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Sigmundsson, Freyr GautiORCID iD iconorcid.org/0000-0002-7376-4664
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Publikasjoner (10 av 40) Visa alla publikasjoner
Nerelius, F., Sigmundsson, F. G., Karlén, N., Wretenberg, P. & Joelson, A. (2024). Patient-reported Outcome after Surgical Evacuation of Postoperative Spinal Epidural Hematomas at One-year Follow-up. Spine, 49(10), 701-707
Åpne denne publikasjonen i ny fane eller vindu >>Patient-reported Outcome after Surgical Evacuation of Postoperative Spinal Epidural Hematomas at One-year Follow-up
Vise andre…
2024 (engelsk)Inngår i: Spine, ISSN 0362-2436, E-ISSN 1528-1159, Vol. 49, nr 10, s. 701-707Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

STUDY DESIGN: Retrospective analysis of prospectively collected data from the National Swedish Spine Register (Swespine).

OBJECTIVE: To evaluate the effects of symptomatic spinal epidural hematoma (SSEH) requiring reoperation on one-year patient-reported outcome measures (PROMs) in a large cohort of patients treated surgically for lumbar spinal stenosis (LSS).

SUMMARY OF BACKGROUND DATA: Studies exploring the outcomes of reoperations after SSEH are scarce and often lack validated outcome measures. As SSEH is considered a serious complication, understanding of the outcome following hematoma evacuation is important.

MATERIALS AND METHODS: After retrieving data from 2007 to 2017 from Swespine, we included all patients with LSS without concomitant spondylolisthesis who were treated surgically with decompression without fusion. Patients with evacuated SSEH were identified in the registry. Back/leg pain numerical rating scales (NRS), the Oswestry Disability Index (ODI), and EQ VAS were used for outcome assessment. PROMs before and one-year after decompression surgery were compared between evacuated patients and all other patients. Multivariate linear regression was performed to determine if hematoma evacuation predicted inferior one-year PROM scores.

RESULTS: A total of 113 patients with an evacuated SSEH were compared with 19527 patients with no evacuation. One-year after decompression surgery, both groups showed significant improvement in all PROMs. When comparing the two groups' one-year improvement there were no significant differences in any PROM. The proportion of patients achieving the minimum important change was not significantly different for any PROM. Multivariate linear regression found that hematoma evacuation significantly predicted inferior one-year ODI (β=4.35, P=0.043), but it was not a significant predictor of inferior NRS Back (β=0.50, P=0.105), NRS Leg (β=0.41, P=0.221), or EQ VAS (β=-1.97, P=0.470). CONCLUSIONS: A surgically evacuated SSEH does not affect outcome in terms of back/leg pain or health-related quality of life. Commonly used PROM surveys may not capture neurologic deficits associated with SSEH.

sted, utgiver, år, opplag, sider
Wolters Kluwer, 2024
Emneord
decompression, incidence, patient-reported outcome measures, postoperative spinal epidural hematoma, spinal stenosis, spine surgery
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-106100 (URN)10.1097/BRS.0000000000004720 (DOI)001245713500003 ()37235784 (PubMedID)2-s2.0-85191583143 (Scopus ID)
Tilgjengelig fra: 2023-05-29 Laget: 2023-05-29 Sist oppdatert: 2024-07-25bibliografisk kontrollert
Randers, E. M., Kibsgård, T. J., Stuge, B., Westberg, A., Sigmundsson, F. G., Joelson, A. & Gerdhem, P. (2024). Patient-reported outcomes after minimally invasive sacro-iliac joint surgery: a cohort study based on the Swedish Spine Registry. Acta Orthopaedica, 95, 284-289
Åpne denne publikasjonen i ny fane eller vindu >>Patient-reported outcomes after minimally invasive sacro-iliac joint surgery: a cohort study based on the Swedish Spine Registry
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2024 (engelsk)Inngår i: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 95, s. 284-289Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND AND PURPOSE: There is conflicting evidence regarding treatment outcomes after minimally invasive sacroiliac joint fusion for long-lasting severe sacroiliac joint pain. The primary aim of our cohort study was to investigate change in patient-reported outcome measures (PROMs) after minimally invasive sacroiliac joint surgery in daily practice in the Swedish Spine Registry. Secondary aims were to explore the proportion of patients reaching a patient acceptable symptom score (PASS) and the minimal clinically important difference (MCID) for pain scores, physical function, and health-related quality of life outcomes; furthermore, to evaluate self-reported satisfaction, walking distance, and changes in proportions of patients on full sick leave/disability leave and report complications and reoperations.

METHODS: Data from the Swedish Spine Registry was collected for patients with first-time sacroiliac joint fusion, aged 21 to 70 years, with PROMs available preoperatively, at 1 or 2 years after last surgery. PROMs included Oswestry Disability Index (ODI), Numeric Rating Scale (NRS) for low back pain (LBP) and leg pain, and EQ-VAS, in addition to demographic variables. We calculated mean change from pre- to postoperative and the proportion of patients achieving MCID and PASS.

RESULTS: 68 patients had available pre- and postoperative data, with a mean age of 45 years (range 25-70) and 59 (87%) were female. At follow-up the mean reduction was 2.3 NRS points (95% confidence interval [CI] 1.6-2.9; P < 0.001) for LBP and 14.8 points (CI 10.6-18.9; P < 0.001) for ODI. EQ-VAS improved by 22 points (CI 15.4-30.3, P < 0.001) at follow-up. Approximately half of the patients achieved MCID and PASS for pain (MCID NRS LBP: 38/65 [59%] and PASS NRS LBP: 32/66 [49%]) and physical function (MCID ODI: 27/67 [40%] and PASS ODI: 24/67 [36%]). The odds for increasing the patient's walking distance to over 1 km at follow-up were 3.5 (CI 1.8-7.0; P < 0.0001), and of getting off full sick leave or full disability leave was 0.57 (CI 0.4-0.8; P = 0.001). In the first 3 months after surgery 3 complications were reported, and in the follow-up period 2 reoperations.

CONCLUSION: We found moderate treatment outcomes after minimally invasive sacroiliac joint fusion when applied in daily practice with moderate pain relief and small improvements in physical function.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2024
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-114252 (URN)10.2340/17453674.2024.40817 (DOI)001248566700001 ()38874434 (PubMedID)2-s2.0-85196917482 (Scopus ID)
Tilgjengelig fra: 2024-06-17 Laget: 2024-06-17 Sist oppdatert: 2024-07-24bibliografisk kontrollert
Szigethy, L., Sigmundsson, F. G. & Joelson, A. (2024). Surgically treated degenerative disk disease in twins. European spine journal, 33(4), 1381-1384
Åpne denne publikasjonen i ny fane eller vindu >>Surgically treated degenerative disk disease in twins
2024 (engelsk)Inngår i: European spine journal, ISSN 0940-6719, E-ISSN 1432-0932, Vol. 33, nr 4, s. 1381-1384Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: Previous studies have suggested that genetic factors are important in the development of degenerative disk disease (DDD). However, the concordance rates for the phenotypes requiring surgery are unknown. The purpose of this study was to determine the concordance rates for DDD requiring surgery by studying monozygotic (MZ) and dizygotic (DZ) twin pairs.

METHODS: Patients, aged between 18 and 85 years, operated for DDD between 1996 and 2022 were identified in the national Swedish spine register (Swespine) and matched with the Swedish twin registry (STR) to identify MZ and DZ twins. Pairwise and probandwise concordance rates were calculated.

RESULTS: We identified 11,207 patients, 53% women, operated for DDD. By matching the Swespine patients with the STR, we identified 121 twin pairs (37 MZ and 84 DZ) where one or both twins were surgically treated for DDD. The total twin incidence for operated DDD was 1.1%. For DDD requiring surgery, we found no concordant MZ pair and no concordant DZ pair where both twins were operated for DDD. When we evaluated pairs where at least one twin was operated for DDD, we found two concordant MZ pairs (the co-twins were operated for spinal stenosis) and two  concordant DZ pairs (one co-twin operated for spinal stenosis and one (co-twin operated for disk herniation).

CONCLUSIONS: Our findings suggest that genetic factors are probably not a major etiologic component in most cases of DDD requiring surgery. The findings of this study can be used for counseling patients about the risk for requiring DDD surgery.

sted, utgiver, år, opplag, sider
Springer, 2024
Emneord
Concordance, Degenerative disk disease, Heredity, Twin studies
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-112024 (URN)10.1007/s00586-024-08161-5 (DOI)001173200800002 ()38416191 (PubMedID)2-s2.0-85186217403 (Scopus ID)
Tilgjengelig fra: 2024-02-29 Laget: 2024-02-29 Sist oppdatert: 2024-04-11bibliografisk kontrollert
Szigethy, L., Sigmundsson, F. G. & Joelson, A. (2024). Surgically Treated Degenerative Lumbar Spine Diseases in Twins. Journal of Bone and Joint Surgery. American volume, 106(10), 891-895
Åpne denne publikasjonen i ny fane eller vindu >>Surgically Treated Degenerative Lumbar Spine Diseases in Twins
2024 (engelsk)Inngår i: Journal of Bone and Joint Surgery. American volume, ISSN 0021-9355, E-ISSN 1535-1386, Vol. 106, nr 10, s. 891-895Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: There is growing evidence to suggest a potential genetic component underlying the development and progression of lumbar spine diseases. However, the heritability and the concordance rates for the phenotypes requiring surgery for the common spine diseases lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) are unknown. The aim of this study was to determine the heritability and the concordance rates for LSS and LDH requiring surgery by studying monozygotic (MZ) and dizygotic (DZ) twin pairs.

METHODS: Patients between 18 and 85 years of age who underwent surgery for LSS or LDH between 1996 and 2022 were identified in the national Swedish spine registry (LSS: 45,110 patients; LDH: 39,272 patients), and matched with the Swedish Twin Registry to identify MZ and DZ twins. Pairwise and probandwise concordance rates, heritability estimates, and MZ/DZ concordance ratios were calculated.

RESULTS: We identified 414 twin pairs (92 MZ and 322 DZ pairs) of whom 1 or both twins underwent surgery for LSS. The corresponding number for LDH was 387 twin pairs (118 MZ and 269 DZ pairs). The probandwise concordance rate for LSS requiring surgery was 0.25 (26 of 105) (95% confidence interval [CI], 0.14 to 0.34) for MZ twins and 0.04 (12 of 328) (95% CI, 0.01 to 0.07) for DZ twins. The corresponding values for LDH requiring surgery were 0.03 (4 of 120) (95% CI, 0 to 0.08) and 0.01 (4 of 271) (95% CI, 0 to 0.04), respectively. The probandwise MZ/DZ concordance ratio was 6.8 (95% CI, 2.9 to 21.5) for LSS and 2.3 (95% CI, 0 to 8.9) for LDH. The heritability was significantly higher in LSS compared with LDH (0.64 [95% CI, 0.50 to 0.74] versus 0.19 [95% CI, 0.08 to 0.35]).

CONCLUSIONS: Our findings suggest that genetic factors may play an important role in the risk of developing LSS requiring surgery, whereas heredity seems to be of less importance in LDH requiring surgery. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

sted, utgiver, år, opplag, sider
American Academy of Orthopaedic Surgeons, 2024
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-111852 (URN)10.2106/JBJS.23.00902 (DOI)001248536100008 ()38386722 (PubMedID)2-s2.0-85193310432 (Scopus ID)
Tilgjengelig fra: 2024-02-23 Laget: 2024-02-23 Sist oppdatert: 2024-07-26bibliografisk kontrollert
Joelson, A., Szigethy, L., Wildeman, P., Sigmundsson, F. G. & Karlsson, J. (2023). Associations between future health expectations and patient satisfaction after lumbar spine surgery: a longitudinal observational study of 9929 lumbar spine surgery procedures. BMJ Open, 13(9), Article ID e074072.
Åpne denne publikasjonen i ny fane eller vindu >>Associations between future health expectations and patient satisfaction after lumbar spine surgery: a longitudinal observational study of 9929 lumbar spine surgery procedures
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2023 (engelsk)Inngår i: BMJ Open, E-ISSN 2044-6055, Vol. 13, nr 9, artikkel-id e074072Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: This study aimed to investigate the associations between general health expectations and patient satisfaction with treatment for the two common spine surgery procedures diskectomy for lumbar disk herniation (LDH) and decompression for lumbar spinal stenosis (LSS). DESIGN: Register study with prospectively collected preoperative and 1-year postoperative data.

SETTING: National outcome data from Swespine, the national Swedish spine register.

PARTICIPANTS: A total of 9929 patients, aged between 20 and 85 years, who were self-reported non-smokers, and were operated between 2007 and 2016 for one-level LSS without degenerative spondylolisthesis, or one-level LDH, were identified in the national Swedish spine register (Swespine). We used SF-36 items 11c and 11d to assess future health expectations and present health perceptions. Satisfaction with treatment was assessed using the Swespine satisfaction item.

INTERVENTIONS: One-level diskectomy for LDH or one-level decompression for LSS.

PRIMARY OUTCOME MEASURES: Satisfaction with treatment. RESULTS: For LSS, the year 1 satisfaction ratio among patients with negative future health expectations preoperatively was 60% (95% CI 58% to 63%), while it was 75% (95% CI 73% to 76%) for patients with positive future health expectations preoperatively. The corresponding numbers for LDH were 73% (95% CI 71% to 75%) and 84% (95% CI 83% to 85%), respectively.

CONCLUSIONS: Patients operated for the common lumbar spine diseases LSS or LDH, with negative future general health expectations, were significantly less satisfied with treatment than patients with positive expectations with regard to future general health. These findings are important for patients, and for the surgeons who counsel them, when surgery is a treatment option for LSS or LDH.

sted, utgiver, år, opplag, sider
BMJ Publishing Group Ltd, 2023
Emneord
Adult orthopaedics, Quality of Life, Spine
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-108559 (URN)10.1136/bmjopen-2023-074072 (DOI)001077459700021 ()37748852 (PubMedID)2-s2.0-85172248880 (Scopus ID)
Tilgjengelig fra: 2023-09-26 Laget: 2023-09-26 Sist oppdatert: 2024-01-02bibliografisk kontrollert
Elmose, S. F., Andersen, G. O., Carreon, L. Y., Sigmundsson, F. G. & Andersen, M. O. (2023). Radiological Definitions of Sagittal Plane Segmental Instability in the Degenerative Lumbar Spine - A Systematic Review. Global Spine Journal, 13(2), 523-533
Åpne denne publikasjonen i ny fane eller vindu >>Radiological Definitions of Sagittal Plane Segmental Instability in the Degenerative Lumbar Spine - A Systematic Review
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2023 (engelsk)Inngår i: Global Spine Journal, ISSN 2192-5682, E-ISSN 2192-5690, Vol. 13, nr 2, s. 523-533Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Study Design: Systematic Review.

Objective: To collect and group definitions of segmental instability, reported in surgical studies of patients with lumbar spinal stenosis (LSS) and/or lumbar degenerative spondylolisthesis (LDS). To report the frequencies of these definitions. To report on imaging measurement thresholds for instability in patients and compare these to those reported in biomechanical studies and studies of spine healthy individuals.To report on studies that include a reliability study.

Methods: This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies eligible for inclusion were clinical and biomechanical studies on adult patients with LDS and/or LSS who underwent surgical treatment and had data on diagnostic imaging. A systematic literature search was conducted in relevant literature databases. Full text screening inclusion criteria was definition of segmental instability or any synonym. Two reviewers independently screened articles in a two-step process. Data synthesis presented by tabulate form and narrative synthesis.

Results: We included 118 studies for data extraction, 69% were surgical studies with decompression or fusion as interventions, 31% non-interventional studies. Grouping the definitions of segmental instability according similarities showed that 24% defined instability by dynamic sagittal translation, 26% dynamic translation and dynamic angulation, 8% used a narrative definition. Comparison showed that non-interventional studies with a healthy population more often had a narrative definition.

Conclusion: Despite a reputation of non-consensus, segmental instability in the degenerative lumbar spine can radiologically be defined as > 3 mm dynamic sagittal translation.

sted, utgiver, år, opplag, sider
Sage Publications, 2023
Emneord
systematic review, lumbar segmental instability, lumbar degenerative spondylolisthesis, spinal stenosis, diagnostic imaging, clinical spine surgery
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-99445 (URN)10.1177/21925682221099854 (DOI)000800548900001 ()35606897 (PubMedID)2-s2.0-85130994896 (Scopus ID)
Tilgjengelig fra: 2022-06-10 Laget: 2022-06-10 Sist oppdatert: 2023-03-15bibliografisk kontrollert
Elmose, S. F., Andersen, M. O., Sigmundsson, F. G. & Carreon, L. Y. (2023). Response to "letter to the Editor Regarding: Magnetic Resonance Imaging Proxies for Segmental Instability in Degenerative Lumbar Spondylolisthesis Patients" [Letter to the editor]. Spine, 48(13), E221-E221
Åpne denne publikasjonen i ny fane eller vindu >>Response to "letter to the Editor Regarding: Magnetic Resonance Imaging Proxies for Segmental Instability in Degenerative Lumbar Spondylolisthesis Patients"
2023 (engelsk)Inngår i: Spine, ISSN 0362-2436, E-ISSN 1528-1159, Vol. 48, nr 13, s. E221-E221Artikkel i tidsskrift, Letter (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Lippincott Williams & Wilkins, 2023
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-107220 (URN)10.1097/BRS.0000000000004635 (DOI)001006696600006 ()2-s2.0-85162894191 (Scopus ID)
Tilgjengelig fra: 2023-07-31 Laget: 2023-07-31 Sist oppdatert: 2023-07-31bibliografisk kontrollert
Joelson, A. & Sigmundsson, F. G. (2022). Additional operation rates after surgery for degenerative spine diseases: minimum 10 years follow-up of 4705 patients in the national Swedish spine register. BMJ Open, 12(12), Article ID e067571.
Åpne denne publikasjonen i ny fane eller vindu >>Additional operation rates after surgery for degenerative spine diseases: minimum 10 years follow-up of 4705 patients in the national Swedish spine register
2022 (engelsk)Inngår i: BMJ Open, E-ISSN 2044-6055, Vol. 12, nr 12, artikkel-id e067571Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objectives: To identify rates of additional operation after the index operation for degenerative lumbar spine diseases.Design Retrospective register study.Setting National outcome data from Swespine, the National Swedish spine register.

Participants: A total of 4705 patients who underwent one-level surgery for degenerative disk disease (DDD) or lumbar spinal stenosis (LSS) with or without degenerative spondylolisthesis (DS) between 1 January 2007 and 31 December 2010 were followed from 1 January 2007 to 31 December 2020 to record all cases of additional lumbar spine operations.Interventions One-level spinal decompression and/or posterolateral fusion for degenerative spine diseases.

Primary outcome measures: Number of additional operations.

Results: Additional operations were more common at adjacent levels for patients with LSS with DS treated with decompression and fusion whereas additional operations were more evenly distributed between the index level and the adjacent levels for DDD treated with fusion and LSS with and without DS treated with decompression only. For patients younger than 60 years, treated with decompression and fusion for LSS with DS, the additional operations were evenly distributed between the index level and the adjacent levels.

Conclusions: There are different patterns of additional operations following the index procedure after surgery for degenerative spine diseases. Rigidity across previously mobile segments is not the only important factor in the development of adjacent segment disease (ASD) after spinal fusion, also the underlying disease and age may play parts in ASD development. The findings of this study can be used in the shared decision-making process when surgery is a treatment option for patients with degenerative lumbar spine diseases as the first operation may be the start of a series of additional spinal operations for other degenerative spinal conditions, either at the index level or at other spinal levels.

sted, utgiver, år, opplag, sider
BMJ Publishing Group Ltd, 2022
Emneord
Spine, Back pain, Adult orthopaedics
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-102636 (URN)10.1136/bmjopen-2022-067571 (DOI)000901531900022 ()36600338 (PubMedID)2-s2.0-85144516132 (Scopus ID)
Tilgjengelig fra: 2022-12-09 Laget: 2022-12-09 Sist oppdatert: 2023-08-28bibliografisk kontrollert
Sigmundsson, F. G., Joelson, A. & Strömqvist, F. (2022). Additional operations after surgery for lumbar disc prolapse: indications, type of surgery, and long-term follow-up of primary operations performed from 2007 to 2008. The Bone & Joint Journal, 104-B(5), 627-632
Åpne denne publikasjonen i ny fane eller vindu >>Additional operations after surgery for lumbar disc prolapse: indications, type of surgery, and long-term follow-up of primary operations performed from 2007 to 2008
2022 (engelsk)Inngår i: The Bone & Joint Journal, ISSN 2049-4394, E-ISSN 2049-4408, Vol. 104-B, nr 5, s. 627-632Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIMS: Lumbar disc prolapse is a frequent indication for surgery. The few available long-term follow-up studies focus mainly on repeated surgery for recurrent disease. The aim of this study was to analyze all reasons for additional surgery for patients operated on for a primary lumbar disc prolapse.

METHODS: We retrieved data from the Swedish spine register about 3,291 patients who underwent primary surgery for a lumbar disc prolapse between January 2007 and December 2008. These patients were followed until December 2020 to record all additional lumbar spine operations and the reason for them.

RESULTS: In total, 681 of the 3,291 patients (21%) needed one or more additional operations. More than three additional operations was uncommon (2%; 15/906). Overall, 906 additional operations were identified during the time period, with a mean time to the first of these of 3.7 years (SD 3.6). The most common reason for an additional operation was recurrent disc prolapse (47%; 426/906), followed by spinal stenosis or degenerative spondylolisthesis (19%; 176/906), and segmental pain (16%; 145/906). The most common surgical procedures were revision discectomy (43%; 385/906) and instrumented fusion (22%; 200/906). Degenerative spinal conditions other than disc prolapse became a more common reason for additional surgery with increasing length of follow-up. Most patients achieved the minimally important change (MIC) for the patient-reported outcomes after the index surgery. After the third additional spinal operation, only 20% (5/25) achieved the MIC in terms of leg pain, and 29% (7/24) in terms of the EuroQol five-dimension index questionnaire visual analogue scale.

CONCLUSION: More than one in five patients operated on for a lumbar disc prolapse underwent further surgery during the 13-year follow-up period. Recurrent disc prolapse was the most common reason for additional surgery, followed by spinal stenosis and segmental pain. This study shows that additional operations after primary disc surgery are needed more frequently than previously reported, and that the outcome profoundly deteriorates after the second additional operation. The findings from this study can be used in the shared decision-making process. Cite this article: Bone Joint J 2022;104-B(5):627-632.

sted, utgiver, år, opplag, sider
British Editorial Society of Bone and Joint Surgery (JBJS), 2022
Emneord
Complications, Degenerative disc disease, Degenerative spine, Lumbar disc herniation, Outcome, Patient-reported outcome measures (PROMs), Recurrent disc herniation, Reoperation, degenerative spondylolisthesis, discectomy, leg pain, lumbar disc, lumbar spine, primary surgery, spinal stenosis, spine, visual analogue scale (VAS)
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-98850 (URN)10.1302/0301-620X.104B5.BJJ-2021-1706.R2 (DOI)35491575 (PubMedID)
Tilgjengelig fra: 2022-05-04 Laget: 2022-05-04 Sist oppdatert: 2022-05-04bibliografisk kontrollert
Elmose, S. F., Andersen, M. O., Sigmundsson, F. G. & Carreon, L. Y. (2022). Magnetic Resonance Imaging Proxies for Segmental Instability in Degenerative Lumbar Spondylolisthesis Patients. Spine, 47(21), 1473-1482
Åpne denne publikasjonen i ny fane eller vindu >>Magnetic Resonance Imaging Proxies for Segmental Instability in Degenerative Lumbar Spondylolisthesis Patients
2022 (engelsk)Inngår i: Spine, ISSN 0362-2436, E-ISSN 1528-1159, Vol. 47, nr 21, s. 1473-1482Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Study design: Retrospective cohort study.

Objective: The aim was to investigate whether findings on magnetic resonance imaging (MRI) can be proxies (MRIPs) for segmental instability in patients with degenerative lumbar spinal stenosis (LSS) and/or degenerative spondylolisthesis (LDS) L4/L5.

Background: LDS has a heterogeneous nature. Some patients have a dynamic component of segmental instability associated with LDS. Studies have shown that MRI can show signs of instability.

Methods: Patients with LSS or LDS at L4/L5 undergoing decompressive surgery +/- fusion from 2010 to 2017, with preoperative standing lateral spine radiographs and supine lumbar MRI and enrolled in Danish national spine surgical database, DaneSpine. Instability defined as slip of >3 mm on radiographs. Patients divided into two groups based upon presence of instability. Outcome measures: radiograph: sagittal slip (mm). MRIPs for instability: sagittal slip >3 mm, facet joint angle (degrees), facet joint effusion (mm), disk height index (%), and presence of vacuum phenomena. Optimal thresholds for MRIPs was determined by receiver operating characteristic (ROC) curves and area under the curve (AUC). Logistic regression to investigate association between instability and MRIPs.

Results: Two hundred thirty-two patients: 47 stable group and 185 unstable group. The two groups were comparable with regard to baseline patient-reported outcome measures. Thresholds for MRIPs: bilateral facet joint angle >= 46 degrees; bilateral facet effusion >= 1.5 mm and disk height index >= 13%. Logistic regression showed statistically significant association with MRIPs except vacuum phenomena, ROC curve AUC of 0.951. By absence of slip on MRI logistic regression showed statistically significant association between instability on radiograph and the remaining MRIPs, ROC curve AUC 0.757.

Conclusion: Presence of MRIPs for instability showed statistically significant association with instability and excellent ability to predict instability on standing radiograph in LSS and LDS patients. Even in the absence of slip on MRI the MRIPs had a good ability to discriminate presence of instability.

sted, utgiver, år, opplag, sider
Wolters Kluwer, 2022
Emneord
lumbar degenerative spondylolisthesis, magnetic resonance imaging proxies, segmental instability
HSV kategori
Identifikatorer
urn:nbn:se:oru:diva-101953 (URN)10.1097/BRS.0000000000004437 (DOI)000865487700003 ()35877558 (PubMedID)2-s2.0-85139571096 (Scopus ID)
Tilgjengelig fra: 2022-10-27 Laget: 2022-10-27 Sist oppdatert: 2022-10-27bibliografisk kontrollert
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-7376-4664