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Nyström, Pontus
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Selegård, R., Musa, A., Nyström, P., Aili, D., Bengtsson, T. & Khalaf, H. (2019). Plantaricins markedly enhance the effects of traditional antibiotics against Staphylococcus epidermidis. Future microbiology, 14(3), 195-206
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2019 (Engelska)Ingår i: Future microbiology, ISSN 1746-0913, Vol. 14, nr 3, s. 195-206Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

AIM: Bacteriocins are considered as promising alternatives to antibiotics against infections. In this study, the plantaricins (Pln) A, E, F, J and K were investigated for their antimicrobial activity against Staphylococcus epidermidis.

MATERIALS & METHODS: The effects on membrane integrity were studied using liposomes and viable bacteria, respectively.

RESULTS: We show that PlnEF and PlnJK caused rapid and significant lysis of S. epidermidis, and induced lysis of liposomes. The PlnEF and PlnJK displayed similar mechanisms by targeting and disrupting the bacterial cell membrane. Interestingly, Pln enhanced the effects of different antibiotics by 30- to 500-fold.

CONCLUSION: This study shows that Pln in combination with low concentrations of antibiotics is efficient against S. epidermidis and may be developed as potential treatment of infections.

Ort, förlag, år, upplaga, sidor
Future Medicine, 2019
Nyckelord
Pln, antibiotic, combination therapy, liposome, membrane lysis, plantaricin, synergy
Nationell ämneskategori
Infektionsmedicin Mikrobiologi inom det medicinska området
Identifikatorer
urn:nbn:se:oru:diva-71656 (URN)10.2217/fmb-2018-0285 (DOI)000460352400005 ()30648887 (PubMedID)2-s2.0-85062167749 (Scopus ID)
Forskningsfinansiär
Magnus Bergvalls Stiftelse, 2015-00823KK-stiftelsen, 20150244 20150086Vetenskapsrådet, 2016-04874
Tillgänglig från: 2019-01-22 Skapad: 2019-01-22 Senast uppdaterad: 2019-03-19Bibliografiskt granskad
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