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Bankole, Landry-Cyrille
Publications (2 of 2) Show all publications
Bankole, L.-C., Millet, G. Y., Temesi, J., Bachasson, D., Ravelojaona, M., Wuyam, B., . . . Feasson, L. (2016). Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy A randomized controlled trial. Medicine (Baltimore, Md.), 95(31), Article ID e4497.
Open this publication in new window or tab >>Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy A randomized controlled trial
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2016 (English)In: Medicine (Baltimore, Md.), ISSN 0025-7974, E-ISSN 1536-5964, Vol. 95, no 31, article id e4497Article in journal (Refereed) Published
Abstract [en]

Background: Previous randomized controlled trials investigating exercise training programs in facioscapulohumeral muscular dystrophy (FSHD) patients are scarce and of short duration only. This study assessed the safety and efficacy of a 6-month home-ased exercise training program on fitness, muscle, and motor function in FSHD patients.

Methods: Sixteen FSHD patients were randomly assigned to training (TG) and control (CG) groups (both n=8) in a home-based exercise intervention. Training consisted of cycling 3 times weekly for 35minutes (combination of strength, high-intensity interval, and low-intensity aerobic) at home for 24 weeks. Patients in CG also performed an identical training program (CTG) after 24 weeks. The primary outcome was change in peak oxygen uptake (VO2 peak) measured every 6 weeks. The principal secondary outcomes were maximal quadriceps strength (MVC) and local quadriceps endurance every 12 weeks. Other outcome measures included maximal aerobic power (MAP) and experienced fatigue every 6 weeks, 6-minute walking distance every 12 weeks, and muscle characteristics from vastus lateralis biopsies taken pre- and postintervention.

Results: The compliance rate was 91% in TG. Significant improvements with training were observed in the VO2 peak (+19%, P= 0.002) and MAP by week 6 and further to week 24. Muscle endurance, MVC, and 6-minute walking distance increased and experienced fatigue decreased. Muscle fiber cross-sectional area and citrate synthase activity increased by 34% (P=0.008) and 46% (P=0.003), respectively. Dystrophic pathophysiologic patterns were not exacerbated. Similar improvements were experienced by TG and CTG.

Conclusions: A combined strength and interval cycling exercise-training program compatible with patients' daily professional and social activities leads to significant functional benefits without compromising muscle tissue.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2016
Keywords
combined strength and endurance training, exercise training, facioscapulohumeral muscular dystrophy, home-based, myopathy, randomized controlled trial
National Category
General Practice
Research subject
Family Medicine
Identifiers
urn:nbn:se:oru:diva-52151 (URN)10.1097/MD.0000000000004497 (DOI)000380789800083 ()27495097 (PubMedID)2-s2.0-84983250815 (Scopus ID)
Note

Funding Agencies:

Association Francaise contra la Myopathie (AFM)

Örebro University

Rhone-Alpes Region

Available from: 2016-09-14 Created: 2016-09-14 Last updated: 2018-07-16Bibliographically approved
Bankole, L.-C., Feasson, L., Ponsot, E. & Kadi, F. (2013). Fibre type-specific satellite cell content in two models of muscle disease. Histopathology, 63(6), 826-832
Open this publication in new window or tab >>Fibre type-specific satellite cell content in two models of muscle disease
2013 (English)In: Histopathology, ISSN 0309-0167, E-ISSN 1365-2559, Vol. 63, no 6, p. 826-832Article in journal (Refereed) Published
Abstract [en]

Aims: Muscle satellite cells (SCs) are responsible for the regenerative events following muscle fibre injury. This study aimed to improve our understanding of SC behaviour in two models of muscle disorder with different pathological mechanisms and onset of disease.

Methods and results: Pax7(+)SC content was assessed in types I and II fibres of patients with Duchenne muscular dystrophy (DMD; n=9; age 132years), polymyositis/dermatomyositis (PM/DM; n=9; age 52 +/- 12years) and in controls (n=5; age 26 +/- 5years). Pax7(+)SCs number in type I and II fibres was higher (P<0.05) in DMD and in PM/DM compared to controls. Type I fibres were associated with a higher number of Pax7(+)SCs compared to type II fibres only in DMD; Pax7(+)SCs number in type I fibres was about threefold higher in DMD compared to PM/DM (P<0.05). In DMD, Pax7(+)SC content in small regenerating fibres (0.09 +/- 0.09 SCs/fibre) was similar to that in fibres from healthy skeletal muscle. The proportion of activated SCs (Ki-67(+)SCs) was fivefold lower in DMD (0.4 +/- 0.4%) compared to PM/DM (2.8 +/- 2%). Pax7(+) cells located outside the basal lamina were observed in DMD muscles only.

Conclusion: The capacity to generate new SCs is increased even in severely impaired muscles and a fibre type-specific enhancement of SC occurs in type I muscle fibres in DMD.

Keywords
Duchenne muscular dystrophy, Pax7, polymyositis and dermatomyositis, regeneration
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:oru:diva-32755 (URN)10.1111/his.12231 (DOI)000327018300009 ()
Note

Funding Agency: French Muscular Dystrophy Association (AFM-Telethon)

Available from: 2013-12-13 Created: 2013-12-13 Last updated: 2017-12-06Bibliographically approved
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