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Nilsson, A. & Kadi, F. (2018). Fysisk aktivitet gav positiva effekter på graden av åldersinflammation [Letter to the editor]. Läkartidningen, 115(16), 720-720, Article ID E43F.
Open this publication in new window or tab >>Fysisk aktivitet gav positiva effekter på graden av åldersinflammation
2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, no 16, p. 720-720, article id E43FArticle in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Stockholm: Läkartidningen Förlag AB, 2018
National Category
Medical and Health Sciences Gerontology, specialising in Medical and Health Sciences Rheumatology and Autoimmunity
Research subject
Sports Physiology/Medicine
Identifiers
urn:nbn:se:oru:diva-68435 (URN)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-09-14Bibliographically approved
Kadi, F. & Nilsson, A. (2018). Motion mot inflammation: fysisk aktivitet viktigt för äldres hälsa. Idrottsforskning, Article ID 9 jan.
Open this publication in new window or tab >>Motion mot inflammation: fysisk aktivitet viktigt för äldres hälsa
2018 (Swedish)In: Idrottsforskning, ISSN 2002-3944, article id 9 janArticle in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Stockholm: Centrum för Idrottsforskning, 2018
National Category
Medical and Health Sciences Physiotherapy Rheumatology and Autoimmunity
Research subject
Sports Physiology/Medicine
Identifiers
urn:nbn:se:oru:diva-68436 (URN)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-08-16Bibliographically approved
Nilsson, A., Bergens, O. & Kadi, F. (2018). Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels. Medicine & Science in Sports & Exercise, 50(7), 1502-1507
Open this publication in new window or tab >>Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels
2018 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 50, no 7, p. 1502-1507Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To examine the influence of reallocating time spent at different objectively measured physical activity (PA) behaviours on markers of systemic inflammation in older women with different levels of metabolic risk.

METHODS: Accelerometer-based monitoring of PA was conducted in a population of community-dwelling older women (n = 111; age = 65-70 yr) for determination of daily sedentary time, time in light (LPA) and moderate-to-vigorous physical activity (MVPA). Blood samples were collected for the assessment of the systemic inflammatory markers CRP, fibrinogen and adiponectin. Metabolic risk was assessed by standardized procedures based on definitions for the metabolic syndrome. Data were analysed by linear regression models based on isotemporal substitution analysis.

RESULTS: Reallocating 30 minutes of sedentary time with either time in LPA (β = -0.47; p<0.05) or MVPA (β = -0.42; p<0.05) was related to reduced fibrinogen level, whereas no corresponding effect was evident when shifting time in LPA with time in MVPA, while holding sedentary time constant. In contrast, reallocating a 30-minute time period in sedentary (β = -0.70; p<0.01) or LPA (β = -0.71; p<0.01) with MVPA was associated with a significant reduction in CRP level, while no impact on CRP was observed when a time period of sedentary behavior was replaced with LPA. Importantly, all significant influences on fibrinogen and CRP by displacement of different PA behaviours remained after adjustment for metabolic risk status among participants. No significant associations with adiponectin were observed.

CONCLUSION: Altogether, this work supports the existence of different intensity thresholds mediating beneficial effects of PA on important clinical markers of systemic inflammation in older women across different stages of disease prevention.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018
Keywords
EXERCISE TRAINING, ELDERLY, ISOTEMPORAL, SEDENTARY BEHAVIOR, METABOLIC RISK, ACUTE PHASE PROTEIN
National Category
Occupational Health and Environmental Health Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-65195 (URN)10.1249/MSS.0000000000001582 (DOI)000435348900020 ()29462102 (PubMedID)2-s2.0-85045633896 (Scopus ID)
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-07-25Bibliographically approved
Montiel Rojas, D., Nilsson, A., Ponsot, E., Brummer, R. J., Fairweather-Tait, S., Jennings, A., . . . Kadi, F. (2018). Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults. Frontiers in Physiology, 9, Article ID 1110.
Open this publication in new window or tab >>Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults
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2018 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 1110Article in journal (Refereed) Published
Abstract [en]

The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. A total of 1,221 adults (65-79 years) were recruited from five European countries within the framework of NU-AGE study. The physical functioning construct was based on the 36-item Short Form Health Survey. Handgrip strength was used as a single indicator of muscle function and LTL was assessed using quantitative real-time PCR. Women had significantly longer (p < 0.05) LTL than men. Participants in Poland had significantly shorter LTL than in the other study centers, whereas participants in the Netherlands had significantly longer LTL than most of the other centers (p < 0.01). An analysis of LTL as a continuous outcome against physical functioning by using linear models revealed inconsistent findings. In contrast, based on an analysis of contrasting telomere lengths (first vs. fifth quintile of LTL), a significant odds ratio (OR) of 1.7 (95% CI: 1.1 -2.6; p < 0.05) of having functional limitation was observed in those belonging to the first LTL quintile compared to the fifth. Interestingly, having the shortest LTL was still related to a higher likelihood of having physical limitation when compared to all remaining quintiles (OR: 1.5, 95% CI: 1.1 -2.1; p < 0.05), even after adjustment by study center, age, sex, and overweight status. Collectively, our findings suggest that short LTL is an independent risk factor that accounts for functional decline in elderly European populations. The influence of LTL on functional limitation seems driven by the detrimental effect of having short telomeres rather than reflecting a linear dose-response relationship.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018
Keywords
aging, ethnicity, handgrip strength, SF-36, physical function
National Category
Physiology
Identifiers
urn:nbn:se:oru:diva-68587 (URN)10.3389/fphys.2018.01110 (DOI)000441323300001 ()2-s2.0-85051645979 (Scopus ID)
Funder
EU, FP7, Seventh Framework Programme, 266486
Available from: 2018-08-27 Created: 2018-08-27 Last updated: 2018-09-14Bibliographically approved
Edholm, P., Strandberg, E. & Kadi, F. (2017). A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women. In: : . Paper presented at Nobel Day Festivities, Örebro, Sweden, December 10, 2017.
Open this publication in new window or tab >>A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women
2017 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences Sport and Fitness Sciences Physiology
Identifiers
urn:nbn:se:oru:diva-66427 (URN)
Conference
Nobel Day Festivities, Örebro, Sweden, December 10, 2017
Available from: 2018-04-09 Created: 2018-04-09 Last updated: 2018-04-10Bibliographically approved
Edholm, P., Strandberg, E. & Kadi, F. (2017). A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women. In: : . Paper presented at European College of Sport Science Congress, Bochum, Germany, 5-8 July, 2017.
Open this publication in new window or tab >>A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women
2017 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Physiology Sport and Fitness Sciences Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:oru:diva-66426 (URN)
Conference
European College of Sport Science Congress, Bochum, Germany, 5-8 July, 2017
Available from: 2018-04-09 Created: 2018-04-09 Last updated: 2018-04-10Bibliographically approved
Särnblad, S., Ponsot, E. & Kadi, F. (2017). Acute effects on glycemia of different types of exercise in youths with type 1 diabetes. In: : . Paper presented at ISPAD 2017, Innsbruck, Austria, October 18-21, 2017.
Open this publication in new window or tab >>Acute effects on glycemia of different types of exercise in youths with type 1 diabetes
2017 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:oru:diva-61856 (URN)
Conference
ISPAD 2017, Innsbruck, Austria, October 18-21, 2017
Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-11-01Bibliographically approved
Kadi, F., Nilsson, A., Wåhlin-Larsson, B. & Bergens, O. (2017). Chronic Systemic Inflammation, Physical Activity and Skeletal Muscle in Elderly. Paper presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM 2017), Denver, CO, USA, May 30 - June 3, 2017. Medicine & Science in Sports & Exercise, 49(5), 234-234
Open this publication in new window or tab >>Chronic Systemic Inflammation, Physical Activity and Skeletal Muscle in Elderly
2017 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 49, no 5, p. 234-234Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

PURPOSE: It t is hypothesized that chronic systemic inflammation is influenced by physical activity level and is involved in the age-related decline in muscle function. The impact of physical activity behaviours on the level of C-reactive protein (CRP) and tumour necrosis factor alpha (TNF-α) in elderly women is investigated. The impact of chronic systemic inflammation on muscle mass and the cellular and molecular mechanisms behind the putative inflammation-mediated action on human muscle cells are explored.

METHODS: Total amount of sedentary time, 30-minute periods of sedentary time and breaks in sedentary behaviour and time spent in moderate-to-vigorous physical activity (MVPA) were assessed using accelerometry in a cohort of 89 elderly women. Serum HsCRP and TNF-α are were measured. The proliferative and metabolic capacity of human muscle cells obtained from vastus lateralis and exposed to CRP are assessed.

RESULTS: No variables of sedentary behaviour were significantly associated with the level of CRP or TNF-α. In contrast, time spent in MVPA was inversely associated with the level of CRP, independently of sedentary behaviour and waist circumference, but not TNF-α. Serum CRP levels were inversely associated to skeletal muscle mass. Elevated serum CRP levels were associated to reduced proliferative rate of human muscle cells and changes in the regulation of the size muscle cells.

CONCLUSIONS: Elevation in the inflammatory status in elderly is influenced by the amount of time spent in MVPA and exerts detrimental effects on skeletal muscle mass.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017
National Category
Geriatrics Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-62913 (URN)10.1249/01.mss.0000517490.55576.6c (DOI)000413842900639 ()
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM 2017), Denver, CO, USA, May 30 - June 3, 2017
Available from: 2017-12-01 Created: 2017-12-01 Last updated: 2018-08-11Bibliographically approved
Tarum, J., Folkesson, M., Atherton, P. J. & Kadi, F. (2017). Electrical pulse stimulation: an in vitro exercise model for the induction of human skeletal muscle cell hypertrophy. A proof-of-concept study. Experimental Physiology, 102(11), 1405-1413
Open this publication in new window or tab >>Electrical pulse stimulation: an in vitro exercise model for the induction of human skeletal muscle cell hypertrophy. A proof-of-concept study
2017 (English)In: Experimental Physiology, ISSN 0958-0670, E-ISSN 1469-445X, Vol. 102, no 11, p. 1405-1413Article in journal (Refereed) Published
Abstract [en]

New Findings:

  • What is the central question of this study?

Is electrical pulse stimulation (EPS) an in vitro exercise model able to elicit the hypertrophy of human muscle cells?

  • What is the main finding and its importance?

The addition of a restitution period of 8h after EPS induces the enlargement of human muscle cells, a major physiological end-point to resistance exercise. This is supported by downregulationof myostatin, a negative regulator of muscle mass, and increased phosphorylated mTOR and 4E-BP1, key factors in the growth cascade. This proof-of-concept study provides a model of physiologically mediated muscle growth, which will be the basis for future studies aiming to depict molecular events governing the hypertrophy of human muscle cells.

Electrical pulse stimulation (EPS) of muscle cells has previouslybeenused as an in vitro exercise model. The present study aimedto establish an EPS protocol promoting the hypertrophy ofhuman muscle cells, which represents a major physiological end-point to resistance exercise in humans. We hypothesized that adding a resting period after EPS would be crucial for the occurrence of the morphological change. Myoblasts obtained from human muscle biopsies (n=5) were differentiated into multinucleated myotubes and exposed to 8h of EPS consisting of 2ms pulses at 12V, with a frequency of 1Hz. Myotube size was assessed using immunohistochemistry immediately, 4 and 8h after completed EPS. Gene expression and phosphorylation status of selected markers of hypertrophy were assessed using RT-PCR and Western blotting, respectively. Release of the myokine interleukin-6 in culture medium was measured using enzyme-linked immunosorbent assay. We demonstrated a significant increase (31 +/- 14%; P=0.03) in the size of myotubes when EPS was followed by an 8h resting period, but not immediately or 4h after completion of EPS. The response was supported by downregulation (P=0.04) of the gene expression of myostatin, a negative regulator of muscle mass, and an increase in phosphorylated mTOR (P=0.03) and 4E-BP1 (P=0.01), which are important factors in the cellular growth signalling cascade. The present work demonstrates that EPS is an in vitro exercise model promoting the hypertrophy of human muscle cells, recapitulating a major physiological end-point to resistance exercise in human skeletal muscle.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
Cell growth, muscle contraction, myotube morphology
National Category
Physiology
Identifiers
urn:nbn:se:oru:diva-61685 (URN)10.1113/EP086581 (DOI)000414175100010 ()28861930 (PubMedID)2-s2.0-85032974682 (Scopus ID)
Available from: 2017-11-14 Created: 2017-11-14 Last updated: 2018-09-24Bibliographically approved
Sillanpää, E., Niskala, P., Laakkonen, E. K., Ponsot, E., Alén, M., Kaprio, J., . . . Sipilä, S. (2017). Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy. Twin Research and Human Genetics, 20(2), 119-131
Open this publication in new window or tab >>Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy
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2017 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 20, no 2, p. 119-131Article in journal (Refereed) Published
Abstract [en]

Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3.7 years in the user sister, while their co-twins had never used HRT. LTL was measured by qPCR and SMTLs by southern blot. Body and muscle composition were estimated by bioimpedance and computed tomography, respectively. Physical performance was measured by jumping height and grip strength. HRT users and non-users did not differ in LTL or mean or minimum SMTL. Within-pair correlations were high in LTL (r = 0.69, p = .020) and in mean (r = 0.74, p = .014) and minimum SMTL (r = 0.88, p = .001). Body composition and performance were better in users than non-users. In analyses of individuals, LTL was associated with BMI (r 2 = 0.30, p = .030), percentage total body (r 2 = 0.43, p = .014), and thigh (r 2 = 0.55, p = .004) fat, while minimum SMTL was associated with fat-free mass (r 2 = 0.27, p = .020) and thigh muscle area (r 2 = 0.42, p = .016). We found no associations between HRT use and telomere length. Longer LTLs were associated with lower total and regional fat, while longer minimum SMTLs were associated with higher fat-free mass and greater thigh muscle area. This suggests that telomeres measured from different tissues may have different associations with measures of body composition.

Place, publisher, year, edition, pages
Cambridge, United Kingdom: Cambridge University Press, 2017
Keywords
Estrogen, telomeres, percentage of fat, fat-free mass, computed tomography, bioimpedance, twin design, post-menopausal
National Category
Medical Genetics Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:oru:diva-55958 (URN)10.1017/thg.2017.1 (DOI)000398563000003 ()28193312 (PubMedID)2-s2.0-85012257856 (Scopus ID)
Note

Funding Agencies:

EC FP7 Collaborative Project MYOAGE  GA-223576

Academy of Finland  265240  263278

Finnish Ministry of Culture and Education  251316  89/672/2008

Post doc research grant from the Academy of Finland  260001

Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2018-01-13Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9831-0896

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