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Gustafsson, J., Montiel Rojas, D., Romare, M. G. A., Johansson, E., Folkesson, M., Pernigoni, M., . . . Edholm, P. (2025). Cold- and hot-water immersion are not more effective than placebo for the recovery of physical performance and training adaptations in national level soccer players. European Journal of Applied Physiology
Öppna denna publikation i ny flik eller fönster >>Cold- and hot-water immersion are not more effective than placebo for the recovery of physical performance and training adaptations in national level soccer players
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2025 (Engelska)Ingår i: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

PURPOSE: Cold- and hot-water immersion (CWI and HWI, respectively) are popular post-exercise recovery methods in competitive soccer. The aims of this study were to (1) compare the effect of post-exercise CWI, HWI and placebo on the recovery of physical performance in national level soccer players, and (2) investigate whether repeated use of these recovery modalities has an impact on training adaptations over a 15 week period.

METHODS: For Part I, 40 male soccer players (15-19 years) were randomized to either CWI (10 °C, 10 min), HWI (42 °C, 20 min), or placebo (6 min, sham laser), applied after a 90 min simulated soccer match (SSM). Physical performance was assessed using submaximal aerobic, 20 m sprint, countermovement jump (CMJ), and knee extension strength tests [i.e., maximum voluntary isometric contraction (MVIC) and time to exhaustion (TTE) at 60% of MVIC] performed at Pre-SSM and 0, 21 and 45 h Post-SSM. For Part II, 19 participants applied their respective recovery modality (~ twice a week) in their usual training. After 15 weeks, physical performance and body composition were assessed and compared to pre-intervention.

RESULTS: All three modalities similarly affected the recovery of physical performance during the 21-45 h Post-SSM period (p < 0.05). Moreover, no significant effects of the recovery modalities on body composition and on development of physical performance were found over the 15 week recovery intervention (p > 0.05).

CONCLUSION: Compared to a placebo, CWI and HWI do not improve post-match recovery of physical performance and do not impact long-term training adaptations in highly trained soccer players.

Ort, förlag, år, upplaga, sidor
Springer, 2025
Nyckelord
Athletes, Cooling, Exercise, Fatigue, Football, Heating
Nationell ämneskategori
Idrottsvetenskap och fitness
Identifikatorer
urn:nbn:se:oru:diva-121636 (URN)10.1007/s00421-025-05835-w (DOI)001506960700001 ()40498100 (PubMedID)2-s2.0-105007666764 (Scopus ID)
Forskningsfinansiär
Örebro universitetKK-stiftelsen
Tillgänglig från: 2025-06-16 Skapad: 2025-06-16 Senast uppdaterad: 2025-06-19Bibliografiskt granskad
Horwath, O., Montiel Rojas, D., Ponsot, E., Féasson, L. & Kadi, F. (2025). Increased muscle satellite cell content and preserved telomere length in response to combined exercise training in patients with FSHD. Journal of Physiology, 603(5), 1057-1069
Öppna denna publikation i ny flik eller fönster >>Increased muscle satellite cell content and preserved telomere length in response to combined exercise training in patients with FSHD
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2025 (Engelska)Ingår i: Journal of Physiology, ISSN 0022-3751, E-ISSN 1469-7793, Vol. 603, nr 5, s. 1057-1069Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Facioscapulohumeral muscular dystrophy (FSHD) is an inherited muscle disease characterized by weakness and muscle wasting. In the absence of available treatments, exercise training has emerged as a potential strategy to attenuate muscle tissue deterioration. However, little is known about the impact of chronic exercise on degenerative events and regenerative capacity in FSHD muscle. Muscle biopsies were obtained from 16 FSHD patients before and after a 24 week training program combining aerobic-, strength- and high-intensity exercise (Control; n = 8, Training; n = 8). Histochemical and immunohistochemical approaches were applied to assess histopathological signs, markers of regeneration, inflammatory infiltrates and satellite cell content. Muscle telomere length was measured as an indicator of the remaining regenerative capacity. The proportion of muscle fibres expressing developmental myosins and centralized myonuclei was not exacerbated after the intervention. Similarly, no alterations were observed in the number of inflammatory infiltrates (CD68+ cells). Alongside muscle hypertrophy in slow (P = 0.022) and fast fibres (P = 0.022 and P = 0.008), satellite cell content increased specifically in fast fibres (+75 %, P = 0.015), indicating a functional satellite cell pool in FSHD muscle. Importantly, exercise training was not associated with a shortening of muscle telomere length, suggesting that muscle cell turnover was not accelerated despite an expansion of the satellite cell pool. Our findings suggest that combined exercise training elicits beneficial muscular adaptations without impairing important indicators of skeletal muscle regenerative capacity in patients with FSHD. KEY POINTS: A 24 week combined exercise training program is a safe and well-tolerated strategy to attenuate skeletal muscle deterioration in facioscapulohumeral muscular dystrophy (FSHD) patients. Markers of histopathology, muscle fibre regeneration and inflammatory infiltrates were not exacerbated following exercise training in FSHD muscle. Here, we show novel data that exercise training in FSHD patients induced muscle fibre hypertrophy and triggered an expansion of the satellite cell pool specifically in fast fibres. Exercise training in these patients is not associated with a shortening of muscle telomere length thereby indicating a preserved capacity for muscle regeneration.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2025
Nyckelord
Pax7, facioscapulohumeral muscular dystrophy, muscle fibre, muscle regeneration, myogenesis
Nationell ämneskategori
Fysioterapi
Identifikatorer
urn:nbn:se:oru:diva-119120 (URN)10.1113/JP287033 (DOI)39891610 (PubMedID)2-s2.0-85216535063 (Scopus ID)
Tillgänglig från: 2025-02-06 Skapad: 2025-02-06 Senast uppdaterad: 2025-03-07Bibliografiskt granskad
Särnblad, S., Ponsot, E., Leprêtre, P.-M. & Kadi, F. (2021). Acute effects of aerobic continuous, intermittent and resistance exercise on glycemia in adolescents males with type 1 diabetes. Pediatric Diabetes, 22(4), 610-617
Öppna denna publikation i ny flik eller fönster >>Acute effects of aerobic continuous, intermittent and resistance exercise on glycemia in adolescents males with type 1 diabetes
2021 (Engelska)Ingår i: Pediatric Diabetes, ISSN 1399-543X, E-ISSN 1399-5448, Vol. 22, nr 4, s. 610-617Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: Increased levels of physical activity is often associated with reduced HbA1c in individuals with diabetes. However, the effect on glycemic control differs between different programs of exercise. The aim of this study was to compare the acute effects on glycemia of resistance and two aerobic continuous and intermittent exercise bouts in adolescent males with type 1 diabetes.

METHODS: Eight active males with type 1 diabetes (17.5±0.8 years, BMI: 20.8±2.2 kg/m2 , HbA1c: 7.2±0.5 % (54.9±5.3 mmol/mol)) performed four experimental sessions - non-exercise (control), resistance exercise (RE) and two isocaloric continuous (CE) and intermittent (IE) cycling exercise trials - in a randomized order. Each session consisted of 45 minutes of exercise (except for the control modality) and 60 minutes of passive recovery. Venous blood was drawn for assessment of plasma glucose (PG). A two-way repeated-measures ANOVA was used for statistical comparisons.

RESULTS: A significant time-to-exercise interaction effect on PG was detected. PG significantly decreased during IE (-5.1±1.6 mmol/L) and CE (-5.4 ± 1.8 mmol/L) but not during RE (-1.0 ± 1.4 mmol/L, ns). Additionally, decreases in PG after IE and CE were sustained throughout the recovery period.

CONCLUSIONS: While intermittent and continuous aerobic exercises are associated with a lowering of glycemia in male adolescents with type 1 diabetes, glycemia remained stable without significant alterations after resistance exercise. These findings hold important implications related to clinical exercise advice and disease management in adolescents with type 1 diabetes.

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell Publishing Inc., 2021
Nyckelord
adolescents, exercise, type 1 diabetes
Nationell ämneskategori
Endokrinologi och diabetes
Identifikatorer
urn:nbn:se:oru:diva-90088 (URN)10.1111/pedi.13194 (DOI)000630299900001 ()33650298 (PubMedID)2-s2.0-85102656839 (Scopus ID)
Anmärkning

Funding Agencies:

Childhood diabetes foundation, Linköping, Sweden  

Nyckelfonden, Örebro County Research foundation, Sweden 

Tillgänglig från: 2021-03-03 Skapad: 2021-03-03 Senast uppdaterad: 2021-06-02Bibliografiskt granskad
Strandberg, E., Ponsot, E., Piehl-Aulin, K., Falk, G. & Kadi, F. (2019). Resistance Training Alone or Combined With N-3 PUFA-Rich Diet in Older Women: Effects on Muscle Fiber Hypertrophy. The journals of gerontology. Series A, Biological sciences and medical sciences, 74(4), 489-494
Öppna denna publikation i ny flik eller fönster >>Resistance Training Alone or Combined With N-3 PUFA-Rich Diet in Older Women: Effects on Muscle Fiber Hypertrophy
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2019 (Engelska)Ingår i: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 74, nr 4, s. 489-494Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We aimed to examine cellular and molecular changes in skeletal muscle of recreationally active older women in response to 24 weeks of combined resistance training and N-3 PUFA-rich healthy diet. Sixty-three women (65-70 years) were randomized into resistance training and healthy diet rich in N-3PUFAs (RT-HD), resistance training only (RT) and controls (CON). Fiber type-specific morphological characteristics and gene expression of inflammatory biomarkers and regulators of muscle mass were analyzed in m. vastus lateralis biopsies obtained before the intervention and 4 days after the last training session. Gene expression of the proinflammatory cytokine IL-1β was downregulated (p < .05) and that of the regulator of cellular growth mTOR (p < 0.05) was upregulated in skeletal muscle of RT-HD only. There was also a significant hypertrophy of fast type IIA muscle fibers in RT-HD only (+23%, p < .05). In conclusion, resistance training combined to an N-3 PUFA-rich healthy diet but not alone triggers local anti-inflammatory and growth responses, favoring skeletal muscle hypertrophy in already recreationally active older women.

Ort, förlag, år, upplaga, sidor
Oxford University Press, 2019
Nyckelord
Exercise, Inflammation, Muscles, Sarcopenia, mTOR
Nationell ämneskategori
Fysiologi och anatomi Geriatrik
Identifikatorer
urn:nbn:se:oru:diva-73206 (URN)10.1093/gerona/gly130 (DOI)000462601700007 ()30052800 (PubMedID)2-s2.0-85062936694 (Scopus ID)
Anmärkning

Funding Agency:

Swedish National Center for Research in Sports  P2012/102  P2014-0117

Tillgänglig från: 2019-03-18 Skapad: 2019-03-18 Senast uppdaterad: 2025-02-10Bibliografiskt granskad
Montiel Rojas, D., Nilsson, A., Ponsot, E., Brummer, R. J., Fairweather-Tait, S., Jennings, A., . . . Kadi, F. (2018). Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults. Frontiers in Physiology, 9, Article ID 1110.
Öppna denna publikation i ny flik eller fönster >>Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults
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2018 (Engelska)Ingår i: Frontiers in Physiology, E-ISSN 1664-042X, Vol. 9, artikel-id 1110Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. A total of 1,221 adults (65-79 years) were recruited from five European countries within the framework of NU-AGE study. The physical functioning construct was based on the 36-item Short Form Health Survey. Handgrip strength was used as a single indicator of muscle function and LTL was assessed using quantitative real-time PCR. Women had significantly longer (p < 0.05) LTL than men. Participants in Poland had significantly shorter LTL than in the other study centers, whereas participants in the Netherlands had significantly longer LTL than most of the other centers (p < 0.01). An analysis of LTL as a continuous outcome against physical functioning by using linear models revealed inconsistent findings. In contrast, based on an analysis of contrasting telomere lengths (first vs. fifth quintile of LTL), a significant odds ratio (OR) of 1.7 (95% CI: 1.1 -2.6; p < 0.05) of having functional limitation was observed in those belonging to the first LTL quintile compared to the fifth. Interestingly, having the shortest LTL was still related to a higher likelihood of having physical limitation when compared to all remaining quintiles (OR: 1.5, 95% CI: 1.1 -2.1; p < 0.05), even after adjustment by study center, age, sex, and overweight status. Collectively, our findings suggest that short LTL is an independent risk factor that accounts for functional decline in elderly European populations. The influence of LTL on functional limitation seems driven by the detrimental effect of having short telomeres rather than reflecting a linear dose-response relationship.

Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2018
Nyckelord
aging, ethnicity, handgrip strength, SF-36, physical function
Nationell ämneskategori
Fysiologi och anatomi
Identifikatorer
urn:nbn:se:oru:diva-68587 (URN)10.3389/fphys.2018.01110 (DOI)000441323300001 ()2-s2.0-85051645979 (Scopus ID)
Forskningsfinansiär
EU, FP7, Sjunde ramprogrammet, 266486
Tillgänglig från: 2018-08-27 Skapad: 2018-08-27 Senast uppdaterad: 2025-02-10Bibliografiskt granskad
Särnblad, S., Ponsot, E. & Kadi, F. (2017). Acute effects on glycemia of different types of exercise in youths with type 1 diabetes. In: : . Paper presented at ISPAD 2017, Innsbruck, Austria, October 18-21, 2017.
Öppna denna publikation i ny flik eller fönster >>Acute effects on glycemia of different types of exercise in youths with type 1 diabetes
2017 (Engelska)Konferensbidrag, Poster (med eller utan abstract) (Refereegranskat)
Nationell ämneskategori
Pediatrik
Forskningsämne
Pediatrik
Identifikatorer
urn:nbn:se:oru:diva-61856 (URN)
Konferens
ISPAD 2017, Innsbruck, Austria, October 18-21, 2017
Tillgänglig från: 2017-10-18 Skapad: 2017-10-18 Senast uppdaterad: 2017-11-01Bibliografiskt granskad
Sillanpää, E., Niskala, P., Laakkonen, E. K., Ponsot, E., Alén, M., Kaprio, J., . . . Sipilä, S. (2017). Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy. Twin Research and Human Genetics, 20(2), 119-131
Öppna denna publikation i ny flik eller fönster >>Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy
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2017 (Engelska)Ingår i: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 20, nr 2, s. 119-131Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3.7 years in the user sister, while their co-twins had never used HRT. LTL was measured by qPCR and SMTLs by southern blot. Body and muscle composition were estimated by bioimpedance and computed tomography, respectively. Physical performance was measured by jumping height and grip strength. HRT users and non-users did not differ in LTL or mean or minimum SMTL. Within-pair correlations were high in LTL (r = 0.69, p = .020) and in mean (r = 0.74, p = .014) and minimum SMTL (r = 0.88, p = .001). Body composition and performance were better in users than non-users. In analyses of individuals, LTL was associated with BMI (r 2 = 0.30, p = .030), percentage total body (r 2 = 0.43, p = .014), and thigh (r 2 = 0.55, p = .004) fat, while minimum SMTL was associated with fat-free mass (r 2 = 0.27, p = .020) and thigh muscle area (r 2 = 0.42, p = .016). We found no associations between HRT use and telomere length. Longer LTLs were associated with lower total and regional fat, while longer minimum SMTLs were associated with higher fat-free mass and greater thigh muscle area. This suggests that telomeres measured from different tissues may have different associations with measures of body composition.

Ort, förlag, år, upplaga, sidor
Cambridge, United Kingdom: Cambridge University Press, 2017
Nyckelord
Estrogen, telomeres, percentage of fat, fat-free mass, computed tomography, bioimpedance, twin design, post-menopausal
Nationell ämneskategori
Medicinsk genetik och genomik Gynekologi, obstetrik och reproduktionsmedicin
Identifikatorer
urn:nbn:se:oru:diva-55958 (URN)10.1017/thg.2017.1 (DOI)000398563000003 ()28193312 (PubMedID)2-s2.0-85012257856 (Scopus ID)
Anmärkning

Funding Agencies:

EC FP7 Collaborative Project MYOAGE  GA-223576

Academy of Finland  265240  263278

Finnish Ministry of Culture and Education  251316  89/672/2008

Post doc research grant from the Academy of Finland  260001

Tillgänglig från: 2017-03-10 Skapad: 2017-03-10 Senast uppdaterad: 2025-02-11Bibliografiskt granskad
Mackey, A. L., Rasmussen, L. K., Kadi, F., Schjerling, P., Helmark, I. C., Ponsot, E., . . . Kjaer, M. (2016). Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication. The FASEB Journal, 30(6), 2266-2281
Öppna denna publikation i ny flik eller fönster >>Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication
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2016 (Engelska)Ingår i: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 30, nr 6, s. 2266-2281Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

With this study we investigated the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in human skeletal muscle regeneration. Young men ingested NSAID [1200 mg/d ibuprofen (IBU)] or placebo (PLA) daily for 2 wk before and 4 wk after an electrical stimulation-induced injury to the leg extensor muscles of one leg. Muscle biopsies were collected from the vastus lateralis muscles before and after stimulation (2.5 h and 2, 7, and 30 d) and were assessed for satellite cells and regeneration by immunohistochemistry and real-time RT-PCR, and we also measured telomere length. After injury, and compared with PLA, IBU was found to augment the proportion of ActiveNotch1(+) satellite cells at 2 d [IBU, 29 ± 3% vs. PLA, 19 ± 2% (means ± sem)], satellite cell content at 7 d [IBU, 0.16 ± 0.01 vs. PLA, 0.12 ± 0.01 (Pax7(+) cells/fiber)], and to expedite muscle repair at 30 d. The PLA group displayed a greater proportion of embryonic myosin(+) fibers and a residual ∼2-fold increase in mRNA levels of matrix proteins (all P < 0.05). Endomysial collagen was also elevated with PLA at 30 d. Minimum telomere length shortening was not observed. In conclusion, ingestion of NSAID has a potentiating effect on Notch activation of satellite cells and muscle remodeling during large-scale regeneration of injured human skeletal muscle.-Mackey, A. L., Rasmussen, L. K., Kadi, F., Schjerling, P., Helmark, I. C., Ponsot, E., Aagaard, P., Durigan, J. L. Q., Kjaer, M. Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication.

Ort, förlag, år, upplaga, sidor
Bethesda, USA: Federation of American Societies for Experimental Biology, 2016
Nyckelord
Pax7, electrical stimulation, telomere length, extracellular matrix, Notch signaling pathway
Nationell ämneskategori
Fysiologi och anatomi Cell- och molekylärbiologi
Forskningsämne
Molekylärbiologi
Identifikatorer
urn:nbn:se:oru:diva-49204 (URN)10.1096/fj.201500198R (DOI)000376878300018 ()26936358 (PubMedID)2-s2.0-84971654983 (Scopus ID)
Anmärkning

Funding Agencies:

U.S. National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Nordea Foundation 223576

European Commission

Danish Rheumatism Association

Team Danmark

Anti Doping Danmark

Oster-Jorgensen og Romhild Andersen Fonden

King Christian IX and Queen Louise's Anniversary grant (Kong Christian IX og Dronning Louises Jubilaeumslegat)

Danish Agency for Science Technology and Innovation (Medical Research Council)

Lundbeck Foundation

Tillgänglig från: 2016-03-11 Skapad: 2016-03-10 Senast uppdaterad: 2025-02-10Bibliografiskt granskad
Leprêtre, P. M., Ponsot, E., Särnblad, S. & Kadi, F. (2016). Cardiorespiratory responses to incremental exercise in Type 1 diabetic patients: a comparison between patients with poor and good glycaemia control. In: : . Paper presented at 26ièmes Journées Européennes de la Société Française de Cardiologie, Paris, France, 13-16 jan., 2016.
Öppna denna publikation i ny flik eller fönster >>Cardiorespiratory responses to incremental exercise in Type 1 diabetic patients: a comparison between patients with poor and good glycaemia control
2016 (Engelska)Konferensbidrag, Poster (med eller utan abstract) (Refereegranskat)
Nyckelord
Diabetes
Nationell ämneskategori
Medicin och hälsovetenskap Endokrinologi och diabetes
Forskningsämne
Pediatrik
Identifikatorer
urn:nbn:se:oru:diva-53314 (URN)
Konferens
26ièmes Journées Européennes de la Société Française de Cardiologie, Paris, France, 13-16 jan., 2016
Tillgänglig från: 2016-10-28 Skapad: 2016-10-28 Senast uppdaterad: 2017-10-18Bibliografiskt granskad
Bankole, L.-C., Millet, G. Y., Temesi, J., Bachasson, D., Ravelojaona, M., Wuyam, B., . . . Feasson, L. (2016). Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy A randomized controlled trial. Medicine, 95(31), Article ID e4497.
Öppna denna publikation i ny flik eller fönster >>Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy A randomized controlled trial
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2016 (Engelska)Ingår i: Medicine, ISSN 0025-7974, E-ISSN 1536-5964, Vol. 95, nr 31, artikel-id e4497Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Previous randomized controlled trials investigating exercise training programs in facioscapulohumeral muscular dystrophy (FSHD) patients are scarce and of short duration only. This study assessed the safety and efficacy of a 6-month home-ased exercise training program on fitness, muscle, and motor function in FSHD patients.

Methods: Sixteen FSHD patients were randomly assigned to training (TG) and control (CG) groups (both n=8) in a home-based exercise intervention. Training consisted of cycling 3 times weekly for 35minutes (combination of strength, high-intensity interval, and low-intensity aerobic) at home for 24 weeks. Patients in CG also performed an identical training program (CTG) after 24 weeks. The primary outcome was change in peak oxygen uptake (VO2 peak) measured every 6 weeks. The principal secondary outcomes were maximal quadriceps strength (MVC) and local quadriceps endurance every 12 weeks. Other outcome measures included maximal aerobic power (MAP) and experienced fatigue every 6 weeks, 6-minute walking distance every 12 weeks, and muscle characteristics from vastus lateralis biopsies taken pre- and postintervention.

Results: The compliance rate was 91% in TG. Significant improvements with training were observed in the VO2 peak (+19%, P= 0.002) and MAP by week 6 and further to week 24. Muscle endurance, MVC, and 6-minute walking distance increased and experienced fatigue decreased. Muscle fiber cross-sectional area and citrate synthase activity increased by 34% (P=0.008) and 46% (P=0.003), respectively. Dystrophic pathophysiologic patterns were not exacerbated. Similar improvements were experienced by TG and CTG.

Conclusions: A combined strength and interval cycling exercise-training program compatible with patients' daily professional and social activities leads to significant functional benefits without compromising muscle tissue.

Ort, förlag, år, upplaga, sidor
Lippincott Williams & Wilkins, 2016
Nyckelord
combined strength and endurance training, exercise training, facioscapulohumeral muscular dystrophy, home-based, myopathy, randomized controlled trial
Nationell ämneskategori
Allmänmedicin
Forskningsämne
Allmänmedicin
Identifikatorer
urn:nbn:se:oru:diva-52151 (URN)10.1097/MD.0000000000004497 (DOI)000380789800083 ()27495097 (PubMedID)2-s2.0-84983250815 (Scopus ID)
Anmärkning

Funding Agencies:

Association Francaise contra la Myopathie (AFM)

Örebro University

Rhone-Alpes Region

Tillgänglig från: 2016-09-14 Skapad: 2016-09-14 Senast uppdaterad: 2022-02-10Bibliografiskt granskad
Organisationer
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-8071-4745

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