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Nilsson, A., Halvardsson, P. & Kadi, F. (2019). Adherence to DASH-Style Dietary Pattern Impacts on Adiponectin and Clustered Metabolic Risk in Older Women. Nutrients, 11(4), Article ID 805.
Open this publication in new window or tab >>Adherence to DASH-Style Dietary Pattern Impacts on Adiponectin and Clustered Metabolic Risk in Older Women
2019 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, no 4, article id 805Article in journal (Refereed) Published
Abstract [en]

While dietary patterns are related to the age-related progression of chronic diseases, to what extent different dietary patterns influence inflammatory and metabolic risk factors in older adults remains to be elucidated. Additionally, potential moderating effects by physical activity (PA) become important to clarify. Here, we hypothesize that dietary patterns are linked to inflammatory and metabolic biomarkers and that these links are independent of PA. The present study aims to explore links between two dietary constructs and biomarkers of systemic inflammation and metabolic health in older women, while considering time spent in moderate-to-vigorous PA (MVPA). A cross-sectional analysis of a sample of 112 community-dwelling older women (65-70 years old) was performed. Dietary constructs based on the Dietary Approach to Stop Hypertension (DASH) and the dietary inflammatory index (DII) were determined from food records. MVPA was objectively assessed using accelerometry. Metabolic outcomes (waist circumference, systolic/diastolic blood pressures and levels of glucose, triglycerides and high-density lipoprotein (HDL)-cholesterol) and inflammatory biomarkers (C-reactive protein (CRP), fibrinogen and adiponectin) were determined using standardized procedures and a clustered metabolic risk score was derived. Adherence to DASH-style diet was significantly (p < 0.05) associated with a lower clustered metabolic risk, where women in the highest adherence group had a significantly (p < 0.05) lower waist circumference and blood glucose level compared to those in the lowest group. Further, a significantly higher (p < 0.05) adiponectin level was observed in the high DASH adherence group compared to those with low adherence. Notably, adjustment by waist circumference did not alter links with either adiponectin or blood glucose level. Importantly, all observed links remained significant after further adjustment for time in MVPA. Finally, no significant associations were observed when the dietary pattern was defined by the DII. The findings of this study demonstrate that DASH-style diets promote a systemic anti-inflammatory environment, while also mitigating clustered metabolic risk in older women. A key finding is that favourable impacts of the DASH-style diet are independent of time spent in moderate-to-vigorous PA, which further strengthens healthy eating behaviours as a key target for clinical and public health interventions designed to prevent age-related metabolic abnormalities.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
diet, dietary inflammatory index, inflammation, CRP, moderate-to-vigorous physical activity, aging
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-74644 (URN)10.3390/nu11040805 (DOI)000467749800098 ()30970648 (PubMedID)2-s2.0-85064722097 (Scopus ID)
Note

Funding Agency:

Food and Health Initiative at Örebro University

Available from: 2019-06-10 Created: 2019-06-10 Last updated: 2019-09-20Bibliographically approved
Bergens, O., Nilsson, A. & Kadi, F. (2019). Cardiorespiratory Fitness Does Not Offset Adiposity-Related Systemic Inflammation in Physically Active Older Women. Journal of Clinical Endocrinology and Metabolism, 104(9), 4119-4126
Open this publication in new window or tab >>Cardiorespiratory Fitness Does Not Offset Adiposity-Related Systemic Inflammation in Physically Active Older Women
2019 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 104, no 9, p. 4119-4126Article in journal (Refereed) Published
Abstract [en]

CONTEXT: Chronic inflammation increases diabetes risk and may be exacerbated by excess adipose tissue. Whether cardiovascular fitness can offset chronic inflammation associated with excess adipose tissue in older adults is unclear.

OBJECTIVE: The study aimed to examine the influence of cardiorespiratory fitness on links between adiposity and pro- and anti-inflammatory biomarkers related to metabolic risk in physically active older women.

DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study comprising older community-dwelling women (n = 109; age, 65-70 yr).

MAIN OUTCOME: Cardiorespiratory fitness was assessed using a standardized submaximal test and participants were categorized into high and low adiposity-related metabolic risk (body mass index, waist-to-hip ratio (WHR) and total fat mass). The inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, IL-18, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein (MIP-1α) were analyzed.

RESULTS: Regardless of adiposity measure, women in the metabolic high-risk group had significantly (P<0.05) elevated CRP and lower adiponectin levels. Levels of IL-6 and MIP1-α were significantly elevated in the high-risk group defined by WHR and total fat mass. IL-18 level was significantly elevated in the high-risk group based on WHR only. Importantly, a high cardiorespiratory fitness level did not attenuate the detrimental links between adiposity measures and inflammation.

CONCLUSIONS: Altogether, cardiorespiratory fitness does not offset the detrimental links between adiposity and several inflammatory biomarkers related to metabolic risk in physically active older women. Reducing abdominal adipose tissue in older adults should be emphasized in efforts aiming to attenuate age-related systemic inflammation and metabolic risk regardless of cardiorespiratory fitness.

Place, publisher, year, edition, pages
Williams & Wilkins Co., 2019
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:oru:diva-74240 (URN)10.1210/jc.2019-00067 (DOI)000484208900057 ()31058998 (PubMedID)
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-09-20Bibliographically approved
Nilsson, A., Tarum, J. & Kadi, F. (2019). Detrimental Links Between Inflammation and Muscle Mass are Moderated by Physical Activity in Older Adults. Paper presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019. Medicine & Science in Sports & Exercise, 51(6), 215-215
Open this publication in new window or tab >>Detrimental Links Between Inflammation and Muscle Mass are Moderated by Physical Activity in Older Adults
2019 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 51, no 6, p. 215-215Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

While age-related elevations in systemic inflammation may contribute to the accelerated loss of skeletal muscle mass, previous findings have been based on a limited number of biomarkers. Moreover, whether links between inflammation and muscle mass are independent of protein intake and habitual physical activity (PA) remain unknown.

PURPOSE: The aim of the study was to explore links between skeletal muscle mass and inflammatory biomarkers in older women with different metabolic risk status, while accounting for adherence to guidelines on protein intake and PA.

METHODS: Skeletal muscle mass index (SMI) was assessed in 112 women (67±1.5 years) by bioelectrical impedance together with the equation of Janssen et al. (2002) to obtain muscle mass expressed in relation to body weight. Fasting blood samples were obtained following standardized protocols. Acute-phase proteins C-reactive protein (CRP) and fibrinogen were determined, together with the following inflammatory biomarkers: Adiponectin, Oncostatin-M (OSM), Leukemia inhibitory factor-receptor (LIF-R), Interleukin-6 (IL-6), IL-8, IL-12, and IL-18. Protein intake and PA were determined during 6 days by food record and accelerometry, respectively. Classification of metabolic risk status was based on the metabolic syndrome. Multivariate regression models were used to explore links between SMI and inflammatory biomarkers while adjusting for adherence to PA and protein intake guidelines and metabolic risk status.

RESULTS: Variations in SMI were inversely linked to levels of CRP (β-coefficient: -0.47; p< 0.05) and OSM (-0.20 p< 0.05), where the OSM link was attenuated after further adjustment for PA. In contrast, positive links between SMI and adiponectin (0.19 p< 0.05) and LIF-R (0.24 p< 0.05) were observed, which both remained significant in fully adjusted models. Links to other biomarkers were non-significant.

CONCLUSIONS: Several inflammatory markers are linked to skeletal muscle mass in older adults, where detrimental or beneficial actions are indicated depending on the biomarker. While adherence to PA guidelines moderates some of these links, others seem unaffected by either PA and protein intake or metabolic risk status. Further research is needed to elucidate mechanisms underlying these observations.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-76068 (URN)10.1249/01.mss.0000561153.98240.7a (DOI)000481662800608 ()
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019
Available from: 2019-09-05 Created: 2019-09-05 Last updated: 2019-09-20Bibliographically approved
Nilsson, A., Santoro, A., Franceschi, C. & Kadi, F. (2019). Detrimental links between physical inactivity, metabolic risk and N-glycomic biomarkers of aging. Experimental Gerontology, 124, Article ID UNSP 110626.
Open this publication in new window or tab >>Detrimental links between physical inactivity, metabolic risk and N-glycomic biomarkers of aging
2019 (English)In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 124, article id UNSP 110626Article in journal (Refereed) Published
Abstract [en]

Background: N-linked enzymatic glycosylation modulates the function of proteins and contributes to development of age-related metabolic abnormalities. Whether physical activity (PA) is linked to a specific N-glycan profile and can offset detrimental links between N-glycans and metabolic risk profile has never been explored. The aim of the present study is to assess serum N-glycan profile in older women with different PA levels and metabolic risk status.

Materials and methods: Components of the metabolic syndrome (MetS) and serum N-glycans analyzed using DSAFACE technology were assessed in 109 older community-dwelling women (65-70 yrs). Ten peaks, each representing a unique N-glycan structure were detected. Moderate-to-vigorous PA (MVPA) was assessed objectively using accelerometry. All analyses were adjusted by covariates.

Results: Significantly elevated levels of NGA2FB (peak 2) and NA3F (peak 9) and lower level of the alpha(1,6)-arm monogalactosylated (NG1(6)A2F) (peak 3) were demonstrated in women with MetS compared to their healthier peers (p < 0.05). Importantly, women adhering to the PA guideline of time in MVPA had a 10% and a 12% lower level of NA3 (peak 8) and NA4 (peak 10), respectively, compared to those less active even after adjustment by MetS and covariates (p < 0.05). Interestingly, time spent in PA below the MVPA threshold was not linked to N-glycans.

Conclusion: Novel links between PA behaviors and N-glycan profile are demonstrated in older adults, regardless of metabolic risk status. This proposed effect on N-glycans requires engagement in MVPA. This supports public health efforts to promote adherence to PA guidelines in older adults across different stages of disease prevention.

Place, publisher, year, edition, pages
Elsevier, 2019
National Category
Geriatrics
Identifiers
urn:nbn:se:oru:diva-75703 (URN)10.1016/j.exger.2019.05.015 (DOI)000476589500008 ()31158451 (PubMedID)2-s2.0-85066934490 (Scopus ID)
Available from: 2019-08-14 Created: 2019-08-14 Last updated: 2019-09-20Bibliographically approved
Santoro, A., Guidarelli, G., Ostan, R., Giampieri, E., Fabbri, C., Bertarelli, C., . . . Bazzocchi, A. (2019). Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study. European Radiology, 29(9), 4968-4979
Open this publication in new window or tab >>Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study
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2019 (English)In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 29, no 9, p. 4968-4979Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.

METHODS: A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.

RESULTS: BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.

CONCLUSIONS: The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.

KEY POINTS: • Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. • No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, gp130, TNF-α-R1, and TNF-α-R2. • Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.

Place, publisher, year, edition, pages
Springer, 2019
Keywords
Aging, Body composition, DXA, Inflammation, Sarcopenia
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-72377 (URN)10.1007/s00330-018-5973-2 (DOI)000478873300048 ()30715588 (PubMedID)2-s2.0-85061105446 (Scopus ID)
Note

Funding Agency:

European Union  266486

Available from: 2019-02-11 Created: 2019-02-11 Last updated: 2019-08-23Bibliographically approved
Kadi, F., Nilsson, A., Santoro, A. & Franceschi, C. (2019). Impact Of Physical Activity On N-glycan Profile In Older Adults. Paper presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019. Medicine & Science in Sports & Exercise, 51(6), 542-542
Open this publication in new window or tab >>Impact Of Physical Activity On N-glycan Profile In Older Adults
2019 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 51, no 6, p. 542-542Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

The biological mechanisms underlying the beneficial effects of regular physical activity (PA) on prevention of chronic diseases are not fully understood. It is currently suggested that N-linked enzymatic glycosylation, a post-translational modification modulating the biological function of several proteins, may contribute to disease development. Nevertheless, the influence of PA on N-glycans in humans has never been explored.

PURPOSE: To explore serum N-glycan profile in a sample of community-dwelling older women with different objectively assessed PA levels and metabolic risk status.

METHODS: Components of the metabolic syndrome (MetS) and serum N-glycans analyzed using DSA-FACE technology were assessed in 109 older community-dwelling women (65-70 yrs). Ten peaks, each representing a unique N-glycan structure were detected. Adherence to PA guidelines was determined using accelerometry. Participants daily engaged in 30 minutes of MVPA were classified as meeting PA guidelines.

RESULTS: Significant differences in N-glycan peaks were indicated when comparing women adhering to the PA guideline to those less active: when adjusted by MetS, a 12% (p = 0.006) and a 13% (p = 0.004) lower level of NA3 (peak 8) and NA4 (peak 10), respectively, were evident among the physically active women compared to those less active. In contrast to findings based on the MVPA threshold, no differences in N-glycan peaks were observed between PA groups when based on the lower intensity threshold, which may indicate that the influence on N-glycan levels by PA is intensity-sensitive.

CONCLUSIONS: Adherence to PA guidelines is related to a favorable N-glycan profile, regardless of metabolic risk status. This proposed effect on N-glycans only occurs above the moderate PA-intensity threshold. Our findings support the promotion of a physically active lifestyle as a supporting non-pharmacological public health approach.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-76069 (URN)10.1249/01.mss.0000562129.57753.ad (DOI)000481662802132 ()
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019
Available from: 2019-09-05 Created: 2019-09-05 Last updated: 2019-09-20Bibliographically approved
Edholm, P., Nilsson, A. & Kadi, F. (2019). Physical function in older adults: Impacts of past and present physical activity behaviors. Scandinavian Journal of Medicine and Science in Sports, 29(3), 415-421
Open this publication in new window or tab >>Physical function in older adults: Impacts of past and present physical activity behaviors
2019 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 29, no 3, p. 415-421Article in journal (Refereed) Published
Abstract [en]

While physical activity (PA) may counteract age-related functional decline and loss of independence at old age, to what extent physical function is influenced by past or present PA behaviors is currently unclear. Therefore, the aim of the study was to examine relationships between both past and present PA behaviors and components of physical function in older women. A physical function score based on the 6-minute walk test, squat jump, and single-leg-stance balance was aggregated in 60 older women (65-70 years). Present PA behavior was assessed by accelerometry (Actigraph) and past leisure-time PA was self-reported, where times in sports-related activities and in walking were analyzed separately. Analysis of differences in physical function across tertiles of PA behaviors was adjusted by DXA-derived fat mass. Physical activity level at present age and engagements in sports-related activities before retirement age, excluding walking, were both associated (P < 0.05) to physical function. Time spent in PA of at least moderate intensity was associated with physical function (P < 0.05), whereas no corresponding relationships to either sedentary time or time in light intensity PA were observed. In conclusion, PA behaviors at present age and engagement in sports-related activities performed during adulthood are both related to physical function in older women. Being physically active at old age infers beneficial effects on physical function, even in individuals with a past or present sedentary lifestyle, which supports public health efforts aiming at increasing daily time in PA of at least moderate intensity to preserve physical function in older women.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
aerobic capacity, aging, exercise, muscle strength, sedentary
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-72758 (URN)10.1111/sms.13350 (DOI)000458294800011 ()30506596 (PubMedID)2-s2.0-85059033224 (Scopus ID)
Funder
Swedish National Centre for Research in Sports, P2012/102 P2014/117 P2015/120
Available from: 2019-02-25 Created: 2019-02-25 Last updated: 2019-09-20Bibliographically approved
Strandberg, E., Ponsot, E., Piehl-Aulin, K., Falk, G. & Kadi, F. (2019). Resistance Training Alone or Combined With N-3 PUFA-Rich Diet in Older Women: Effects on Muscle Fiber Hypertrophy. The journals of gerontology. Series A, Biological sciences and medical sciences, 74(4), 489-494
Open this publication in new window or tab >>Resistance Training Alone or Combined With N-3 PUFA-Rich Diet in Older Women: Effects on Muscle Fiber Hypertrophy
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2019 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 74, no 4, p. 489-494Article in journal (Refereed) Published
Abstract [en]

We aimed to examine cellular and molecular changes in skeletal muscle of recreationally active older women in response to 24 weeks of combined resistance training and N-3 PUFA-rich healthy diet. Sixty-three women (65-70 years) were randomized into resistance training and healthy diet rich in N-3PUFAs (RT-HD), resistance training only (RT) and controls (CON). Fiber type-specific morphological characteristics and gene expression of inflammatory biomarkers and regulators of muscle mass were analyzed in m. vastus lateralis biopsies obtained before the intervention and 4 days after the last training session. Gene expression of the proinflammatory cytokine IL-1β was downregulated (p < .05) and that of the regulator of cellular growth mTOR (p < 0.05) was upregulated in skeletal muscle of RT-HD only. There was also a significant hypertrophy of fast type IIA muscle fibers in RT-HD only (+23%, p < .05). In conclusion, resistance training combined to an N-3 PUFA-rich healthy diet but not alone triggers local anti-inflammatory and growth responses, favoring skeletal muscle hypertrophy in already recreationally active older women.

Place, publisher, year, edition, pages
Oxford University Press, 2019
Keywords
Exercise, Inflammation, Muscles, Sarcopenia, mTOR
National Category
Physiology Geriatrics
Identifiers
urn:nbn:se:oru:diva-73206 (URN)10.1093/gerona/gly130 (DOI)000462601700007 ()30052800 (PubMedID)2-s2.0-85062936694 (Scopus ID)
Note

Funding Agency:

Swedish National Center for Research in Sports  P2012/102  P2014-0117

Available from: 2019-03-18 Created: 2019-03-18 Last updated: 2019-06-19Bibliographically approved
Konz, T., Santoro, A., Goulet, L., Bazzocchi, A., Battista, G., Nicoletti, C., . . . Rezzi, S. (2019). Sex-Specific Associations of Blood-Based Nutrient Profiling With Body Composition in the Elderly. Frontiers in Physiology, 9, Article ID 1935.
Open this publication in new window or tab >>Sex-Specific Associations of Blood-Based Nutrient Profiling With Body Composition in the Elderly
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2019 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 1935Article in journal (Refereed) Published
Abstract [en]

The intake of adequate amounts and types of nutrients is key for sustaining health and a good quality of life, particularly in the elderly population. There is considerable evidence suggesting that physiological changes related to age and sex modify nutritional needs, and this may be related to age-associated changes in body composition (BC), specifically in lean and fat body mass. However, there is a clear lack of understanding about the association of nutrients in blood and BC parameters in the elderly. This study investigated the relationships among blood nutrients (amino acids, fatty acids, major elements, trace-elements, and vitamins), BC and nutrient intake in a population of 176 healthy male and female Italian adults between the ages of 65 and 79 years. 89 blood markers, 77 BC parameters and dietary intake were evaluated. Multivariate data analysis was applied to infer relationships between datasets. As expected, the major variability between BC and the blood nutrient profile (BNP) observed was related to sex. Aside from clear sex-specific differences in BC, female subjects had higher BNP levels of copper, copper-to-zinc ratio, phosphorous and holotranscobalamin II and lower concentrations of branched-chain amino acids (BCAAs) and proline. Fat mass, percentage of fat mass, percentage of lean mass and the skeletal muscle index (SMI) correlated the most with BNP in both sexes. Our data showed positive correlations in male subjects among ethanolamine, glycine, albumin, and sulfur with SMI, while palmitoleic acid and oleic acid exhibited negative correlations. This differed in female subjects, where SMI was positively associated with albumin, folic acid and sulfur, while CRP, proline and cis-8,11,14-eicosatrienoic acid were negatively correlated. We investigated the influence of diet on the observed BNP and BC correlations. Intriguingly, most of the components of the BNP, except for folate, did not exhibit a correlation with nutrient intake data. An understanding of the physiological and biochemical processes underpinning the observed sex-specific correlations between BNP and BC could help in identifying nutritional strategies to manage BC-changes in aging. This would contribute to a deeper understanding of aging-associated nutritional needs with the aim of helping the elderly population to maintain metabolic health.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019
Keywords
nutrient profiling, nutritional status, body composition, elderly, minerals, trace elements, fatty acids, vitamins
National Category
Physiology
Identifiers
urn:nbn:se:oru:diva-72186 (URN)10.3389/fphys.2018.01935 (DOI)000456746500001 ()
Available from: 2019-02-07 Created: 2019-02-07 Last updated: 2019-02-07Bibliographically approved
Gharahdaghi, N., Rudrappa, S., Brook, M. S., Idris, I., Crossland, H., Hamrock, C., . . . Atherton, P. J. (2019). Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men. Journal of Cachexia, Sarcopenia and Muscle
Open this publication in new window or tab >>Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men
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2019 (English)In: Journal of Cachexia, Sarcopenia and Muscle, ISSN 2190-5991, E-ISSN 2190-6009Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia), and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RET). Nonetheless, the efficacy and physiological and molecular impacts of T therapy adjuvant to short-term RET remain poorly defined.

METHODS: O), and breakdown (extrapolated).

RESULTS: , P=0.004). Increases in ribosomal biogenesis (RNA:DNA ratio); mRNA expression relating to T metabolism (androgen receptor: 1.4-fold; Srd5a1: 1.6-fold; AKR1C3: 2.1-fold; and HSD17β3: two-fold); insulin-like growth factor (IGF)-1 signalling [IGF-1Ea (3.5-fold) and IGF-1Ec (three-fold)] and myogenic regulatory factors; and the activity of anabolic signalling (e.g. mTOR, AKT, and RPS6; P < 0.05) were all up-regulated with T therapy. Only T up-regulated mitochondrial citrate synthase activity (P=0.03) and transcription factor A (1.41 ± 0.2-fold, P=0.0002), in addition to peroxisome proliferator-activated receptor-γ co-activator 1-α mRNA (1.19 ± 0.21-fold, P=0.037).

CONCLUSIONS: Administration of T adjuvant to RET enhanced skeletal muscle mass and performance, while up-regulating myogenic gene programming, myocellular translational efficiency and capacity, collectively resulting in higher protein turnover, and net protein accretion. T coupled with RET is an effective short-term intervention to improve muscle mass/function in older non-hypogonadal men.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
Ageing, Protein turnover, Resistance exercise, Skeletal muscle, Testosterone
National Category
Physiology
Identifiers
urn:nbn:se:oru:diva-77030 (URN)10.1002/jcsm.12472 (DOI)31568675 (PubMedID)
Available from: 2019-10-07 Created: 2019-10-07 Last updated: 2019-10-07Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9831-0896

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