear mixed model analyses showed that hemodynamic activity was systematically influenced by time (p < 0.001). The group-averaged time-related level of change across the viewing conditions did not differ when compared with one another (p > 0.05). Larger convergence eye-movement responses under conflicting stimulus-to-accommodation, and stimulus-to-vergence over time, increased Delta HbCO(2) and Delta tHb only in condition Cc and after 8 min of task time (p < 0.10 for min(-6) and min(-8): p < 0.05 for min(-10)).

    Discussion: Collectively, our data suggest that HbCO(2), HHb, and tHb, recorded over the dIPFC with fNIRS, can be used to assay the degree to which supervisory oculomotor control processes are activated during visually deficient near work.

    Fulltekst (pdf)
    Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS
  • Richter, Hans O.
    et al.
    Department of Occupational and Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Forsman, M.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Elcadi, G.H.
    Department of Health and Caring Sciences, Faculty of Health and Occupational Studies, University of Gävle, Gävle, Sweden.
    Brautaset, R.
    School of Optometry, Karolinska Institutet, Stockholm, Sweden.
    Marsh, John E.
    Environmental Psychology, Department of Building, Energy and Environmental Engineering, University of Gävle, Gävle; School of Psychology, University of Central Lancashire, Preston, United Kingdom.
    Zetterberg, C.
    Department of Occupational and Public Health Sciences, Faculty of Health and Occupational Studies, Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Section of Occupational and Environmental Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Corrigendum: Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS2018Inngår i: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 12, artikkel-id 384Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    A Corrigendum on

    Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS

    by Richter, H. O., Forsman, M., Elcadi, G. H., Brautaset, R., Marsh, J. E., and Zetterberg, C. (2018). Front. Hum. Neurosci. 12:298. doi: 10.3389/fnhum.2018.00298

    In the original article, there was a mistake in Figure 5A (left panel) as published.

    Figure 5A (left panel) should show Ctrl Low convergence group, not Conv Low convergence group. The corrected Figure 5A (left panel) appears below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.

    The original article has been updated.

    Fulltekst (pdf)
    Corrigendum: Prefrontal Cortex Oxygenation Evoked by Convergence Load Under Conflicting Stimulus-to-Accommodation and Stimulus-to-Vergence Eye-Movements Measured by NIRS
  • Elcadi, Guilherme H.
    et al.
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Department of Community Medicine and Rehabilitation, Rehabilitation medicine, Umeå University, Umeå, Sweden.
    Forsman, Mikael
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Hallman, David M.
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Aasa, Ulrika
    Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
    Fahlstrom, Martin
    Department of Community Medicine and Rehabilitation, Rehabilitation medicine, Umeå University, Umeå, Sweden; Department of Clinical Sciences, Professional Development, Umeå University, Umeå, Sweden.
    Crenshaw, Albert G.
    Centre for Musculoskeletal Research, University of Gävle, Gävle, Sweden.
    Oxygenation and Hemodynamics Do Not Underlie Early Muscle Fatigue for Patients with Work-Related Muscle Pain2014Inngår i: PLoS ONE, E-ISSN 1932-6203, Vol. 9, nr 4, artikkel-id e95582Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Patients suffering from work-related muscle pain (WRMP) fatigue earlier during exercise than healthy controls. Inadequate oxygen consumption and/ or inadequate blood supply can influence the ability of the muscles to withstand fatigue. However, it remains unknown if oxygenation and hemodynamics are associated with early fatigue in muscles of WRMP patients. In the present study we applied near-infrared spectroscopy (NIRS) on the extensor carpi radialis (ECR) and trapezius (TD) muscles of patients with WRMP (n = 18) and healthy controls (n = 17). Our objective was to determine if there were group differences in endurance times for a low-level contraction of 15% maximal voluntary contraction (MVC) -sustained for 12-13 min, and to see if these differences were associated with differences in muscle oxygenation and hemodynamics. At baseline, oxygen saturation (StO(2)%) was similar between groups for the ECR, but StO2% was significantly lower for TD for the WRMP patients (76%) compared to controls (85%) (P < 0.01). Also, baseline ECR blood flow was similar in the two groups. For both muscles there were a larger number of patients, compared to controls, that did not maintain the 15% MVC for the allotted time. Consequently, the endurance times were significantly shorter for the WRMP patients than controls (medians, ECR: 347 s vs. 582 s; TD: 430 s vs. 723 s respectively). Responses in StO(2)% during the contractions were not significantly different between groups for either muscle, i.e. no apparent difference in oxygen consumption. Overall, we interpret our findings to indicate that the early fatigue for our WRMP patients was not associated with muscle oxygenation and hemodynamics.

    Fulltekst (pdf)
    Oxygenation and Hemodynamics Do Not Underlie Early Muscle Fatigue for Patients with Work-Related Muscle Pain
  • Rasmussen, Joel
    et al.
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Ewald, Jens
    Department of Economics, School of Business, Economics and Law, Gothenburg University, Gothenburg, Sweden.
    Sterner, Thomas
    Department of Economics, School of Business, Economics and Law, Gothenburg University, Gothenburg, Sweden.
    Gender and life-stage dependent reactions to the risk of radioactive contamination: A survey experiment in Sweden2020Inngår i: PLoS ONE, E-ISSN 1932-6203, Vol. 15, nr 4, artikkel-id e0232259Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article proposes and examines gender and life-stage factors as determinants of public worry and risk avoidance in a nuclear fallout scenario. Drawing on a survey (N 2,291) conducted in Sweden, the article demonstrates statistically significant results that women as well as parents with children at home are more likely to express high levels of worry for radiation exposure and have a preference to move away from a fallout area despite assurance of successful remediation. Moreover, a negative relationship is shown between age and both worry for radiation exposure and preference to move. These novel results from Northern Europe thus support a life-stage framing of public risk attitudes. As radiation physicists develop new methods showing that women and children are at higher risk of cancer than other groups at the same radiation exposure, we may actually see the precaution among women and parents as a regulating mechanism for the higher objective risk they face. The results are moreover in agreement with studies of public risk reactions in Japan, creating a strong knowledge base that human-induced radiation pollution is largely an intolerable risk to the public. Considering the public opinion, managing an intolerable risk through risk mitigation by remediation alone is likely insufficient in many cases. A viable strategy would offer a range of social support options that enable individual decision-making and the protection of risk groups.

    Fulltekst (pdf)
    Gender and life-stage dependent reactions to the risk of radioactive contamination: A survey experiment in Sweden
  • Kärrman, Anna
    et al.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Wang, Thanh
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Kallenborn, Roland
    Langseter, Anne Marie
    Grønhovd, Siri Merete
    Ræder, Erik Magnus
    Lyche, Jan Ludvig
    Yeung, Leo W. Y.
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Chen, Fangfang
    Eriksson, Ulrika
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Aro, Rudolf
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Fredriksson, Felicia
    PFASs in the Nordic environment: Screening of Poly- and Perfluoroalkyl Substances (PFASs) and Extractable Organic Fluorine (EOF) in the Nordic Environment2019Rapport (Fagfellevurdert)
    Abstract [en]

    This report describes a screening study of in all ninety-nine conventional and emerging per- and polyfluoroalkyl substances (PFASs) in the Nordic environment. In addition, extractable organic fluorine (EOF) was analysed. The latter can provide the amount, but not identity, of organofluorine in the samples, which in turn can be used to assess the mass balance between known and unknown PFASs. The study was initiated by the Nordic Screening Group and funded by these and the Nordic Council of Ministers through the Chemicals Group. A total of 102 samples were analyzed in this study, including bird eggs, fish, marine mammals, terrestrial mammals, surface water, WWTP effluents and sludge, and air. Samples were collected by institutes from the participating countries and self-governing areas; Denmark, Faroe Islands, Finland, Greenland, Iceland, Norway, and Sweden.

    Fulltekst (pdf)
    PFASs in the Nordic environment
  • Disputas: 2020-06-11 09:00 Örebro universitet, Campus USÖ, hörsal C1, Örebro
    Zhang, Xueli
    Örebro universitet, Institutionen för medicinska vetenskaper.
    Biomarkers for Diagnosis, Therapy and Prognosis in Colorectal Cancer: a study from databases, machine learning predictions to laboratory confirmations2020Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Early diagnosis and better therapy response have been believed to be associated with better prognosis. CRC biomarkers are considered as precise indicators for the early diagnosis and better therapy response. It is, therefore, of importance to find out, analyze and evaluate the CRC biomarkers to further provide the more precis evidence for predicting novel potential biomarkers and eventually to improve early diagnosis, personalized therapy and prognosis for CRC.

    In this study, we started with creating and establishing a CRC biomarker database. (CBD: http://sysbio.suda.edu.cn/CBD/index.html) In the CBD database, there were 870 reported CRC biomarkers collected from the published articles in PubMed. In this version of the CBD, CRC biomarker data was carefully collected, sorted, displayed, and analyzed. The major applications of the CBD are to provide 1) the records of CRC biomarkers (DNA, RNA, protein and others) concerning diagnosis, treatment and prognosis; 2) the basic and clinical research information concerning the CRC biomarkers; 3) the primary results for bioinformatics and biostatics analysis of the CRC biomarkers; 4) downloading/uploading the biomedicine information for CRC biomarkers.

    Based on our CBD and other public databases, we further analyzed the presented CRC biomarkers (DNAs, RNAs, proteins) and predicted novel potential multiple biomarkers (the combination of single biomarkers) with biological networks and pathways analysis for diagnosis, therapy response and prognosis in CRC. We found several hub biomarkers and key pathways for the diagnosis, treatment and prognosis in CRC. Receiver operating characteristic (ROC) test and survival analysis by microarray data revealed that multiple biomarkers could be better biomarkers than the single biomarkers for the diagnosis and prognosis of CRC.

    There are 62 diagnosis biomarkers for colon cancer in our CBD. In the previous studies, we found these present biomarkers were not enough to improve significantly the diagnosis of colon cancer. In order to find out novel biomarkers for the colon cancer diagnosis, we have performed /machine learning (ML) techniques such as support vector machine (SVM) and regression tree to predict candidate to discover diagnostic biomarkers for colon cancer. Based on the protein-protein interaction (PPI) network topology features of the identified biomarkers, we found 12 protein biomarkers which were considered as the candidate colon cancer diagnosis biomarkers. Among these protein biomarkers Chromogranin-A (CHGA)  was the most powerful biomarker, which showed good performance in bioinformatics test and Immunohistochemistry(IHC). We are now expanding this study to CRC.

    Expression of CHGA protein in colon cancer was further verified with a novel logistic regressionbased meta-analysis, and convinced as a valuable diagnostic biomarker as compared with the typical diagnostic biomarkers, such as TP53, KRAS and MKI67.

    microRNAs (miRNAs/miRs) have been considered as potential biomarkers. A novel miRNA-mRNA interaction network-based model was used to predict miRNA biomarkers for CRC and found that miRNA-186-5p, miRNA-10b-5p and miRNA-30e-5p might be the novel biomarkers for CRC diagnosis. In conclusion, we have created a useful CBD database for CRC biomarkers and provided detailed information for how to use the CBD in CRC biomarker investigations. Our studies have been focusing on the biomarkers in diagnosis, therapy and prognosis. Based on our CBD and other powerful cancer associated databases, ML has been used to analyze the characteristics of the CRC biomarkers and predict novel potential CRC biomarkers. The predicted potential biomarkers were further confirmed at biomedical laboratory.

    Delarbeid
    1. CBD: a biomarker database for colorectal cancer
    Åpne denne publikasjonen i ny fane eller vindu >>CBD: a biomarker database for colorectal cancer
    Vise andre…
    2018 (engelsk)Inngår i: Database: The Journal of Biological Databases and Curation, ISSN 1758-0463, E-ISSN 1758-0463, artikkel-id bay046Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Colorectal cancer (CRC) biomarker database (CBD) was established based on 870 identified CRC biomarkers and their relevant information from 1115 original articles in PubMed published from 1986 to 2017. In this version of the CBD, CRC biomarker data were collected, sorted, displayed and analysed. The CBD with the credible contents as a powerful and time-saving tool provide more comprehensive and accurate information for further CRC biomarker research. The CBD was constructed under MySQL server. HTML, PHP and JavaScript languages have been used to implement the web interface. The Apache was selected as HTTP server. All of these web operations were implemented under the Windows system. The CBD could provide to users the multiple individual biomarker information and categorized into the biological category, source and application of biomarkers; the experiment methods, results, authors and publication resources; the research region, the average age of cohort, gender, race, the number of tumours, tumour location and stage. We only collect data from the articles with clear and credible results to prove the biomarkers are useful in the diagnosis, treatment or prognosis of CRC. The CBD can also provide a professional platform to researchers who are interested in CRC research to communicate, exchange their research ideas and further design high-quality research in CRC. They can submit their new findings to our database via the submission page and communicate with us in the CBD.

    sted, utgiver, år, opplag, sider
    Oxford University Press, 2018
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-68074 (URN)10.1093/database/bay046 (DOI)000436293800001 ()29846545 (PubMedID)
    Forskningsfinansiär
    Swedish Cancer SocietySwedish Research Council
    Tilgjengelig fra: 2018-07-25 Laget: 2018-07-25 Sist oppdatert: 2020-05-18bibliografisk kontrollert
    2. Potential Applications of DNA, RNA and Protein Biomarkers in Diagnosis, Therapy and Prognosis for Colorectal Cancer: A Study from Databases to AI-Assisted Verification
    Åpne denne publikasjonen i ny fane eller vindu >>Potential Applications of DNA, RNA and Protein Biomarkers in Diagnosis, Therapy and Prognosis for Colorectal Cancer: A Study from Databases to AI-Assisted Verification
    2019 (engelsk)Inngår i: Cancers, ISSN 2072-6694, Vol. 11, nr 2, artikkel-id 172Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    In order to find out the most valuable biomarkers and pathways for diagnosis, therapy and prognosis in colorectal cancer (CRC) we have collected the published CRC biomarkers and established a CRC biomarker database (CBD: http://sysbio.suda.edu.cn/CBD/index.html). In this study, we analysed the single and multiple DNA, RNA and protein biomarkers as well as their positions in cancer related pathways and protein-protein interaction (PPI) networks to describe their potential applications in diagnosis, therapy and prognosis. CRC biomarkers were collected from the CBD. The RNA and protein biomarkers were matched to their corresponding DNAs by the miRDB database and the PubMed Gene database, respectively. The PPI networks were used to investigate the relationships between protein biomarkers and further detect the multiple biomarkers. The Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Ontology (GO) annotation were used to analyse biological functions of the biomarkers. AI classification techniques were utilized to further verify the significances of the multiple biomarkers in diagnosis and prognosis for CRC. We showed that a large number of the DNA, RNA and protein biomarkers were associated with the diagnosis, therapy and prognosis in various degrees in the CRC biomarker networks. The CRC biomarkers were closely related to the CRC initiation and progression. Moreover, the biomarkers played critical roles in cellular proliferation, apoptosis and angiogenesis and they were involved in Ras, p53 and PI3K pathways. There were overlaps among the DNA, RNA and protein biomarkers. AI classification verifications showed that the combined multiple protein biomarkers played important roles to accurate early diagnosis and predict outcome for CRC. There were several single and multiple CRC protein biomarkers which were associated with diagnosis, therapy and prognosis in CRC. Further, AI-assisted analysis revealed that multiple biomarkers had potential applications for diagnosis and prognosis in CRC.

    sted, utgiver, år, opplag, sider
    MDPI, 2019
    Emneord
    DNA, RNA, protein, single-biomarkers, multiple-biomarkers, cancer-related pathways, colorectal cancer
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-73340 (URN)10.3390/cancers11020172 (DOI)000460747200046 ()30717315 (PubMedID)2-s2.0-85062386858 (Scopus ID)
    Forskningsfinansiär
    Swedish Cancer SocietySwedish Research Council
    Tilgjengelig fra: 2019-03-26 Laget: 2019-03-26 Sist oppdatert: 2020-05-18bibliografisk kontrollert
    3. Loss of CHGA protein as a potential biomarker for colon cancer diagnosis: a study on biomarker discovery by machine learning and confirmation by immunohistochemistry in colorectal cancer tissue microarrays
    Åpne denne publikasjonen i ny fane eller vindu >>Loss of CHGA protein as a potential biomarker for colon cancer diagnosis: a study on biomarker discovery by machine learning and confirmation by immunohistochemistry in colorectal cancer tissue microarrays
    Vise andre…
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81935 (URN)
    Tilgjengelig fra: 2020-05-18 Laget: 2020-05-18 Sist oppdatert: 2020-05-18bibliografisk kontrollert
    4. Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients
    Åpne denne publikasjonen i ny fane eller vindu >>Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients
    2019 (engelsk)Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, nr 12, artikkel-id 2919Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Colon cancer is one of the major causes of cancer death worldwide. The five-year survival rate for the early-stage patients is more than 90%, and only around 10% for the later stages. Moreover, half of the colon cancer patients have been clinically diagnosed at the later stages. It is; therefore, of importance to enhance the ability for the early diagnosis of colon cancer. Taking advantages from our previous studies, there are several potential biomarkers which have been associated with the early diagnosis of the colon cancer. In order to investigate these early diagnostic biomarkers for colon cancer, human chromogranin-A (CHGA) was further analyzed among the most powerful diagnostic biomarkers. In this study, we used a logistic regression-based meta-analysis to clarify associations of CHGA expression with colon cancer diagnosis. Both healthy populations and the normal mucosa from the colon cancer patients were selected as the double normal controls. The results showed decreased expression of CHGA in the early stages of colon cancer as compared to the normal controls. The decline of CHGA expression in the early stages of colon cancer is probably a new diagnostic biomarker for colon cancer diagnosis with high predicting possibility and verification performance. We have also compared the diagnostic powers of CHGA expression with the typical oncogene KRAS, classic tumor suppressor TP53, and well-known cellular proliferation index MKI67, and the CHGA showed stronger ability to predict early diagnosis for colon cancer than these other cancer biomarkers. In the protein-protein interaction (PPI) network, CHGA was revealed to share some common pathways with KRAS and TP53. CHGA might be considered as a novel, promising, and powerful biomarker for early diagnosis of colon cancer.

    sted, utgiver, år, opplag, sider
    MDPI, 2019
    Emneord
    CHGA, colon cancer, biomarker, early diagnosis, logistic regression, meta-analysis, PPI
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-75234 (URN)10.3390/ijms20122919 (DOI)000473756000069 ()31207989 (PubMedID)2-s2.0-85068403124 (Scopus ID)
    Forskningsfinansiär
    Swedish Cancer SocietySwedish Research Council
    Tilgjengelig fra: 2019-07-25 Laget: 2019-07-25 Sist oppdatert: 2020-05-18bibliografisk kontrollert
    5. Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications
    Åpne denne publikasjonen i ny fane eller vindu >>Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications
    2020 (engelsk)Inngår i: Cancers, ISSN 2072-6694, Vol. 12, nr 2, artikkel-id E341Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Colorectal cancer (CRC) is one of the major causes of cancer death worldwide. In general, early diagnosis for CRC and individual therapy have led to better survival for the cancer patients. Accumulating studies concerning biomarkers have provided positive evidence to improve cancer early diagnosis and better therapy. It is, however, still necessary to further investigate the precise biomarkers for cancer early diagnosis and precision therapy and predicting prognosis. In this study, AI-assisted systems with bioinformatics algorithm integrated with microarray and RNA sequencing (RNA-seq) gene expression (GE) data has been approached to predict microRNA (miRNA) biomarkers for early diagnosis of CRC based on the miRNA-messenger RNA (mRNA) interaction network. The relationships between the predicted miRNA biomarkers and other biological components were further analyzed on biological networks. Bayesian meta-analysis of diagnostic test was utilized to verify the diagnostic value of the miRNA candidate biomarkers and the combined multiple biomarkers. Biological function analysis was performed to detect the relationship of candidate miRNA biomarkers and identified biomarkers in pathways. Text mining was used to analyze the relationships of predicted miRNAs and their target genes with 5-fluorouracil (5-FU). Survival analyses were conducted to evaluate the prognostic values of these miRNAs in CRC. According to the number of miRNAs single regulated mRNAs (NSR) and the number of their regulated transcription factor gene percentage (TFP) on the miRNA-mRNA network, there were 12 promising miRNA biomarkers were selected. There were five potential candidate miRNAs (miRNA-186-5p, miRNA-10b-5, miRNA-30e-5p, miRNA-21 and miRNA-30e) were confirmed as CRC diagnostic biomarkers, and two of them (miRNA-21 and miRNA-30e) were previously reported. Furthermore, the combinations of the five candidate miRNAs biomarkers showed better prediction accuracy for CRC early diagnosis than the single miRNA biomarkers. miRNA-10b-5p and miRNA-30e-5p were associated with the 5-FU therapy resistance by targeting the related genes. These miRNAs biomarkers were not statistically associated with CRC prognosis.

    sted, utgiver, år, opplag, sider
    MDPI, 2020
    Emneord
    CRC, biomarkers, diagnosis, miRNA, network models
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-79936 (URN)10.3390/cancers12020341 (DOI)000522477300087 ()32028703 (PubMedID)2-s2.0-85079242365 (Scopus ID)
    Forskningsfinansiär
    Swedish Cancer Society, CAN 2016/341Swedish Research Council Formas, 2016-01098
    Tilgjengelig fra: 2020-02-20 Laget: 2020-02-20 Sist oppdatert: 2020-05-18bibliografisk kontrollert
    Fulltekst (pdf)
    Biomarkers for Diagnosis, Therapy and Prognosis in Colorectal Cancer: a study from databases, machine learning predictions to laboratory confirmations
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  • Wide, Sverre
    Sociologisk Forskning 2014:22014Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2014:2
  • Wide, Sverre
    Sociologisk Forskning 2015:12015Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2015:1
  • Wide, Sverre
    Sociologisk Forskning 2015:22015Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2015:2
  • Wide, Sverre
    Sociologisk Forskning 2016:12016Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2016:1
  • Wide, Sverre
    Sociologisk Forskning 2015:42015Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2015:4
  • Wide, Sverre
    Sociologisk Forskning 2015:32015Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2015:3
  • Wide, Sverre
    Sociologisk Forskning 2016:22016Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2016:2
  • Wide, Sverre
    Sociologisk Forskning 2016:32016Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2016:3
  • Wide, Sverre
    Sociologisk Forskning 2016:42016Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologisk Forskning 2016:4
  • Mjöberg, Jessica
    et al.
    Dalarna University, Falun, Sweden.
    Wide, Sverre
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Aktörer, observatörer, deltagare: Om experiment, självkunskap och det socialas in- och utsida2012Inngår i: En gestalt, många berättelser: En vänbok till Lars-Erik Berg / [ed] Jessica Mjöberg och Anette Lundin, Skövde: Institutionen för teknik och samhälle, Högskolan i Skövde , 2012, s. 160-187Kapittel i bok, del av antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Aktörer, observatörer, deltagare: Om experiment, självkunskap och det socialas in- och utsida
  • Wide, Sverre
    School of Education, Health and Social Studies, Dalarna University, Swe.
    Causation and reason: R.G. Collingwood and causal analysis as the essence of social thinking2017Inngår i: Distinktion Scandinavian Journal of Social Theory, ISSN 1600-910X, E-ISSN 2159-9149, Vol. 18, nr 2, s. 173-195Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    How are we to understand causal relations and analysis in social science? This paper takes R. G. Collingwood’s writing about causation as its point of departure for the answering of this question. Two different kinds of causal relations are distinguished from pseudo-causality; of the former, one is directly connected to reason, the other to our ability to manipulate the world. Their interconnection and significance are discussed and th econclusions are drawn that (a) causality belongs to the realm of human praxis and that (b) causal analysis proper is well suited forthe social sciences. It is further showed that some important explanations are not causal in any of the above-mentioned senses. These explanations could conceivably be called interpretative descriptions, but it is suggested that perhaps they can be understood as examples of causa sui, of something selfcaused.

    Fulltekst (pdf)
    Causation and reason: R. G. Collingwood and causal analysis as the essence of social thinking
  • Wide, Sverre
    En Kaj Håkanson-bibliografi till år 20082008Inngår i: n()n()a()g()e()n()t() : om kunskap, kärlek och ingenting särskiljt: en vänbok till Kaj Håkanson / [ed] Palm, Fredirk; Misheva, Vessela; Wide, Sverre, Uppsala, Sweden: Uppsala University, 2008, s. 26-40Kapittel i bok, del av antologi (Fagfellevurdert)
    Fulltekst (pdf)
    En Kaj Håkanson-bibliografi till år 2008
  • Wide, Sverre
    Inledning2008Inngår i: n()n()a()g()e()n()t(): om kunskap, kärlek och ingenting särskiljt: En vänbok till Kaj Håkanson / [ed] Wide, Sverre; Palm, Fredrik; Misheva, Vessela, Uppsala, Sweden: Uppsala University, 2008, s. 7-10Kapittel i bok, del av antologi (Annet vitenskapelig)
    Fulltekst (pdf)
    Inledning
  • Wide, Sverre
    Dalarna University, Sweden.
    Max Scheler på norska?: Om ursprunget till "Deltakar og tilskodar"2017Inngår i: Norsk sosiologisk tidsskrift, ISSN 1590-7929, E-ISSN 1936-4660, Vol. 1, nr 5, s. 365-379, artikkel-id 05-02Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Hans Skjervheim was one of the most influential philosophers of social science in the Scandinavian countries during the twentieth century. This paper contributes to the understanding of one of his central meta-scientific distinctions – between the participant and the spectator – by relating him to surprisingly similar distinctions found in the works of Max Scheler. It is well-known that Skjervheim studied Scheler, but the latter’s direct (and partly unacknowledged) influence on Skjervheim’s central distinction has not been noticed. Through an examination of similarities between Skjervheim and Scheler, an interpretation of Skjervheim is reached, which renders, so the paper additionally argues, some contemporary criticism of his work less valid than might be thought.

    Fulltekst (pdf)
    Max Scheler på norska?: Om ursprunget till "Deltakar og tilskodar"
  • Wide, Sverre
    Dalarna University, Sweden.
    Recension av: Sociologi genom litteratur: Skönlitteraturens begränsningar och samhällsvetenskapernas förutsättningar. Christofer Edling & Jens Rydgren (red.)2016Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 53, nr 1, s. 92-94Artikkel, omtale (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologi genom litteratur: Skönlitteraturens möjligheter och samhällsvetenskapernas begränsningar. Christofer Edling & Jens Rydgren (red.). Lund: Arkiv, 2015 [Recension]
  • Wide, Sverre
    Redaktören har ordet2016Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 53, nr 4, s. 343-343Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2016Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 53, nr 3, s. 225-225Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2016Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 53, nr 2, s. 99-99Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2015Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 52, nr 4, s. 319-319Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2015Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 52, nr 2, s. 107-108Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2015Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 52, nr 1, s. 3-4Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2014Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 51, nr 2, s. 107-107Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2015Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 52, nr 3, s. 207-207Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Redaktören har ordet2016Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 53, nr 1, s. 3-3Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Redaktören har ordet
  • Wide, Sverre
    Nordiska Sociologiska Förbundets Styrelse, Köpenhamn, Danmark.
    Sociologförbundet har ordet: Rapport från Nordiska sociologförbundets 28:e konferens i Helsingfors 11–13 aug 20162016Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 53, nr 3, s. 339-339Artikkel i tidsskrift (Annet vitenskapelig)
    Fulltekst (pdf)
    Rapport från Nordiska sociologförbundets 28:e konferens i Helsingfors 11–13 aug 2016
  • Wide, Sverre
    Sociologiska institutionen, Uppsala universitet, Uppsala, Sverige.
    Smärta, skönhet och sociomaterialitet: En intervju med Dag Østerberg om begreppen form, förändring och socialitet2009Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 46, nr 3, s. 5-17Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Pain, beauty, and socio-matter. An interview with Dag Østerberg concerning the concepts of form, process, and sociality.

    Professor Dag Østerberg (born 1938) is one of the most prominent Nordic sociologists and the author of many influential books. In this interview he discusses the concept of form in sociology and social thinking and relates it not only to change, but to sociality, pain, beauty, and socio-matter as well. In order to contextualise Østerberg’s discussion, the interview is prefaced by a brief introduction to the traditional understanding of form as related to matter and content.

    Fulltekst (pdf)
    Smärta, skönhet och sociomaterialitet: en intervju med Dag Østerberg om begreppen form, förändring och socialitet
  • Wide, Sverre
    Sociologi som erotik2007Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 44, nr 2, s. 80-85Artikkel i tidsskrift (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologi som erotik
  • Wide, Sverre
    Sociologi, metod och smak2007Inngår i: Sociologisk forskning, ISSN 0038-0342, Vol. 44, nr 4, s. 83-84Artikkel i tidsskrift (Fagfellevurdert)
    Fulltekst (pdf)
    Sociologi, metod och smak
  • Wide, Sverre
    Teori för rädda2008Inngår i: n()n()a()g()e()n()t() : om kunskap, kärlek och ingenting särskiljt: En vänbok till Kaj Håkanson / [ed] Wide, Sverre; Palm, Fredrik; Misheva, Vessela, Uppsala, Sweden: Uppsala University, 2008, s. 236-250Kapittel i bok, del av antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Teori för rädda
  • Wide, Sverre
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap. Dalarna University, Sweden.
    Vad betyder ordet positivism?: Försök till karaktäristik av ett tänkesätt2015Inngår i: En profil i profilen: Vänbok till Bo G Jansson / [ed] Catharina Nyström Höög, Charlotte Lindgren & Sverre Wide, Falun, Sweden: Dalarna University, 2015, s. 179-196Kapittel i bok, del av antologi (Fagfellevurdert)
    Fulltekst (pdf)
    Vad betyder ordet positivism? Försök till karaktäristik av ett tänkesätt
  • Wide, Sverre
    et al.
    Palm, FredrikMisheva, Vessela
    n()n()a()g()e()n()t(): Om kunskap, kärlek och ingenting särskiljt. En vänbok till Kaj Håkanson2008Collection/Antologi (Fagfellevurdert)
    Fulltekst (pdf)
    n()n()a()g()e()n()t()
  • Wide, Sverre
    et al.
    Palm, Fredrik
    Om den vård- och socialpolitiska gruppen: Ett samtal mellan Elisabet Näsman, Fredrik Palm och Sverre Wide2008Inngår i: n()n()a()g()e()n()t() : om kunskap, kärlek och ingenting särskiljt: En vänbok till Kaj Håkanson / [ed] Wide, Sverre; Palm, Fredrik; Misheva, Vessela, Uppsala, Sweden: Uppsala University, 2008, s. 61-70Kapittel i bok, del av antologi (Annet vitenskapelig)
    Fulltekst (pdf)
    Om den vård- och socialpolitiska gruppen: Ett samtal mellan Elisabet Näsman, Fredrik Palm och Sverre Wide
  • Disputas: 2020-06-08 10:00 Örebro universitet, Forumhuset, Hörsal F, Örebro
    Khan, Faisal Ahmad
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Carbapenemase-Producing Enterobacteriaceae in Wastewater-Associated Aquatic Environments2020Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The emergence of carbapenem resistance due to the carbapenem-hydrolyzing enzymes (carbapenemases) in Enterobacteriaceae has led to limited therapeutic options. The increased resistance to these “last-resort” antibiotics is fueled by overuse and misuse of antibiotics in human medicine and agriculture. According to the One-Health concept, the microbiomes of humans, animals and natural environments are interconnected reservoirs of antibiotic resistance genes (ARGs) and changes in one compartment will affect the other compartments. Thus, the environmental waters exposed to the pathogens, ARGs and other contaminants of human origin can play a significant role in the spread of resistance. The study aimed to characterize carbapenemase-producing Enterobacteriaceae (CPE) and ARGs in wastewaters and associated river and lake waters in Örebro, Sweden. The study also analyzed de novo development of resistance in Klebsiella oxytoca during long-term growth in river water and the effect of temperature on the emergence of resistance. OXA-48-producing Escherichia coli (ST131) and VIM-1-producing K.oxytoca (ST172) were repeatedly detected in the wastewaters and associated river, suggesting that these isolates were persistently present in these environments. Furthermore, K. oxytoca ST172 isolated from the river was genetically similar to two isolates previously recovered from patients in a local hospital, which shows the possibility of transmission of CPE from hospital to aquatic environments. A high diversity of ARGs was detected in these environments especially in hospital wastewater where ten different carbapenemase genes were detected. These results emphasized that the effective treatment of wastewaters must be ensured to reduce or eliminate the spread of antibiotic resistance. Increased resistance to meropenem (up to 8-fold) and ceftazidime (>10-fold) was observed in K. oxytoca after exposure to both river and tap water after 600 generations and resistance emerged earlier when the bacteria was grown at the higher temperature. The exposure to contaminants and increased environmental temperature may induce similar changes in the environmental microbiome, generating novel resistant variants at accelerated rates that may pose a significant threat to human health.

    Delarbeid
    1. Carbapenemase-producing Escherichia coli ST38 and Klebsiella oxytoca ST172 are persistent in Swedish wastewaters and associated river
    Åpne denne publikasjonen i ny fane eller vindu >>Carbapenemase-producing Escherichia coli ST38 and Klebsiella oxytoca ST172 are persistent in Swedish wastewaters and associated river
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81831 (URN)
    Tilgjengelig fra: 2020-05-13 Laget: 2020-05-13 Sist oppdatert: 2020-05-13bibliografisk kontrollert
    2. Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden
    Åpne denne publikasjonen i ny fane eller vindu >>Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden
    Vise andre…
    2018 (engelsk)Inngår i: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 37, nr 12, s. 2241-2251Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Carbapenem antibiotics are one of the last-resort agents against multidrug-resistant (MDR) bacteria. The occurrence of carbapenemase-producing Enterobacteriaceae (CPE) in wastewater and aquatic environments is an indication of MDR bacteria in the community. This study evaluated CPE in aquatic environments and compared them to the local hospital isolates in Sweden. Phenotypic and genotypic analyses of antibiotic resistance of environmental and clinical CPE were performed. The relatedness of the isolates and possible clonal dissemination was evaluated using phylogenetic and phyloproteomic analysis. Klebsiella oxytoca carrying carbapenemase genes (blaVIM-1, blaIMP-29) were isolated from wastewater and the recipient river, while K. oxytoca (blaVIM-1) and Klebsiella pneumoniae (blaVIM-1, blaOXA-48, blaNDM-1, blaKPC-3) were isolated from patients at the local clinics or hospital. The K. oxytoca classified as sequence type 172 (ST172) isolated from the river was genotypically related to two clinical isolates recovered from patients. The similarity between environmental and clinical isolates suggests the dispersion of blaVIM-1 producing K. oxytoca ST172 from hospital to aquatic environment and the likelihood of its presence in the community. This is the first report of CPE in aquatic environments in Sweden; therefore, surveillance of aquatic and hospital environments for CPE in other urban areas is important to determine the major transfer routes in order to formulate strategies to prevent the spread of MDR bacteria.

    sted, utgiver, år, opplag, sider
    Springer, 2018
    Emneord
    Antimicrobial resistance, Carbapenemase-producing Enterobacteriaceae, Extended spectrum beta-lactamase, Klebsiella oxytoca, Klebsiella pneumoniae, Multidrug resistance
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-68676 (URN)10.1007/s10096-018-3365-9 (DOI)000449921100003 ()30171482 (PubMedID)2-s2.0-85053311566 (Scopus ID)
    Forskningsfinansiär
    Swedish Research Council Formas, 219-2014-837
    Merknad

    Funding Agency:

    Nyckelfonden at Orebro University Hospital 

    Tilgjengelig fra: 2018-09-03 Laget: 2018-09-03 Sist oppdatert: 2020-05-13bibliografisk kontrollert
    3. Diversity of Antibiotic Resistance Genes in Aquatic Environments Using Culture-Dependent and Independent Methods
    Åpne denne publikasjonen i ny fane eller vindu >>Diversity of Antibiotic Resistance Genes in Aquatic Environments Using Culture-Dependent and Independent Methods
    Vise andre…
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81832 (URN)
    Tilgjengelig fra: 2020-05-13 Laget: 2020-05-13 Sist oppdatert: 2020-05-13bibliografisk kontrollert
    4. Prevalence and Diversity of Antibiotic Resistance Genes in Swedish Aquatic Environments Impacted by Household and Hospital Wastewater
    Åpne denne publikasjonen i ny fane eller vindu >>Prevalence and Diversity of Antibiotic Resistance Genes in Swedish Aquatic Environments Impacted by Household and Hospital Wastewater
    2019 (engelsk)Inngår i: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, artikkel-id 688Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Antibiotic-resistant Enterobacteriaceae and non-lactose fermenting Gram-negative bacteria are a major cause of nosocomial infections. Antibiotic misuse has fueled the worldwide spread of resistant bacteria and the genes responsible for antibiotic resistance (ARGs). There is evidence that ARGs are ubiquitous in non-clinical environments, especially those affected by anthropogenic activity. However, the emergence and primary sources of ARGs in the environment of countries with strict regulations for antibiotics usage are not fully explored. The aim of the present study was to evaluate the repertoire of ARGs of culturable Gram-negative bacteria from directionally connected sites from the hospital to the wastewater treatment plant (WWTP), and downstream aquatic environments in central Sweden. The ARGs were detected from genomic DNA isolated from a population of selectively cultured coliform and Gram-negative bacteria using qPCR. The results show that hospital wastewater was a reservoir of several class B beta-lactamase genes such as bla(IMP)(-1), bla(IMP)(-2), and bla(OXA-23), however, most of these genes were not observed in downstream locations. Moreover, beta-lactamase genes such as bla(OXA-48), bla(CDX-M-8), and bla(SFC-1), bla(VIM-1), and bla(VIM-13) were detected in downstream river water but not in the WWTP. The results indicate that the WWTP and hospital wastewaters were reservoirs of most ARGs and contribute to the diversity of ARGs in associated natural environments. However, this study suggests that other factors may also have minor contributions to the prevalence and diversity of ARGs in natural environments.

    sted, utgiver, år, opplag, sider
    Frontiers Media S.A., 2019
    Emneord
    carbapenemase, urban wastewater, surface water, enterobacteriaceae, VIM-1, extended-spectrum beta-lactamase, antimicrobial resistance gene co-occurrence
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-73758 (URN)10.3389/fmicb.2019.00688 (DOI)000463403600001 ()
    Forskningsfinansiär
    Swedish Research Council Formas, 219-2014-837Knowledge Foundation, 20150084
    Merknad

    Funding Agencies:

    Nyckelfonden at Örebro University Hospital  

    Örebro University 

    Tilgjengelig fra: 2019-04-16 Laget: 2019-04-16 Sist oppdatert: 2020-05-13bibliografisk kontrollert
    5. Environmental Conditions Promote Genetic Changes and Increase Resistance to β-lactam Antibiotics in Klebsiella oxytoca
    Åpne denne publikasjonen i ny fane eller vindu >>Environmental Conditions Promote Genetic Changes and Increase Resistance to β-lactam Antibiotics in Klebsiella oxytoca
    Vise andre…
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81833 (URN)
    Tilgjengelig fra: 2020-05-13 Laget: 2020-05-13 Sist oppdatert: 2020-05-13bibliografisk kontrollert
    Fulltekst (pdf)
    Carbapenemase-Producing Enterobacteriaceae in Wastewater-Associated Aquatic Environments
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  • Disputas: 2020-06-12 13:00 Örebro universitet, Campus USÖ, hörsal C1, Örebro
    Djekic, Demir
    Örebro universitet, Institutionen för medicinska vetenskaper.
    Novel and Traditional Risk Factors for Coronary Artery Disease: Role of Coronary Artery Calcium, Lipidomics, Psychosocial Factors and Diet2020Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    Background: The aim of the research reported in this thesis was to determine the association of novel and traditional risk factors with coronary artery calcium (CAC), a marker of subclinical coronary artery disease (CAD) in healthy individuals. In addition, we investigated the effects of a vegetarian, compared to a meat diet, on novel and traditional risk factors in patients with diagnosed CAD.

    Methods: Studies I-II evaluated the inter-laboratory reproducibility of liquid chromatography-mass spectrometry (LC-MS) lipid analysis and the association of serum lipidome with CAC in a cohort of 70 patients. Studies III and IV analysed data of 1067 participants in the pilot study of the Swedish CArdioPulmonary bioImage Study to determine associations of psychosocial (residential area, education, housing, and social support) and traditional risk factors with CAC. Cardiac computed tomography was used to obtain a coronary artery calcium score (CACS) (Studies I–IV). Study V employed a crossover design in which 31 patients with CAD were randomly allocated to a four-week vegetarian diet alternating with four weeks of an isocaloric meat diet. Enzyme-linked immunosorbent assay was used to measure oxidised LDL-cholesterol. Plasma metabolome, including choline, trimethylamine N-oxide, L-carnitine, and acetyl-carnitine, as well as plasma lipidome were determined with LC-MS. Gut microbiota and faecal short- and branched-chain fatty acids were analysed with 16S rRNA gene sequencing and gas chromatography-MS, respectively.

    Results: In Study I, two laboratories independently identified six lipids in common that differentiated serum of patients with CACS >250 from that of those with CACS=0. Study II, revealed higher levels of phosphatidylcholine(PC)(16:0/20:4) and lower levels of PC(18:2/18:2), PC(36:3) and phosphatidylethanolamine (PE)(20:0/18:2) in patients with CACS >250 than found in those with CACS=0. Study III showed a CACS >0 prevalence of 46.3% and 36.6% in low and high socioeconomic residential areas, respectively, but the traditional risk factor–adjusted odds ratio for CACS >0 was not significantly higher in subjects living in low socioeconomic areas. In Study III, the traditional risk factor–adjusted odds ratio for CACS >100 relative to CACS=0 was significantly higher in women with low education level and living in a rented apartment. Studies III and IV showed traditional risk factor–adjusted odds ratios for CACS >0 to be significantly higher in women with a family history of premature cardiovascular disease and low social support. No relationship of psychosocial factors with CAC was observed in men. The vegetarian diet implemented in Study V significantly lowered mean oxidized LDL-cholesterol (-2.73 U/L), total cholesterol (-0.13 mmol/L), LDL-cholesterol (-0.10 mmol/L), and body mass index (-0.21 kg/m2), as well as the relative abundance of PCs, PEs, and several microbial genera compared with the meat diet. The effect of the vegetarian diet on oxidized LDL-C was associated with higher relative abundance of Ruminococcaceae genera and of Barnesiella and reduced abundance of Flavonifractor. The vegetarian diet lowered the relative abundance of ceramide(d18:1/16:0) and triacylglycerols with saturated fatty acyl chains and raised the relative abundance of triacylglycerols with high carbon and polyunsaturated fatty acyl chains compared with the meat diet.

    Conclusions: Novel and traditional cardiovascular risk factors are associated with subclinical CAD. Psychosocial factors are associated with subclinical CAD in women, but not in men. Short-term intervention with a vegetarian diet in individuals with CAD can positively impact novel and traditional factors that have been associated with risk of future cardiovascular events.

    Delarbeid
    1. Replication of LC-MS untargeted lipidomics results in patients with calcific coronary disease: an interlaboratory reproducibility study
    Åpne denne publikasjonen i ny fane eller vindu >>Replication of LC-MS untargeted lipidomics results in patients with calcific coronary disease: an interlaboratory reproducibility study
    2016 (engelsk)Inngår i: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 222, s. 1042-1048Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    BACKGROUND: Recently a lipidomics approach was able to identify perturbed fatty acyl chain (FAC) and sphingolipid moieties that could stratify patients according to the severity of coronary calcification, a form of subclinical atherosclerosis. Nevertheless, these findings have not yet been reproduced before generalising their application. The aim of this study was to evaluate the reproducibility of lipidomics approaches by replicating previous lipidomic findings in groups of patients with calcific coronary artery disease (CCAD).

    METHODS: Patients were separated into the following groups based on their calcium score (CS); no calcification (CS: 0; n=26), mild calcification (CS: 1-250; n=27) and severe calcification (CS: >250; n=17). Two serum samples were collected from each patient and used for comparative analyses by 2 different laboratories, in different countries and time points using liquid chromatography coupled to mass spectrometry untargeted lipidomics methods.

    RESULTS: Six identical metabolites differentiated patients with severe coronary artery calcification from those with no calcification were found by both laboratories independently. Additionally, relative intensities from the two analyses demonstrated high correlation coefficients. Phosphatidylcholine moieties with 18-carbon FAC were identified in lower intensities and 20:4 FAC in higher intensities in the serum of diseased group. Moreover, 3 common sphingomyelins were detected.

    CONCLUSION: This is the first interlaboratory reproducibility study utilising lipidomics applications in general and specifically in patients with CCAD. Lipid profiling applications in patients with CCAD are very reproducible in highly specialised and experienced laboratories and could be applied in clinical practice in order to spare patients diagnostic radiation.

    sted, utgiver, år, opplag, sider
    Elsevier, 2016
    Emneord
    Lipidomics, Reproducibility, Coronary artery disease, Calcific coronary disease, Metabolomics
    HSV kategori
    Forskningsprogram
    kardiologi
    Identifikatorer
    urn:nbn:se:oru:diva-57882 (URN)10.1016/j.ijcard.2016.07.214 (DOI)000384698300219 ()27543723 (PubMedID)2-s2.0-84982192130 (Scopus ID)
    Forskningsfinansiär
    Swedish Heart Lung Foundation
    Tilgjengelig fra: 2016-10-24 Laget: 2017-06-01 Sist oppdatert: 2020-05-19bibliografisk kontrollert
    2. Serum untargeted lipidomic profiling reveals dysfunction of phospholipid metabolism in subclinical coronary artery disease
    Åpne denne publikasjonen i ny fane eller vindu >>Serum untargeted lipidomic profiling reveals dysfunction of phospholipid metabolism in subclinical coronary artery disease
    Vise andre…
    2019 (engelsk)Inngår i: Vascular Health and Risk Management, ISSN 1176-6344, E-ISSN 1178-2048, Vol. 15, s. 123-135Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Purpose: Disturbed metabolism of cholesterol and triacylglycerols (TGs) carries increased risk for coronary artery calcification (CAC). However, the exact relationship between individual lipid species and CAC remains unclear. The aim of this study was to identify disturbances in lipid profiles involved in the calcification process, in an attempt to propose potential biomarker candidates.

    Patients and methods: We studied 70 patients at intermediate risk for coronary artery disease who had undergone coronary calcification assessment using computed tomography and Agatston coronary artery calcium score (CACS). Patients were divided into three groups: with no coronary calcification (NCC; CACS: 0; n=26), mild coronary calcification (MCC; CACS: 1-250; n=27), or severe coronary calcification (SCC; CACS: >250; n=17). Patients' serum samples were analyzed using liquid chromatography-mass spectrometry in an untargeted lipidomics approach.

    Results: We identified 103 lipids within the glycerolipid, glycerophospholipid, sphingolipid, and sterol lipid classes. After false discovery rate correction, phosphatidylcholine (PC)(16:0/20:4) in higher levels and PC(18:2/18:2), PC(36:3), and phosphatidylethanolamine(20:0/18:2) in lower levels were identified as correlates with SCC compared to NCC. There were no significant differences in the levels of individual TGs between the three groups; however, clustering the lipid profiles showed a trend for higher levels of saturated and monounsaturated TGs in SCC compared to NCC. There was also a trend for lower TG (49:2), TG(51:1), TG(54:5), and TG(56:8) levels in SCC compared to MCC.

    Conclusion: In this study we investigated the lipidome of patients with coronary calcification. Our results suggest that the calcification process may be associated with dysfunction in autophagy. The lipidomic biomarkers revealed in this study may aid in better assessment of patients with subclinical coronary artery disease.

    sted, utgiver, år, opplag, sider
    DOVE Medical Press Ltd., 2019
    Emneord
    coronary artery calcification, coronary artery calcium score, lipidomics, triacylglycerol, lipids, atherosclerosis, autophagy
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-74648 (URN)10.2147/VHRM.S202344 (DOI)000468547500001 ()
    Forskningsfinansiär
    Swedish Heart Lung Foundation
    Tilgjengelig fra: 2019-06-10 Laget: 2019-06-10 Sist oppdatert: 2020-05-19bibliografisk kontrollert
    3. Impact of socioeconomic status on coronary artery calcification
    Åpne denne publikasjonen i ny fane eller vindu >>Impact of socioeconomic status on coronary artery calcification
    Vise andre…
    2018 (engelsk)Inngår i: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 25, nr 16, s. 1756-1764Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Background: Low socioeconomic status is associated with an increased risk of coronary artery disease, but few studies have investigated the potential link between living in an area with a low versus a high socioeconomic status and coronary artery calcification, a marker of subclinical coronary artery disease. Design The design of this study was a cross-sectional study. Methods We evaluated 1067 participants with no history of coronary artery disease from the pilot phase of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Men and women aged 50-64 years were recruited from three high-socioeconomic status ( n = 541) and three low-socioeconomic status ( n = 526) areas in the city of Gothenburg (550,000 inhabitants). The coronary artery calcification score was assessed with the Agatston method using computed tomography, with individuals classified into either no coronary calcification ( n = 625; mean age, 57 years) or any coronary artery calcification ( n = 442; mean age, 59 years (men, 68.5%)). Results Coronary artery calcification was present in 244 (46.3%) and 198 (36.6%) individuals from the low- and high-socioeconomic status areas, respectively. Participants from the low-socioeconomic status areas had a significantly higher risk factor burden. In a multivariable logistic regression model with adjustment for age, sex and cardiovascular risk factors, the odds for coronary artery calcification were not significantly higher among persons living in low-socioeconomic status areas (odds ratio = 1.18, 95% confidence interval = 0.87-1.60). Conclusion In this relatively small cross-sectional study, we observed an association between living in a low-socioeconomic status area and coronary artery calcification. However, this was mostly explained by higher levels of cardiovascular disease risk factors, indicating that the effect of socioeconomic status on the atherosclerotic process works through an increased burden of cardiovascular disease risk factors.

    sted, utgiver, år, opplag, sider
    Sage Publications, 2018
    Emneord
    Socioeconomic status, social classes, neighbourhood, coronary artery calcification, subclinical coronary artery disease, ethnic group, nationality
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-68438 (URN)10.1177/2047487318792103 (DOI)000448077100012 ()30095278 (PubMedID)2-s2.0-85052572798 (Scopus ID)
    Forskningsfinansiär
    Swedish Heart Lung FoundationKnut and Alice Wallenberg FoundationSwedish Research CouncilVINNOVARegion Västra Götaland
    Merknad

    Funding Agency:

    Sahlgrenska Academy at the University of Gothenburg

    Tilgjengelig fra: 2018-08-13 Laget: 2018-08-13 Sist oppdatert: 2020-05-19bibliografisk kontrollert
    4. Social Support and Subclinical Coronary Artery Disease in Middle-Aged Men and Women: Findings from the Pilot of Swedish CArdioPulmonary bioImage Study
    Åpne denne publikasjonen i ny fane eller vindu >>Social Support and Subclinical Coronary Artery Disease in Middle-Aged Men and Women: Findings from the Pilot of Swedish CArdioPulmonary bioImage Study
    Vise andre…
    2020 (engelsk)Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 17, nr 3, artikkel-id 778Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Social support has been associated with coronary artery disease (CAD), particularly in individuals who have sustained a cardiovascular event. This study investigated the relationship between social support and subclinical CAD among 1067 healthy middle-aged men and women. Social support was assessed with validated social integration and emotional attachment measures. Subclinical CAD was assessed as a coronary artery calcium score (CACS) using computed tomography. There was no association between social support and CACS in men. In women, low social support was strongly linked to cardiovascular risk factors, high levels of inflammatory markers, and CACS > 0. In a logistic regression model, after adjustment for 12 cardiovascular risk factors, the odds ratio (95% confidence intervals) for CACS > 0 in women with the lowest social integration, emotional attachment, and social support groups (reference: highest corresponding group) were 2.47 (1.23-5.12), 1.87 (0.93-3.59), and 4.28 (1.52-12.28), respectively. Using a machine learning approach (random forest), social integration was the fourth (out of 12) most important risk factor for CACS > 0 in women. Women with lower compared to higher or moderate social integration levels were about 14 years older in "vascular age". This study showed an association between lack of social support and subclinical CAD in middle-aged women, but not in men. Lack of social support may affect the atherosclerotic process and identify individuals vulnerable to CAD events.

    sted, utgiver, år, opplag, sider
    MDPI, 2020
    Emneord
    Social support, women, coronary artery calcium, coronary artery calcification, subclinical coronary artery disease, inflammation
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-80753 (URN)10.3390/ijerph17030778 (DOI)000517783300103 ()32012689 (PubMedID)2-s2.0-85078872171 (Scopus ID)
    Forskningsfinansiär
    Knut and Alice Wallenberg FoundationSwedish Research CouncilVinnovaRegion Västra GötalandAFA InsuranceSwedish Heart Lung Foundation
    Merknad

    Funding Agencies:

    Sahlgrenska Academy at University of Gothenburg

    Region Örebro County through ALF research fund

    Swedish CArdioPulmonary bioImage Study (SCAPIS) is the Swedish Heart and Lung Foundation

    Tilgjengelig fra: 2020-03-20 Laget: 2020-03-20 Sist oppdatert: 2020-05-19bibliografisk kontrollert
    5. Effects of a vegetarian diet on cardiometabolic risk factors, gut microbiota, and plasma metabolome in subjects with ischemic heart disease - a randomized, cross-over study
    Åpne denne publikasjonen i ny fane eller vindu >>Effects of a vegetarian diet on cardiometabolic risk factors, gut microbiota, and plasma metabolome in subjects with ischemic heart disease - a randomized, cross-over study
    Vise andre…
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81939 (URN)
    Tilgjengelig fra: 2020-05-19 Laget: 2020-05-19 Sist oppdatert: 2020-05-19bibliografisk kontrollert
    Fulltekst (pdf)
    Novel and Traditional Risk Factors for Coronary Artery Disease: Role of Coronary Artery Calcium, Lipidomics, Psychosocial Factors and Diet
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  • Skargren, Fredric
    Örebro universitet, Handelshögskolan vid Örebro Universitet.
    What is the point of benchmarking e-government? An integrative and critical literature review on the phenomenon of benchmarking e-government2020Inngår i: Information Polity, ISSN 1570-1255, E-ISSN 1875-8754, Vol. 25, nr 1, s. 67-89, artikkel-id IP-190131Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This literature review looks at research conducted on the phenomenon of benchmarking e-government during the years 2003 to 2016 and entails 27 articles. The review shows how this field has changed over time, its main findings and what the potential benefits are for the public sector in using the results from benchmarks. The findings reveal how initial research created taxonomies of benchmarks and criticised them for being too focused on measuring online services. This research was followed by even more criticism on how benchmarks can have a negative impact on e-government policy and development. During the same time-period there is research giving methodological support on how to improve ways of benchmarking. Later research offer theoretically and conceptually informed critique of benchmark-studies. The review finds that there are mainly implicit assumptions about the potential benefits in using benchmarks for improving e-government. The article concludes by discussing the implications of the findings in terms of the lack of context and relevance in benchmarks for e-government in relationship to the nature of public administration and makes suggestions for ways forward.

    Fulltekst (pdf)
    What is the point of benchmarking e-government?
  • Disputas: 2020-06-12 09:00 Örebro universitet, Forumhuset, Hörsal F, Örebro
    Karlberg-Traav, Malin
    Örebro universitet, Institutionen för hälsovetenskaper.
    Evidence-based nursing - reflections from different perspectives2020Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The overall aim of this thesis was to describe the use of evidence-based nursing (EBN) with respect to the four cornerstones of EBN: research, nursing theory, the patient’s perspective and clinical competence. Study I explored registered nurses (RNs) self-reported research utilization (RU) in relation to their work climate. A quantitative approach was used; further analyze led to a cluster solution of the measured variables, and low reported RU were compared with higher reported RU. The result showed that an academic degree underpinned the instrumental research utilization (IRU), also women reported higher use of conceptual research utilization (CRU). An association between low RU and dynamism/liveliness was seen, and younger RNs and RNs with shorter working experience reported higher scores for playfulness/humor and conflicts. Study II described how nurses conceived working in a ward where a nursing philosophy had been implemented. A phenomenographic method was used. The philosophy supported the clinical work and underpinned reflection and shared values. A prerequisite was a dedicated leader. The RNs described the care being of high quality. First line nurse managers (FLNMs) role and their experience of opportunities and obstacles to support EBN, was explored in study III. Data was collected using focus groups and analysed using phenomenography. The result showed that the FLNMs need to make an entity of vision and reality to be supportive according of EBN. The last study was an integrative literature review and the perspective of the patient in articles reporting on interventions designed to improve nursing was in focus. The result in study IV showed that the perspective of the patient represents five aspects, and that reporting clinical implications is important. In conclusion; the different perspectives all relates to EBN. Registered nurses need to be encouraged to develop their academic training, to be able to work according to EBN. A nursing philosophy provides time for reflection and a feeling of performing care of high quality. FLNMs need to take their role to support the RNs in order to work evidence-based. Conscious and communicated aspects supported the perspective of the patient.

    Delarbeid
    1. Registered nurses’ self-rated research utilization in relation to their work climate – using cluster analysis to search for patterns
    Åpne denne publikasjonen i ny fane eller vindu >>Registered nurses’ self-rated research utilization in relation to their work climate – using cluster analysis to search for patterns
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81865 (URN)
    Tilgjengelig fra: 2020-05-15 Laget: 2020-05-15 Sist oppdatert: 2020-05-15bibliografisk kontrollert
    2. Conceptions of an implemented nursing philosophy: A phenomenographic study
    Åpne denne publikasjonen i ny fane eller vindu >>Conceptions of an implemented nursing philosophy: A phenomenographic study
    2014 (engelsk)Inngår i: Clinical Nursing Studies, ISSN 2324-7940, E-ISSN 2324-7959, Vol. 2, nr 3, s. 86-96Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Aim: The aim of this study was to describe how nurses conceive their work on a ward where a nursing philosophy has been systematically implemented.

    Introduction: There is no international consensus today in relation to the organizing of nursing on the basis of an established nursing theory.

    Design and method: This study has a phenomenographic methodology, with an epistemological base in life-world perspective. Data were collected through thematized interviews with nurses on a ward where a nursing philosophy has been implemented for several years.

    Result: The conceptions of working with a nursing philosophy is described in an overarching statement formulated as a movement From implicit to explicit - where openness and freedom to speak are essential based on five categories of description (conceptions): Making it happen – the manager´s significance for implementation, Integrating the philosophy within me – creating a collective platform, “Welcome to us” – a caring atmosphere, The patient’s sense of being confirmed – establishing quality of care, “Us and them” –being inside or outside.

    Conclusion: Working with an implemented nursing philosophy seemed to provide support to the nurse in day-to-day work and thereby contributes to shared values. On the basis of the results we are not able to state that the specific nursing philosophy used can be the only contribution to the experienced support.

    sted, utgiver, år, opplag, sider
    Sciedu Press, 2014
    Emneord
    Nursing philosophy, Reflections, Feeling of confidence, Theory, Phenomenography
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81864 (URN)10.5430/cns.v2n3p86 (DOI)
    Tilgjengelig fra: 2020-05-15 Laget: 2020-05-15 Sist oppdatert: 2020-05-15bibliografisk kontrollert
    3. First line nurse managers' experience of opportunities and obstacles to support evidence-based nursing
    Åpne denne publikasjonen i ny fane eller vindu >>First line nurse managers' experience of opportunities and obstacles to support evidence-based nursing
    2018 (engelsk)Inngår i: Nursing Open, E-ISSN 2054-1058, Vol. 5, nr 4, s. 634-641Artikkel i tidsskrift (Fagfellevurdert) Published
    Abstract [en]

    Aim: The aim was to explore first line nurse managers’ experiences of opportunities and obstacles to support evidence‐based nursing.

    Design: A qualitative study with a phenomenographical approach.

    Method: Data were collected through focus group interviews with 15 first line nurse managers’ in four settings.

    Results: The results are presented in four categories of description headed: Manage the everyday work vs. evidence‐based nursing; Uncertainties about evidence‐based nursing and nursing research; Time as a reality, as an approach; and Shaping awareness—towards an active approach to evidence‐based nursing. The overarching category of description has been formulated as follows: The internal relation—how active leadership influences evidence‐based nursing. The outcome space is presented as: The individual path—how to make vision and reality become a working entity around evidence‐based nursing.

    sted, utgiver, år, opplag, sider
    Wiley-Blackwell, 2018
    Emneord
    Coherent strategy, evidence‐based nursing, first line nurse manager, leadership, phenomenography, reflection
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-68352 (URN)10.1002/nop2.172 (DOI)000446838700020 ()30338109 (PubMedID)
    Tilgjengelig fra: 2018-08-07 Laget: 2018-08-07 Sist oppdatert: 2020-05-15bibliografisk kontrollert
    4. Is the patient’s perspective taken into account? – Interventions to improve evidence-based nursing: An integrative literature review
    Åpne denne publikasjonen i ny fane eller vindu >>Is the patient’s perspective taken into account? – Interventions to improve evidence-based nursing: An integrative literature review
    (engelsk)Manuskript (preprint) (Annet vitenskapelig)
    HSV kategori
    Identifikatorer
    urn:nbn:se:oru:diva-81866 (URN)
    Tilgjengelig fra: 2020-05-15 Laget: 2020-05-15 Sist oppdatert: 2020-05-15bibliografisk kontrollert
    Fulltekst (pdf)
    Evidence-based nursing - reflections from different perspectives
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  • Lidskog, Rolf
    et al.
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Berg, Monika
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Gustafsson, Karin M.
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Löfmarck, Erik
    Örebro universitet, Institutionen för humaniora, utbildnings- och samhällsvetenskap.
    Cold Science Meets Hot Weather: Environmental Threats, Emotional Messages and Scientific Storytelling2020Inngår i: Media and Communication, E-ISSN 2183-2439, Vol. 8, nr 1, s. 118-128Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Science is frequently called upon to provide guidance in the work towards sustainable development. However, for science to promote action, it is not sufficient that scientific advice is seen as competent and trustworthy. Such advice must also be perceived as meaningful and important, showing the need and urgency of taking action. This article discusses how science tries to facilitate action. It claims that the use of scientific storytelling—coherent stories told by scientists about environmental trajectories—are central in this; these stories provide meaning and motivate and guide action. To do this, the storylines need to include both a normative orientation and emotional appeals. Two different cases of scientific storytelling are analyzed: one is a dystopic story about a world rushing towards ecological catastrophe, and the other is an optimistic story about a world making dramatic progress. These macrosocial stories offer science-based ways to see the world and aim to foster and guide action. The article concludes by stating that using storylines in scientific storytelling can elicit fear, inspire hope, and guide action. The storylines connect cold and distant scientific findings to passionate imperatives about the need for social transformation. However, this attachment to emotions and values needs to be done reflexively, not only in order to create engagement with an issue but also to counteract a post-truth society where passionate imperatives go against scientific knowledge.

    Fulltekst (pdf)
    Cold Science Meets Hot Weather: Environmental Threats, Emotional Messages and Scientific Storytelling
  • Johansson, Björn
    et al.
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Flygare, Erik
    Örebro universitet, Institutionen för juridik, psykologi och socialt arbete.
    Bryggan: En processutvärdering av en social investering med fokus på elever med destruktivt normbrytande beteende och problematisk skolfrånvaro2020Rapport (Annet vitenskapelig)
    Fulltekst (pdf)
    BRYGGAN: En processutvärdering av en social investering med fokus på elever med destruktivt normbrytande beteende och problematisk skolfrånvaro
  • Öberg, Jacob
    Faculty of Law, Lund University, Lund, Sweden.
    Trust in the Law? Mutual Recognition as a Justification to Domestic Criminal Procedure2020Inngår i: European Constitutional Law Review, ISSN 1574-0196, E-ISSN 1744-5515, Vol. 16, nr 1, s. 33-62Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This article closely analyses mutual recognition as a justification for EU legislative activity in the field of domestic criminal procedure. By looking at the structure, wording and purpose of the Treaties, the article first discusses the proper interpretation of the mutual recognition criterion in Article 82(2) TFEU. It argues for a narrow construction of Article 82(2) TFEU, suggesting that the expression ‘enabling mutual recognition’ is capable of substantially confining EU action on criminal procedure. The article challenges the justification for having EU competence in domestic criminal procedure on the basis that it enables mutual recognition. It advances the proposition that it is very difficult to defend on a conceptual and empirical basis that harmonisation has a positive effect on the operation on mutual recognition.

    Fulltekst (pdf)
    Trust in the Law? Mutual Recognition as a Justificationto Domestic Criminal Procedure