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  • Hall, Matthew
    et al.
    Ulster University, UK.
    Hearn, Jeff
    Hanken School of Economics, Helsinki, Finland.
    Violation by sexual image distribution, “revenge pornography”, cyberabuses, and prevention2018In: 6th International Report. Crime Prevention and Community Safety: Preventing Cybercrime / [ed] Pablo Madriaza, Montreal, Canada: International Centre for the Prevention of Crime (ICPC) , 2018, p. 103-110Chapter in book (Other academic)
  • Hearn, Jeff
    University of Huddersfield, Huddersfield, UK.
    Panel record progress2018In: Network, Vol. 130, p. 38-38Article in journal (Other (popular science, discussion, etc.))
  • Hearn, Jeff
    et al.
    Örebro University, School of Humanities, Education and Social Sciences. University of Huddersfield, Huddersfield, UK; Hanken School of Economics, Helsinki, Finland.
    Hall, Matthew
    University of Ulster, UK; University of Derby, UK.
    “This is my cheating ex”: Gender and sexuality in revenge porn2018In: Sexualities, ISSN 1363-4607, E-ISSN 1461-7382, p. 1-23Article in journal (Refereed)
    Abstract [en]

    Revenge pornography is the online, and at times offline, non-consensual distribution, or sharing, of explicit images by ex-partners, partners, others, or hackers seeking revenge or entertainment. In this article, we discursively analyse a selected range of electronic written texts accompanying explicit images posted by self-identified straight/gay/lesbian (male-to-female, female-to-male, male-to-male, female-to-female postings) on a popular revenge pornography website ‘MyEx.com’. Situating our analysis in debates on gender and sexuality, we examine commonalities and differences in the complex and sometimes contradictory ways in which gender and sexuality are invoked in posters’ accounts of their motivations for revenge pornography.

  • Linton, Gabriel
    et al.
    Örebro University, Örebro University School of Business.
    Klinton, Markus
    Örebro University.
    University entrepreneurship education: A design thinking approach to learning2019In: Journal of Innovation and Entrepreneurship, ISSN 2192-5372, E-ISSN 2192-5372, Vol. 8, no 3, p. 1-11Article in journal (Refereed)
    Abstract [en]

    Background: Entrepreneurship has traditionally been taught from a business administration perspective, where predicting the future is central and where the world is seen as linear with known inputs and outputs. The world of entrepreneurs is a quite different, usually highly uncertain environment, and therefore requires a different type of skill set. In this paper, we conceptualize entrepreneurial learning through a method- and design-based approach and illustrate how a course can be developed and designed.

    Findings: In this paper it is argued that by utilizing design thinking and a methods approach, learning from a “through” approach can be achieved. This learning is more focused on the entrepreneurial process, highlighting the role of skills and mindset. This learning approach enables student-centered learning and focus on skills more applicable to entrepreneurs. It is also argued that the entrepreneurship process is not linear; therefore, creativity is central and finding structure is an unstructured process. Design thinking emphasizes a practical approach where students step outside the classroom. This experimentation and interaction in the real world of users and customers with real feedback is important in combination with reflection exercises.

    Conclusions: This paper highlights how a methods approach and entrepreneurship education with a “through” perspective can be achieved by utilizing design thinking. This is elaborated conceptually and illustrated with an example. We argue that a methods approach for teaching entrepreneurship is beneficial, where design thinking can be one valuable tool and approach for teaching entrepreneurship.

  • Solana-Tramunt, Mònica
    et al.
    Dept of Sports Sciences, FPCEE Blanquerna, Ramon Llull University, Barcelona, Spain.
    Morales, Jose
    Dept of Sports Sciences, FPCEE Blanquerna, Ramon Llull University, Barcelona, Spain.
    Buscà, Bernat
    Dept of Sports Sciences, FPCEE Blanquerna, Ramon Llull University, Barcelona, Spain.
    Carbonell, Marina
    Clinical Biochemistry Dept, Germans Trias i Pujol Hospital, Autonomous University of Barcelona, Badalona, Barcelona, Spain.
    Rodríguez-Zamora, Lara
    Environmental Physiology Group, Dept of Health Sciences, Mid Sweden University, Östersund, Sweden.
    Heart Rate Variability in Elite Synchronized Swimmers2018In: International Journal of Sports Physiology and Performance, ISSN 1555-0265, E-ISSN 1555-0273, p. 1-24Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To determine whether heart rate variability (HRV) was correlated with other training load and training tolerance markers for monitoring the effect of a training session on elite synchronized swimmers.

    METHODS:: , SC, and RPE and relative changes (Δ%) in the natural logarithm of the root mean square successive difference of intervals (LnRMSSD). We also calculated the smallest worthwhile change (SWC) of the averaged pre and post LnRMSSD measurements.

    RESULTS:: (6.8±2.7) was correlated positively with Δ%LnRMSSD and Δ%SC.

    CONCLUSIONS:: , Δ%SC, and RPE indicated reduced sympathetic activation and positive adaptation to the stress imposed by the session. Isolated HRV assessment may reveal a controversial interpretation of the autonomic nervous system status or the training tolerance in elite SS athletes that are influenced by diving response.

  • Carrasco-Marginet, Marta
    et al.
    INEFC-Barcelona Sports Sciences Research Group, National Institute of Physical Education of Catalonia, Universitat de Barcelona, Barcelona, Spain.
    Castizo-Olier, Jorge
    INEFC-Barcelona Sports Sciences Research Group, National Institute of Physical Education of Catalonia, Universitat de Barcelona, Barcelona, Spain.
    Rodríguez-Zamora, Lara
    Department of Health Sciences, Mid Sweden University, Östersund, Sweden; Swedish Winter Sports Research Centre, Mid Sweden University,Östersund, Sweden.
    Iglesias, Xavier
    INEFC-Barcelona Sports Sciences Research Group, National Institute of Physical Education of Catalonia, Universitat de Barcelona, Barcelona, Spain.
    Rodríguez, Ferran A.
    INEFC-Barcelona Sports Sciences Research Group, National Institute of Physical Education of Catalonia, Universitat de Barcelona, Barcelona, Spain.
    Chaverri, Diego
    INEFC-Barcelona Sports Sciences Research Group, National Institute of Physical Education of Catalonia, Universitat de Barcelona, Barcelona, Spain.
    Brotons, Daniel
    Sport and Health Area of the Catalan Sport Council, Government of Catalonia, Barcelona, Spain.
    Irurtia, Alfredo
    INEFC-Barcelona Sports Sciences Research Group, National Institute of Physical Education of Catalonia, Universitat de Barcelona, Barcelona, Spain.
    Bioelectrical impedance vector analysis (BIVA) for measuring the hydration status in young elite synchronized swimmers2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 6, article id e0178819Article in journal (Refereed)
    Abstract [en]

    PURPOSE: The assessment of body hydration is a complex process, and no measurement is valid for all situations. Bioelectrical impedance vector analysis (BIVA) has emerged as a relatively novel technique for assessing hydration status in sports. We applied BIVA a) to determine hydration changes evoked by an intense synchronized swimming (SS) training session; b) to characterize the sample of young elite swimmers in relation with a nonathletic reference population; and c) to generate its 50%, 75% and 95% percentiles of the bioelectrical variables.

    METHODS: Forty-nine elite SS female swimmers of two age categories, comen (Co: 13.9 ± 0.9 years, n = 34) and junior (Jr: 16.3 ± 0.6 years, n = 15), performed a long, high intensity training session. Body mass (BM) and bioelectrical variables (R, resistance; Xc, reactance; PA, phase angle; and Z, impedance module) were assessed pre- and post-training. BIVA was used to characterize 1) the distribution pattern of the bioelectrical vector (BIA vector) for both age groups, and 2) pre- to post-training BIA vector migration. Bioelectrical variables were also correlated with BM change values.

    RESULTS: Most swimmers were mostly located outside the 75% and some beyond the 95% percentile of the bioelectrical tolerance ellipses of the general population. The BIA vector showed statistically significant differences in both Co (T2 = 134.7, p = 0.0001) and Jr (T2 = 126.2, p < 0.001). Both groups were also bioelectrically different (T2 = 17.6, p < 0.001). After the training session, a decrease in BM (p = 0.0001) and an increase in BIA variables (p = 0.01) was observed. BIVA also showed a significant pre-post vector migration both in Co (T2 = 82.1; p < 0.001) and Jr (T2 = 41.8; p < 0.001). No correlations were observed between BM changes and bioelectrical variables.

    CONCLUSIONS: BIVA showed specific bioelectrical characteristics in young elite SS athletes. Considering the decrease in BM and the migration of the BIA vector, we conclude that the homeostatic hydration status of these young elite female swimmers was affected by the execution of intense training sessions. From a methodological perspective, BIVA appears to be sensitive enough to detect subtle hydration changes, but further research is needed to ensure its validity and reliability. Moreover, these findings highlight the importance of ensuring adequate fluid intake during training in young SS athletes.

  • Hedström, Karin
    et al.
    Örebro University, Örebro University School of Business.
    Melin, Ulf
    Söderström, Fredrik
    Identitet, arbete och privatliv: smarta ID-kort2018In: Ett smartare samhälle: sju perspektiv på digitaliseringen av vår vardag / [ed] Gröning, Lotta & Wihlborg, Elin, Linköping: Linköping University Electronic Press, 2018, p. 112-128Chapter in book (Other (popular science, discussion, etc.))
  • Bernhard, Irene
    et al.
    University West, Trollhättan, Sweden.
    Gustafsson, Mariana
    Linköping University, Linköping, sweden.
    Hedström, Karin
    Örebro University, Örebro University School of Business.
    Sefyrin, Johanna
    Linköping University, Linköping, Sweden.
    Wihlborg, Elin
    Linköping University, Linköping, Sweden.
    A Digital Society For All?: Meanings, Practices and Policies for Digital Diversity2019In: Proceedings of the 52nd Hawaii International Conference on System Sciences, 2019, p. 3067-3076Conference paper (Refereed)
    Abstract [en]

    The concept of digital divides has been on the agenda in research and policy making for at least the last 20 years. But it is still, a challenge to grasp this concept that is so elusive and transforming. Inclusion, access and equality are still key values for democratic governance and must be addressed in particular when forming and contributing to a digital government. This paper seeks to intervene in current debates on digital divides and digital inclusion by analyzing two cases of responses among street-level public administration in relation to e-government services in Sweden. The case studies are strategically chosen and conducted in national agencies and in local public libraries. Three lines of contributions are discussed, firstly the importance to care for equality secondly the need to see the non-users, and thirdly to discuss the potential of putting focus on digital diversity.

  • Pittura, Lucia
    et al.
    Laboratorio di Ecotossicologia e Chimica ambientale, Dipartimento di Scienze della Vita e dell’Ambiente, Università Politecnica delle Marche, Ancona, Italy.
    Avio, Carlo G.
    Laboratorio di Ecotossicologia e Chimica ambientale, Dipartimento di Scienze della Vita e dell’Ambiente, Università Politecnica delle Marche, Ancona, Italy.
    Giuliani, Maria E.
    Laboratorio di Ecotossicologia e Chimica ambientale, Dipartimento di Scienze della Vita e dell’Ambiente, Università Politecnica delle Marche, Ancona, Italy.
    d’Errico, Giuseppe
    Laboratorio di Ecotossicologia e Chimica ambientale, Dipartimento di Scienze della Vita e dell’Ambiente, Università Politecnica delle Marche, Ancona, Italy.
    Keiter, Steffen
    Örebro University, School of Science and Technology.
    Cormier, Bettie
    Örebro University, School of Science and Technology. UMR Centre National de la Recherche Scientifique 5805 EPOC, University of Bordeaux, Talence, France.
    Gorbi, Stefania
    Laboratorio di Ecotossicologia e Chimica ambientale, Dipartimento di Scienze della Vita e dell’Ambiente, Università Politecnica delle Marche, Ancona, Italy.
    Regoli, Francesco
    Laboratorio di Ecotossicologia e Chimica ambientale, Dipartimento di Scienze della Vita e dell’Ambiente, Università Politecnica delle Marche, Ancona, Italy; Consorzio Interuniversitario per le Scienze del Mare, CoNISMa, ULR Ancona, Ancona, Italy.
    Microplastics as Vehicles of Environmental PAHs to Marine Organisms: Combined Chemical and Physical Hazards to the Mediterranean Mussels, Mytilus galloprovincialis2018In: Frontiers in Marine Science, E-ISSN 2296-7745, Vol. 5, no Apr, article id 103Article in journal (Refereed)
    Abstract [en]

    The ubiquitous occurrence of microplastics (MPs) in the marine environment is raising concern for interactions with marine organisms. These particles efficiently adsorb persistent organic pollutants from surrounding environment and, due to the small size, they are easily available for ingestion at all trophic levels. Once ingested, MPs can induce mechanical damage, sub- lethal effects and various cellular responses, further modulated by possible release of adsorbed chemicals or additives. In this study, ecotoxicological effects of MPs and their interactions with benzo(a)pyrene (BaP), chosen as a model compound for polycyclic aromatic hydrocarbons (PAHs) were investigated in Mediterranean mussels, Mytilus galloprovincialis. Organisms were exposed for four weeks to 10 mg/L of low-density polyethylene (LD-PE) microparticles (2.34x107 particles/L, size range 20-25 µm), both virgin and pre-contaminated with BaP (15µg/g). Organisms were also exposed for comparison to BaP dosed alone at 150 ng/L, corresponding to the amount adsorbed on microplastics. Tissue localization of microplastics was histologically evaluated; chemical analyses and a wide battery of biomarkers covering molecular, biochemical and cellular levels allowed to evaluate BaP bioaccumulation, alterations of immune system, antioxidant defenses, onset of oxidative stress, peroxisomal proliferation, genotoxicity and neurotoxicity. Obtained data were elaborated within a quantitative weight of evidence (WOE) model which, using weighted criteria, provided synthetic hazard indices, for both chemical and cellular results, before their integration in a combined index. Microplastics were localized in haemolymph, gills and especially digestive tissues where a potential transfer of BaP from MPs was also observed. Significant alterations were measured on the immune system, while more limited effects occurred on the oxidative status, neurotoxicity and genotoxicity, with a different susceptibility of analyzed pathways, depending on tissue, time and typology of exposure. Molecular analyses confirmed the general lack of significant variations on transcriptional activity of antioxidant and stress genes. The overall results suggest that microplastics induce a slight cellular toxicity under short-term (28 days) exposure conditions. However, modulation of immune responses, along with bioaccumulation of BaP, pose the still unexplored risk that these particles, under conditions of more chronic exposure (months to years) or interacting with other stressors, may provoke long-term, subtle effects on organisms’ health status.

  • Folbre, Nancy
    et al.
    Olin Wright, Erik
    Andersson, Jenny
    Hearn, Jeff
    Örebro University, School of Humanities, Education and Social Sciences.
    Himmelweit, Sue
    Open University, UK.
    Sterling, Andrew
    The multiple directions of social progress: ways forward2018In: Rethinking Society for the 21st Century: Report of the International Panel on Social Progress. Volume 3 Transformations in Values, Norms, Culture / [ed] International Panel on Social Progress, Cambridge UK: Cambridge University Press, 2018, p. 815-846Chapter in book (Refereed)
  • Hearn, Jeff
    Örebro University, School of Humanities, Education and Social Sciences.
    Not Ending but Continuing …2017In: Making the Invisible Visible: Report of the Nordic MenEngage Conference, 16 February 2017, Reform Resource Centre, Oslo, 2017 / [ed] Reform Resource Centre, Oslo, Oslo, Norway, 2017Conference paper (Other (popular science, discussion, etc.))
  • Nilsson, Jakob
    Stockholm University, Stockholm, Sweden.
    The Untimely-Image: On Contours of the New in Political Film-Thinking2012Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This study creates and develops a concept called the untimely-image including two sub-concepts called contours of the new and the untimely-site. The untimely-image concerns the clearing for and the expression of figures of “potential” in thought in the form of moving-images. The aim of these concepts is to form a critical framework for evaluating and conceptualizing political film as expressive, not of the new itself but of its “untimely” contours.

    The untimely-image, and its many implications, is developed over the course of six chapters. Chapter 1 extensively defines “contours” and “new” as operative in this study, and also introduces a theme that runs through all the chapters: how to think the contours of the new in relation to the cult of the new in consumer culture and in relation to the larger mechanisms of advanced capitalism. Chapter 2 defines the parameters of the untimely-image as specifically regarding moving images, and continues the development of this concept. In Chapters 3 to 6, The Wire (David Simon, 2002-2008) serves the double function of complicating and giving specification to the elaboration of the untimely-image as well as a case in which the untimely-image is used as a critical framework. The Wire and the untimely-image relate in processes of juxtaposition, wherein they meet, cross over, separate, and reproblematize each other. An untimely-image is fully defined in relation to concrete political issues. The untimely-image is therefore advanced by articulating the components and characteristics that, independently of the concrete issue, remain in every case, as well as by putting the concept to work regarding two specific problems in The Wire: its expression of blackness and its mapping of advanced capitalism.

  • Egeberg Holmgren, Linn
    et al.
    Stockholm University, Stockholm, Sweden.
    Hearn, Jeff
    Örebro University, School of Humanities, Education and Social Sciences. University of Huddersfield, Huddersfield, UK; Hanken School of Economics, Helsinki, Finland.
    Erkekleri Feminizmin İçinde ve Dışında Çerçevelemek: [Framing ‘men in and not in feminism]2017In: Fe Dergi: Feminist Eleştiri, ISSN 1309-128X, Vol. 9, no 2, p. 85-101Article in journal (Refereed)
    Abstract [en]

    This article addresses some aspects of the “Man Question” in feminism, by way of the analysis ofmen’s diverse gender-conscious positionings in relation to gender, gender equality and feminism. Itbuilds on earlier work, making use of theoretical models in feminist literature combined with themicro-sociological concept of passing. Consideration is also given to men’s non-gender-consciouspositionings. The article is primarily concerned with the theoretical and empirical complexities,contradictions and ambiguities of men’s positionings, as when they are self-defined as “feminists” (orsimilar identifications) in radical or deconstructive ways. In this, a Swedish interview data is used.Sweden is considered particularly interesting, with a qualified societal consensus on gender equalityand a broadly positive place accorded to men’s relations with feminism. The authors argue in the finalsection that there is a need to further dialogue between analyses of men/masculinities and themultidimensionality of feminisms, as well as a need for more empirical studies of men’s different(pro)feminist positionings in order to elaborate the theoretical implications of different socialcontexts. The framing presented seeks to provide greater possibilities for such complex, nuanced andsituated understandings of men’s relation to feminism, theoretically, analytically and politically.

  • D'Souza, K.
    et al.
    Dalhousie Medicine New Brunswick, United States.
    Nzirorera, C.
    Dalhousie Medicine New Brunswick, United States.
    Cowie, A.M.
    Dalhousie Medicine New Brunswick, United States.
    Paramel Varghese, Geena
    Dalhousie Medicine New Brunswick, United States.
    Trivedi, P.
    Dalhousie Medicine New Brunswick, United States.
    Eichmann, T.O.
    Department of Biochemistry and Molecular Biology, Dalhousie University, Institute of Molecular Biosciences, Saint John, Canada.
    Biswas, D.
    Dalhousie Medicine New Brunswick, United States.
    Touaibia, M.
    University of Graz, Center for Explorative Lipidomics, BioTechMed-Graz, Department of Chemistry and Biochemistry, Graz, Austria.
    Morris, A.J.
    Dalhousie Medicine New Brunswick, United States; Université de Moncton, Division of Cardiovascular Medicine, Moncton, Canada.
    Aidinis, V.
    University of Kentucky, Lexington Veterans Affairs Medical Center, Division of Immunology, Lexington, United States.
    Kane, D.A.
    Biomedical Sciences Research Center “Alexander Fleming”, Department of Human Kinetics, Athens, Greece.
    Pulinilkunnil, T.
    Dalhousie Medicine New Brunswick, United States.
    Kienesberger, P.C.
    Dalhousie Medicine New Brunswick, United States.
    Autotaxin-Lysophosphatidic Acid Signaling Contributed to Obesity-Induced Insulin Resistance in Muscle and Impairs Mitochondrial Metabolism2018In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 59, no 10, p. 1805-1817Article in journal (Refereed)
    Abstract [en]

    Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin resistance. However, it remains unclear whether the ATX-LPA pathway influences insulin function and energy metabolism in target tissues, particularly skeletal muscle, the major site of insulin-stimulated glucose disposal. The objective of this study was to test whether the ATX-LPA pathway impacts tissue insulin signaling and mitochondrial metabolism in skeletal muscle during obesity. Male mice with heterozygous ATX deficiency (ATX +/-) were protected from obesity, systemic insulin resistance, and cardiomyocyte dysfunction following high-fat high-sucrose (HFHS) feeding. HFHS-fed ATX +/- mice also had improved insulin-stimulated AKT phosphorylation in white adipose tissue, liver, heart, and skeletal muscle. Preserved insulin-stimulated glucose transport in muscle from HFHS fed ATX +/- mice was associated with improved mitochondrial pyruvate oxidation in the absence of changes in fat oxidation and ectopic lipid accumulation. Similarly, incubation with LPA decreased insulin-stimulated AKT phosphorylation and mitochondrial energy metabolism in C2C12 myotubes at baseline and following palmitate-induced insulin resistance. Taken together, our results suggest that the ATX-LPA pathway contributes to obesity-induced insulin resistance in metabolically relevant tissues. Our data also suggest that LPA directly impairs skeletal muscle insulin signaling and mitochondrial function. Preserved insulin-stimulated glucose transport in muscle from HFHS fed ATX +/- mice was associated with improved mitochondrial pyruvate oxidation in the absence of changes in fat oxidation and ectopic lipid accumulation. Similarly, incubation with LPA decreased insulin-stimulated AKT phosphorylation and mitochondrial energy metabolism in C2C12 myotubes at baseline and following palmitate-induced insulin resistance. Taken together, our results suggest that the ATX-LPA pathway contributes to obesity-induced insulin resistance in metabolically relevant tissues. Our data also suggest that LPA directly impairs skeletal muscle insulin signaling and mitochondrial function. Preserved insulin-stimulated glucose transport in muscle from HFHS fed ATX +/- mice was associated with improved mitochondrial pyruvate oxidation in the absence of changes in fat oxidation and ectopic lipid accumulation. Similarly, incubation with LPA decreased insulin-stimulated AKT phosphorylation and mitochondrial energy metabolism in C2C12 myotubes at baseline and following palmitate-induced insulin resistance. Taken together, our results suggest that the ATX-LPA pathway contributes to obesity-induced insulin resistance in metabolically relevant tissues. Our data also suggest that LPA directly impairs skeletal muscle insulin signaling and mitochondrial function. incubation with LPA decreased insulin-stimulated AKT phosphorylation and mitochondrial energy metabolism in C2C12 myotubes at baseline and following palmitate-induced insulin resistance. Taken together, our results suggest that the ATX-LPA pathway contributes to obesity-induced insulin resistance in metabolically relevant tissues. Our data also suggest that LPA directly impairs skeletal muscle insulin signaling and mitochondrial function. incubation with LPA decreased insulin-stimulated AKT phosphorylation and mitochondrial energy metabolism in C2C12 myotubes at baseline and following palmitate-induced insulin resistance. Taken together, our results suggest that the ATX-LPA pathway contributes to obesity-induced insulin resistance in metabolically relevant tissues. Our data also suggest that LPA directly impairs skeletal muscle insulin signaling and mitochondrial function.

  • Paramel Varghese, Geena
    et al.
    Örebro University, School of Medical Sciences. Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, Canada.
    D’Souza, K.
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, Canada.
    Kienesberger, P.
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, Canada.
    Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance2018In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 4, article id 399Article, review/survey (Refereed)
    Abstract [en]

    Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). The majority of circulating LPA is produced by the secreted enzyme autotaxin (ATX). Alterations in LPA signaling, in conjunction with changes in autotaxin (ATX) expression and activity, have been implicated in metabolic and inflammatory disorders including obesity, insulin resistance, and cardiovascular disease. This review summarizes our current understanding of the sources and metabolism of LPA with focus on the influence of diet on circulating LPA. Furthermore, we explore how the ATX-LPA pathway impacts obesity and obesity-associated disorders, including impaired glucose homeostasis, insulin resistance, and cardiovascular disease.

  • Glatz, Terese
    et al.
    Örebro University, School of Law, Psychology and Social Work.
    Källström, Åsa
    Örebro University, School of Law, Psychology and Social Work.
    Hellfeldt, Karin
    Örebro University, School of Law, Psychology and Social Work.
    Thunberg, Sara
    Örebro University, School of Law, Psychology and Social Work.
    Physical Violence in Family Sub-Systems: Links to Peer Victimization and Long-Term Emotional and Behavioral Problems2018In: Journal of family Violence, ISSN 0885-7482, E-ISSN 1573-2851, p. 1-11Article in journal (Refereed)
    Abstract [en]

    Although childhood violence by any person is negative for children, little is known about whether violence by different family members is linked differently to problems in young adulthood, as family relationships might play different roles in children’s individual development. In this study, we examine parent and sibling violence and associations with emotional and behavioral problems, directly and indirectly via peer victimization. We used retrospective reports from 347 young adults (aged 20–24) who all reported childhood family physical violence, and we performed a path analysis using Mplus. The results showed that participants who had been victimized by a sibling only or by both a sibling and parent were more likely to report peer victim- ization than were participants who had been victimized by parents only. Peer victimization was, in turn, linked to more aggres- sion, criminality, and anxiety. Theoretical and clinical implications of these results are discussed.

  • Hearn, Jeff
    Örebro University, School of Humanities, Education and Social Sciences. University of Huddersfield, Huddersfield, UK; Hanken School of Economics, Helsinki, Finland; University of South Africa, Pretoria, South Africa.
    Moving men, changing men, othering men: Reflections on and beyond politics, care and representation2018In: Quaderns-e de l'Institut Català d'Antropologia [The Catalan Institute of Anthropology Quarterly], ISSN 1696-8298, Vol. 24, p. 29-58Article in journal (Refereed)
    Abstract [en]

    In recent years, there has been a large, perhaps surprising, growth of critical studies on men and masculinities, across the humanities and social sciences, and to a more limited extent in the natural sciences and technology, along with a variety of political and policy interventions on men and masculinities. In this paper, I examine some of the ways in which a critical gendered focus on men and masculinities can both re-centre men and de-centre men, paying particular attention to the central themes of politics, representation and care. A key challenge is how to name men and masculinities, and at the same time deconstruct men and masculinities, to avoid potential re-centrings of power, at the local, national and transnational levels. Finally, and in these contexts and with these contradictions, I consider the possibilities and pitfalls of the abolition of "men" as social category of power, with special reference to questions of age, ageing and the body.

  • Hildén, Ebba
    et al.
    Karlstads University, Karlstad, Sweden.
    Löfdahl Hultman, Annica
    Karlstads University, Karlstad, Sweden.
    Bergh, Andreas
    Örebro University, School of Humanities, Education and Social Sciences.
    Undervisning från svenska förskolechefers perspektiv: Spänningar mellan förväntningar och erfarenheter2018In: Barn, ISSN 0800-1669, Vol. 3, no 4, p. 147-162Article in journal (Refereed)
    Abstract [en]

    This study aims to contribute knowledge about Swedish preschool managers’ usage of the concept of teaching in preschool. Concept analysis (Koselleck 2004) is carried out, which is supported by the analytical concepts of horizon of expectation and space of experience. The empirical material consists of sound recorded talks and a survey with open questions about teaching in preschool with one follow-up-interview in order to deepen the survey results. The results of the analysis show preschool managers expectations on the staff to starting to use the concept, however, without no radical changes in their practice. Rather, as one manager expressed – it is about to ”gild” the practice. Nevertheless, the study shows that the concept holds a range of tensions, where for example earlier collegial responsibility is challenged by a more divided responsibility. Such tensions enable possible changes in the meaning of the concept as well as changes in preschool practice.

  • Bagger, Anette
    et al.
    Umeå University, Umeå, Sweden.
    Roos, Helena
    Linneaus University, Sweden.
    Engvall, Margareta
    Linköping University, Linköping, Sweden.
    Investigating the politics of meaning(s) in Nordic research on special education mathematics​: developing a methodology​2018In: Perspectives on professional development of mathematics teachers: Proceedings of MADIF 11. The eleventh research seminar of the  Swedish Society for Research in  Mathematics Education Karlstad, January 23–24, 2018​ / [ed] J. Häggstroöm, Y. Liljekvist, J. Bergman, Ärlebäck, M. Fahlgren & O. Olande, Göteborg: Svensk förening för MatematikDidaktisk Forskning - SMDF, 2018, p. 141-150Conference paper (Refereed)
    Abstract [en]

    This paper aims to develop a methodology to explore the politics of meaning in special education mathematics research. Mediated meaning, directions of intentionalities and perspectives on special education have been analysed in eight reviewed articles.  Results indicate that the politics of meaning in the Nordic sample are about processes of normalisation and effectiveness through methods and approaches. The teacher is emphasised as the centre for change and development also when it comes to organisational factors. Disabilities are not researched, perhaps cloaked by an overall relational approach or due to research paying attention to milder difficulties. The deve- loped methodology seems to be fruitful and will be applied on a broader international sample.

  • Nilsson, Jakob
    The Ambivalence of Universalization in Albert Kahn's Archive of the Planet (Notes Towards an Empirical Investigation)2009In: SITE Magazine, no 28, p. 14-20Article in journal (Other academic)
  • Bagger, Anette
    Umeå University, Umeå, Sweden.
    "It is only a test": Social aspects of displaying knowledge in mathematics for second language learners2018Manuscript (preprint) (Other academic)
    Abstract [en]

    This article discusses social dimensions connected to assessment in mathematics for second language learners in Sweden. The data consist of two semi-structured interviews with students in the ninth grade of compulsory school. Foucault’s thinking on discourse and positioning was advocated as a frame for analysis. The units for analysis were students’ statements about caring and the other in connection to the display of knowledge in mathematics. Results show that caring of and for others are important resources in managing assessment and believing in the future.

  • Kelemen [Capannini-Kelemen], Katalin
    Örebro University, School of Law, Psychology and Social Work.
    A common law jogrendszerek2018Other (Refereed)
  • Westberg, Johannes
    Örebro University, School of Humanities, Education and Social Sciences.
    Folkskolestadgan 175 år: Vad innebar den?2017In: Vägval i skolans historia, no 4, p. 1-7Article in journal (Other (popular science, discussion, etc.))
    Abstract [sv]

    Den 18 juni 1842 signerade kung Karl XIV Johan, i stadgan betecknad som “med Guds Nåde, Sweriges, Norriges, Göthes och Wendes Konung”, Kongl. Maj:ts Nådiga Stadga angående Folkunderwisningen i Riket. Denna stadga, som under 2017 fyllde 175 år, har allt sedan sin tillkomst varit omdiskuterad.

  • Baianstovu, Rúna Í
    et al.
    Örebro University, School of Law, Psychology and Social Work.
    Cinthio, Hanna
    Särnstedt, Emmie
    Strid, Sofia
    Örebro University, School of Humanities, Education and Social Sciences.
    Det hedersrelaterade våldets och förtryckets uttryck och samhällets utmaningar: En kartläggning i Göteborg, Malmö och Stockholm 2017-2018: Del II: Redovisning av den kvalitativa delstudien i Göteborg, Malmö och Stockholm2018Report (Other academic)
  • Linton, Gabriel
    Örebro University, Örebro University School of Business.
    The Future, Entrepreneurship, and Innovation: A note on the importance of the getting entrepreneurship and innovation right for a sustainable futureManuscript (preprint) (Other academic)
  • Czégény, Gyula
    et al.
    University of Pécs, Pécs, Hungary.
    Körösi, Laszlo
    University of Pécs, Pécs, Hungary.
    Strid, Åke
    Örebro University, School of Science and Technology.
    Hideg, Éva
    University of Pécs, Pécs, Hungary.
    Multiple roles for Vitamin B6in plant acclimation to UV-B2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, no 1, article id 1259Article in journal (Refereed)
    Abstract [en]

    Direct and indirect roles of vitamin B6in leaf acclimation to supplementary UV-B radiation are shown in vitamin B6deficient Arabidopsis thalianamutant rsr4-1 and C24 wild type. Responses to 4 days of 3.9 kJ m-2d-1 biologically effective UV-B dose were compared in terms of leaf photochemistry, vitamer content, and antioxidant enzyme activities; complemented with a comprehensive study of vitamer ROS scavenging capacities. Under UV-B, rsr4-1 leaves lost more (34%) photochemical yield than C24 plants (24%). In the absence of UV-B, rsr4-1 leaves contained markedly less pyridoxal-5’-phosphate (PLP) than C24 ones, but levels increased up to the C24 contents in response to UV-B. Activities of class-III ascorbate and glutathione peroxidases increased in C24 leaves upon the UV-B treatment but not in the rsr4-1 mutant. SOD activities remained the same in C24 but decreased by more than 50% in rsr4-1 under UV-B. Although PLP was shown to be an excellent antioxidant in vitro, our results suggest that the UV-B protective role of B6 vitamers is realized indirectly, via supporting peroxidase defence rather than by direct ROS scavenging. We hypothesize that the two defence pathways are linked through the PLP-dependent biosynthesis of cystein and heme, affecting peroxidases.

  • Nilsing Strid, Emma
    Linköping University, Linköping, Sweden.
    The Sick Leave Process: Sick Leave Guidelines, Sickness Certificates, and Experiences of Professionals2013Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Decisions on entitlement to sickness benefits and return to work interventions have substantial impact on individuals’ lives and on society. In most Western European countries, such decisions are based on sickness certificates, which should provide information on how a disease or injury reduces the individual’s work ability. These are challenging and complex assessments. In 2008, guidelines for the management of sick leave were implemented in Sweden, emphasizing early assessments of work ability and return to work, and increasing the quality demands of sickness certificates by underscoring descriptions of activity limitations related to work. The overall aim of this thesis was to gain a deeper knowledge of the sick leave process with special emphasis on the content of sickness certificates and primary health care (PHC) professionals’ experiences with the process. Specific aims were to compare the quality of sickness certificates regarding descriptions of functioning by the use of WHO’s International Classification of Functioning, disability, and health (ICF), as well as the prescribed interventions before versus after implementation of the Swedish sick leave guidelines.

    The thesis comprises three studies. A cross-sectional design was used in studies I and II, which included 475 and 501 new sickness certificates consecutively collected in Östergötland County, Sweden, in 2007 and 2009, respectively. Text on functioning was analysed with a deductive content analysis using the ICF. Study III was an exploratory study using data from four semi-structured focus group discussions with a purposeful sample of PHC professionals (n=18) in Östergötland County. An inductive content analysis was used in this study.

    The thesis comprises three studies. A cross-sectional design was used in studies I and II, which included 475 and 501 new sickness certificates consecutively collected in Östergötland County, Sweden, in 2007 and 2009, respectively. Text on functioning was analysed with a deductive content analysis using the ICF. Study III was an exploratory study using data from four semi-structured focus group discussions with a purposeful sample of PHC professionals (n=18) in Östergötland County. An inductive content analysis was used in this study.

    An overall conclusion drawn from this thesis is that patient functioning and needs might not be adequately communicated in the sick leave process. Despite the implementation of sick leave guidelines, this information is limited in sickness certificates and the collaboration is poor among the involved stakeholders, i.e., health care, the social insurance office, the employer and the OHS. The basis for decisions on entitlement to sickness benefits could be improved by including a description of the patients’ activity limitations or participation restrictions related to work demands. One way to enhance the decision basis might be to use the available team competencies at the PHC.

    List of papers
    1. Description of functioning in sickness certificates
    Open this publication in new window or tab >>Description of functioning in sickness certificates
    2011 (English)In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 39, no 5, p. 508-516Article in journal (Refereed) Published
    Abstract [en]

    Aims: Sickness certificates are to provide information on a disease and its consequences on the patients functioning. This information has implications for the patients rights to sickness benefits and return-to-work measures. The objective of this study was to investigate the description of functioning in sickness certificates according to WHOs International Classification of Functioning, Disability, and Health (ICF), and to describe the influence of patients age, gender, diagnostic group, and affiliation of certifying physician.

    Method: A content analysis of written statements regarding how the disease limits the patients functioning with ICF as a framework was performed in 475 sickness certificates, consecutively collected in Ostergotland County, Sweden.

    Results: Musculoskeletal diseases (MSD) were the largest diagnostic group, followed by mental disorders (MD). Certificates were mainly issued from physicians at hospitals and in primary health care (PHC). ICF was applicable for classifying statements regarding functioning in 311 certificates (65%). The distribution of components was 58% body functions, 26% activity, and 7% participation. The descriptions were primarily restricted to the use of at least one component; namely, body functions. Subgroup analysis showed that descriptions of activity and participation were more common in certificates for MD and MSD, or those issued by PHC physicians. A multiple regression analysis with the activity component as dependent variable confirmed the results by showing that activity was related to both diagnosis and affiliation.

    Conclusions: In a consecutive sample of sickness certificates, it was shown that information on functioning is scarce. When functioning was described, it was mainly body oriented.

    Place, publisher, year, edition, pages
    Sage Publications, 2011
    Keywords
    International Classification of Functioning; Disability; and Health; mental disorders; musculoskeletal diseases; physicians assessment of work capacity; sick leave
    National Category
    Medical and Health Sciences Occupational Health and Environmental Health
    Identifiers
    urn:nbn:se:oru:diva-70716 (URN)10.1177/1403494811399954 (DOI)000292539900009 ()21343312 (PubMedID)22-s2.0-79960479393 (Scopus ID)
    Funder
    Swedish Social Insurance Agency
    Note

    The final, definitive version of this paper has been published in: Scandinavian Journal of Public Health, (39), 5, 508-516, 2011. Emma Nilsing, Elsy Söderberg, Helena Normelli and Birgitta Öberg, Description of functioning in sickness certificates http://dx.doi.org/10.1177/1403494811399954 by SAGE Publications Ltd, All rights reserved. http://www.uk.sagepub.com/

    Funding Agency:

    County Council in Östergotland, Sweden [IHS 7/0728]

    Available from: 2018-12-13 Created: 2018-12-13 Last updated: 2018-12-14Bibliographically approved
    2. Sickness certificates: what information do they provide about rehabilitation?
    Open this publication in new window or tab >>Sickness certificates: what information do they provide about rehabilitation?
    2014 (English)In: Disability and Rehabilitation, ISSN 0963-8288, E-ISSN 1464-5165, Vol. 36, no 15, p. 1299-1304Article in journal (Refereed) Published
    Abstract [en]

    Purpose: To investigate whether patients are prescribed rehabilitation early in a new sick leave period, and whether this prescription is associated with age, sex, diagnosis, description of functioning, and affiliation of certifying physician.

    Methods: A cross-sectional study using data from sickness certificates issued during a total sick leave period, collected consecutively during 2 weeks in 2007 in Östergötland County, Sweden. Rehabilitation prescribed in the first certificate or within 28 days after the start of sick leave was defined as early rehabilitation.

    Results: Musculoskeletal diseases (MSD) were the largest diagnostic group, followed by mental disorders (MD). The mean certified duration of sick leave was 94 days (SD 139), longest for MD patients. Early rehabilitation was prescribed in 27% of all certificates and in 45% of certificates for MSD and MD diagnoses. Logistic regression analysis indicated that prescription of early rehabilitation was associated with certificates issued for MSD and MD, youngest patients, and certificates issued by primary health care physicians. The final model explained 29% of variation in the prescription of early rehabilitation.

    Conclusion: There is a modest prescription of early rehabilitation in sickness certificates, based on younger age and MSD or MD diagnosis. This indicates that patients’ rehabilitation needs may not have been identified.

    Place, publisher, year, edition, pages
    Informa Healthcare, 2014
    Keywords
    Sick leave, musculoskeletal diseases, mental disorders, physicians, physiotherapy, vocational rehabilitation, Sweden
    National Category
    Physiotherapy
    Identifiers
    urn:nbn:se:oru:diva-70719 (URN)10.3109/09638288.2013.836252 (DOI)000340450300010 ()24063292 (PubMedID)2-s2.0-84904504200 (Scopus ID)
    Funder
    Swedish Social Insurance Agency
    Note

    Funding Agency:

    County Council in Östergotland, Sweden [7/0728]

    Available from: 2018-12-13 Created: 2018-12-13 Last updated: 2018-12-14Bibliographically approved
    3. Sickness certificates in Sweden: did the new guidelines improve their quality?
    Open this publication in new window or tab >>Sickness certificates in Sweden: did the new guidelines improve their quality?
    2012 (English)In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 12, article id 907Article in journal (Refereed) Published
    Abstract [en]

    Background: Long-term sickness absence is high in many Western countries. In Sweden and many other countries, decisions on entitlement to sickness benefits and return to work measures are based on information provided by physicians in sickness certificates. The quality demands, as stressed by the Swedish sick leave guidelines from 2008, included accurate sickness certificates with assessment of functioning clearly documented. This study aims to compare quality of sickness certificates between 2007 and 2009 in Ostergotland County, Sweden. Quality is defined in terms of descriptions of functioning with the use of activity and participation according to WHOs International Classification of Functioning, Disability and Health (ICF), and in prescriptions of early rehabilitation.

    Methods: During two weeks in 2007 and four weeks in 2009, all certificates had been collected upon arrival to the social insurance office in Ostergotland County, Sweden. Four hundred seventy-five new certificates were included in 2007 and 501 in 2009. Prolongations of sick leave were included until the last date of sick listing. Free text on functioning was analysed deductively using the ICF framework, and placed into categories (body functions/structures, activity, participation, no description) for statistical analysis.

    Results: The majority of the certificates were issued for musculoskeletal diseases or mental disorders. Text on functioning could be classified into the components of ICF in 65% and 78% of sickness certificates issued in 2007 and 2009, respectively. Descriptions according to body components such as "sensations of pain" or "emotional functions" were given in 58% of the certificates from 2007 and in 65% from 2009. The activity component, for example "walking" or "handling stress", was more frequent in certificates issued in 2009 compared with 2007 (33% versus 26%). Prescriptions of early rehabilitation increased from 27% in 2007 to 35% in 2009, primarily due to more counseling.

    Conclusions: An improvement of the quality between certificates collected in 2007 and 2009 was demonstrated in Ostergotland County, Sweden. The certificates from 2009 provided more information linkable to ICF and incorporated an increased use of activity limitations when describing patients functioning. Still, activity limitations and prescriptions of early rehabilitation were only present in one-third of the sickness certificates.

    Place, publisher, year, edition, pages
    BioMed Central, 2012
    Keywords
    Sickness certificates, International Classification of Functioning, Disability and Health (ICF), Rehabilitation, Sick leave, Physicians, Functioning, Work ability, Sweden
    National Category
    Medical and Health Sciences Occupational Health and Environmental Health
    Identifiers
    urn:nbn:se:oru:diva-70717 (URN)10.1186/1471-2458-12-907 (DOI)000311617300001 ()23101724 (PubMedID)2-s2.0-84867754555 (Scopus ID)
    Funder
    Swedish Social Insurance Agency
    Note

    Funding Agency:

    County Council in Östergotland, Sweden |IHS 7/0728|

    Available from: 2018-12-13 Created: 2018-12-13 Last updated: 2018-12-14Bibliographically approved
    4. Primary Healthcare Professionals' Experiences of the Sick Leave Process: A Focus Group Study in Sweden
    Open this publication in new window or tab >>Primary Healthcare Professionals' Experiences of the Sick Leave Process: A Focus Group Study in Sweden
    2013 (English)In: Journal of occupational rehabilitation, ISSN 1053-0487, E-ISSN 1573-3688, Vol. 23, no 3, p. 450-461Article in journal (Refereed) Published
    Abstract [en]

    Purpose The aim of this study was to explore primary healthcare (PHC) professionals' experiences of the sick leave process. Methods This is an explorative study using data from four semi-structured focus group discussions with a purposeful sample of PHC professionals in A-stergotland County, Sweden. Content analysis with an inductive approach was used in the analysis. Results Four key themes emerged from the analysis; priority to the sick leave process, handling sickness certifications, collaboration within PHC and with other stakeholders, and work ability assessments. Patients' need for sick leave was handled from each professional group's perspective. Collaboration was considered important, but difficult to achieve and all the competencies available at the PHC centre were not used for work ability assessments. There was insufficient knowledge of patients' work demands and contact with an employer was rare, and the strained relationship with the social insurance officers affected the collaboration. Conclusions This study highlights the challenges physicians and other PHC professionals face when handling the need for sick leave, especially when encountering patients with symptom-based diagnoses, and the influence of non-medical factors. Hindrances to good practice were increased demands, collaboration, and role responsibility. The challenges in the sick leave process concerned both content and consequences related to poor collaboration within PHC and with representatives from various organizations, primarily employers and social insurance officers. Further research on how to develop a professional approach for handling the sick leave process is needed.

    Place, publisher, year, edition, pages
    Springer, 2013
    Keywords
    Sick leave, Work ability, Rehabilitation, Return to work, Physicians, Healthcare professionals, Sickness certificates, Primary healthcare, Sweden
    National Category
    Medical and Health Sciences Occupational Health and Environmental Health
    Identifiers
    urn:nbn:se:oru:diva-70715 (URN)10.1007/s10926-013-9418-0 (DOI)000322880900015 ()23345119 (PubMedID)2-s2.0-84883134156 (Scopus ID)
    Available from: 2018-12-13 Created: 2018-12-13 Last updated: 2018-12-14Bibliographically approved
  • Nilsing Strid, Emma
    et al.
    Division of Physiotherapy, Linköpings University, Linköping, Sweden.
    Söderberg, Elsy
    Linköpings University, Linköping, Sweden.
    Öberg, Birgitta
    Linköpings University, Linköping, Sweden.
    Sickness certificates: what information do they provide about rehabilitation?2014In: Disability and Rehabilitation, ISSN 0963-8288, E-ISSN 1464-5165, Vol. 36, no 15, p. 1299-1304Article in journal (Refereed)
    Abstract [en]

    Purpose: To investigate whether patients are prescribed rehabilitation early in a new sick leave period, and whether this prescription is associated with age, sex, diagnosis, description of functioning, and affiliation of certifying physician.

    Methods: A cross-sectional study using data from sickness certificates issued during a total sick leave period, collected consecutively during 2 weeks in 2007 in Östergötland County, Sweden. Rehabilitation prescribed in the first certificate or within 28 days after the start of sick leave was defined as early rehabilitation.

    Results: Musculoskeletal diseases (MSD) were the largest diagnostic group, followed by mental disorders (MD). The mean certified duration of sick leave was 94 days (SD 139), longest for MD patients. Early rehabilitation was prescribed in 27% of all certificates and in 45% of certificates for MSD and MD diagnoses. Logistic regression analysis indicated that prescription of early rehabilitation was associated with certificates issued for MSD and MD, youngest patients, and certificates issued by primary health care physicians. The final model explained 29% of variation in the prescription of early rehabilitation.

    Conclusion: There is a modest prescription of early rehabilitation in sickness certificates, based on younger age and MSD or MD diagnosis. This indicates that patients’ rehabilitation needs may not have been identified.

  • Nilsing Strid, Emma
    et al.
    Department of Medical and Health Sciences, Division of Physiotherapy, Linköping University, Linköping, Sweden.
    Söderberg, Elsy
    Linköping University, Linköping, Sweden.
    Öberg, Birgitta
    Linköping University, Linköping, Sweden.
    Sickness certificates in Sweden: did the new guidelines improve their quality?2012In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 12, article id 907Article in journal (Refereed)
    Abstract [en]

    Background: Long-term sickness absence is high in many Western countries. In Sweden and many other countries, decisions on entitlement to sickness benefits and return to work measures are based on information provided by physicians in sickness certificates. The quality demands, as stressed by the Swedish sick leave guidelines from 2008, included accurate sickness certificates with assessment of functioning clearly documented. This study aims to compare quality of sickness certificates between 2007 and 2009 in Ostergotland County, Sweden. Quality is defined in terms of descriptions of functioning with the use of activity and participation according to WHOs International Classification of Functioning, Disability and Health (ICF), and in prescriptions of early rehabilitation.

    Methods: During two weeks in 2007 and four weeks in 2009, all certificates had been collected upon arrival to the social insurance office in Ostergotland County, Sweden. Four hundred seventy-five new certificates were included in 2007 and 501 in 2009. Prolongations of sick leave were included until the last date of sick listing. Free text on functioning was analysed deductively using the ICF framework, and placed into categories (body functions/structures, activity, participation, no description) for statistical analysis.

    Results: The majority of the certificates were issued for musculoskeletal diseases or mental disorders. Text on functioning could be classified into the components of ICF in 65% and 78% of sickness certificates issued in 2007 and 2009, respectively. Descriptions according to body components such as "sensations of pain" or "emotional functions" were given in 58% of the certificates from 2007 and in 65% from 2009. The activity component, for example "walking" or "handling stress", was more frequent in certificates issued in 2009 compared with 2007 (33% versus 26%). Prescriptions of early rehabilitation increased from 27% in 2007 to 35% in 2009, primarily due to more counseling.

    Conclusions: An improvement of the quality between certificates collected in 2007 and 2009 was demonstrated in Ostergotland County, Sweden. The certificates from 2009 provided more information linkable to ICF and incorporated an increased use of activity limitations when describing patients functioning. Still, activity limitations and prescriptions of early rehabilitation were only present in one-third of the sickness certificates.

  • Nilsing Strid, Emma
    et al.
    Division of Physiotherapy, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
    Söderberg, Elsy
    Linköping University, Linköping, Sweden.
    Normelli, Helena
    Linköping University, Linköping, Sweden.
    Öberg, Birgitta
    Linköping University, Linköping, Sweden.
    Description of functioning in sickness certificates2011In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 39, no 5, p. 508-516Article in journal (Refereed)
    Abstract [en]

    Aims: Sickness certificates are to provide information on a disease and its consequences on the patients functioning. This information has implications for the patients rights to sickness benefits and return-to-work measures. The objective of this study was to investigate the description of functioning in sickness certificates according to WHOs International Classification of Functioning, Disability, and Health (ICF), and to describe the influence of patients age, gender, diagnostic group, and affiliation of certifying physician.

    Method: A content analysis of written statements regarding how the disease limits the patients functioning with ICF as a framework was performed in 475 sickness certificates, consecutively collected in Ostergotland County, Sweden.

    Results: Musculoskeletal diseases (MSD) were the largest diagnostic group, followed by mental disorders (MD). Certificates were mainly issued from physicians at hospitals and in primary health care (PHC). ICF was applicable for classifying statements regarding functioning in 311 certificates (65%). The distribution of components was 58% body functions, 26% activity, and 7% participation. The descriptions were primarily restricted to the use of at least one component; namely, body functions. Subgroup analysis showed that descriptions of activity and participation were more common in certificates for MD and MSD, or those issued by PHC physicians. A multiple regression analysis with the activity component as dependent variable confirmed the results by showing that activity was related to both diagnosis and affiliation.

    Conclusions: In a consecutive sample of sickness certificates, it was shown that information on functioning is scarce. When functioning was described, it was mainly body oriented.

  • Nilsing Strid, Emma
    et al.
    Division of Physiotherapy, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
    Söderberg, Elsy
    Linköping University, Linköping, Sweden.
    Berterö, Carina
    Linköping University, Linköping, Sweden.
    Öberg, Birgitta
    Linköping University, Linköping, Sweden.
    Primary Healthcare Professionals' Experiences of the Sick Leave Process: A Focus Group Study in Sweden2013In: Journal of occupational rehabilitation, ISSN 1053-0487, E-ISSN 1573-3688, Vol. 23, no 3, p. 450-461Article in journal (Refereed)
    Abstract [en]

    Purpose The aim of this study was to explore primary healthcare (PHC) professionals' experiences of the sick leave process. Methods This is an explorative study using data from four semi-structured focus group discussions with a purposeful sample of PHC professionals in A-stergotland County, Sweden. Content analysis with an inductive approach was used in the analysis. Results Four key themes emerged from the analysis; priority to the sick leave process, handling sickness certifications, collaboration within PHC and with other stakeholders, and work ability assessments. Patients' need for sick leave was handled from each professional group's perspective. Collaboration was considered important, but difficult to achieve and all the competencies available at the PHC centre were not used for work ability assessments. There was insufficient knowledge of patients' work demands and contact with an employer was rare, and the strained relationship with the social insurance officers affected the collaboration. Conclusions This study highlights the challenges physicians and other PHC professionals face when handling the need for sick leave, especially when encountering patients with symptom-based diagnoses, and the influence of non-medical factors. Hindrances to good practice were increased demands, collaboration, and role responsibility. The challenges in the sick leave process concerned both content and consequences related to poor collaboration within PHC and with representatives from various organizations, primarily employers and social insurance officers. Further research on how to develop a professional approach for handling the sick leave process is needed.

  • Chadalavada, Ravi Teja
    et al.
    Örebro University, School of Science and Technology.
    Andreasson, Henrik
    Örebro University, School of Science and Technology.
    Schindler, Maike
    Örebro University, School of Science and Technology.
    Palm, Rainer
    Örebro University, School of Science and Technology.
    Lilienthal, Achim
    Örebro University, School of Science and Technology.
    Accessing your navigation plans! Human-Robot Intention Transfer using Eye-Tracking Glasses2018In: Advances in Manufacturing Technology XXXII: Proceedings of the 16th International Conference on Manufacturing Research, incorporating the 33rd National Conference on Manufacturing Research, September 11–13, 2018, University of Skövde, Sweden / [ed] Case K. &Thorvald P., Amsterdam, Netherlands: IOS Press, 2018, p. 253-258Conference paper (Refereed)
    Abstract [en]

    Robots in human co-habited environments need human-aware task and motion planning, ideally responding to people’s motion intentions as soon as they can be inferred from human cues. Eye gaze can convey information about intentions beyond trajectory and head pose of a person. Hence, we propose eye-tracking glasses as safety equipment in industrial environments shared by humans and robots. This paper investigates the possibility of human-to-robot implicit intention transference solely from eye gaze data.  We present experiments in which humans wearing eye-tracking glasses encountered a small forklift truck under various conditions. We evaluate how the observed eye gaze patterns of the participants related to their navigation decisions. Our analysis shows that people primarily gazed on that side of the robot they ultimately decided to pass by. We discuss implications of these results and relate to a control approach that uses human eye gaze for early obstacle avoidance.

  • Tilton-Weaver, Lauree
    Örebro University, School of Law, Psychology and Social Work.
    An introduction to the special issue on sleep2018In: Journal of Adolescence, ISSN 0140-1971, E-ISSN 1095-9254, Vol. 68, p. 217-220Article in journal (Refereed)
  • Pitti, Ilaria
    Örebro University, School of Humanities, Education and Social Sciences.
    Being women in a male preserve: an ethnography of female football ultras2018In: Journal of Gender Studies, ISSN 0958-9236, E-ISSN 1465-3869Article in journal (Refereed)
    Abstract [en]

    This article looks at the characteristics of contemporary sports audiences from the perspective of gender, focusing on the phenomenon of female ultras or ‘professional’ football fans. Drawing on ethnographic research conducted in an Italian football ultrasgroup composed of male and female fans, this paper offers an analysis of female participation in communities of organized supporters. In examining the role and position of women inside the considered group, the paper pays attention to their perception of the existing gender differences showing how female ultras explain inequalities on the basis of ‘natural’ and ‘innate’ differences and capacities between men and women. Existing patterns of male dominance are supported by female fans’ own discourses and performance of their gender identity in the ‘male preserve’. Rather than questioning male dominance and gender hierarchies, female supporters’ efforts appear aimed at being recognized as ultras ‘despite being women’.

  • Wetter-Edman, Katarina
    et al.
    FOU i Sörmland, Landstinget Sörmland, Eskilstuna, Sweden..
    Malmberg, Lisa
    FOU i Sörmland, Landstinget Sörmland, Eskilstuna, Sweden.
    Utskrivning eller hemgång?: Att samverka personcentrerat genom tjänstedesign2018Report (Other (popular science, discussion, etc.))
    Abstract [en]

    This report presents the results of an intervention research project and follow-up carried out in 2017. The project teams, consisting of employees from Sörmland's municipalities and county council, endeavoured to interpret how the guidelines for safe and efficient discharge processes might be put into practice. Collaboration between different actors in the county council and municipalities is crucial to ensure a positive patient experience and a safe return after hospitalization. The Law (2017: 612) on co-operation in the discharge process, as well as local guidelines for safe retirement and effective collaboration that support the application of the law, seek to achieve exactly these outcomes. Following the introduction of the new guidelines in 2017, the research project aimed to investigate and work actively with the guidelines and their subsequent implementation. During 8 months from April to November 2017, the project included 55 participants, in 8 teams, from more than 20 different organizations within Sörmland’s municipalities and county council. The teams worked on adapting and/or finding new solutions to routines and flows in the discharge process that corresponded to the new guidelines. The project work was grounded in service design methodology and incorporated a patient as well as next-of-kin perspective. Service design is both an approach and methodology with the user's needs and experiences as its cornerstone. Utilizing service design enables the examination of several possible solutions, and the iterative testing of the solutions with relevant actors. The teams used approaches and methods from service design to develop and update routines, activities and processes, while upholding the patient as central to their work. The goal of this project was to develop person-centred approaches and routines through service design, and that these should be reflected in the guideline document. In most cases, the teams came up with solutions that led to increased collaboration and changes in work routines. The analysis shows that the solutions aim at enhancing both the safety of the individual and streamlining the work processes, through increased patient /user/ next-of-kin involvement. Furthermore, the analysis of the teams’ work shows that through a joint focus on the end user, cooperation between units is facilitated. Among other things, the project has contributed to the renaming of the guidelines from ‘Safe and Effective discharge process’ to ‘Secure return to home and Effective Collaboration’. However, the direct impact on the guidelines in general is otherwise difficult to assess and quantify. In summary, the guidelines that the project has worked with cannot be seen as person-centred in their application. A person-centred approach is included in the values stated in the guidelines but is not integrated with the ensuing instructions and process flows. However, by using service design, the organizations have created routines that conform to the guidelines and are personcentred. They are based on the patient's perspective and promote their involvement in the discharge process. In addition, the work has supported the participants by creating collaboration between organizations.

  • Westerlund, Bo
    et al.
    Industrial Design, University of Arts, Crafts and Design, Stockholm.
    Wetter-Edman, Katarina
    Industrial Design, University of Arts, Crafts and Design, Stockholm.
    Design beyond service and product - Educating for new vistas of design education: Final report2018Report (Other academic)
    Abstract [en]

    Konstfack has had financing from KK-stiftelsen (The Knowledge Foundation) for two years to address emerging design challenges in the increasingly complex contexts that design is engaging with. Examples are healthcare, design for sustainable development, social innovation, service design. The objective has been to explore potential expansion and supplementary developments of the currently well-functioning specialisation Individual Study Plan in Design. This has been done in the project Design, beyond service and product – educating for new vistas of design professions. People from academia, consultancy, business and the public sector have been invited to workshops, seminars and symposia in order to learn from them regarding the current situation and anticipated needs. The project has also done study visits to design schools, organisations and businesses. The report presents reflections on design competencies and a few possible ways to proceed at Konstfack.

  • Public defence: 2019-02-22 13:00 Örebro universitet, Campus USÖ, hörsal C1, Örebro
    Lindstedt, Katarina
    Örebro University, School of Medical Sciences.
    A life put on hold: inside and outside perspectives on illness, treatment, and recovery in adolescents with restrictive eating disorders2019Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of this thesis was to study adolescents with restrictive eating disorders in relation to illness, treatment, and recovery from an inside and outside perspective. Studies I and II are based on data from a national quality register for eating-disorder treatment. Studies III and IV are based on interviews with adolescents previously treated in outpatient care for a restrictive eating disorder. The results showed that 55% of the adolescents were in remission at the end of treatment, and 85% were within a healthy weight range. The average treatment duration was 15 months. Over the years 1999–2014, remission rates and weight recovery increased, whereas treatment duration decreased. Young patients who received mainly family-based treatment had the highest probability of achieving remission at one-year followup, but the patients themselves were most satisfied with individual therapy. The interviews with the adolescents revealed that they often felt a strong ambivalence during the first treatment sessions, both regarding being defined as sick and the involvement of their parents. In retrospect they believed that family involvement was important, but that individual treatment sessions were crucial. The informants highlighted that trust in the therapist was the key to successful treatment. The adolescents’ narratives drew a picture of a life that was “put on hold” during the time of illness, as their involvement in social contexts outside the family was strongly influenced. It was in these contexts that their problems first became visible, and the quality of their interpersonal relationships played a great role in the recovery process. The results suggest that treatment for adolescents with restrictive eating disorders should be better adapted to changed social structures and patients’ individual contexts – a relevant area for future research.

    List of papers
    1. Adolescents with full or subthreshold anorexia nervosa in a naturalistic sample: characteristics and treatment outcome
    Open this publication in new window or tab >>Adolescents with full or subthreshold anorexia nervosa in a naturalistic sample: characteristics and treatment outcome
    2017 (English)In: Journal of Eating Disorders, E-ISSN 2050-2974, Vol. 5, no 1, article id 4Article in journal (Refereed) Published
    Abstract [en]

    Background: Anorexia Nervosa (AN) destroys developmentally important early years of many young people and knowledge is insufficient regarding course, treatment outcome and prognosis. Only a few naturalistic studies have been conducted within the field of eating disorder (ED) research. In this naturalistic study we included adolescents with AN or subthreshold AN treated in outpatient care, and the overall aim was to examine sample characteristics and treatment outcome. Additional aims were to examine potential factors associated with remission as an outcome variable, and possible differences between three time periods for treatment onset.

    Methods: Participants were identified through the Swedish national quality register for eating disorder treatment (SwEat), in which patients are registered at treatment onset and followed up once a year until end of treatment (EOT). Inclusion criteria were: medical or self-referral to one of the participating treatment units between 1999 and 2014, 13-19 years of age at initial entry into SwEat and diagnosed with AN or subthreshold AN. The total sample consisted of 3997 patient from 83 different treatment units.

    Results: The results show that 55% of the participants were in remission and approximately 85% were within a healthy weight range at EOT. Of those who ended treatment according to plan, 70% were in remission and 90% within a healthy weight range. The average treatment duration was approximately 15 months. About one third of the patients terminated treatment prematurely, which was associated with a decreased chance of achieving remission. Remission rates and weight recovery increased over time, while treatment duration decreased. Considering treatment outcome, the results did not show any differences between patients with AN or subthreshold AN.

    Conclusions: The present study shows a relatively good prognosis for adolescent patients with AN or subthreshold AN in routine care and the results indicate that treatment for adolescents with ED in Sweden has become more effective over the past 15 years. The results of the present study contribute to the scope of treatment research and the large-scale naturalistic setting secures the generalizability to a clinical environment. However, more research is needed into different forms of evidence, new research strategies and diversity of treatment approaches.

    Place, publisher, year, edition, pages
    BioMed Central, 2017
    Keywords
    Adolescents, Anorexia nervosa, Eating disorders, Naturalistic sample, Treatment
    National Category
    Nutrition and Dietetics
    Identifiers
    urn:nbn:se:oru:diva-57066 (URN)10.1186/s40337-017-0135-5 (DOI)000395733900001 ()28265410 (PubMedID)2-s2.0-85014399551 (Scopus ID)
    Note

    Funding Agencies:

    Region Örebro County

    Örebro University

    Available from: 2017-04-18 Created: 2017-04-18 Last updated: 2019-01-23Bibliographically approved
    2. Adolescents with full or subthreshold anorexia nervosa in a naturalistic sample: treatment interventions and patient satisfaction
    Open this publication in new window or tab >>Adolescents with full or subthreshold anorexia nervosa in a naturalistic sample: treatment interventions and patient satisfaction
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Psychiatry
    Identifiers
    urn:nbn:se:oru:diva-71699 (URN)
    Available from: 2019-01-23 Created: 2019-01-23 Last updated: 2019-01-23Bibliographically approved
    3. Being me and being us: adolescents' experiences of treatment for eating disorders
    Open this publication in new window or tab >>Being me and being us: adolescents' experiences of treatment for eating disorders
    2015 (English)In: Journal of eating disorders, ISSN 2050-2974, Vol. 3, no 9Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND: This qualitative study addresses adolescents' perception of treatment for eating disorders. The importance of involving parents in treatment of young people with eating disorders, especially young people with Anorexia Nervosa, is emphasized in a number of studies. Even so, this form of treatment does not work for everybody, not even within a limited diagnostic group. Previous research has revealed that many young people are not entirely satisfied with their treatment. However, there is a lack of knowledge concerning the perspectives of adolescents in outpatient treatment, whose treatment often involves family. The aim of the present study was to investigate how young people with experience from adolescent outpatient treatment for eating disorders, involving family-based and individual based interventions, perceive their time in treatment.

    METHODS: This study was conducted using a hermeneutic phenomenological approach. Fifteen participants were recruited in collaboration with four specialized eating disorder units and interviewed with the purpose to gather narratives.

    RESULTS: The analysis revealed that the adolescents sometimes felt more or less forced into treatment, and strong ambivalent feelings about if and how to participate in treatment permeated the adolescents' narratives. The common factors which emerged in the narratives were assembled under the two major themes: Having to involve family in treatment - in one way or another and Making progress in treatment - a matter of trust.

    CONCLUSIONS: It is of great importance to involve family in treatment in order to understand the problems of the adolescents in their context and be able to take advantage of the resource that parents constitute. However, in certain situations, it is necessary to prioritise individual treatment interventions so that instead of sorting out difficult family situations the therapist focuses on enhancing the young people's resilience, thus enabling them to tackle problematic situations in life.

    Place, publisher, year, edition, pages
    BioMed Central, 2015
    Keywords
    Eating disorders, adolescents, treatment, qualitative research
    National Category
    Psychiatry Other Clinical Medicine
    Research subject
    Medicine
    Identifiers
    urn:nbn:se:oru:diva-44821 (URN)10.1186/s40337-015-0051-5 (DOI)000214989700042 ()25834734 (PubMedID)2-s2.0-84941146283 (Scopus ID)
    Note

    Funding agencies:

    SwEat-Swedish Eating Disorder Register

    Available from: 2015-06-08 Created: 2015-06-03 Last updated: 2019-01-23Bibliographically approved
    4. A life put on hold: adolescents' experiences of having an eating disorder in relation to social contexts outside the family
    Open this publication in new window or tab >>A life put on hold: adolescents' experiences of having an eating disorder in relation to social contexts outside the family
    2018 (English)In: Journal of Multidisciplinary Healthcare, ISSN 1178-2390, E-ISSN 1178-2390, Vol. 11, p. 425-437Article in journal (Refereed) Published
    Abstract [en]

    Background: As suffering from an eating disorder often entails restrictions on a person's everyday life, one can imagine that it is an important aspect of recovery to help young people learn to balance stressful demands and expectations in areas like the school environment and spare-time activities that include different forms of interpersonal relationships.

    Purpose: The aim of the present study was to investigate how adolescents with experience from a restrictive eating disorder describe their illness and their time in treatment in relation to social contexts outside the family.

    Patients and methods: This qualitative study is based on narratives of 15 adolescents with experience from outpatient treatment for eating disorders with a predominately restrictive symptomatology, recruited in collaboration with four specialized eating-disorder units. Data were explored through inductive thematic analysis.

    Results: The adolescents' descriptions of their illness in relation to their social contexts outside the family follow a clear timeline that includes narratives about when and how the problem arose, time in treatment, and the process that led to recovery. Three main themes were found: 1) the problems emerging in everyday life (outside the family); 2) a life put on hold and 3) creating a new life context.

    Conclusion: Young people with eating disorders need to learn how to balance demands and stressful situations in life, and to grasp the confusion that often preceded their illness. How recovery progresses, and how the young people experience their life contexts after recovery, depends largely on the magnitude and quality of peer support and on how school and sports activities affect and are affected by the eating disorder.

    Place, publisher, year, edition, pages
    DOVE Medical Press Ltd., 2018
    Keywords
    restrictive eating disorder, patients' perspectives, qualitative research, thematic analysis, recovery
    National Category
    Psychiatry
    Identifiers
    urn:nbn:se:oru:diva-68969 (URN)10.2147/JMDH.S168133 (DOI)000443480600001 ()
    Note

    Funding Agencies:

    Region Örebro County  

    Örebro University 

    Available from: 2018-09-19 Created: 2018-09-19 Last updated: 2019-01-23Bibliographically approved
  • Lidskog, Rolf
    Örebro University, School of Humanities, Education and Social Sciences.
    Invented communities and social vulnerability: The local post-disaster dynamics of extreme environmental events2018In: Sustainability, ISSN 2071-1050, E-ISSN 2071-1050, Vol. 10, no 12, article id 4457Article in journal (Refereed)
    Abstract [en]

    This paper investigates post-disaster dynamics at the local level, in particular how local identity and social cohesion are affected after an extreme event. A particular case is investigated: the largest forest fire in modern Swedish history, which took place in 2014. The empirical material consists of interviews with forest professionals and organizations involved with the fire or the postfire work and a postal survey to all people directly affected by the wildfire. The analysis finds that the experience of the wildfire and its social interpretation led to the invention of a particular community identity, one that strengthened the self-understanding of the community. Thus, the post-disaster dynamics are pivotal for what social practices that emerge and what local identities are invented and thus may greatly affect the capacity of a community to handle extreme events.

  • Engman, Linnea
    et al.
    Örebro University, School of Law, Psychology and Social Work.
    Flink, Ida
    Örebro University, School of Law, Psychology and Social Work.
    Ter Kuile, Moniek
    Linton, Steven J.
    Örebro University, School of Law, Psychology and Social Work.
    CBT group treatment for vulvovaginal pain with partner involvement: a single case experimental design pilot2018Conference paper (Refereed)
    Abstract [en]

    Background: Recurring pain in the vulvovaginal regional induced by touch or pressure is thought to be the most frequent cause of superficial dyspareunia in premenopausal women. Its prevalence is 7-15% in community samples and has a serious impact on couples sexual function, sexual satisfaction, general psychological well-being and overall quality of life.

    The last decade of research suggests that psychological factors, such as fear of pain, catastrophizing, and avoidance behavior may contribute to the maintenance and exacerbation of dyspareunia. Conventional cognitive behavioral therapy (CBT) interventions aim at reducing pain, restoring sexual function and improving the romantic relationship by targeting the thoughts, emotions, behaviors and couple interactions associated with the experience of dyspareunia. Furthermore, given the interpersonal sexual context in which dyspareunia is most often triggered, relationship factors is an important area to address.

    Research Questions: The primary purpose is to evaluate whether a CBT group program with partner involvement improves pain during penetration in women with superficial dyspareunia. Secondary objectives are to evaluate women’s (and their partner’s) sexuality (sexual function & satisfaction), psychological adjustment (negative and positive penetration beliefs, pain coping behaviour) and relationship factors (relationship satisfaction). 

    Methods: The current study consists of a CBT group treatment program of 10 group sessions and 3 individual couple sessions distributed over a period of 6 months. The study will employ a single case experimental design with multiple baselines (N=6) where each individual represents a case and is randomized to a specific length of baseline. The primary and secondary outcomes will be measured weekly through both baseline and treatment phase to enable investigation of changes in outcome between the two phases. Additionally, secondary outcomes for both women and their partners are measured pre- and post-treatment. Single case experimental designs are recommended as a first step to investigate individual responses to psychological interventions as well as testing interventions as a pilot before implementing treatments in extensive RCT studies (Morley, 2017).

    Results: Data collection is in progress and will be completed early June 2018. The results of the study will be presented at the conference.

  • Nahar, Nour
    et al.
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Rahman, Aminur
    Örebro University, School of Science and Technology. Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Ghosh, Sibdas
    School of Arts and Science, Iona College, New Rochelle, NY, USA.
    Nawani, Neelu
    Microbial Diversity Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Tathawade, Pune, India.
    Mandal, Abul
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Functional studies of AtACR2 gene putatively involved in accumulation, reduction and/or sequestration of arsenic species in plants2017In: Biologia (Bratislava), ISSN 0006-3088, E-ISSN 1336-9563, Vol. 72, no 5, p. 520-526Article in journal (Refereed)
    Abstract [en]

    Food-based exposure to arsenic is a human carcinogen and can severely impact human health resulting in many cancerous diseases and various neurological and vascular disorders. This project is a part of our attempts to develop new varieties of crops for avoiding arsenic contaminated foods. For this purpose, we have previously identified four key genes, and molecular functions of two of these, AtACR2 and AtPCSl, have been studied based on both in silico and in vivo experiments. In the present study, a T-DNA tagged mutant, (SALK-143282C with mutation in AtACR2 gene) of Arabidopsis thaliana was studied for further verification of the function of AtACR2 gene. Semi-quantitative RT-PCR analyses revealed that this mutant exhibits a significantly reduced expression of the AtACR2 gene. When exposed to 100 μM of arsenate (AsV) for three weeks, the mutant plants accumulated arsenic approximately three times higher (778 μg/g d. wt.) than that observed in the control plants (235 μg/g d. wt.). In contrast, when the plants were exposed to 100 μM of arsenite (AsIII), no significant difference in arsenic accumulation was observed between the control and the mutant plants (535 μg/g d. wt. and 498 μg/g d. wt., respectively). Also, when arsenate and arsenite was measured separately either in shoots or roots, significant differences in accumulation of these substances were observed between the mutant and the control plants. These results suggest that AtACR2 gene is involved not only in accumulation of arsenic in plants, but also in conversion of arsenate to arsenite inside the plant cells. © 2017 Institute of Molecular Biology, Slovak Academy of Sciences.

  • Nawani, Neelu
    et al.
    Microbial Diversity Research Centre, Dr D Y Patil Biotechnology and Bioinformatics Institute, Dr D Y Patil Vidyapeeth, Pune, India.
    Rahman, Aminur
    System Biology Research Centre, School of Biosciences, University of Skövde, Skövde, Sweden.
    Nahar, Noor
    System Biology Research Centre, School of Biosciences, University of Skövde, Skövde, Sweden.
    Saha, Anandakumar
    Department of Zoology, University of Rajshahi, Bangladesh.
    Kapadnis, Balasaheb
    Department of Microbiology, Savitribai Phule University of Pune, Pune, India.
    Mandal, Abul
    System Biology Research Centre, School of Biosciences, University of Skövde, Skövde, Sweden.
    Status of metal pollution in rivers flowing through urban settlements at Pune and its effect on resident microflora2016In: Biologia (Bratislava), ISSN 0006-3088, E-ISSN 1336-9563, Vol. 71, no 5, p. 494-507Article in journal (Refereed)
    Abstract [en]

    This study illustrates the sporadic distribution of metals in fluvial systems flowing from catchments to urban settlements. This is a detailed study prognosticating the deteriorating quality of rivers at specific locations due to metal pollution. Heavy metals like cadmium, lead, nickel and mercury are prominent in industrial sector. Contour plots derived using spatial and temporal data could determine the focal point of metal pollution and its gradation. Metal values recorded were cadmium 157 mg/L, lead 47 mg/L, nickel 61 mg/L and mercury 0.56 mg/L. Prokaryote diversity was less in polluted water and it harboured metal tolerant bacteria, which were isolated from these polluted sites. Actinomycetes like Streptomyces and several other bacteria like Stenotrophomonas and Pseudomonas isolated from the polluted river sites exhibited changes in morphology in presence of heavy metals. This stress response offered remedial measures as Streptomyces were effective in biosorption of cadmium, nickel and lead and Stenotrophomonas and Pseudomonas were effective in the bioaccumulation of lead and cadmium. The amount of 89 mg of lead and 106 mg of nickel could be adsorbed on one gram of Streptomyces biomass-based biosorbent. Such biological remedies can be further explored to remove metals from polluted sites and from metal contaminated industrial or waste waters.

  • Islam, Md Shofikul
    et al.
    University of Rajshahi, Bangladesh; Islamic University, Kushtia, Bangladesh.
    Mohanto, Nayan Chandra
    University of Rajshahi, Rajshahi, Bangladesh.
    Karim, Md Rezaul
    Islamic University, Kushtia, Bangladesh.
    Aktar, Sharmin
    University of Rajshahi, Rajshahi, Bangladesh.
    Hoque, Md Mominul
    University of Rajshahi, Rajshahi, Bangladesh.
    Rahman, Atiqur
    University of Rajshahi, Rajshahi, Bangladesh.
    Jahan, Momotaj
    University of Rajshahi, Rajshahi, Bangladesh.
    Khatun, Rabeya
    University of Rajshahi, Rajshahi, Bangladesh.
    Aziz, Abdul
    University of Rajshahi, Rajshahi, Bangladesh.
    Abdus Salam, Kazi
    University of Rajshahi, Rajshahi, Bangladesh; National institutes of Health, Bethesda, USA.
    Saud, Zahangir Alam
    University of Rajshahi, Rajshahi, Bangladesh.
    Hossain, Mostaque
    Kaliganj Upazila Health Complex, Gazipur, Dhaka, Bangladesh.
    Rahman, Aminur
    Systems Biology Research Centre, School of Bioscience, University of Skövde, Skövde, Sweden.
    Mandal, Abul
    Systems Biology Research Centre, School of Bioscience, University of Skövde, Skövde, Sweden.
    Haque, Azizul
    Medical University of South Carolina, Charleston, SC, USA.
    Miyataka, Hideki
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
    Himeno, Seiichiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
    Hossain, Khaled
    Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh.
    Elevated concentrations of serum matrix metalloproteinase-2 and -9 and their associations with circulating markers of cardiovascular diseases in chronic arsenic-exposed individuals2015In: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 14, no 1, article id 92Article in journal (Refereed)
    Abstract [en]

    Background: Cardiovascular diseases (CVDs) and cancers are the major causes of chronic arsenic exposure-related morbidity and mortality. Matrix metalloproteinase-2 (MMP-2) and −9 (MMP-9) are deeply involved in the pathogenesis of CVDs and cancers. This study has been designed to evaluate the interactions of arsenic exposure with serum MMP-2 and MMP-9 concentrations especially in relation to the circulating biomarkers of CVDs.

    Methods: A total of 373 human subjects, 265 from arsenic-endemic and 108 from non-endemic areas in Bangladesh were recruited for this study. Arsenic concentrations in the specimens were measured by inductively coupled plasma mass spectroscopy (ICP-MS) and serum MMPs were quantified by immunoassay kits.

    Results: Serum MMP-2 and MMP-9 concentrations in arsenic-endemic population were significantly (p < 0.001) higher than those in non-endemic population. Both MMPs showed significant positive interactions with drinking water (rs = 0.208, p < 0.001 for MMP-2; rs = 0.163, p <0.01 for MMP-9), hair (rs= 0.163, p < 0.01 for MMP-2; rs = 0.173, p < 0.01 for MMP-9) and nail (rs= 0.160, p < 0.01 for MMP-2; rs = 0.182, p < 0.001 for MMP-9) arsenic of the study subjects. MMP-2 concentrations were 1.02, 1.03 and 1.05 times, and MMP-9 concentrations were 1.03, 1.06 and 1.07 times greater for 1 unit increase in log-transformed water, hair and nail arsenic concentrations, respectively, after adjusting for covariates (age, sex, BMI, smoking habit and hypertension). Furthermore, both MMPs were increased dose-dependently when the study subjects were split into three (≤10, 10.1-50 and > 50 μg/L) groups based on the regulatory upper limit of water arsenic concentration set by WHO and Bangladesh Government. MMPs were also found to be significantly (p < 0.05) associated with each other. Finally, the concentrations of both MMPs were correlated with several circulating markers related to CVDs.

    Conclusions: This study showed the significant positive associations and dose–response relationships of arsenic exposure with serum MMP-2 and MMP-9 concentrations. This study also showed the interactions of MMP-2 and MMP-9 concentrations with the circulating markers of CVDs suggesting the MMP-2 and MMP-9 -mediated mechanism of arsenic-induced CVDs.

  • Rahman, Aminur
    et al.
    Örebro University, School of Science and Technology. Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Nahar, Noor
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Jass, Jana
    Örebro University, School of Science and Technology.
    Olsson, Björn
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Mandal, Abul
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Complete genome sequence of Lysinibacillus sphaericus B1-CDA: a bacterium that accumulates arsenics2016In: Genome Announcements, ISSN 2169-8287, E-ISSN 2169-8287, Vol. 4, no 1, article id e00999-15Article in journal (Refereed)
    Abstract [en]

    Here, we report the genomic sequence and genetic composition of an arsenic resistant bacterium Lysinibacillus sphaericus B1-CDA. Assembly of the sequencing reads revealed that the genome size is ~4.5 Mb encompassing ~80% of the chromosomal DNA.

  • Rahman, Aminur
    et al.
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Nahar, Noor
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Olsson, Björn
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Mandal, Abul
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Complete Genome Sequence of Enterobacter cloacae B2-DHA: a Chromium-Resistant Bacterium2016In: Genome Announcements, ISSN 2169-8287, E-ISSN 2169-8287, Vol. 4, no 3, article id e00483-16Article in journal (Refereed)
    Abstract [en]

    Previously, we reported a chromium-resistant bacterium, Enterobacter cloacae B2-DHA, isolated from the landfills of tannery industries in Bangladesh. Here, we investigated its genetic composition using massively parallel sequencing and comparative analysis with other known Enterobacter genomes. Assembly of the sequencing reads revealed a genome of ~4.21 Mb in size.

  • Ali, Nurshad
    et al.
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Hoque, Ashraful
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Haque, Abedul
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Abdus Salam, Kazi
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Karim, Rezaul
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh; Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
    Rahman, Aminur
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Islam, Khairul
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Alam Saud, Zahangir
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Khalek, Abdul
    bDepartment of Statistics, Rajshahi University, Rajshahi, Bangladesh.
    Azim Akhand, Anwarul
    Department of Genetic Engineering and Biotechnology, Dhaka University, Dhaka, Bangladesh.
    Hossain, Mostaque
    Department of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh.
    Mandal, Abul
    School of Life Sciences, University of Skövde, Skövde, Sweden.
    Karim, Rezaul
    Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
    Miyataka, Hideki
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
    Himeno, Seiichiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
    Hossain, Khaled
    Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.
    Association between arsenic exposure and plasma cholinesterase activity: a population based study in Bangladesh2010In: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 9, article id 36Article in journal (Refereed)
    Abstract [en]

    Background: Arsenic is a potent pollutant that has caused an environmental catastrophe in certain parts of the world including Bangladesh where millions of people are presently at risk due to drinking water contaminated by arsenic. Chronic arsenic exposure has been scientifically shown as a cause for liver damage, cancers, neurological disorders and several other ailments. The relationship between plasma cholinesterase (PChE) activity and arsenic exposure has not yet been clearly documented. However, decreased PChE activity has been found in patients suffering liver dysfunction, heart attack, cancer metastasis and neurotoxicity. Therefore, in this study, we evaluated the PChE activity in individuals exposed to arsenic via drinking water in Bangladesh.

    Methods: A total of 141 Bangladeshi residents living in arsenic endemic areas with the mean arsenic exposure of 14.10 ± 3.27 years were selected as study subjects and split into tertile groups based on three water arsenic concentrations: low (< 129 μg/L), medium (130-264 μg/L) and high (> 265 μg/L). Study subjects were further sub-divided into two groups (≤50 μg/L and > 50 μg/L) based on the recommended upper limit of water arsenic concentration (50 μg/L) in Bangladesh. Blood samples were collected from the study subjects by venipuncture and arsenic concentrations in drinking water, hair and nail samples were measured by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). PChE activity was assayed by spectrophotometer.

    Results: Arsenic concentrations in hair and nails were positively correlated with the arsenic levels in drinking water. Significant decreases in PChE activity were observed with increasing concentrations of arsenic in water, hair and nails. The average levels of PChE activity in low, medium and high arsenic exposure groups were also significantly different between each group. Lower levels of PChE activity were also observed in the > 50 μg/L group compared to the ≤50 μg/L group. Moreover, PChE activity was significantly decreased in the skin (+) symptoms group compared to those without (-).

    Conclusions: We found a significant inverse relationship between arsenic exposure and PChE activity in a human population in Bangladesh. This research demonstrates a novel exposure-response relationship between arsenic and PChE activity which may explain one of the biological mechanisms through which arsenic exerts its neuro-and hepatotoxicity in humans.

  • Rahman, Aminur
    et al.
    Örebro University, School of Science and Technology. Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Olsson, Björn
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Jass, Jana
    Örebro University, School of Science and Technology.
    Nawani, Neelu
    Microbial Diversity Research Centre, Dr. D.Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Tathawade, Pune, India.
    Ghosh, Sibdas
    School of Arts and Science, Iona College, New Rochelle, NY, USA.
    Mandal, Abul
    Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
    Genome Sequencing Revealed Chromium and Other Heavy Metal Resistance Genes in E. cloacae B2-Dha2017In: Journal of Microbial & Biochemical Technology, E-ISSN 1948-5948, Vol. 9, no 5, p. 191-199Article in journal (Refereed)
    Abstract [en]

    The previously described chromium resistant bacterium, Enterobacter cloacae B2-DHA, was isolated from leather manufacturing tannery landfill in Bangladesh. Here we report the entire genome sequence of this bacterium containing chromium and other heavy metal resistance genes. The genome size and the number of genes, determined by massive parallel sequencing and comparative analysis with other known Enterobacter genomes, are predicted to be 4.22 Mb and 3958, respectively. Nearly 160 of these genes were found to be involved in binding, transport, and catabolism of ions as well as efflux of inorganic and organic compounds. Specifically, the presence of two chromium resistance genes, chrR and chrA was verified by polymerase chain reaction. The outcome of this research highlights the significance of this bacterium in bioremediation of chromium and other toxic metals from the contaminated sources.

  • Banaee, Hadi
    et al.
    Örebro University, School of Science and Technology.
    Schaffernicht, Erik
    Örebro University, School of Science and Technology.
    Loutfi, Amy
    Örebro University, School of Science and Technology.
    Data-Driven Conceptual Spaces: Creating Semantic Representations for Linguistic Descriptions of Numerical Data2018In: The journal of artificial intelligence research, ISSN 1076-9757, E-ISSN 1943-5037, Vol. 63, p. 691-742Article in journal (Refereed)
    Abstract [en]

    There is an increasing need to derive semantics from real-world observations to facilitate natural information sharing between machine and human. Conceptual spaces theory is a possible approach and has been proposed as mid-level representation between symbolic and sub-symbolic representations, whereby concepts are represented in a geometrical space that is characterised by a number of quality dimensions. Currently, much of the work has demonstrated how conceptual spaces are created in a knowledge-driven manner, relying on prior knowledge to form concepts and identify quality dimensions. This paper presents a method to create semantic representations using data-driven conceptual spaces which are then used to derive linguistic descriptions of numerical data. Our contribution is a principled approach to automatically construct a conceptual space from a set of known observations wherein the quality dimensions and domains are not known a priori. This novelty of the approach is the ability to select and group semantic features to discriminate between concepts in a data-driven manner while preserving the semantic interpretation that is needed to infer linguistic descriptions for interaction with humans. Two data sets representing leaf images and time series signals are used to evaluate the method. An empirical evaluation for each case study assesses how well linguistic descriptions generated from the conceptual spaces identify unknown observations. Furthermore,  comparisons are made with descriptions derived on alternative approaches for generating semantic models.

  • Roderick, Noah
    Örebro University, School of Humanities, Education and Social Sciences.
    How to be a Realist about Similarity: Towards a Theory of Features in Object-Oriented Philosophy2018In: Open Philosophy, E-ISSN 2543-8875, Vol. 1, no 1, p. 327-341Article in journal (Refereed)
    Abstract [en]

    This essay calls for an independent theory of features in object-oriented philosophy. Theories offeatures are in general motivated by at least two interconnected demands: 1) to explain why objects have thecharacteristics they have, 2) to explain how regular divisions in those characteristics can be intuited. Whilea theory of universal properties may be the most internally consistent means of addressing these demands,an object-oriented metaphysics needs to address them without a concept of shared features. This meansthat regular divisions of invariant features and our intuitions of them cannot be explained by the repetitionof self-same characteristics or natural laws. They can instead be explained by the immanent repetition ofsimilar features. However, this requires a new, radically aesthetic understanding of what it means to besimilar in the first place, one in which similarity is an emergent process rather than a state of affairs existingbetween resembling particulars.

  • Tolgfors, Björn
    Örebro University, School of Health Sciences.
    Transformative assessment in physical education2018In: European Physical Education Review, ISSN 1356-336X, E-ISSN 1741-2749, p. 1-15Article in journal (Refereed)
    Abstract [en]

    This article focuses on assessment processes in the school subject of physical education (PE). Inspired by Torrance, the overarching research question is: ‘What might assessment involve if it focuses on the development and identification of collective understanding, collaboratively produced through educational experiences?’ The purpose of the study is to illustrate what characterises transformative assessment and show how it can be addressed in PE practice. A combination of group interviews with teachers, lesson observations and individual interviews with students and teachers was used to gather the empirical material. The analysis was based on three aspects of transformative assessment: responsibilisation; subjectification; and collaboration. Three empirical illustrations show what transformative assessment might involve in relation to learning tasks such as: the training log; the group choreography; and the case of exercise physiology. The views presented in this article contribute to the knowledge about the field in the following ways. First, the illustrations show that the ‘whats’, ‘hows’, ‘whoms’ and ‘whys’ in the assessment practice are often negotiable, which prevents a simplified understanding of the four aspects of assessment literacy: comprehension; application; interpretation; and critical engagement. Second, the notion of transformative assessment could hinder a reductive use of assessment for learning and promote collaborative learning and social justice in today’s heterogeneous PE practices.

  • Wu, Min
    et al.
    Chalmers University of Technology, Gothenburg, Sweden.
    Farkas, Daniel
    Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden; School of Science and Technology, Örebro University, Örebro, Sweden.
    Eriksson, Leif A.
    University of Gothenburg, Gothenburg, Sweden.
    Strid, Åke
    Örebro University, School of Science and Technology.
    Proline 411 biases the conformation of the intrinsically disordered plant UVR8 photoreceptor C27 domain altering the functional properties of the peptide2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 818Article in journal (Refereed)
    Abstract [en]

    UVR8 (UV RESISTANCE LOCUS 8) is a UV-B photoreceptor responsible for initiating UV-B signalling in plants. UVR8 is a homodimer in its signalling inactive form. Upon absorption of UV radiation, the protein monomerizes into its photoactivated state. In the monomeric form, UVR8 binds the E3 ubiquitin ligase COP1 (CONSTITUTIVELY PHOTOMORPHOGENIC 1), triggering subsequent UV-B-dependent photomorphogenic development in plants. Recent in vivoexperiments have shown that the UVR8 C-terminal region (aa 397-423; UVR8C27) alone is sufficient to regulate the activity of COP1. In this work, CD spectroscopy and NMR experiments showed that the UVR8C27domain was non-structured but gained secondary structure at higher temperatures leading to increased order. Bias-exchange metadynamics simulations were also performed to evaluate the free energy landscape of UVR8C27. An inverted free energy landscape was revealed, with a disordered structure in the global energy minimum. Flanking the global energy minimum, more structured states were found at higher energies. Furthermore, stabilization of the low energy disordered state was attributed to a proline residue, P411, as evident from P411A mutant data. P411 is also a key residue in UVR8 binding to COP1. UVR8C27is therefore structurally competent to function as a molecular switch for interaction of UVR8 with different binding partners since at higher free energies different structural conformations are being induced in this peptide. P411 has a key role for this function.