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Andersson, A., Tuvblad, C., Chen, Q., Du Rietz, E., Cortese, S., Kuja-Halkola, R. & Larsson, H. (2020). Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis. Journal of Child Psychology and Psychiatry and Allied Disciplines
Open this publication in new window or tab >>Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis
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2020 (English)In: Journal of Child Psychology and Psychiatry and Allied Disciplines, ISSN 0021-9630, E-ISSN 1469-7610Article, review/survey (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with other psychiatric disorders. Twin studies have established that these co-occurrences are in part due to shared genetic risks. However, the strength of these genetic overlaps and the potential heterogeneity accounted for by type of psychiatric symptoms, age, and methods of assessment remain unclear. We conducted a systematic review to fill this gap.

METHODS: ) were used as effect size measures.

RESULTS:  = .50 (0.33-0.65).

CONCLUSIONS: These findings indicate that the co-occurrence of externalizing, internalizing, and neurodevelopmental disorder symptoms in individuals with ADHD symptoms in part is due to a shared genetic risk.

Place, publisher, year, edition, pages
Blackwell Publishing, 2020
Keywords
ADHD, externalizing, genetic, internalizing, neurodevelopmental, overlap, twins
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-80610 (URN)10.1111/jcpp.13233 (DOI)32157695 (PubMedID)
Available from: 2020-03-13 Created: 2020-03-13 Last updated: 2020-03-13Bibliographically approved
Tuvblad, C., Sild, M., Frogner, L. & Booij, L. (2019). Behavioral Genetics of Aggression and Intermittent Explosive Disorder. In: Emil Coccaro, Michael McCloskey (Ed.), Intermittent Explosive Disorder: Etiology, Assessment, and Treatment. Academic Press
Open this publication in new window or tab >>Behavioral Genetics of Aggression and Intermittent Explosive Disorder
2019 (English)In: Intermittent Explosive Disorder: Etiology, Assessment, and Treatment / [ed] Emil Coccaro, Michael McCloskey, Academic Press, 2019Chapter in book (Other academic)
Place, publisher, year, edition, pages
Academic Press, 2019
National Category
Psychology
Identifiers
urn:nbn:se:oru:diva-72624 (URN)9780128138588 (ISBN)
Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-02-21Bibliographically approved
Fullerton, A. F., Jackson, N. J., Tuvblad, C., Raine, A. & Baker, L. A. (2019). Early Childhood Head Injury Attenuates Declines in Impulsivity and Aggression Across Adolescent Development in Twins. Neuropsychology, 33(8), 1035-1044
Open this publication in new window or tab >>Early Childhood Head Injury Attenuates Declines in Impulsivity and Aggression Across Adolescent Development in Twins
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2019 (English)In: Neuropsychology, ISSN 0894-4105, E-ISSN 1931-1559, Vol. 33, no 8, p. 1035-1044Article in journal (Refereed) Published
Abstract [en]

Objective: Head injury during development has been associated with behavioral changes such as impulsivity and antisocial behavior. This study investigates the extent to which behavioral changes associated with childhood head injury are sustained through adolescence and emerging adulthood.

Method: Survey data was collected at 5 waves spanning 12 years (ages 9-20) from the University of Southern California Risk Factors for Antisocial Behavior twin study. Impulsivity was measured by errors of commission in a Go/NoGo behavioral task, and aggression was measured through youth self-report using the Reactive-Proactive Aggression Questionnaire. Head injury was assessed retrospectively using caregiver questionnaires at twin ages 14-15 years and self-reported at ages 19-20 years.

Results: Participants with a head injury in early childhood showed significant delay in the normative developmental decline of impulsivity relative to the noninjured by mid-adolescence (ages 14-15.) Moreover, earlier age at injury was related to a slower decrease in impulsivity and greater increase in reactive aggression scores. Finally, among discordant monozygotic twin pairs, the twin with a head injury experienced significantly less decline in impulsivity by ages 19-20 than the noninjured co-twin.

Conclusions: These findings indicate early childhood head injury may play a significant role in blunting the decline in impulsivity across development, exposing an additional risk factor for antisocial behavior.

Place, publisher, year, edition, pages
American Psychological Association, 2019
Keywords
impulsivity, head injury, development, adolescence, twins
National Category
Psychology
Identifiers
urn:nbn:se:oru:diva-78001 (URN)10.1037/neu0000570 (DOI)000494295100001 ()31259562 (PubMedID)
Funder
Swedish Research Council, 2018-01041
Note

Funding Agencies:

United States Department of Health & Human Services

National Institutes of Health (NIH) - USA

NIH National Institute of Mental Health (NIMH) R01 MH58354

NIMH Independent Science Award  K02 MH0114

University of Southern California Undergraduate Research funds

Available from: 2019-11-22 Created: 2019-11-22 Last updated: 2019-11-22Bibliographically approved
Tuvblad, C., Wang, P., Patrick, C. J., Berntsen, L., Raine, A. & Baker, L. A. (2019). Genetic and environmental influences on disinhibition, boldness, and meanness as assessed by the triarchic psychopathy measure in 19-20-year-old twins. Psychological Medicine, 49(9), 1500-1509
Open this publication in new window or tab >>Genetic and environmental influences on disinhibition, boldness, and meanness as assessed by the triarchic psychopathy measure in 19-20-year-old twins
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2019 (English)In: Psychological Medicine, ISSN 0033-2917, E-ISSN 1469-8978, Vol. 49, no 9, p. 1500-1509Article in journal (Refereed) Published
Abstract [en]

Background: The Triarchic Psychopathy Measure (TriPM) provides Disinhibition, Boldness, and Meanness scales for assessing the three trait domains of the triarchic model. Here we examined the genetic and environmental etiology of these three domains, including evaluation of potential sex differences.

Methods: A total of 1016 men and women ages 19–20 years were drawn from the University of Southern California Risk Factors for Antisocial Behavior twin study.

Results: Scores for the three TriPM scales were correlated to differing degrees, with the strongest phenotypic correlation between Disinhibition and Meanness. No sex differences were found in the genetic and environmental influences underlying these three domains, suggesting that the same genes and life experiences contribute to these traits in young men and women. For TriPM Disinhibition and Boldness, genetic factors explained about half or less of the variance, with the rest of the variance being explained by non-shared environmental factors. For TriPM Meanness, on the other hand, genetic, shared environmental, and non-shared environmental factors accounted for the variance. The phenotypic correlation between Disinhibition and Meanness was explained in part by common genes (26%), with the remainder attributable about equally to common shared (39%), and non-shared environmental influences (35%).

Conclusions: These findings contribute to our understanding of psychopathic personality traits by demonstrating the importance of heritable factors for disinhibition and boldness facets of psychopathy, and the importance of shared environmental influences for the meanness facet.

Place, publisher, year, edition, pages
Cambridge University Press, 2019
Keywords
Boldness, disinhibition, heritability, meanness, psychopathy, TriPM, twins
National Category
Psychology
Identifiers
urn:nbn:se:oru:diva-72365 (URN)10.1017/S0033291718002052 (DOI)000474922400009 ()30160231 (PubMedID)2-s2.0-85053012350 (Scopus ID)
Note

Funding Agency:

NIMH  K02 MH01114-08

Available from: 2019-02-10 Created: 2019-02-10 Last updated: 2019-11-08Bibliographically approved
Silventoinen, K., Tuvblad, C. & Kaprio, J. (2019). Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts. Obesity, 27(5), 855-865
Open this publication in new window or tab >>Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts
2019 (English)In: Obesity, ISSN 1930-7381, E-ISSN 1930-739X, Vol. 27, no 5, p. 855-865Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.

METHODS: A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.

RESULTS: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.

CONCLUSIONS: Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2019
National Category
Psychology
Identifiers
urn:nbn:se:oru:diva-73579 (URN)10.1002/oby.22451 (DOI)000465255700021 ()30950584 (PubMedID)2-s2.0-85063874197 (Scopus ID)
Funder
Swedish Heart Lung FoundationSwedish Asthma and Allergy AssociationSwedish Research Council, 340-2013-5867Stockholm County Council
Available from: 2019-04-08 Created: 2019-04-08 Last updated: 2019-06-19Bibliographically approved
Silventoinen, K., Tuvblad, C. & Kaprio, J. (2019). The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. Twin Research and Human Genetics, 22(6), 800-808, Article ID PII S1832427419000355.
Open this publication in new window or tab >>The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins
2019 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 22, no 6, p. 800-808, article id PII S1832427419000355Article in journal (Refereed) Published
Abstract [en]

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m(2)) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

Place, publisher, year, edition, pages
Cambridge University Press, 2019
Keywords
Twins, international comparisons, heritability, height, BMI, birth size, education
National Category
Medical Genetics Psychology
Identifiers
urn:nbn:se:oru:diva-80760 (URN)10.1017/thg.2019.35 (DOI)000517442200060 ()31364586 (PubMedID)2-s2.0-85070056867 (Scopus ID)
Available from: 2020-03-20 Created: 2020-03-20 Last updated: 2020-03-20Bibliographically approved
Fröberg, S., Larsson, H. & Tuvblad, C. (2019). The genetic and environmental overlap between callous-unemotional traits and ADHD symptoms among five year old twins. Paper presented at 49th Annual Meeting of the Behavior-Genetics-Association (BGA), Karolinska Institutet, Stockholm, Sweden, June 26-29, 2019. Behavior Genetics, 49(6), 522-522
Open this publication in new window or tab >>The genetic and environmental overlap between callous-unemotional traits and ADHD symptoms among five year old twins
2019 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 49, no 6, p. 522-522Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Disruptive behavior disorders (e.g., attention-deficit/hyperactivity disorder [ADHD], oppositional defiant disorder [ODD], conduct disorder [CD]) affect 5–10% of youth and represent the primary reason for youth referrals to clinicians (APA, 2013). DSM-V includes callous-unemotional (CU) traits (specifier ‘with prosocial emotions’) to CD (APA, 2013; Frick et al. 2014). Research suggests an association between CU traits and ADHD symptoms (Graziano et al. 2016; Babinski et al. 2017; Haas et al. 2018). The genetic and environmental overlap between CU traits and ADHD symptoms were examined in a sample of 1189 five year-old children using teacher-ratings, the PrEschool Twin Study in Sweden (PETSS). The correlations between CU traits and hyperactivity/impulsivity, and between CU traits and inattention were rp = 0.53, p\0.05 and 0.44, p\0.05, respectively. For CU traits, genetic factors accounted for 25%, p\0.05 of the variance, the shared environment accounted for 48%, p\0.05, and the non-shared environment for 27%, p\0.05. For hyperactivity/impulsivity, genetic factors accounted for 85%, p\0.05 of the variance and the non-shared environment accounted for 15%, p\0.05. For inattention, genetic factors accounted for 43%, p\0.05 of the variance, the shared envi ronment accounted for 38%, p\0.05, and the non-shared environment for 19%, p\0.05. For CU traits and hyperactivity/impulsivity, rg = 0.58 (0.36, 0.88), rc= 0.84 (0.46, 1.00), re= 0.24 (0.10, 0.37). For CU traits and inattention, rg = 0.33 (0.00, 0.61), rc= 0.63 (0.43, 0.82), re= 0.30 (0.17, 0.43). These findings indicate that CU traits and ADHD symptoms partly share a common genetic and environmental etiology.

Place, publisher, year, edition, pages
Springer, 2019
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-78624 (URN)10.1007/s10519-019-09973-8 (DOI)000494050500129 ()
Conference
49th Annual Meeting of the Behavior-Genetics-Association (BGA), Karolinska Institutet, Stockholm, Sweden, June 26-29, 2019
Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2019-12-16Bibliographically approved
Fröberg, S., Patrick, C. J. & Tuvblad, C. (2019). The Role of the Startle Reflex in Psychopathic Personality from Childhood to Adulthood: A Systematic Review. In: : . Paper presented at 8th Biennial Conference of the Society for the Scientific Study of Psychopathy, Las Vegas, Nevada, USA, May 2-5, 2019.
Open this publication in new window or tab >>The Role of the Startle Reflex in Psychopathic Personality from Childhood to Adulthood: A Systematic Review
2019 (English)Conference paper, Poster (with or without abstract) (Other academic)
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:oru:diva-74657 (URN)
Conference
8th Biennial Conference of the Society for the Scientific Study of Psychopathy, Las Vegas, Nevada, USA, May 2-5, 2019
Available from: 2019-06-11 Created: 2019-06-11 Last updated: 2019-06-13Bibliographically approved
Liu, J., Wong, K.-Y. K., Dong, F., Raine, A. & Tuvblad, C. (2019). The Schizotypal Personality Questionnaire - Child (SPQ-C): Psychometric properties and relations to behavioral problems with multi-informant ratings. Psychiatry Research, 275, 204-211
Open this publication in new window or tab >>The Schizotypal Personality Questionnaire - Child (SPQ-C): Psychometric properties and relations to behavioral problems with multi-informant ratings
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2019 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 275, p. 204-211Article in journal (Refereed) Published
Abstract [en]

The Schizotypal Personality Questionnaire (SPQ) is one of the most widely used screening tools for schizotypy in adults. The Schizotypal Personality Questionnaire-Child version (SPQ-C) was recently developed to assess schizotypy in children and has a similar three-factor structure to the adult SPQ (i.e., Cognitive-Perceptual, Interpersonal-Affective, and Disorganization). However, few studies to date have reported on the psychometric properties and the usefulness of the SPQ-C in Eastern populations, including Mainland China. This study presents the first psychometric assessment of the Chinese SPQ-C in Mainland China. Exploratory factor analysis and confirmatory factor analysis were used to assess the factor structure of the SPQ-C in 1668 children (M = 12.10, SD = 0.60 years) from the China Jintan Child Cohort Study. Our findings document a three-factor structure and partial measurement invariance across residential location and gender, replicating the psychometric properties of the SPQ-C in English. The Chinese SPQ-C further correlates with standard behavioral problems (i.e., Child Behavior Checklist, Youth Self-Report and Teacher Report Form), demonstrating construct validity and utility as a child psychopathology assessment tool. Our findings provide the first robust psychometric evidence for a three-factor structure of the Chinese SPQ-C in a large Mainland Chinese sample, and suggest that the SPQ-C is suitable as a screening tool for schizotypy in community children who may be at risk for behavioral problems and later psychosis.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Behavior problems, Child, Chinese, Externalizing, Internalizing, Psychometric analysis, Schizotypal personality disorder, Schizotypy
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-74210 (URN)10.1016/j.psychres.2019.03.006 (DOI)000469156400029 ()30928723 (PubMedID)2-s2.0-85063466117 (Scopus ID)
Funder
Swedish Research Council, 2018-01041
Note

Funding Agencies:

National Institute of Environmental Health Sciences  

National Institutes of Health  R01-ES-018858  K02-ES-019878  K01-ES015877 

Available from: 2019-05-10 Created: 2019-05-10 Last updated: 2019-06-19Bibliographically approved
Hur, Y.-M., Bogl, L. H., Ordoñana, J. R., Taylor, J., Hart, S. A., Tuvblad, C., . . . Willemsen, G. (2019). Twin Family Registries Worldwide: An Important Resource for Scientific Research. Twin Research and Human Genetics, 22(6), 427-437
Open this publication in new window or tab >>Twin Family Registries Worldwide: An Important Resource for Scientific Research
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2019 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, Vol. 22, no 6, p. 427-437Article in journal, Editorial material (Refereed) Published
Abstract [en]

Much progress has been made in twin research since our last special issue on twin registries (Hur, Y.-M., & Craig, J. M. (2013). Twin Research and Human Genetics, 16, 1-12.). This special issue provides an update on the state of twin family registries around the world. This issue includes 61 papers on twin family registries from 25 countries, of which 3 describe consortia based on collaborations of several twin family registries. The articles included in this issue discuss the establishment and maintenance of twin registries, recruitment strategies, methods of zygosity assessment, research aims and major findings from twin family cohorts, as well as other important topics related to twin studies. The papers amount to approximately 1.3 million monozygotic, dizygotic twins and higher order multiples and their family members who participate in twin studies around the world. Nine new twin family registries have been established across the world since our last issue, which demonstrates that twin registers are increasingly important in studies of the determinants and correlates of complex traits from disease susceptibility to healthy development.

Place, publisher, year, edition, pages
Cambridge University Press, 2019
Keywords
Environment, genetics, multiple birth, recruitment of twins, twin family registry, zygosity assessment
National Category
Medical Genetics
Identifiers
urn:nbn:se:oru:diva-79314 (URN)10.1017/thg.2019.121 (DOI)000517442200001 ()31937381 (PubMedID)2-s2.0-85078052166 (Scopus ID)
Available from: 2020-02-21 Created: 2020-02-21 Last updated: 2020-03-20Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0001-8768-6954

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