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Wikström, Sverre
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Wikström, S., Lindh, C. H., Shu, H. & Bornehag, C.-G. (2019). Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women. Scientific Reports, 9, Article ID 9179.
Åpne denne publikasjonen i ny fane eller vindu >>Early pregnancy serum levels of perfluoroalkyl substances and risk of preeclampsia in Swedish women
2019 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, artikkel-id 9179Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Preeclampsia is a major cause of maternal and fetal morbidity. Emerging research shows an association with environmental exposures. The present aim was to investigate associations between early pregnancy serum levels of perfluoroalkyl substances (PFAS) and preeclampsia. Within the Swedish SELMA study, eight PFAS were measured at median 10 gestational weeks and cases of preeclampsia were postnatally identified from registers. Associations between individual PFAS and preeclampsia were assessed, adjusting for parity, age, weight and smoking. Out of 1,773 women in the study group, 64 ( 3.6%), developed preeclampsia. A doubling of PFOS and PFNA exposure, corresponding to an inter-quartile increase, was associated with an increased risk for preeclampsia of about 38-53% respectively. Serum PFOS within the highest quartile was associated with an odds ratio of 2.68 ( CI 95%: 1.17-6.12), equal to the increased risk associated with nulliparity, when compared to exposure in the first quartile. The same associations were identified, although with higher risk estimates, in analyses restricted to nulliparous women. For other PFAS, there were no associations. In conclusion and consistent with limited previous research only on PFOS, increasing serum levels of PFOS and PFNA during early pregnancy were associated with a clinically relevant risk of preeclampsia, adjusting for established confounders.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2019
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-75224 (URN)10.1038/s41598-019-45483-7 (DOI)000472597400082 ()31235847 (PubMedID)2-s2.0-85067898845 (Scopus ID)
Forskningsfinansiär
Swedish Research Council Formas
Merknad

Funding Agencies:

County Council of Värmland  

Örebro University 

Tilgjengelig fra: 2019-07-26 Laget: 2019-07-26 Sist oppdatert: 2019-07-26bibliografisk kontrollert
Bornehag, C.-G., Lindh, C., Reichenberg, A., Wikström, S., Unenge Hallerback, M., Evans, S. F., . . . Swan, S. H. (2018). Association of Prenatal Phthalate Exposure With Language Development in Early Childhood. JAMA pediatrics
Åpne denne publikasjonen i ny fane eller vindu >>Association of Prenatal Phthalate Exposure With Language Development in Early Childhood
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2018 (engelsk)Inngår i: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development.

Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies.

Design, Setting, and Participants: Data for this study were obtained from the Swedish Environmental Longitudinal Mother and Child, Asthma and Allergy (SELMA) study conducted in prenatal clinics throughout Värmland county in Sweden and The Infant Development and the Environment Study (TIDES) conducted in 4 academic centers in the United States. Participants recruited into both studies were women in their first trimester of pregnancy who had literacy in Swedish (SELMA) or English or Spanish (TIDES). This study included mothers and their children from both the SELMA study (n = 963) and TIDES (n = 370) who had complete data on prenatal urinary phthalate metabolite levels, language delay, and modeled covariables. For SELMA, the data were collected from November 1, 2007, to June 30, 2013, and data analysis was conducted from November 1, 2016, to June 30, 2018. For TIDES, data collection began January 1, 2010, and ended March 29, 2016, and data analysis was performed from September 15, 2016, to June 30, 2018.

Main Outcomes and Measures: Mothers completed a language development questionnaire that asked the number of words their children could understand or use at a median of 30 months of age (SELMA) and 37 months of age (TIDES). The responses were categorized as fewer than 25, 25 to 50, and more than 50 words, with 50 words or fewer classified as language delay.

Results: In the SELMA study, 963 mothers, 455 (47.2%) girls, and 508 [52.8%] boys were included. In TIDES, 370 mothers, 185 (50.0%) girls, and 185 (50.0%) boys were included in this analysis. The prevalence of language delay was 10.0% in both SELMA (96 reported) and TIDES (37 reported), with higher rates of delay in boys than girls (SELMA: 69 [13.5%] vs 27 [6.0%]; TIDES: 12 [12.4%] vs 14 [7.6%]). In crude analyses, the metabolite levels of dibutyl phthalate and butyl benzyl phthalate were statistically significantly associated with language delay in both cohorts. In adjusted analyses, a doubling of prenatal exposure of dibutyl phthalate and butyl benzyl phthalate metabolites increased the odds ratio (OR) for language delay by approximately 25% to 40%, with statistically significant results in the SELMA study (dibutyl phthalate OR, 1.29 [95% CI, 1.03-1.63; P = .03]; butyl benzyl phthalate OR, 1.26 [95% CI, 1.07-1.49; P = .003]). A doubling of prenatal monoethyl phthalate exposure was associated with an approximately 15% increase in the OR for language delay in the SELMA study (OR, 1.14; 95% CI, 1.00-1.31; P = .05), but no such association was found in TIDES (OR, 0.98; 95% CI, 0.79-1.23).

Conclusions and Relevance: In findings from this study, prenatal exposure to dibutyl phthalate and butyl benzyl phthalate was statistically significantly associated with language delay in children in both the SELMA study and TIDES. These findings, along with the prevalence of prenatal exposure to phthalates, the importance of language development, and the inconsistent results from a 2017 Danish study, suggest that the association of phthalates with language delay may warrant further examination.

sted, utgiver, år, opplag, sider
American Medical Association, 2018
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-69995 (URN)10.1001/jamapediatrics.2018.3115 (DOI)000452130600014 ()30383084 (PubMedID)2-s2.0-85055817441 (Scopus ID)
Tilgjengelig fra: 2018-11-07 Laget: 2018-11-07 Sist oppdatert: 2019-01-07bibliografisk kontrollert
Wikström, S., Hövel, H., Hansen Pupp, I., Fellman, V., Hüppi, P. S., Ley, D. & Hellström-Westas, L. (2018). Early Electroencephalography Suppression and Postnatal Morbidities Correlate with Cerebral Volume at Term-Equivalent Age in Very Preterm Infants. Neonatology, 113(1), 15-20
Åpne denne publikasjonen i ny fane eller vindu >>Early Electroencephalography Suppression and Postnatal Morbidities Correlate with Cerebral Volume at Term-Equivalent Age in Very Preterm Infants
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2018 (engelsk)Inngår i: Neonatology, ISSN 1661-7800, E-ISSN 1661-7819, Vol. 113, nr 1, s. 15-20Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Early brain activity is associated with long-term outcome. Establishing a relation also with postnatal brain growth may increase our understanding of early life influences on preterm brain development.

OBJECTIVES: The aim of this study was to investigate whether early electroencephalography (EEG) activity in infants born very preterm is associated with brain volumes at term, and whether postnatal morbidity affects this association.

METHODS: Very preterm infants (n = 38) with a median gestational age (GA) of 25.6 weeks had early recordings of single-channel EEG. The percentage of suppressed EEG, i.e., interburst intervals (IBI%) between 24 and 72 h of age, was analyzed in relation to brain volumes on magnetic resonance imaging performed at term-equivalent age, taking into account neonatal morbidities.

RESULTS: Early electrocortical depression and a higher IBI% were associated with increased cerebrospinal fluid volume (CSFV) and lower total brain volume relative to intracranial volume, also after adjustment for GA, postnatal morbidities, morphine administration, and postnatal head growth. Overall, an increase in IBI% to 1 SD from the mean corresponded with an increase in CSFV to +0.7 SD and a decrease in brain volume to -0.7 SD. The presence of 2 or more postnatal morbidities were associated with around 10% lower brain volumes.

CONCLUSIONS: More suppressed early EEG activity of very preterm infants is associated with lower brain volume and increased CSFV at term age, also when adjusting for postnatal morbidities. The findings indicate the importance of pre- and early postpartal determinants of postnatal brain growth, possibly also including activity-dependent mechanisms for brain growth.

sted, utgiver, år, opplag, sider
S. Karger, 2018
Emneord
Brain development, Cerebrospinal fluid, Electroencephalography, Magnetic resonance imaging, Preterm
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-62462 (URN)10.1159/000479423 (DOI)000418304700003 ()28934743 (PubMedID)2-s2.0-85029758648 (Scopus ID)
Forskningsfinansiär
Swedish Research Council, 0037 14940 0084
Merknad

Funding Agencies:

Linnea and Josef Carlsson Foundation, Region Skåne, Sweden  

County Council of Värmland

Örebro University  

Uppsala University, Sweden 

Tilgjengelig fra: 2017-12-04 Laget: 2017-12-04 Sist oppdatert: 2018-01-12bibliografisk kontrollert
Mellström, E., Forsman, C., Engh, L., Hallerbäck, M. U. & Wikström, S. (2018). Methylphenidate and Reduced Overweight in Children With ADHD. Journal of Attention Disorders
Åpne denne publikasjonen i ny fane eller vindu >>Methylphenidate and Reduced Overweight in Children With ADHD
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2018 (engelsk)Inngår i: Journal of Attention Disorders, ISSN 1087-0547, E-ISSN 1557-1246Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

OBJECTIVE: The objective of this study was to investigate odds ratios of overweight/obesity in children with ADHD and to compare the change in body mass index (BMI) after initiation of methylphenidate treatment in normal versus overweight/obese children.

METHOD: This population-based study included 724 children (<18 years), of whom 197 were girls. Odds ratios for overweight and obesity were calculated, comparing the study group with a reference group from the same area. After initiation of methylphenidate treatment, changes in BMI were assessed for up to 3 years.

RESULTS: Children with ADHD had an odds ratio of 1.87 (95% confidence interval [CI]: [1.60, 2.19]) for overweight/obesity. A decrease in BMI standard deviation score was identified 1 to 3 years into treatment. The decrease was beneficially greater in overweight/obese as compared with normal weight children-mean ( SD) -0.64 (0.80) versus -0.39 (0.68); p = .001-and greater in girls.

CONCLUSION: Medication with methylphenidate may facilitate favorable weight development in children with ADHD and overweight/obesity.

sted, utgiver, år, opplag, sider
Sage Publications, 2018
Emneord
ADHD, children, pharmacological treatment, weight
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-70006 (URN)10.1177/1087054718808045 (DOI)30371133 (PubMedID)
Tilgjengelig fra: 2018-11-06 Laget: 2018-11-06 Sist oppdatert: 2018-11-08bibliografisk kontrollert
Bornehag, C.-G., Reichenberg, A., Unenge Hallerback, M., Wikström, S., Koch, H. M., Jonsson, B. A. & Swan, S. H. (2018). Prenatal exposure to acetaminophen and children's language development at 30 months. European psychiatry, 51, 98-103
Åpne denne publikasjonen i ny fane eller vindu >>Prenatal exposure to acetaminophen and children's language development at 30 months
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2018 (engelsk)Inngår i: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 51, s. 98-103Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: To examine prenatal APAP exposure in relation to language development in offspring at 30 months of age.

METHOD: A population-based pregnancy cohort study including 754 women who enrolled in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study in pregnancy week 8-13. Two exposure measures were used: (1) maternally reported number of APAP tablets taken between conception and enrollment; (2) APAP urinary concentration at enrollment. Language development at 30 months was assessed by nurse's evaluation and parental questionnaire, including the number of words the child used (<25, 25-50 and >50). Main study outcome; parental report of use of fewer than 50 words, termed language delay (LD).

RESULTS: 59.2% of women enrolled in weeks 8-13 reported taking APAP between conception and enrollment. APAP was measurable in all urine samples and urinary APAP was correlated with the number of APAP taken during pregnancy (P<0.01). Language delay was more prevalent in boys (12.6%) than girls (4.1%) (8.5% in total). Both the number of APAP tablets and urinary APAP concentration were associated with greater LD in girls but not in boys. The adjusted odds ratio (OR) for LD among girls whose mothers reported >6 vs. 0 APAP tablets was 5.92 (95% confidence interval (CI) 1.10-31.94). The OR for LD in girls whose mothers' urinary APAP was in the highest compared to the lowest quartile was 10.34 (95% CI 1.37-77.86). While it cannot be ruled out, our available data do not support confounding by indication.

CONCLUSIONS: Given the prevalence of prenatal APAP use and the importance of language development, these findings, if replicated, would suggest that pregnant women should limit their use of this analgesic during pregnancy.

sted, utgiver, år, opplag, sider
Elsevier, 2018
Emneord
Children, Language delay, Prenatal paracetamol exposure
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-74355 (URN)10.1016/j.eurpsy.2017.10.007 (DOI)000434683700015 ()29331486 (PubMedID)2-s2.0-85040241655 (Scopus ID)
Forskningsfinansiär
Swedish Research Council Formas
Merknad

Funding agencies:

National Institute of Environmental Health Sciences

County Council of Värmland

Tilgjengelig fra: 2019-05-22 Laget: 2019-05-22 Sist oppdatert: 2019-06-18bibliografisk kontrollert
Shu, H., Wikström, S., Jönsson, B. A. G., Lindh, C. H., Svensson, Å., Nånberg, E. & Bornehag, C.-G. (2018). Prenatal phthalate exposure was associated with croup in Swedish infants. Acta Paediatrica, 107(6), 1011-1019
Åpne denne publikasjonen i ny fane eller vindu >>Prenatal phthalate exposure was associated with croup in Swedish infants
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2018 (engelsk)Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, nr 6, s. 1011-1019Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIM: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants.

METHODS: From 2007-2010 we used liquid chromatography tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1,062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders.

RESULTS: There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1,062 infants during the first year of life, when adjusted for potential confounders. A dose response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life.

CONCLUSION: Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2018
Emneord
Croup, Exposure, Phthalate, Pregnant, SELMA study
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-64845 (URN)10.1111/apa.14245 (DOI)000431956700017 ()29385277 (PubMedID)2-s2.0-85046728033 (Scopus ID)
Forskningsfinansiär
Swedish Research Council FormasSwedish Asthma and Allergy Association
Merknad

Funding Agencies:

Swedish Foundation for Health Care Sciences and Allergy Research  

County Council of Värmland 

Tilgjengelig fra: 2018-02-07 Laget: 2018-02-07 Sist oppdatert: 2018-12-13bibliografisk kontrollert
Derakhshan, A., Shu, H., Broeren, M. A. C., de Poortere, R. A., Wikström, S., Peeters, R. P., . . . Korevaar, T. I. M. (2018). Reference ranges and determinants of thyroid function during early pregnancy: the SELMA study. Journal of Clinical Endocrinology and Metabolism, 103(9), 3548-3556
Åpne denne publikasjonen i ny fane eller vindu >>Reference ranges and determinants of thyroid function during early pregnancy: the SELMA study
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2018 (engelsk)Inngår i: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 103, nr 9, s. 3548-3556Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Context: Establishing reference ranges as well as identifying and quantifying the determinants of thyroid function during pregnancy is important for proper clinical interpretation and optimizing research efforts. However, such data are sparse, specifically for (F)T3 measurements and most studies do not take into account thyroid antibodies or hCG.

Objective: To determine reference ranges and to identify/quantify determinants of TSH, FT4, FT3, TT4 and TT3.

Design, Setting and Participants: This study included 2,314 participants of the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study, a population-based prospective pregnancy cohort of mother-child pairs. Reference ranges were calculated by 2.5-97.5th percentiles after excluding TPOAb and/or TgAb positive women.

Intervention: None.

Main Outcome Measures: TSH, FT4, FT3, TT4 and TT3 in prenatal serum.

Results: After exclusion of TPOAb positive women, reference range were: TSH: 0.11-3.48 mU/L, FT4: 11.6-19.4 pmol/L, FT3: 3.72-5.92 pg/mL, TT4: 82.4-166.2 pmol/L and TT3: 1.28-2.92 nmol/L. Additional exclusion of TgAb positive women did not change the reference ranges substantially. Exposure to tobacco smoke, as assessed by questionnaires and serum cotinine, was associated with lower TSH and higher FT3 and TT3. BMI and gestational age were the main determinants of TSH (only for BMI), FT4, FT3, TT4 and TT3.

Conclusions: We show that the exclusion of TgAb positive women on top of excluding TPOAb positive women hardly affects clinical reference ranges. We identified various relevant clinical determinants of TSH, FT4, FT3, TT4 and TT3 which could reflect endocrine disrupting effects and/or effects on thyroid hormone transport or deiodination.

sted, utgiver, år, opplag, sider
Oxford University Press, 2018
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-68366 (URN)10.1210/jc.2018-00890 (DOI)000444322000052 ()29982605 (PubMedID)
Forskningsfinansiär
Swedish Research Council Formas
Merknad

Funding Agencies:

Exchange in Endocrinology Expertise (3E) program of the European Union of Medical Specialists (UEMS), Section and Board of Endocrinology  

ZOnMW VIDI  016.176.331 

Erasmus MC MRACE grant  

County Council of Värmland, Sweden 

Tilgjengelig fra: 2018-08-13 Laget: 2018-08-13 Sist oppdatert: 2018-10-04bibliografisk kontrollert
Shu, H., Lindh, C. H., Wikström, S. & Bornehag, C.-G. (2018). Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study. PLoS ONE, 13(12), Article ID e0209255.
Åpne denne publikasjonen i ny fane eller vindu >>Temporal trends and predictors of perfluoroalkyl substances serum levels in Swedish pregnant women in the SELMA study
2018 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 12, artikkel-id e0209255Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Perfluoroalkyl substances (PFAS) are used in numerous consumer products. They are persistent, bioaccumulating, and suspected to be endocrine disrupting chemicals (EDCs). A growing body of research has reported the association between PFAS exposure and adverse health effects. Concerns have been raised with special focus in childhood development.

METHODS: Perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), perfluorohexane sulfonate (PFHxS) and perfluorooctane sulfonate (PFOS) were analyzed by LC/MS/MS in serum from 1,616 pregnant women in the Swedish SELMA study. The serum samples were collected in the first trimester (median week 10). Least square geometric means (LSGM) of PFAS were estimated for each year period for, adjusted for potential determinants including parity, fish intake in the family, and mother's age.

RESULTS: Six PFAS (PFNA, PFDA, PFUnDA, PFHxS, PFOA, and PFOS) were detected above levels of detection (LOD) in more than 99% of the SELMA women, while PFHpA, and PFDoDA were detected above LOD in 73.4% and 46.7% respectively. Parity, maternal age, maternal smoking, and fish intake during pregnancy were found to be significantly associated (p<0.05) with serum PFAS levels in the pregnant women. Finally, serum concentration of six PFAS (PFNA, PFDA, PFHxS, PFHpA, PFOA and PFOS) were significantly decreasing (range 14-31%) during the period of 30 months from 2007-2010.

CONCLUSIONS: Our analysis shows that six out of eight PFAS could be identified in serum of more than 99% of SELMA subjects with a significant slightly decreasing trend for five of these compounds. Furthermore, parity, higher fish intake and mothers age are determinants for serum levels of PFAS in pregnant women.

sted, utgiver, år, opplag, sider
Public Library of Science, 2018
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-71185 (URN)10.1371/journal.pone.0209255 (DOI)000454627200036 ()30596681 (PubMedID)2-s2.0-85059262806 (Scopus ID)
Forskningsfinansiär
Swedish Environmental Protection AgencyEU, Horizon 2020, 634880
Tilgjengelig fra: 2019-01-08 Laget: 2019-01-08 Sist oppdatert: 2019-01-17bibliografisk kontrollert
Wikström, S. & Holst, E. (2017). Spädbarnsbotulism: skäl att inte ge honung till barn under ett år. Läkartidningen, 114, Article ID ELMF.
Åpne denne publikasjonen i ny fane eller vindu >>Spädbarnsbotulism: skäl att inte ge honung till barn under ett år
2017 (svensk)Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 114, artikkel-id ELMFArtikkel i tidsskrift (Fagfellevurdert) Published
Abstract [sv]

Infant botulism - why honey should be avoided for children up to one year Infant botulism means that Clostridium botulinum colonize and produce toxin in the infant gut, usually during the first year of life. Illness severity varies widely and the incidence may be under-estimated. Infant botulism should be considered in cases of acute muscle weakness or floppiness in infants, especially when accompanied by constipation or feeding difficulties. Respiratory failure and need for mechanical ventilation is common, but full recovery is gradually obtained. Diagnosis is based on stool culture and toxin detection in stool. Botulinum spores are frequently present in honey, which should consequently be avoided for infants.

sted, utgiver, år, opplag, sider
Läkartidningen Förlag AB, 2017
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-61748 (URN)28742188 (PubMedID)
Tilgjengelig fra: 2017-10-31 Laget: 2017-10-31 Sist oppdatert: 2019-03-22bibliografisk kontrollert
Wikholm, E., Malmborg, P., Forssberg, M., Hederos, C.-A. & Wikström, S. (2016). Iron Deficiency Is Common During Remission in Children With Inflammatory Bowel Disease. Global pediatric health, 3
Åpne denne publikasjonen i ny fane eller vindu >>Iron Deficiency Is Common During Remission in Children With Inflammatory Bowel Disease
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2016 (engelsk)Inngår i: Global pediatric health, ISSN 2333-794X, Vol. 3Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim was to study prevalence of iron deficiency in children with inflammatory bowel disease (IBD) during remission. In addition, there was an observational evaluation of hematological response to oral iron. A population-based retrospective study including 90 Swedish children (median 13 years) with IBD was performed. Patient records covered in median 25 months. Iron deficiency was present in 70/77 children (91%) in which iron status could be assessed. In clinical and biochemical remission, iron deficiency was found in 57/67 (85%) of children, and 23 (34%) of them had iron deficiency anemia. Thirty-six iron-deficient children were prescribed oral iron supplementation and 32 (89%) improved hemoglobin levels over 6 months. In conclusion, iron deficiency is common during clinical remission in children with IBD, even in cohorts with low prevalence of anemia. Therefore, regular biochemical screening for iron deficiency is warranted during all stages of disease, irrespective of symptoms and inflammatory blood markers.

sted, utgiver, år, opplag, sider
Sage Publications, 2016
Emneord
anemia, children, inflammatory bowel disease, iron deficiency, iron supplementation
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-74356 (URN)10.1177/2333794X16633672 (DOI)27336004 (PubMedID)
Tilgjengelig fra: 2019-05-22 Laget: 2019-05-22 Sist oppdatert: 2019-06-05bibliografisk kontrollert
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