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Bankole, Landry-Cyrille
Publikasjoner (2 av 2) Visa alla publikasjoner
Bankole, L.-C., Millet, G. Y., Temesi, J., Bachasson, D., Ravelojaona, M., Wuyam, B., . . . Feasson, L. (2016). Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy A randomized controlled trial. Medicine (Baltimore, Md.), 95(31), Article ID e4497.
Åpne denne publikasjonen i ny fane eller vindu >>Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy A randomized controlled trial
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2016 (engelsk)Inngår i: Medicine (Baltimore, Md.), ISSN 0025-7974, E-ISSN 1536-5964, Vol. 95, nr 31, artikkel-id e4497Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Previous randomized controlled trials investigating exercise training programs in facioscapulohumeral muscular dystrophy (FSHD) patients are scarce and of short duration only. This study assessed the safety and efficacy of a 6-month home-ased exercise training program on fitness, muscle, and motor function in FSHD patients.

Methods: Sixteen FSHD patients were randomly assigned to training (TG) and control (CG) groups (both n=8) in a home-based exercise intervention. Training consisted of cycling 3 times weekly for 35minutes (combination of strength, high-intensity interval, and low-intensity aerobic) at home for 24 weeks. Patients in CG also performed an identical training program (CTG) after 24 weeks. The primary outcome was change in peak oxygen uptake (VO2 peak) measured every 6 weeks. The principal secondary outcomes were maximal quadriceps strength (MVC) and local quadriceps endurance every 12 weeks. Other outcome measures included maximal aerobic power (MAP) and experienced fatigue every 6 weeks, 6-minute walking distance every 12 weeks, and muscle characteristics from vastus lateralis biopsies taken pre- and postintervention.

Results: The compliance rate was 91% in TG. Significant improvements with training were observed in the VO2 peak (+19%, P= 0.002) and MAP by week 6 and further to week 24. Muscle endurance, MVC, and 6-minute walking distance increased and experienced fatigue decreased. Muscle fiber cross-sectional area and citrate synthase activity increased by 34% (P=0.008) and 46% (P=0.003), respectively. Dystrophic pathophysiologic patterns were not exacerbated. Similar improvements were experienced by TG and CTG.

Conclusions: A combined strength and interval cycling exercise-training program compatible with patients' daily professional and social activities leads to significant functional benefits without compromising muscle tissue.

sted, utgiver, år, opplag, sider
Lippincott Williams & Wilkins, 2016
Emneord
combined strength and endurance training, exercise training, facioscapulohumeral muscular dystrophy, home-based, myopathy, randomized controlled trial
HSV kategori
Forskningsprogram
Allmänmedicin
Identifikatorer
urn:nbn:se:oru:diva-52151 (URN)10.1097/MD.0000000000004497 (DOI)000380789800083 ()27495097 (PubMedID)2-s2.0-84983250815 (Scopus ID)
Merknad

Funding Agencies:

Association Francaise contra la Myopathie (AFM)

Örebro University

Rhone-Alpes Region

Tilgjengelig fra: 2016-09-14 Laget: 2016-09-14 Sist oppdatert: 2018-07-16bibliografisk kontrollert
Bankole, L.-C., Feasson, L., Ponsot, E. & Kadi, F. (2013). Fibre type-specific satellite cell content in two models of muscle disease. Histopathology, 63(6), 826-832
Åpne denne publikasjonen i ny fane eller vindu >>Fibre type-specific satellite cell content in two models of muscle disease
2013 (engelsk)Inngår i: Histopathology, ISSN 0309-0167, E-ISSN 1365-2559, Vol. 63, nr 6, s. 826-832Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aims: Muscle satellite cells (SCs) are responsible for the regenerative events following muscle fibre injury. This study aimed to improve our understanding of SC behaviour in two models of muscle disorder with different pathological mechanisms and onset of disease.

Methods and results: Pax7(+)SC content was assessed in types I and II fibres of patients with Duchenne muscular dystrophy (DMD; n=9; age 132years), polymyositis/dermatomyositis (PM/DM; n=9; age 52 +/- 12years) and in controls (n=5; age 26 +/- 5years). Pax7(+)SCs number in type I and II fibres was higher (P<0.05) in DMD and in PM/DM compared to controls. Type I fibres were associated with a higher number of Pax7(+)SCs compared to type II fibres only in DMD; Pax7(+)SCs number in type I fibres was about threefold higher in DMD compared to PM/DM (P<0.05). In DMD, Pax7(+)SC content in small regenerating fibres (0.09 +/- 0.09 SCs/fibre) was similar to that in fibres from healthy skeletal muscle. The proportion of activated SCs (Ki-67(+)SCs) was fivefold lower in DMD (0.4 +/- 0.4%) compared to PM/DM (2.8 +/- 2%). Pax7(+) cells located outside the basal lamina were observed in DMD muscles only.

Conclusion: The capacity to generate new SCs is increased even in severely impaired muscles and a fibre type-specific enhancement of SC occurs in type I muscle fibres in DMD.

Emneord
Duchenne muscular dystrophy, Pax7, polymyositis and dermatomyositis, regeneration
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-32755 (URN)10.1111/his.12231 (DOI)000327018300009 ()
Merknad

Funding Agency: French Muscular Dystrophy Association (AFM-Telethon)

Tilgjengelig fra: 2013-12-13 Laget: 2013-12-13 Sist oppdatert: 2017-12-06bibliografisk kontrollert
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