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Hurtig-Wennlöf, AnitaORCID iD iconorcid.org/0000-0003-1067-8627
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Publications (10 of 53) Show all publications
Fernberg, U., Op't Roodt, J., Fernström, M. & Hurtig-Wennlöf, A. (2019). Body composition is a strong predictor of local carotid stiffness in Swedish, young adults: the cross sectional Lifestyle, biomarkers, and atherosclerosis study. BMC Cardiovascular Disorders, 19(1), Article ID 205.
Open this publication in new window or tab >>Body composition is a strong predictor of local carotid stiffness in Swedish, young adults: the cross sectional Lifestyle, biomarkers, and atherosclerosis study
2019 (English)In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 19, no 1, article id 205Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Obesity has nearly tripled worldwide during the last four decades, especially in young adults, and is of growing concern since it is a risk factor for cardiovascular diseases (CVD). We explored how different body composition measurements are associated with intima media thickness (cIMT) and local stiffness in the common carotid artery, in a subsample of healthy, young women and men, from the Swedish Lifestyle, Biomarkers, and Atherosclerosis (LBA) Study.

METHODS: From the LBA study, a subsample of 220 randomly selected, self-reported healthy individuals, 18-25 years old, were collected for the automatized local stiffness measurements; arterial distensibility, Young's elastic modulus, and β stiffness index. Blood pressure and mean arterial pressure (MAP) was measured using automatic blood pressure equipment. Body mass index (BMI) was calculated, waist circumference was measured, and percentage of body fat assessed using an impedance body composition analyzer. The carotid artery was scanned by ultrasound and analyzed using B-mode edge wall tracking. cIMT was measured and local stiffness measurements were calculated with carotid blood pressure, measured with applanation tonometry.

RESULTS: No association was found between cIMT and body composition. Local carotid stiffness was associated with body composition, and women had less stiff arteries than men (p < 0.001). Of the local stiffness measurements, arterial distensibility had the strongest associations with body composition measurements in both women and men (p < 0.05). Multiple regression analyses showed that BMI in women and BMI and percentage of body fat in men had the highest impact on arterial distensibility (p < 0.01 in both women and men).

CONCLUSIONS: Arterial distensibility was the local stiffness measurement with the strongest associations to different body composition measurements, in both women and men. In this age group, body composition measurements seem to be stronger predictors of common carotid arterial stiffness than MAP, and is a convenient way of detecting young adults who need cardiovascular risk follow-up and lifestyle counseling.

Place, publisher, year, edition, pages
BioMed Central, 2019
Keywords
Arterial distensibility, Arterial stiffness, Body composition, Carotid artery, Cross-sectional study, Epidemiological, Intima media thickness, Young adults
National Category
Nutrition and Dietetics Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-76105 (URN)10.1186/s12872-019-1180-6 (DOI)000483032600001 ()31455254 (PubMedID)2-s2.0-85071644915 (Scopus ID)
Note

Funding Agency:

Asset Management Arm (AFA)  130275

Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-11-15Bibliographically approved
Pettersson-Pablo, P., Nilsson, T. K., Breimer, L. H. & Hurtig-Wennlöf, A. (2019). Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults - the Lifestyle, Biomarkers, and Atherosclerosis study. Scandinavian Journal of Clinical and Laboratory Investigation, 79(3), 182-187
Open this publication in new window or tab >>Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults - the Lifestyle, Biomarkers, and Atherosclerosis study
2019 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 79, no 3, p. 182-187Article in journal (Refereed) Published
Abstract [en]

The primary aim was to appraise the relationship between body fat percentage and the inflammatory markers C-reactive protein (CRP) and orosomucoid in a population of young, non-smoking, healthy, Swedish adults, without any chronic diseases. A secondary aim was to compare whether these associations differed between the women using estrogen contraceptives and those who did not. We assessed the association in linear regression models between body fat percentage based on a bio-impedance measurement and plasma concentrations of CRP and orosomucoid in men and women aged 18-26 years, n = 834. Statistically significant associations were found between body fat percentage and both biomarkers of inflammation, with β coefficients of 0.30 (95% CI 0.24-0.37) and 0.28 (0.22-0.35) for CRP and orosomucoid, respectively (p < .001). Adjustment for established risk factors marginally lowered the effects sizes (partial betas, 0.28 and 0.20, respectively), while the strong statistically significant associations remained. In the female cohort, estrogen and non-estrogen using subpopulations did not significantly differ in the correlations between body fat percentage and the inflammatory biomarkers, even adjusted for established cardiometabolic risk factors. In conclusion, in healthy young adults, higher levels of body fat percentage are associated with elevations in plasma biomarkers of inflammation, suggesting that a systemic inflammatory process, promoting atherosclerosis, may commence already at this early stage in life. CRP and orosomucoid plasma concentrations differed between users and non-users of estrogen contraceptives, but both subgroups showed similar correlations between increasing body fat percentage and increasing plasma concentrations of the biomarkers of inflammation.

Place, publisher, year, edition, pages
Taylor & Francis, 2019
Keywords
C-reactive protein, adiposity, cardiovascular diseases, inflammation, orosomucoid, risk factors
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-72790 (URN)10.1080/00365513.2019.1576219 (DOI)000465174400005 ()30767573 (PubMedID)2-s2.0-85061928996 (Scopus ID)
Funder
AFA Insurance, 130275
Note

Funding Agencies:

Region Örebro County's Research Committee, Örebro, Sweden  OLL-780061 

Nyckelfonden, Örebro, Sweden  OLL-787681 

Available from: 2019-02-26 Created: 2019-02-26 Last updated: 2019-06-19Bibliographically approved
Pettersson-Pablo, P., Nilsson, T. K., Cao, Y., Breimer, L. & Hurtig-Wennlöf, A. (2019). Cluster Analysis And Risk Score Calculation Of Surrogate Markers Of Vascular Health, And Their Association With Cardiometabolic Risk Factors In A Healthy Young Adults. Paper presented at 87th Congress of the European-Atherosclerosis-Society (EAS), Maastricht, Netherlands, May 26-29, 2019. Atherosclerosis, 287, E191-E191
Open this publication in new window or tab >>Cluster Analysis And Risk Score Calculation Of Surrogate Markers Of Vascular Health, And Their Association With Cardiometabolic Risk Factors In A Healthy Young Adults
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2019 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 287, p. E191-E191Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Elsevier, 2019
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-76189 (URN)10.1016/j.atherosclerosis.2019.06.578 (DOI)000482110800576 ()
Conference
87th Congress of the European-Atherosclerosis-Society (EAS), Maastricht, Netherlands, May 26-29, 2019
Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-10Bibliographically approved
Lindkvist, M., Fernberg, U., Ljungberg, L., Fälker, K., Fernström, M., Hurtig-Wennlöf, A. & Grenegård, M. (2019). Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults. Thrombosis Research, 174, 5-12
Open this publication in new window or tab >>Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults
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2019 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 174, p. 5-12Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Platelet aggregation and secretion can be induced by a large number of endogenous activators, such as collagen, adenosine diphosphate (ADP) and epinephrine. Conversely, the blood vessel endothelium constitutively release platelet inhibitors including nitric oxide (NO) and prostacyclin. NO and prostacyclin are also well-known vasodilators and contribute to alterations in local blood flow and systemic blood pressure.

MATERIALS AND METHODS: In this study we investigated individual variations in platelet reactivity and arterial functions including blood pressure and flow-mediated vasodilation (FMD) in 43 young, healthy individuals participating in the Lifestyle, Biomarkers and Atherosclerosis (LBA) study. Platelet aggregation and dense granule secretion were measured simultaneously by light transmission and luminescence. FMD was measured with ultrasound.

RESULTS: The platelet function assay showed inter-individual differences in platelet reactivity. Specifically, a sub-group of individuals had platelets with an increased response to low concentrations of ADP and epinephrine, but not collagen. When the NO-donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) was combined with high doses of these platelet activators, the results indicated for sub-groups of NO-sensitive and NO-insensitive platelets. The individuals with NO-sensitive platelets in response to SNAP in combination with collagen had a higher capacity of FMD of the arteria brachialis.

CONCLUSIONS: Platelet reactivity towards ADP, epinephrine and NO differs between young, healthy individuals. Some individuals have a more effective response towards NO, both in the aspect of platelet inhibition ex vivo, as well as vasodilation in vivo.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Adenosine diphosphate, Collagen, Epinephrine, Nitric oxide, Platelet activation, Vasodilation
National Category
Physiology Hematology Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-70787 (URN)10.1016/j.thromres.2018.12.008 (DOI)000456949100002 ()30543988 (PubMedID)2-s2.0-85058021347 (Scopus ID)
Funder
AFA Insurance, 130275Knowledge Foundation
Available from: 2018-12-18 Created: 2018-12-18 Last updated: 2019-03-26Bibliographically approved
Jonsson, M., Ahlsson, A., Hurtig-Wennlöf, A., Vidlund, M., Cao, Y. & Westerdahl, E. (2019). In-Hospital Physiotherapy and Physical Recovery 3 Months After Lung Cancer Surgery: A Randomized Controlled Trial. Integrative Cancer Therapies, 18, Article ID UNSP 1534735419876346.
Open this publication in new window or tab >>In-Hospital Physiotherapy and Physical Recovery 3 Months After Lung Cancer Surgery: A Randomized Controlled Trial
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2019 (English)In: Integrative Cancer Therapies, ISSN 1534-7354, E-ISSN 1552-695X, Vol. 18, article id UNSP 1534735419876346Article in journal (Refereed) Published
Abstract [en]

Background: Lung cancer is the most frequently diagnosed cancer and one of the leading causes of cancer deaths. Surgery is the primary approach for curative treatment. Postoperative complications are common, and physiotherapy is often routinely provided for their prevention and treatment, even though the evidence is limited. The aim of this study was to examine the effect of in-hospital physiotherapy on postoperative physical capacity, physical activity, and lung function among patients undergoing lung cancer surgery.

Methods: A total of 107 patients undergoing elective thoracic surgery were included in a single-blinded randomized controlled trial, and randomized to a study group, receiving in-hospital physiotherapy treatment, or a control group, not receiving in-hospital physiotherapy treatment. The patients were assessed preoperatively and 3 months after surgery. The in-hospital physiotherapy treatment consisted of early mobilization, ambulation, breathing exercises, and thoracic range of motion exercises. Physical capacity was assessed with the 6-minute walk test. Level of physical activity was objectively assessed with an accelerometer and subjectively assessed with the International Physical Activity Questionnaire Modified for the Elderly.

Results: Physical capacity for the whole sample was significantly decreased 3 months postoperatively compared with preoperative values (P = .047). There were no statistically significant differences between the groups regarding physical capacity, physical activity, spirometric values, or dyspnea. However, patients in the study group increased their level of self-reported physical activity from preoperatively to 3 months postoperatively, while the patients in the control group did not.

Conclusions: No difference in physical capacity, physical activity, or lung function was found 3 months postoperatively in lung cancer surgery patients receiving in-hospital physiotherapy compared with control patients.

Place, publisher, year, edition, pages
Sage Publications, 2019
Keywords
lung cancer, physiotherapy, physical activity, surgery, physical function
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-77077 (URN)10.1177/1534735419876346 (DOI)000486724600001 ()31530046 (PubMedID)
Funder
Swedish Cancer Society, CAN 2015/721
Note

Funding Agencies:

Research Committee of Orebro County Council  OLL-363321 OLL-686781

Swedish Heart and Lung Patients National Association  E o86/13

Available from: 2019-10-08 Created: 2019-10-08 Last updated: 2019-10-08Bibliographically approved
Jonsson, M., Hurtig-Wennlöf, A., Ahlsson, A., Vidlund, M., Cao, Y. & Westerdahl, E. (2019). In-hospital physiotherapy improves physical activity level after lung cancer surgery: a randomized controlled trial. Physiotherapy, 105(4), 434-441
Open this publication in new window or tab >>In-hospital physiotherapy improves physical activity level after lung cancer surgery: a randomized controlled trial
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2019 (English)In: Physiotherapy, ISSN 0031-9406, E-ISSN 1873-1465, Vol. 105, no 4, p. 434-441Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Patients undergoing lung cancer surgery are routinely offered physiotherapy. Despite its routine use, effects on postoperative physical recovery have yet not been demonstrated. The aim of this study was to investigate whether physiotherapy could improve postoperative in-hospital physical activity level and physical capacity.

DESIGN: Single-blind randomized controlled trial.

SETTING: Thoracic surgery department at a University Hospital.

PARTICIPANTS: Patients undergoing elective thoracic surgery (n=94) for confirmed or suspected lung cancer were assessed during hospital stay.

INTERVENTION: Daily physiotherapy, consisting of mobilization, ambulation, shoulder exercises and breathing exercises. The control group received no physiotherapy treatment.

OUTCOMES: In-hospital physical activity assessed with the Actigraph GT3X+ accelerometer, six-minute walk test, spirometry and dyspnea scores.

RESULTS: The treatment group reached significantly more accelerometer counts (2010 (1508) vs 1629 (1146), mean difference 495 [95% CI 44 to 1109]), and steps per hour (49 (47) vs 37 (34), mean difference 14 [95% CI 3 to 30]), compared to the control group, during the first three postoperative days. No significant differences in six-minute walk test (percent of preoperative 71% vs 79%, P=0.13), spirometry (FEV1 percent of preoperative 69% vs 69%, P=0.83) or dyspnoea (M-MRC 2 vs 2, P=0.74) between the groups were found.

CONCLUSIONS: Patients receiving in-hospital physiotherapy showed increased level of physical activity during the first days after lung cancer surgery, compared to an untreated control group. However, no effects on the six-minute walk test or spirometric values were found. The clinical importance of an increased physical activity level during the early postoperative period needs to be further evaluated.

CLINICAL TRIAL REGISTRATION NUMBER: NCT01961700.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Lung cancer, Physical activity, Physical therapy, Randomized clinical trial
National Category
Surgery Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-73624 (URN)10.1016/j.physio.2018.11.001 (DOI)000496916200005 ()30871894 (PubMedID)2-s2.0-85062599637 (Scopus ID)
Funder
Swedish Cancer Society, CAN 2015/721
Note

Funding Agencies:

Research Committee of Örebro County Council  OLL363321 OLL-686781

Swedish Heart and Lung Patients National Association  E o86/13

Available from: 2019-04-10 Created: 2019-04-10 Last updated: 2019-12-03Bibliographically approved
Lobenius Palmér, K., Sjöqvist, B., Hurtig-Wennlöf, A. & Lundqvist, L.-O. (2018). Accelerometer-Assessed Physical Activity and Sedentary Time in Youth With Disabilities. Adapted Physical Activity Quarterly, 35(1), 1-19
Open this publication in new window or tab >>Accelerometer-Assessed Physical Activity and Sedentary Time in Youth With Disabilities
2018 (English)In: Adapted Physical Activity Quarterly, ISSN 0736-5829, E-ISSN 1543-2777, Vol. 35, no 1, p. 1-19Article in journal (Refereed) Published
Abstract [en]

This study compared accelerometer-assessed habitual physical activity (PA), sedentary time, and meeting PA recommendations among 102 youth with disabilities (7-20 years) in four subgroups-physical/visual impairments, intellectual disability, autism spectrum disorders, and hearing impairment-and 800 youth with typical development (8-16 years). Low proportions of youth with disabilities met PA recommendations, and they generally were less physically active and more sedentary than youth with typical development. The hearing impairment and autism spectrum disorder groups were the most and least physically active, respectively. Older age and to some extent female sex were related to less PA and more sedentary time. Considering the suboptimal levels of PA in youth with disabilities, effective interventions directed at factors associated with PA among them are needed.

Place, publisher, year, edition, pages
Human Kinetics, 2018
Keywords
autism spectrum disorder, deaf/hearing impaired, health, intellectual disability, physical disabilities
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-62402 (URN)10.1123/apaq.2015-0065 (DOI)000429368400001 ()29072484 (PubMedID)
Note

Funding Agencies:

Royal Wedding Fund  

National Association for Disabled Children  

Adolescent Research Foundation-RBU's Research Foundation  

Sunnerdahl Handikappfond  

Odd Fellows, Örebro  

Centre for Rehabilitation Research and Research Committee at Region Örebro County 

Available from: 2017-12-28 Created: 2017-12-28 Last updated: 2018-08-16Bibliographically approved
Jonsson, M., Hurtig-Wennlöf, A., Ahlsson, A., Vidlund, M., Cao, Y. & Westerdahl, E. (2018). Physical activity level during the first three days after lung cancer surgery improves with physiotherapy: a randomized controlled trial. Paper presented at 28th International Congress of the European-Respiratory-Society (ERS), Paris, France, September 15-19, 2018. European Respiratory Journal, 52(Suppl. 62), Article ID OA5189.
Open this publication in new window or tab >>Physical activity level during the first three days after lung cancer surgery improves with physiotherapy: a randomized controlled trial
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2018 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52, no Suppl. 62, article id OA5189Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Objectives: Physical inactivity is common after lung cancer surgery. Patients undergoing lung cancer surgery are routinely offered physiotherapy. Despite its routine use, any effect on postoperative physical activity has not yet been demonstrated. The aim of this study was to investigate whether physiotherapy could improve physical activity during the first days after surgery.

Methods: A total of 94 patients undergoing elective surgery for confirmed or suspected lung cancer were consecutevily included and randomized to treatment group (n=50) or control group (n=44). The treatment group received daily physiotherapy, consisting of mobilization and ambulation, shoulder exercises and breathing exercises. The control group received no physiotherapy. Physical activity was assessed with the Actigraph GT3X+ accelerometer.

Results: The patients in the treatment group reached significantly more counts (1692 vs 1197, p=0.029) and steps per hour (39 vs 25, p=0.013), during the first three days, compared to the control group.

Conclusions: Physical activity during the first three days is increased by physiotherapy treament. The long term effect of in-hospital physiotherapy needs to be further evaluated.

Place, publisher, year, edition, pages
European Respiratory Society, 2018
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:oru:diva-72098 (URN)10.1183/13993003.congress-2018.OA5189 (DOI)000455567100486 ()
Conference
28th International Congress of the European-Respiratory-Society (ERS), Paris, France, September 15-19, 2018
Available from: 2019-02-05 Created: 2019-02-05 Last updated: 2019-02-05Bibliographically approved
Fernström, M., Fernberg, U., Eliason, G. & Hurtig-Wennlöf, A. (2017). Aerobic fitness is associated with low cardiovascular disease risk: the impact of lifestyle on early risk factors for atherosclerosis in young healthy Swedish individuals - the Lifestyle, Biomarker, and Atherosclerosis study. Vascular Health and Risk Management, 13, 91-99
Open this publication in new window or tab >>Aerobic fitness is associated with low cardiovascular disease risk: the impact of lifestyle on early risk factors for atherosclerosis in young healthy Swedish individuals - the Lifestyle, Biomarker, and Atherosclerosis study
2017 (English)In: Vascular Health and Risk Management, ISSN 1176-6344, E-ISSN 1178-2048, Vol. 13, p. 91-99Article in journal (Refereed) Published
Abstract [en]

Background: The progression of cardiovascular disease (CVD) and atherosclerosis is slow and develops over decades. In the cross-sectional Swedish Lifestyle, Biomarker, and Atherosclerosis study, 834 young, self-reported healthy adults aged 18.0-25.9 years have been studied to identify early risk factors for atherosclerosis.

Purpose: The aims of this study were to 1) assess selected cardiometabolic biomarkers, carotid intima-media thickness (cIMT) as a marker of subclinical atherosclerosis, and lifestyle-related indicators (food habits, handgrip strength, and oxygen uptake, VO(2)max);2) analyze the associations between cIMT and lifestyle factors; and 3) identify subjects at risk of CVD using a risk score and to compare the characteristics of subjects with and without risk of CVD.

Method: Blood samples were taken in a fasting state, and food habits were reported through a questionnaire. cIMT was measured by ultrasound, and VO2 max was measured by ergometer bike test. The risk score was calculated according to Wildman.

Result: cIMT (mean +/- standard deviation) was 0.50 +/- 0.06 mm, and VO2 max values were 37.8 +/- 8.5 and 42.9 +/- 9.9 mL/kg/min, in women and men, respectively. No correlation was found between aerobic fitness expressed as VO2 max (mL/kg/min) and cIMT. Using Wildman's definition, 12% of the subjects were classified as being at risk of CVD, and 15% had homeostasis model assessment of insulin resistance. A total of 35% of women and 25% of men had lower high-density lipoprotein cholesterol than recommended. Food habits did not differ between those at risk and those not at risk. However, aerobic fitness measured as VO2 max (mL/kg/min) differed; 47% of the subjects at risk had low aerobic fitness compared to 23% of the nonrisk subjects (P<0.001).

Conclusion: High aerobic fitness is associated with low CVD risk in Swedish young adults. The high prevalence of young adults observed with unfavorable levels of high-density lipoprotein cholesterol and homeostasis model assessment of insulin resistance raises concerns about future CVD risk.

Place, publisher, year, edition, pages
DOVE Medical Press Ltd., 2017
Keywords
cIMT, cholesterol, insulin resistance, body fat, diet, aerobic fitness
National Category
Cardiac and Cardiovascular Systems
Research subject
Cardiology
Identifiers
urn:nbn:se:oru:diva-56877 (URN)10.2147/VHRM.S125966 (DOI)000396188000002 ()28352184 (PubMedID)2-s2.0-85015747630 (Scopus ID)
Note

Funding Agency:

AFA insurance

Available from: 2017-03-29 Created: 2017-03-29 Last updated: 2019-10-22Bibliographically approved
Fernberg, U., Fernström, M. & Hurtig-Wennlöf, A. (2017). Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study. European Journal of Preventive Cardiology, 24(17), 1809-1818
Open this publication in new window or tab >>Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study
2017 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 24, no 17, p. 1809-1818Article in journal (Refereed) Published
Abstract [en]

Background: Early changes in the large muscular arteries are already associated with risk factors as hypertension and obesity in adolescence and young adulthood. The present study examines the association between arterial stiffness measurements, pulse wave velocity and augmentation index and lifestyle-related factors, body composition and cardiorespiratory fitness, in young, healthy, Swedish adults.

Design: This study used a population-based cross-sectional sample.

Methods: The 834 participants in the study were self-reported healthy, non-smoking, age 18-25 years. Augmentation index and pulse wave velocity were measured with applanation tonometry. Cardiorespiratory fitness was measured by ergometer bike test to estimate maximal oxygen uptake. Body mass index (kg/m(2)) was calculated and categorised according to classification by the World Health Organisation.

Results: Young Swedish adults with obesity and low cardiorespiratory fitness have significantly higher pulse wave velocity and augmentation index than non-obese young adults with medium or high cardiorespiratory fitness. The observed U-shaped association between pulse wave velocity and body mass index categories in women indicates that it might be more beneficial to be normal weight than underweight when assessing the arterial stiffness with pulse wave velocity. The highest mean pulse wave velocity was found in overweight/obese individuals with low cardiorespiratory fitness. The lowest mean pulse wave velocity was found in normal weight individuals with high cardiorespiratory fitness. Cardiorespiratory fitness had a stronger effect than body mass index on arterial stiffness in multiple regression analyses.

Conclusions: The inverse association between cardiorespiratory fitness and arterial stiffness is observed already in young adults. The study result highlights the importance of high cardiorespiratory fitness, but also that underweight individuals may be a possible risk group that needs to be further studied.

Place, publisher, year, edition, pages
Sage Publications, 2017
Keywords
Arterial stiffness, pulse wave analysis, cardiorespiratory fitness, body mass index, young adult, atherosclerosis
National Category
Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:oru:diva-62511 (URN)10.1177/2047487317720796 (DOI)000414856300004 ()28696134 (PubMedID)2-s2.0-85033405287 (Scopus ID)
Funder
AFA Insurance
Available from: 2017-11-21 Created: 2017-11-21 Last updated: 2019-10-22Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-1067-8627

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