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Ericson Jogsten, IngridORCID iD iconorcid.org/0000-0002-6330-789X
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Publications (10 of 47) Show all publications
Stylianou, M., Björnsdotter, M., Olsson, P.-E., Ericson Jogsten, I. & Jass, J. (2019). Distinct transcriptional response of Caenorhabditis elegans to different exposure routes of perfluorooctane sulfonic acid. Environmental Research, 168, 406-413
Open this publication in new window or tab >>Distinct transcriptional response of Caenorhabditis elegans to different exposure routes of perfluorooctane sulfonic acid
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2019 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 168, p. 406-413Article in journal (Refereed) Published
Abstract [en]

Although people are exposed daily to per- and polyfluorinated alkyl substances (PFASs), the biological consequences are poorly explored. The health risks associated with PFAS exposure are currently based on chemical analysis with a weak correlation to potential harmful effects in man and animals. In this study, we show that perfluorooctane sulfonic acid (PFOS), often the most enriched PFAS in the environment, can be transferred via bacteria to higher organisms such as Caenorhabditis elegans. C. elegans nematodes were exposed to PFOS directly in buffer or by feeding on bacteria pretreated with PFOS, and this led to distinct gene expression profiles. Specifically, heavy metal and heat shock associated genes were significantly, although inversely, expressed following the different PFOS exposures. The innate immunity receptor for microbial pathogens, clec-60, was shown for the first time to be down-regulated by PFOS. This is in line with a previous study indicating that PFOS is associated with children's susceptibility to certain infectious diseases. Furthermore, bar-1, a gene associated with various cancers was highly up-regulated only when C. elegans were exposed to PFOS pretreated live bacteria. Furthermore, dead bacterial biomass had higher binding capacity for linear and isomeric PFOS than live bacteria, which correlated to the higher levels of PFOS detected in C. elegans when fed the treated E. toll, respectively. These results reveal new aspects concerning trophic chain transport of PFOS.

Place, publisher, year, edition, pages
Academic Press, 2019
Keywords
PFOS biosorption, PFOS isomers, Nematode, Escherichia coli, Food chain
National Category
Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-71130 (URN)10.1016/j.envres.2018.10.019 (DOI)000452938700043 ()30388497 (PubMedID)2-s2.0-85055720038 (Scopus ID)
Funder
Knowledge Foundation, 20140180
Note

Funding Agency:

Örebro University

Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-01-08Bibliographically approved
Bjurlid, F., Roos, A., Ericson Jogsten, I. & Hagberg, J. (2018). Temporal trends of PBDD/Fs, PCDD/Fs, PBDEs and PCBs in ringed seals from the Baltic Sea (Pusa hispida botnica) between 1974 and 2015. Science of the Total Environment, 616-617, 1374-1383
Open this publication in new window or tab >>Temporal trends of PBDD/Fs, PCDD/Fs, PBDEs and PCBs in ringed seals from the Baltic Sea (Pusa hispida botnica) between 1974 and 2015
2018 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 616-617, p. 1374-1383Article in journal (Refereed) Published
Abstract [en]

Temporal trends in exposure to persistent organic pollutants (POPs) were assessed in 22 pooled samples gathered from 69 individuals of Baltic ringed seal (Pusa hispida botnica) from 1974 to 2015. Samples were analysed for polybrominated dibenzo-p-dioxins and furans (PBDD/Fs), polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs), polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs). No previous study has reported on the occurrence of PBDD/Fs in marine mammals in the Baltic Sea. Concentrations of pollutants in Baltic ringed seal, a marine mammal and top predator, can be used as an indicator of pollutants concentrations in the Baltic region.

Visual inspection of data did not show any temporal trends for PBDD/Fs, while the PCDD/Fs and PCBs showed decreasing concentrations between 1974 and 2015. PBDEs increased until the end of the 1990s and then decreased until the end of the period. ∑ PBDD/Fs ranged from 0.5–52.3 pg/g lipid weight (l.w.) (0.08–4.8 pg TEQ/g l.w.), with 1,2,3,4,6,7,8-HpBDF contributing on average 61% to ∑ PBDD/Fs. ∑ PCDD/Fs ranged from 103 to 1480 pg/g l.w. (39–784 pg TEQ/g l.w.), with 1,2,3,6,7,8-HxCDD, 1,2,3,7,8-PeCDD and 2,3,4,7,8-PeCDF showing the highest average concentrations. PBDD/F toxic equivalents (TEQ) contributed on average 1.1% to the total (PBDD/F + PCDD/F) TEQ. The ∑ PBDEs concentration range was 18.7–503 ng/g l.w., with BDE #47 the predominant congener. The concentration range for ∑ PCBs was 2.8–40.1 μg/g l.w., with #138 and #153 the most abundant congeners. Visual inspection of the data showed decreasing concentrations for all compound groups except PBDD/Fs. A slight increase in the PBDD/Fs concentrations was observed from 2004 onwards. This observation needs to be investigated further.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Dioxins, Furans, POPs, Marine mammal
National Category
Other Chemistry Topics Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-63413 (URN)10.1016/j.scitotenv.2017.10.178 (DOI)000424121800137 ()29066193 (PubMedID)2-s2.0-85038955003 (Scopus ID)
Note

Funding Agency:

Swedish Environmental Protection Agency  2213-15-022

Available from: 2017-12-18 Created: 2017-12-18 Last updated: 2018-08-16Bibliographically approved
Geng, D., Kukucka, P. & Ericson Jogsten, I. (2017). Analysis of brominated flame retardants and their derivatives by atmospheric pressure chemical ionization using gas chromatography coupled to tandem quadrupole mass spectrometry. Talanta: The International Journal of Pure and Applied Analytical Chemistry, 162, 618-624
Open this publication in new window or tab >>Analysis of brominated flame retardants and their derivatives by atmospheric pressure chemical ionization using gas chromatography coupled to tandem quadrupole mass spectrometry
2017 (English)In: Talanta: The International Journal of Pure and Applied Analytical Chemistry, ISSN 0039-9140, E-ISSN 1873-3573, Vol. 162, p. 618-624Article in journal (Refereed) Published
Abstract [en]

A validated method using an atmospheric pressure chemical ionization source for coupling gas chromatography (GC-APCI) to tandem quadrupole mass spectrometry (MS/MS) for the determination of brominated flame retardants (BFRs) is presented. Polybrominated diphenyl ethers (PBDEs), their methoxylated derivatives (MeO-PBDEs) and other emerging BFRs were included in this study. The method showed good linearity and repeatability. The relative standard deviation (RSD) of the relative response factors (RRFs) of all compounds was less than 16%. Repeatability for BFRs was tested on one or two concentration levels of calibration standardswith RSDs for RRFs below 16%. The lowest calibration standards (0.075 –0.1 pg/μL for emerging BFRs, BDE 209 and MeO-PBDEs mixtures, 0.625 –6.25 pg/μL for Br1-9 PBDEs mixtures) were used as instrument detection limits (IDL). The method was applied on biotic samples, including fish, osprey, and seal. In general, BDE209 and decabromodiphenyl ethane (DBDPE) were detected in 50% of the seal samples. A 100% detection rate was achieved for 6-MeO-BDE47 in all the samples (72 –580 pg/g ww in osprey samples, 24 000 –96 000 pg/g ww in seal samples and 78–99 pg/g ww in fish samples). AllBr3-6PBDEs (BDE28, 47, 99, 100, 153, 154) were detected in all the samples (ranging from 12 to 20 000 pg/g ww), while BDE183 was detected in 60% of the osprey eggs, 20% of the seal samples and below MDL in all fish samples. The results presented indicate the capability of the GC-APCI-MS/MS system for the detection and quantification of BFRs.

Place, publisher, year, edition, pages
Amsterdam, Netherlands: Elsevier, 2017
Keywords
BFR, PBDE, MeO-PBDE, gas chromatography-atmospheric pressure chemical ionization (GC-APCI), tandem quadrupole mass spectrometry (MS/MS)
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
urn:nbn:se:oru:diva-53049 (URN)10.1016/j.talanta.2016.10.060 (DOI)000389088700083 ()27837880 (PubMedID)2-s2.0-84994381585 (Scopus ID)
Note

Funding Agencies:

China Scholarship Council 201206400003

Czech Ministry of Education, Youth and Sports LO1214  LM2015051

Ingrid Ericson Jogsten 20140057

Available from: 2016-10-19 Created: 2016-10-19 Last updated: 2017-11-29Bibliographically approved
Ericson Jogsten, I. & Yeung, L. W. Y. (2017). Analysis of ultra-short chain perfluoroalkyl substances in Swedish environmental waters. Örebro, Sweden: Örebro university
Open this publication in new window or tab >>Analysis of ultra-short chain perfluoroalkyl substances in Swedish environmental waters
2017 (English)Report (Other academic)
Abstract [en]

The purpose of this study was to investigate the environmental occurrence of ultra-short chain perfluoroalkyl substances (PFASs) in Swedish water samples. So far established protocols have focused on measuring PFASs with a carbon chain length of four or more carbons. In this study, perfluoroalkyl sulfonates of chain lengths of two, perfluoroethane sulfonate (PFEtS), and three, perfluoropropane sulfonate (PFPrS), carbons have been measured using a newly established instrumental method employing supercritical fluid separation (SFC) coupled to tandem mass spectrometry detection.

A total of 26 samples were analysed, including ground water, surface water, rain water and snow. The sample locations included military and civilian airports, a former hard chromium plating facility, the vicinity of a hazardous waste management facility and background areas (lake surface water, rain and snow). Results show that both PFPrS and PFEtS could be detected in environmental samples using SFC separation coupled to triple quadrupole detection. Out of the 26 samples analysed, the ultra-short-chain PFPrS could be detected and quantified in 22 samples. The concentrations for PFPrS in all the samples ranged between 0.93 ng/l to 39 000 ng/l. The ultra-short-chain PFPEtS could be quantified in all of the 26 samples, with a concentration range between 0.07 and 5 700 ng/l. The highest concentrations represents highly contaminated ground water samples collected from a military airport. In the samples, PFPrS had a relative contribution to total PFAS concentration of 6 and 10 %, indicating the importance of measuring these compounds in environmental samples.

Place, publisher, year, edition, pages
Örebro, Sweden: Örebro university, 2017. p. 18
Keywords
Ultra-short chain PFAS, water
National Category
Analytical Chemistry Environmental Sciences
Research subject
Chemistry; Environmental Chemistry
Identifiers
urn:nbn:se:oru:diva-64607 (URN)
Funder
Swedish Environmental Protection Agency, 2219-16-030
Available from: 2018-01-29 Created: 2018-01-29 Last updated: 2018-02-02Bibliographically approved
Riddell, N., van Bavel, B., Ericson Jogsten, I., McCrindle, R., McAlees, A. & Chittim, B. (2017). Coupling of supercritical fluid chromatography to mass spectrometry for the analysis of Dechlorane Plus: Examination of relevant negative ion atmospheric pressure chemical ionization mechanisms. Talanta: The International Journal of Pure and Applied Analytical Chemistry, 171, 68-73
Open this publication in new window or tab >>Coupling of supercritical fluid chromatography to mass spectrometry for the analysis of Dechlorane Plus: Examination of relevant negative ion atmospheric pressure chemical ionization mechanisms
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2017 (English)In: Talanta: The International Journal of Pure and Applied Analytical Chemistry, ISSN 0039-9140, E-ISSN 1873-3573, Vol. 171, p. 68-73Article in journal (Refereed) Published
Abstract [en]

During an investigation of the potential associated with coupling packed column supercritical fluid chromatography (pSFC) to mass spectrometry for the analysis of Dechlorane Plus and related compounds, it was found that negative ion atmospheric pressure chemical ionization (APCI) was a promising ionization technique. In the course of maximizing the responses associated with the target analytes, it proved useful to examine some aspects of the complex nature and reactivity of the corona discharge plasma generated to explain the observed ionization products. Various dopants/reagents were screened for both APCI and atmospheric pressure photoionization (APPI) in negative ion mode and mechanisms of ionization involving superoxide were elucidated based on the results obtained. Superoxide formation was found to be temperature dependent and directly related to the intensity of the ion cluster [M-Cl+O](-) obtained for the target DP analytes. Furthermore, triethylamine was identified as a reagent capable of suppressing unwanted side reactions during the ionization process and maximizing response associated with the analytes of interest. The applicability of pSFC-APCI/MS for the separation and detection of Dechlorane Plus and related compounds was demonstrated by analyzing Lake Ontario sediment and comparing the results with values reported in the scientific literature.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
Supercritical fluid chromatography, Negative, APCI/MS, Dechlorane Plus, Ionization, Superoxide, Environmental analysis
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-58921 (URN)10.1016/j.talanta.2017.04.066 (DOI)000403511500010 ()28551155 (PubMedID)2-s2.0-85018946787 (Scopus ID)
Available from: 2017-08-21 Created: 2017-08-21 Last updated: 2017-10-05Bibliographically approved
Riddell, N., van Bavel, B., Ericson Jogsten, I., McCrindle, R., McAlees, A. & Chittim, B. (2017). Coupling supercritical fluid chromatography to positive ion atmospheric pressure ionization mass spectrometry: Ionization optimization of halogenated environmental contaminants. International Journal of Mass Spectrometry, 421, 156-163
Open this publication in new window or tab >>Coupling supercritical fluid chromatography to positive ion atmospheric pressure ionization mass spectrometry: Ionization optimization of halogenated environmental contaminants
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2017 (English)In: International Journal of Mass Spectrometry, ISSN 1387-3806, E-ISSN 1873-2798, Vol. 421, p. 156-163Article in journal (Refereed) Published
Abstract [en]

Currently used analytical techniques for halogenated aromatic environmental contaminants such as polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs), also known as legacy persistent organic pollutants, are based on gas chromatographic separation of target analytes and detection by mass spectrometry. The coupling of packed column supercritical fluid chromatography (SFC) to atmospheric pressure ionization mass spectrometry (API/MS) could allow for the concurrent analysis of thermally labile and legacy halogenated environmental contaminants if ionization can be sufficiently optimized. The evaluation of positive ion atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI) as well as possible charge transfer dopants for the generation of molecular ion isotopomeric clusters of halogenated environmental contaminants with minimal fragmentation has been completed. Using the investigated parameters, positive ion APPI was found to be the more sensitive technique. Of the aromatic and cycloalkane dopants investigated, only fluorobenzene and trifluorotoluene were found to be effective dopants for the halogenated aromatic target analytes (PCDDs, PCDFs, and PCBs). Experiments involving deuterated dopants confirmed that reactive species generated by cycloalkanes were quenched by the SFC eluent rendering them unusable in conjunction with the investigated separation technique. Alternatively, aromatic dopants were found to be less susceptible to quenching by the SFC eluent and fluorobenzene was determined to be the most effective charge transfer dopant for PCDDs, PCDFs, and PCBs. To demonstrate the applicability of the optimized ionization conditions, SFC-API/MS has been used for the concurrent analysis of legacy halogenated aromatic environmental contaminants (PCDDs, PCDFs, and PCBs) and thermally labile analytes (alpha, beta, and gamma isomers of hexabromocyclododecane).

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
SFC, Positive APPI-MS, Environmental contaminants, PCDD, PCDF, PCB
National Category
Atom and Molecular Physics and Optics
Identifiers
urn:nbn:se:oru:diva-62782 (URN)10.1016/j.ijms.2017.07.005 (DOI)000414114100018 ()2-s2.0-85024100973 (Scopus ID)
Available from: 2017-11-24 Created: 2017-11-24 Last updated: 2018-08-11Bibliographically approved
Kvist, M., Yeung, L. W. Y. & Ericson Jogsten, I. (2017). Detection of ultra-short chain perfluoroalkyl substances in Swedish environmental waters. In: : . Paper presented at 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) (Dioxin 2017), Vancouver, Canada, August 20-25, 2017.
Open this publication in new window or tab >>Detection of ultra-short chain perfluoroalkyl substances in Swedish environmental waters
2017 (English)Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

The ubiquitous distribution of perfluoroalkyl substances (PFASs) has been documented worldwide in different environmental samples including humans. In Sweden, severe PFAS contamination in drinking water has resulted in elevated blood PFAS concentrations in residents living in contaminated areas. In many cases, the use of aqueous film forming-foams (AFFFs) at both civil and military airports has resulted in this contamination, as PFASs are one of the active ingredients in AFFFs. According to a nationwide survey, it was estimated that 30 % of the Swedish population has their closest drinking water source contaminated with these substances. A guideline value for safe use of drinking water set by the Swedish Food Agencyis the sum of eleven PFASs including perfluoroalkylated sulfonates (PFSAs; C4, C6, C8), perfluoroalkylated carboxylates (PFCAs; C4-C10) and 6:2 fluorotelomer sulfonate.This is set to 90 ng/L, while the health based limit, based on the tolerable daily intake,is set to 900 ng/L. In the US, Barzen-Hansen et al.showed the presence of ultra-short chain PFASs, perfluoropropanesulfonate (PFPrS) and perfluoroethanesulfonate (PFEtS), in five AFFFs. In ground water samples from eleven US military bases, PFEtS was detected in eight out of eleven samples ranging from 11-7500 ng/L, while PFPrS was detected in all samples, ranging from 19-63000 ng/L). Conventional reversed-phase LC using C18 column is not suitable to chromatograph these ultra-short chain PFAS, because they are highly polar; ion-exchange column has been demonstrated useful for separating these ultra-short chain PFAS. In this study a new analytical approach employing supercritical fluid chromatography (SFC) was developed for chromatographic separation of these ultra-short chain PFASs. Environmental water samples (surface water, ground water, rain water, snow and sediment) from various locations with suspected PFAS contamination were analyzed to investigate the potential occurrence of these ultra-short chain compounds in the Swedish environment. Solid phase extraction according to ISO method was used to concentrate water samples prior to instrumental analyses using both UPLC-MS/MS and UPC2-MS/MS.

Results show that both PFPrS and PFEtS could be detected in environmental samples from Sweden using SFC separation coupled to triple quadrupole detection. Out of the 26 samples analysed,the ultra-short-chain PFPrS could be detected and quantified in 22 samples. The concentrations for PFPrS in all the samples ranged between 0.93 ng/l to 390 μg/l. The ultra-short-chain PFPEtS could be quantified in 24 out of the 26 samples, with a concentration range between 0.07-5 680 ng/l. The highest concentrations represents highly contaminated ground water samples collected from a military airport.

Keywords
Supercritical fluid chromatography, ultra-short chain PFAS
National Category
Analytical Chemistry
Research subject
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-64649 (URN)
Conference
37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) (Dioxin 2017), Vancouver, Canada, August 20-25, 2017
Funder
Swedish Environmental Protection AgencyKnowledge FoundationSwedish Research Council Formas
Available from: 2018-01-30 Created: 2018-01-30 Last updated: 2019-04-02Bibliographically approved
Riddell, N., van Bavel, B., Ericson Jogsten, I., McCrindle, R., McAlees, A. & Chittim, B. (2017). Examination of technical mixtures of halogen-free phosphorus based flame retardants using multiple analytical techniques. Chemosphere, 176(June 2017), 333-341
Open this publication in new window or tab >>Examination of technical mixtures of halogen-free phosphorus based flame retardants using multiple analytical techniques
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2017 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 176, no June 2017, p. 333-341Article in journal (Refereed) Published
Abstract [en]

The application of phosphorus based flame retardants as replacements for commonly used halogenated flame retardants has been gaining interest due to the possibility that these compounds may have a less significant impact on human and environmental health. Unfortunately, little is known about the chemical compositions of many of the technical products (which often are mixtures) and a single separation technique for concurrent analysis of these types of compounds has not been identified. This paper reports the results of an investigation into the constituents of three halogen free organophosphate flame retardants (OPFRs), resorcinol bis(diphenyl phosphate) (RDBPP), bisphenol A bis(diphenyl phosphate) (BPA-BDPP), and 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO). The major components of commercial samples of RDBPP and BPA-BDPP were isolated by preparative TLC and characterized by NMR. A commercial sample of DOPO was found to be essentially pure, but its analysis is complicated by the fact that it can exist in ring-open and ring-closed forms. With the structures of the components confirmed by NMR, multiple analytical separation techniques (gas chromatography (GC), liquid chromatography (LC), and packed column supercritical fluid chromatography (pSFC)) were investigated for the analysis of these three technical products. Packed column supercritical fluid chromatography allows the separation of the components of all three OPFRs, including the two forms of DOPO, in a single run.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
Organophosphate flame retardants (OPFRs); pSFC/MS method; NMR; RDBPP; BPA-BDPP; DOPO
National Category
Other Chemistry Topics Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-57461 (URN)10.1016/j.chemosphere.2017.02.129 (DOI)000399849300038 ()28282639 (PubMedID)2-s2.0-85015851681 (Scopus ID)
Available from: 2017-04-25 Created: 2017-04-25 Last updated: 2017-09-11Bibliographically approved
Mullin, L. G., Ladak, A., Cleland, G. & Ericson Jogsten, I. (2016). Biomonitoring of GC and LC amenable environmental contaminants using a single MS platform. Paper presented at 36th International Symposium on Halogenated Persistent Organic Pollutants, Dioxin 2016, Florence, Italy, August 28 - September 2, 2016. Organohalogen Compounds, 78
Open this publication in new window or tab >>Biomonitoring of GC and LC amenable environmental contaminants using a single MS platform
2016 (English)In: Organohalogen Compounds, ISSN 1026-4892, Vol. 78Article in journal (Refereed) Published
Abstract [en]

Monitoring of environmental contaminants in biological samples is typically performed by targeted analysis using a tandem quadrupole system on separate GC and LC platforms in order to cover the expansive range of compounds. Use of multiple systems can add complexity to the analysis and increase turnaround times for samples to be reported. The work that will be presented will show the analysis of common environmental contaminants in a biomonitoring context on a single high resolution mass spectrometric (HRMS) platform. The compounds of interest include:

  • GC amenable compounds: Halogenated pesticides, BFRs, PCBs and PCDD/Fs
  • LC amenable compounds: Perfluoroalkyl substances, HBCDD/TBBP-A and phosphorus-based flame retardants
Place, publisher, year, edition, pages
Eco-Informa Press, 2016
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-65616 (URN)
Conference
36th International Symposium on Halogenated Persistent Organic Pollutants, Dioxin 2016, Florence, Italy, August 28 - September 2, 2016
Available from: 2018-03-09 Created: 2018-03-09 Last updated: 2018-04-05Bibliographically approved
Riddell, N., Mullin, L. G., van Bavel, B., Ericson Jogsten, I., McAlees, A., Brazeau, A., . . . Chittim, B. (2016). Enantioselective Analytical- and Preparative-Scale Separation of Hexabromocyclododecane Stereoisomers Using Packed Column Supercritical Fluid Chromatography. Molecules, 21(11), Article ID 1509.
Open this publication in new window or tab >>Enantioselective Analytical- and Preparative-Scale Separation of Hexabromocyclododecane Stereoisomers Using Packed Column Supercritical Fluid Chromatography
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2016 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 21, no 11, article id 1509Article in journal (Refereed) Published
Abstract [en]

Hexabromocyclododecane (HBCDD) is an additive brominated flame retardant which has been listed in Annex A of the Stockholm Convention for elimination of production and use. It has been reported to persist in the environment and has the potential for enantiomer-specific degradation, accumulation, or both, making enantioselective analyses increasingly important. The six main stereoisomers of technical HBCDD (i.e., the (+) and (-) enantiomers of α-, β-, and γ-HBCDD) were separated and isolated for the first time using enantioselective packed column supercritical fluid chromatography (pSFC) separation methods on a preparative scale. Characterization was completed using published chiral liquid chromatography (LC) methods and elution profiles, as well as X-ray crystallography, and the isolated fractions were definitively identified. Additionally, the resolution of the enantiomers, along with two minor components of the technical product (δ- and ε-HBCDD), was investigated on an analytical scale using both LC and pSFC separation techniques, and changes in elution order were highlighted. Baseline separation of all HBCDD enantiomers was achieved by pSFC on an analytical scale using a cellulose-based column. The described method emphasizes the potential associated with pSFC as a green method of isolating and analyzing environmental contaminants of concern.

Place, publisher, year, edition, pages
Basel, Switzerland: MDPI AG, 2016
Keywords
hexabromocyclododecane, enantiomeric separation, supercritical fluid chromatography
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-53487 (URN)10.3390/molecules21111509 (DOI)000389918200091 ()27834934 (PubMedID)2-s2.0-84997428723 (Scopus ID)
Available from: 2016-11-15 Created: 2016-11-14 Last updated: 2017-11-29Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-6330-789X

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