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Hylén, U., Eklund, D., Humble, M. B., Bartoszek, J., Särndahl, E. & Bejerot, S. (2020). Increased inflammasome activity in markedly ill psychiatric patients: An explorative study. Journal of Neuroimmunology, 339, Article ID 577119.
Åpne denne publikasjonen i ny fane eller vindu >>Increased inflammasome activity in markedly ill psychiatric patients: An explorative study
Vise andre…
2020 (engelsk)Inngår i: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 339, artikkel-id 577119Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim of this study was to investigate inflammatory perturbations in 40 patients with severe and complex psychiatric disorders by studying the activity of the NLRP3 inflammasome, with a trans-diagnostic approach. Gene expression of CASP1, NLRP3, PYCARD, IL1B, IL1RN, TNF showed a significant increase in the patient group compared to a matched control group. Plasma levels of IL1Ra, IL-18, TNF, IL-6 and CRP were increased in the patient group. Within the patient group, increased gene expression of inflammatory markers correlated with increased disease severity. The findings support the inflammation hypothesis for markedly ill psychiatric patients across diagnostic groups.

HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-79288 (URN)10.1016/j.jneuroim.2019.577119 (DOI)31786499 (PubMedID)2-s2.0-85075532475 (Scopus ID)
Tilgjengelig fra: 2020-01-21 Laget: 2020-01-21 Sist oppdatert: 2020-01-22bibliografisk kontrollert
Manouilenko, I., Humble, M. B., Georgieva, J. & Bejerot, S. (2017). Brainstem Auditory Evoked Potentials for diagnosing Autism Spectrum Disorder, ADHD and Schizophrenia Spectrum Disorders in adults: A blinded study. Psychiatry Research, 257, 21-26
Åpne denne publikasjonen i ny fane eller vindu >>Brainstem Auditory Evoked Potentials for diagnosing Autism Spectrum Disorder, ADHD and Schizophrenia Spectrum Disorders in adults: A blinded study
2017 (engelsk)Inngår i: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 257, s. 21-26Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim of the present study was to examine the clinical utility of complex auditory brainstem response (c-ABR) and investigate if c-ABR is helpful in the diagnostic procedure. Thirty-one adult psychiatric patients, thoroughly diagnosed with autism spectrum disorder (ASD) (n=16), ADHD (n=8), or schizophrenia spectrum disorder (SSD) (n=7) and 15 healthy controls (HC), were blindly assessed with SensoDetect BERA. This c-ABR correctly identified psychiatric diagnoses in 4 patients (13%) and provided partially correct diagnoses in 11 more patients. Of the 15 HC, 6 were misclassified as psychiatric patients. The Cohen´s kappa coefficient (κ) was substantial for HC (κ=0.67), fair for SSD (κ=0.37), slight for ADHD (κ=0.09) and without agreement in ASD (κ=-0.03). In conclusion, we found the c-ABR method unhelpful and unreliable as a tool in clinical diagnostics.

sted, utgiver, år, opplag, sider
Clare, Ireland: Elsevier, 2017
Emneord
Auditory brainstem response, double-blind method, mental disorder
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-61468 (URN)10.1016/j.psychres.2017.06.085 (DOI)000413385300004 ()28710948 (PubMedID)2-s2.0-85022338791 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, K2012-62X -22130-04-6
Merknad

Funding Agencies:

Praktikertjanst AB, Stockholm, Sweden  

Stockholm County Council  20110307 

Karolinska Institutet  20110307 

Region Örebro County, Sweden 

Tilgjengelig fra: 2017-10-13 Laget: 2017-10-13 Sist oppdatert: 2018-08-06bibliografisk kontrollert
Bejerot, S., Edman, G., Frisén, L. & Humble, M. B. (2017). Evidence-Based Brief Obsessive-Compulsive Scale [Letter to the editor]. Journal of Central Nervous System Disease, 9, Article ID UNSP 1179573517702867.
Åpne denne publikasjonen i ny fane eller vindu >>Evidence-Based Brief Obsessive-Compulsive Scale
2017 (engelsk)Inngår i: Journal of Central Nervous System Disease, ISSN 1179-5735, E-ISSN 1179-5735, Vol. 9, artikkel-id UNSP 1179573517702867Artikkel i tidsskrift, Letter (Annet vitenskapelig) Published
sted, utgiver, år, opplag, sider
Sage Publications, 2017
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-58957 (URN)10.1177/1179573517702867 (DOI)000404684800001 ()28579868 (PubMedID)
Tilgjengelig fra: 2017-08-18 Laget: 2017-08-18 Sist oppdatert: 2017-10-05bibliografisk kontrollert
Glans, M., Bejerot, S. & Humble, M. B. (2017). Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population. BJPsych Open, 3(5), 236-242
Åpne denne publikasjonen i ny fane eller vindu >>Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population
2017 (engelsk)Inngår i: BJPsych Open, E-ISSN 2056-4724, Vol. 3, nr 5, s. 236-242Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Generalised joint hypermobility (GJH) is reportedly overrepresented among clinical cases of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and developmental coordination disorder (DCD). It is unknown if these associations are dimensional and, therefore, also relevant among non-clinical populations.

AIMS: To investigate if GJH correlates with sub-syndromal neurodevelopmental symptoms in a normal population.

METHOD: Hakim-Grahame's 5-part questionnaire (5PQ) on GJH, neuropsychiatric screening scales measuring ADHD and ASD traits, and a DCD-related question concerning clumsiness were distributed to a non-clinical, adult, Swedish population (n=1039).

RESULTS: In total, 887 individuals met our entry criteria. We found no associations between GJH and sub-syndromal symptoms of ADHD, ASD or DCD.

CONCLUSIONS: Although GJH is overrepresented in clinical cases with neurodevelopmental disorders, such an association seems absent in a normal population. Thus, if GJH serves as a biomarker cutting across diagnostic boundaries, this association is presumably limited to clinical populations.

sted, utgiver, år, opplag, sider
Royal College of Psychiatrists, 2017
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-62454 (URN)10.1192/bjpo.bp.116.004325 (DOI)000418507300005 ()28959454 (PubMedID)
Forskningsfinansiär
Swedish Research Council, K2012-62X-22130-04-6The Karolinska Institutet's Research FoundationStockholm County Council
Tilgjengelig fra: 2017-12-04 Laget: 2017-12-04 Sist oppdatert: 2020-01-23bibliografisk kontrollert
Humble, M. B. & Reis, M. (2017). Paroxetine concentrations in obsessive-compulsive disorder: Support for a therapeutic interval. European psychiatry, 41(Suppl.), S322-S322
Åpne denne publikasjonen i ny fane eller vindu >>Paroxetine concentrations in obsessive-compulsive disorder: Support for a therapeutic interval
2017 (engelsk)Inngår i: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 41, nr Suppl., s. S322-S322Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
Abstract [en]

Introduction: Previous studies of concentrations of serotonin reuptake inhibitors (SRIs) versus therapeutic efficacy have yielded inconsistent results. Even if the relationships between the individual's serotonergic system and the clinical symptoms of obsessive-compulsive disorder (OCD) are poorly understood, the SRIs are consistently effective in OCD. However, studies on SRI concentrations in OCD treatment are rare.

Objectives/aims: To identify possible links between paroxetine concentrations and anti-obsessive response.

Methods: In a randomised, double-blind trial, comparing clomipramine, paroxetine and placebo in OCD treatment, serum paroxetine levels were measured after 1 week and after 4 weeks of treatment in 18 patients. Anti-obsessive response was assessed with Yale-Brown obsessive compulsive scale (Y-BOCS) and patients’ global evaluation (PGE), after 12 weeks of treatment.

Results: Serum paroxetine concentrations after 4 weeks suggested a therapeutic interval between 50 and 240 nmol/L (13–63 ng/mL). The mean Y-BOCS decrease was 54% inside versus 7% outside this interval (t = 3.96; P = 0.0011).

Conclusions: Paroxetine levels seemingly predicted clinical outcome. Studies with a greater number of patients are necessary in order to confirm this finding and to discern whether it is useful in clinical practice.

sted, utgiver, år, opplag, sider
Elsevier, 2017
HSV kategori
Forskningsprogram
Psykiatri
Identifikatorer
urn:nbn:se:oru:diva-58970 (URN)10.1016/j.eurpsy.2017.02.245 (DOI)000404952400060 ()
Tilgjengelig fra: 2017-08-04 Laget: 2017-08-04 Sist oppdatert: 2018-08-01bibliografisk kontrollert
Bejerot, S., Nilsonne, G. & Humble, M. B. (2017). Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults. Lancet psychiatry, 4(6), 437-437
Åpne denne publikasjonen i ny fane eller vindu >>Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults
2017 (engelsk)Inngår i: Lancet psychiatry, ISSN 2215-0374, E-ISSN 2215-0366, Vol. 4, nr 6, s. 437-437Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Elsevier, 2017
HSV kategori
Forskningsprogram
Psykiatri
Identifikatorer
urn:nbn:se:oru:diva-58103 (URN)10.1016/S2215-0366(17)30160-8 (DOI)000402787900011 ()28495546 (PubMedID)
Tilgjengelig fra: 2017-06-19 Laget: 2017-06-19 Sist oppdatert: 2018-07-31bibliografisk kontrollert
Humble, M. B. (2016). Obsessive-compulsive disorder, serotonin and oxytocin: treatment response and side effects. (Doctoral dissertation). Örebro: Örebro university
Åpne denne publikasjonen i ny fane eller vindu >>Obsessive-compulsive disorder, serotonin and oxytocin: treatment response and side effects
2016 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Obsessive-compulsive disorder (OCD), with a prevalence of 1-2 %, frequently leads a chronic course. Persons with OCD are often reluctant to seek help and, if they do, their OCD is often missed. This is unfortunate, since active treatment may substantially improve social function and quality of life. Serotonin reuptake inhibitors (SRIs) have welldocumented efficacy in OCD, but delayed response may be problematic. Methods to predict response have been lacking. Because SRIs are effective, pathophysiological research on OCD has focussed on serotonin. However, no clear aberrations of serotonin have been found, thus other mechanisms ought to be involved.

Our aims were to facilitate clinical detection and assessment of OCD, to search for biochemical correlates of response and side-effects in SRI treatment of OCD and to identify any possible involvement of oxytocin in the pathophysiology of OCD.

In study I, we tested in 402 psychiatric out-patients the psychometric properties of a concise rating scale, “Brief Obsessive Compulsive Scale” (BOCS). BOCS was shown to be easy to use and have excellent discriminant validity in relation to other common psychiatric diagnoses.

Studies II-V were based on 36 OCD patients from a randomised controlled trial of paroxetine, clomipramine or placebo. In study II, contrary to expectation, we found that the change (decrease) of serotonin in whole blood was most pronounced in non-responders to SRI. This is likely to reflect inflammatory influence on platelet turnover rather than serotonergic processes within the central nervous system.

In studies IV-V, we found relations between changes of oxytocin in plasma and the anti-obsessive response, and between oxytocin and the SRI related delay of orgasm, respectively. In both cases, the relation to central oxytocinergic mechanisms is unclear. In males, delayed orgasm predicted anti-obsessive response.

sted, utgiver, år, opplag, sider
Örebro: Örebro university, 2016. s. 133
Serie
Örebro Studies in Medicine, ISSN 1652-4063 ; 148
Emneord
Adverse effects, Obsessive-compulsive disorder, Orgasm, Oxytocin, Randomised controlled trial, Rating scale, Response prediction, Serotonin, Serotonin uptake inhibitors, Sexual function
HSV kategori
Forskningsprogram
Psykiatri
Identifikatorer
urn:nbn:se:oru:diva-51438 (URN)978-91-7529-153-6 (ISBN)
Disputas
2016-09-26, Campus USÖ, hörsal C3, Södra Grev Rosengatan, Örebro, 13:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2016-07-25 Laget: 2016-07-25 Sist oppdatert: 2018-01-10bibliografisk kontrollert
Humble, M. B. & Bejerot, S. (2016). Orgasm, Serotonin Reuptake Inhibition, and Plasma Oxytocin in Obsessive-Compulsive Disorder. Gleaning From a Distant Randomized Clinical Trial. Sexual medicine, 4(3), e145-e155
Åpne denne publikasjonen i ny fane eller vindu >>Orgasm, Serotonin Reuptake Inhibition, and Plasma Oxytocin in Obsessive-Compulsive Disorder. Gleaning From a Distant Randomized Clinical Trial
2016 (engelsk)Inngår i: Sexual medicine, ISSN 2050-1161, Vol. 4, nr 3, s. e145-e155Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: Serotonin reuptake inhibitors (SRIs) are widely used for the treatment of psychiatric disorders, including obsessive-compulsive disorder (OCD). SRIs commonly cause delayed orgasm, the mechanism of which is poorly understood. Oxytocin is involved in sexual function and is interconnected with serotonin within the brain. SRIs are reported to affect the oxytocin system, but possible relations between SRI-induced changes of sexual function and oxytocin are unexplored in humans. In a randomized, double-blinded, placebo-controlled trial of OCD, the anti-obsessive efficacy and adverse events of SRIs and oxytocin measurements were studied.

Aims: To identify possible correlates between oxytocin levels and sexual function; find out whether sexual side effects correlate with levels of oxytocin and/or paroxetine and clomipramine; and test whether changes in sexual functioning are related to an anti-obsessive response.

Methods Reported sexual function and oxytocin plasma levels at rest were studied in 31 adults (15 men and 16 women) with OCD who participated in a randomized, double-blinded trial comparing the SRIs clomipramine and paroxetine with placebo. Sexual adverse effects were quantified by a clinician-administered semistructured interview. Anti-obsessive response was based on the Yale-Brown Obsessive-Compulsive Scale.

Main outcome measures: Ratings on the Sexual Symptom Checklist, plasma oxytocin, serum paroxetine and clomipramine levels, and Yale-Brown Obsessive-Compulsive Scale scores.

RESULTS: Baseline oxytocin levels were positively correlated with baseline OCD severity, but not with sexual functioning. Impaired orgasm at week 6 was reported by 73% of SRI-treated and 20% of placebo-treated patients (P = .03). Impaired orgasm was related to higher oxytocin levels after 4 weeks of SRI treatment (P < .01) but not to SRI concentrations. In men, an association between impaired orgasm and anti-obsessive treatment response was found (P = .028).

CONCLUSION: This pilot study suggests that some collateral effects of SRIs, particularly delayed orgasm, might be influenced by changes within the oxytocinergic system and are related to anti-obsessive mechanisms. Early-onset delayed orgasm in SRI-treated patients could serve as a predictor for OCD treatment response.

sted, utgiver, år, opplag, sider
Oxford, United Kingdom: Elsevier, 2016
Emneord
Obsessive-Compulsive Disorder; Oxytocin/Plasma; Serotonin; Clomipramine; Paroxetine; Serotonin Uptake Inhibitors; Response Prediction; Adverse Effects; Randomized Controlled Trial; Sexual Physiology
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-50976 (URN)10.1016/j.esxm.2016.04.002 (DOI)000389259700003 ()27320409 (PubMedID)2-s2.0-85006216627 (Scopus ID)
Tilgjengelig fra: 2016-06-21 Laget: 2016-06-21 Sist oppdatert: 2018-07-14bibliografisk kontrollert
Meehan, A. D., Humble, M. B., Yazarloo, P., Järhult, J. & Wallin, G. (2016). Reply to comments From Dr Lozano, et al - Concerning the prevalence of lithium-associated hyperparathyroidism [Letter to the editor]. Journal of Clinical Psychopharmacology, 36(2), 191-192
Åpne denne publikasjonen i ny fane eller vindu >>Reply to comments From Dr Lozano, et al - Concerning the prevalence of lithium-associated hyperparathyroidism
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2016 (engelsk)Inngår i: Journal of Clinical Psychopharmacology, ISSN 0271-0749, E-ISSN 1533-712X, Vol. 36, nr 2, s. 191-192Artikkel i tidsskrift, Letter (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Philadelphia, USA: Lippincott Williams & Wilkins, 2016
HSV kategori
Forskningsprogram
Psykiatri
Identifikatorer
urn:nbn:se:oru:diva-49642 (URN)10.1097/JCP.0000000000000477 (DOI)000372100800024 ()26872121 (PubMedID)2-s2.0-84957900522 (Scopus ID)
Tilgjengelig fra: 2016-04-12 Laget: 2016-04-05 Sist oppdatert: 2019-03-01bibliografisk kontrollert
Fernell, E., Bejerot, S., Westerlund, J., Miniscalco, C., Simila, H., Eyles, D., . . . Humble, M. B. (2015). Autism spectrum disorder and low vitamin D at birth: a sibling control study. Molecular Autism, 6, Article ID 3.
Åpne denne publikasjonen i ny fane eller vindu >>Autism spectrum disorder and low vitamin D at birth: a sibling control study
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2015 (engelsk)Inngår i: Molecular Autism, ISSN 2040-2392, ISSN 2040-2392, Vol. 6, artikkel-id 3Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Insufficient vitamin D activity has attracted increasing interest as a possible underlying risk factor in disorders of the central nervous system, including autism.

Methods: In this study, 25-hydroxyvitamin D (25(OH) D) was analysed in 58 Sweden-born sibling pairs, in which one child had autism spectrum disorder (ASD) and the other did not. The study group consisted of two representative samples; 47 Gothenburg sibling pairs with mixed ethnicities and 11 Stockholm sibling pairs with Somali background. 25(OH) D levels were analysed in the stored dried blood spots taken in the neonatal period for metabolic screening.

Results: The collapsed group of children with ASD had significantly lower vitamin D levels (M = 24.0 nM, SD = 19.6) as compared with their siblings (M = 31.9 nM, SD = 27.7), according to a paired samples t-test (P = 0.013). The difference was-most likely-not only accounted for by a difference in season of birth between ASD and non-ASD siblings since the mean 25(OH)D levels differed with similar effect size between the sibling pairs born during winter and summer, respectively. All children with African/Middle East background, both the children with ASD and their non-ASD siblings, had vitamin D deficiency.

Conclusions: The findings suggest that low prenatal vitamin D may act as a risk factor for ASD, however, there is a need for replication with larger samples. Future research should study whether or not adequate supplementation of vitamin D to pregnant women might lower the risk for ASD in the offspring.

Emneord
Autism spectrum disorder, Vitamin D, 25-hydroxyvitamin D, Neonatal, Dried blood spots
HSV kategori
Forskningsprogram
Neurologi
Identifikatorer
urn:nbn:se:oru:diva-44116 (URN)10.1186/2040-2392-6-3 (DOI)000350599000002 ()
Forskningsfinansiär
Swedish Research Council, 523-2011-3646
Merknad

Funding Agency:

'Föreningen Mjölkdroppen' in Stockholm

Tilgjengelig fra: 2015-04-08 Laget: 2015-04-08 Sist oppdatert: 2020-01-23bibliografisk kontrollert
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-6726-7787