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Santoro, A., Bazzocchi, A., Guidarelli, G., Ostan, R., Giampieri, E., Mercatelli, D., . . . Franceschi, C. (2018). A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features. Frontiers in Physiology, 9, Article ID 1693.
Open this publication in new window or tab >>A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features
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2018 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 1693Article in journal (Refereed) Published
Abstract [en]

Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65-79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67%, p < 2.2e-16) and lower lean mass (Lean Mass index: by -18%, p < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56%, p < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52%, p < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23%, p < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34%, p < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18%, p < 2.2e-16). Moreover, five BC profiles in women and six in men have been identified by a cluster analysis based on BC parameters. Finally, these data can serve as reference for normative average and variability of BC in the elderly populations across Europe.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018
Keywords
body composition, DXA, elderly, sex, Europe, fat, lean and bone mass
National Category
Physiology
Identifiers
urn:nbn:se:oru:diva-70775 (URN)10.3389/fphys.2018.01693 (DOI)000451924100001 ()
Funder
EU, FP7, Seventh Framework Programme, 266486
Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2018-12-17Bibliographically approved
Nilsson, A. & Kadi, F. (2018). Fysisk aktivitet gav positiva effekter på graden av åldersinflammation [Letter to the editor]. Läkartidningen, 115(16), 720-720, Article ID E43F.
Open this publication in new window or tab >>Fysisk aktivitet gav positiva effekter på graden av åldersinflammation
2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, no 16, p. 720-720, article id E43FArticle in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Stockholm: Läkartidningen Förlag AB, 2018
National Category
Medical and Health Sciences Gerontology, specialising in Medical and Health Sciences Rheumatology and Autoimmunity
Research subject
Sports Physiology/Medicine
Identifiers
urn:nbn:se:oru:diva-68435 (URN)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-09-14Bibliographically approved
Nilsson, A., Montiel Rojas, D. & Kadi, F. (2018). Impact of Meeting Different Guidelines for Protein Intake on Muscle Mass and Physical Function in Physically Active Older Women. Nutrients, 10(9), Article ID 1156.
Open this publication in new window or tab >>Impact of Meeting Different Guidelines for Protein Intake on Muscle Mass and Physical Function in Physically Active Older Women
2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 9, article id 1156Article in journal (Refereed) Published
Abstract [en]

The role of dietary protein intake on muscle mass and physical function in older adults is important for the prevention of age-related physical limitations. The aim of the present study was to elucidate links between dietary protein intake and muscle mass and physical function in older women meeting current guidelines of objectively assessed physical activity. In 106 women (65 to 70 years old), protein intake was assessed using a 6-day food record and participants were classified into high and low protein intake groups using two Recommended Dietary Allowance (RDA) thresholds (0.8 gkg(-1) bodyweight (BW) and 1.1 gkg(-1) BW). Body composition, aerobic fitness, and quadriceps strength were determined using standardized procedures, and self-reported physical function was assessed using the SF-12 Health Survey. Physical activity was assessed by accelerometry and self-report. Women below the 0.8 gkg(-1) BW threshold had a lower muscle mass (p < 0.05) with no differences in physical function variables. When based on the higher RDA threshold (1.1 gkg(-1) BW), in addition to significant differences in muscle mass, women below the higher threshold had a significantly (p < 0.05) higher likelihood of having physical limitations. In conclusion, the present study supports the RDA threshold of 0.8 gkg(-1) BW of proteins to prevent the loss of muscle mass and emphasizes the importance of the higher RDA threshold of at least 1.1 gkg(-1) BW to infer additional benefits on constructs of physical function. Our study also supports the role of protein intake for healthy ageing, even in older adults meeting guidelines for physical activity.

Place, publisher, year, edition, pages
MDPI, 2018
Keywords
elderly, muscle strength, nutrition, physical activity, physical functioning, Recommended Dietary Allowance (RDA), sarcopenia
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-70225 (URN)10.3390/nu10091156 (DOI)000448659900029 ()30149519 (PubMedID)2-s2.0-85052592694 (Scopus ID)
Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-20Bibliographically approved
Rantala, R., Kadi, F. & Chaillou, T. (2018). Low temperature affects the morphology and impairs glutamine-induced hypertrophic response in human primary myotubes. In: : . Paper presented at Europhysiology, London, UK, September 14-16, 2018.
Open this publication in new window or tab >>Low temperature affects the morphology and impairs glutamine-induced hypertrophic response in human primary myotubes
2018 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Cold water immersion and other strategies are extensively used by athletes to reduce muscle temperature (TEMP) and are believed to limit muscle soreness and improve recovery after strenuous exercise. However, it remains unclear whether low TEMP affects skeletal muscle hypertrophy and protein synthesis in response to anabolic stimuli. In this study, we used an in vitro model to investigate whether a reduced TEMP (32°C, TEMP in skeletal muscle during cold water immersion vs. 37°C, core TEMP) affects the growth and impairs glutamine (GLUT)-induced hypertrophic response in human myotubes. Myoblasts from human muscle biopsies (n=8) were first differentiated into myotubes during 48h at 37°C. Then, myotubes were treated with GLUT to induce hypertrophy and were incubated at either 37 or 32°C during 1h (T1), 8h (T8) or 48h (T48). Myotube area (a marker of myotube size) was assessed at T48 by using immunocytology. Protein synthesis (puromycin incorporation) and phosphorylation levels of two components of the mechanistic target of rapamycin (mTOR) pathway [P70 S6 kinase (P70S6K) and eukaryotic translation initiation factor 4E (4E-BP1] were assessed at T1 and T8 from western blot analysis. Ribosome biogenesis was evaluated at T8 by determining total RNA concentration, and by assessing the levels of 18S ribosomal RNA (18S rRNA), precursor 45S rRNA (pre-45S rRNA) and MYC mRNA from quantitative polymerase chain reaction. Data were analysed by a two-way ANOVA for repeated measures. A first major observation was that low TEMP induced morphological alterations (short myotube segments and larger myotube area). Importantly, GLUT-induced myotube hypertrophy was only observed at 37°C (+40%, P<0,01 at 37°C; +4%, NS at 32°C). Similarly, GLUT stimulated protein synthesis at T1 (main effect, P<0,01), with a 53% increase at 37°C (P<0,05) and a 23% increase at 32°C (NS). Protein synthesis was reduced at 32°C at T8 (main effect, P<0,01), while GLUT increased protein synthesis at 37°C (+17%, P<0,01) but not at 32°C (-7%, NS). GLUT-induced 4E-BP1 phosphorylation at T1 was found at 37°C (+16%, P<0,01) but not at 32°C (-1%, NS). Moreover, GLUT increased the phosphorylation of P70S6K at T8 by 50% at 37°C (P<0,01) and by 26% at 32°C (P<0,05). Overall, total RNA concentration, levels of MYC mRNA, 18S rRNA and pre-45S rRNA were reduced at 32°C. In conclusion, this study indicates that low TEMP affects myotube morphology. In addition, we demonstrate that low TEMP impairs GLUT-induced myotube hypertrophy and protein synthesis, a result accompanied by a minored activation of the mTOR pathway. The impaired ribosome biogenesis observed at 32°C at T8 may also contribute to the reduced protein synthesis at this time point. These findings suggest that reducing muscle TEMP after resistance exercise may be detrimental for muscle hypertrophy and training adaptations.

 

National Category
Medical and Health Sciences Physiology
Identifiers
urn:nbn:se:oru:diva-70158 (URN)
Conference
Europhysiology, London, UK, September 14-16, 2018
Available from: 2018-11-13 Created: 2018-11-13 Last updated: 2018-11-13Bibliographically approved
Kadi, F. & Nilsson, A. (2018). Motion mot inflammation: fysisk aktivitet viktigt för äldres hälsa. Idrottsforskning, Article ID 9 jan.
Open this publication in new window or tab >>Motion mot inflammation: fysisk aktivitet viktigt för äldres hälsa
2018 (Swedish)In: Idrottsforskning, ISSN 2002-3944, article id 9 janArticle in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Stockholm: Centrum för Idrottsforskning, 2018
National Category
Medical and Health Sciences Physiotherapy Rheumatology and Autoimmunity
Research subject
Sports Physiology/Medicine
Identifiers
urn:nbn:se:oru:diva-68436 (URN)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-08-16Bibliographically approved
Nilsson, A., Bergens, O. & Kadi, F. (2018). Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels. Medicine & Science in Sports & Exercise, 50(7), 1502-1507
Open this publication in new window or tab >>Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels
2018 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 50, no 7, p. 1502-1507Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To examine the influence of reallocating time spent at different objectively measured physical activity (PA) behaviours on markers of systemic inflammation in older women with different levels of metabolic risk.

METHODS: Accelerometer-based monitoring of PA was conducted in a population of community-dwelling older women (n = 111; age = 65-70 yr) for determination of daily sedentary time, time in light (LPA) and moderate-to-vigorous physical activity (MVPA). Blood samples were collected for the assessment of the systemic inflammatory markers CRP, fibrinogen and adiponectin. Metabolic risk was assessed by standardized procedures based on definitions for the metabolic syndrome. Data were analysed by linear regression models based on isotemporal substitution analysis.

RESULTS: Reallocating 30 minutes of sedentary time with either time in LPA (β = -0.47; p<0.05) or MVPA (β = -0.42; p<0.05) was related to reduced fibrinogen level, whereas no corresponding effect was evident when shifting time in LPA with time in MVPA, while holding sedentary time constant. In contrast, reallocating a 30-minute time period in sedentary (β = -0.70; p<0.01) or LPA (β = -0.71; p<0.01) with MVPA was associated with a significant reduction in CRP level, while no impact on CRP was observed when a time period of sedentary behavior was replaced with LPA. Importantly, all significant influences on fibrinogen and CRP by displacement of different PA behaviours remained after adjustment for metabolic risk status among participants. No significant associations with adiponectin were observed.

CONCLUSION: Altogether, this work supports the existence of different intensity thresholds mediating beneficial effects of PA on important clinical markers of systemic inflammation in older women across different stages of disease prevention.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018
Keywords
EXERCISE TRAINING, ELDERLY, ISOTEMPORAL, SEDENTARY BEHAVIOR, METABOLIC RISK, ACUTE PHASE PROTEIN
National Category
Occupational Health and Environmental Health Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-65195 (URN)10.1249/MSS.0000000000001582 (DOI)000435348900020 ()29462102 (PubMedID)2-s2.0-85045633896 (Scopus ID)
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-07-25Bibliographically approved
Montiel Rojas, D., Nilsson, A., Ponsot, E., Brummer, R. J., Fairweather-Tait, S., Jennings, A., . . . Kadi, F. (2018). Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults. Frontiers in Physiology, 9, Article ID 1110.
Open this publication in new window or tab >>Short Telomere Length Is Related to Limitations in Physical Function in Elderly European Adults
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2018 (English)In: Frontiers in Physiology, ISSN 1664-042X, E-ISSN 1664-042X, Vol. 9, article id 1110Article in journal (Refereed) Published
Abstract [en]

The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. A total of 1,221 adults (65-79 years) were recruited from five European countries within the framework of NU-AGE study. The physical functioning construct was based on the 36-item Short Form Health Survey. Handgrip strength was used as a single indicator of muscle function and LTL was assessed using quantitative real-time PCR. Women had significantly longer (p < 0.05) LTL than men. Participants in Poland had significantly shorter LTL than in the other study centers, whereas participants in the Netherlands had significantly longer LTL than most of the other centers (p < 0.01). An analysis of LTL as a continuous outcome against physical functioning by using linear models revealed inconsistent findings. In contrast, based on an analysis of contrasting telomere lengths (first vs. fifth quintile of LTL), a significant odds ratio (OR) of 1.7 (95% CI: 1.1 -2.6; p < 0.05) of having functional limitation was observed in those belonging to the first LTL quintile compared to the fifth. Interestingly, having the shortest LTL was still related to a higher likelihood of having physical limitation when compared to all remaining quintiles (OR: 1.5, 95% CI: 1.1 -2.1; p < 0.05), even after adjustment by study center, age, sex, and overweight status. Collectively, our findings suggest that short LTL is an independent risk factor that accounts for functional decline in elderly European populations. The influence of LTL on functional limitation seems driven by the detrimental effect of having short telomeres rather than reflecting a linear dose-response relationship.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2018
Keywords
aging, ethnicity, handgrip strength, SF-36, physical function
National Category
Physiology
Identifiers
urn:nbn:se:oru:diva-68587 (URN)10.3389/fphys.2018.01110 (DOI)000441323300001 ()2-s2.0-85051645979 (Scopus ID)
Funder
EU, FP7, Seventh Framework Programme, 266486
Available from: 2018-08-27 Created: 2018-08-27 Last updated: 2018-09-14Bibliographically approved
Edholm, P., Strandberg, E. & Kadi, F. (2017). A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women. In: : . Paper presented at Nobel Day Festivities, Örebro, Sweden, December 10, 2017.
Open this publication in new window or tab >>A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women
2017 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences Sport and Fitness Sciences Physiology
Identifiers
urn:nbn:se:oru:diva-66427 (URN)
Conference
Nobel Day Festivities, Örebro, Sweden, December 10, 2017
Available from: 2018-04-09 Created: 2018-04-09 Last updated: 2018-04-10Bibliographically approved
Edholm, P., Strandberg, E. & Kadi, F. (2017). A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women. In: : . Paper presented at European College of Sport Science Congress, Bochum, Germany, 5-8 July, 2017.
Open this publication in new window or tab >>A healthy diet rich in N-3 PUFAS enhances the effects of resistance training in elderly women
2017 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Physiology Sport and Fitness Sciences Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:oru:diva-66426 (URN)
Conference
European College of Sport Science Congress, Bochum, Germany, 5-8 July, 2017
Available from: 2018-04-09 Created: 2018-04-09 Last updated: 2018-04-10Bibliographically approved
Särnblad, S., Ponsot, E. & Kadi, F. (2017). Acute effects on glycemia of different types of exercise in youths with type 1 diabetes. In: : . Paper presented at ISPAD 2017, Innsbruck, Austria, October 18-21, 2017.
Open this publication in new window or tab >>Acute effects on glycemia of different types of exercise in youths with type 1 diabetes
2017 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:oru:diva-61856 (URN)
Conference
ISPAD 2017, Innsbruck, Austria, October 18-21, 2017
Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2017-11-01Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9831-0896

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