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Udumyan, Ruzan
Publications (10 of 43) Show all publications
Kantor, E. D., Udumyan, R., Giovannucci, E. L., Valdimarsdottir, U. A., Signorello, L. B., Montgomery, S. & Fall, K. (2019). Association of Blood Marker of Inflammation in Late Adolescence With Premature Mortality. JAMA pediatrics
Open this publication in new window or tab >>Association of Blood Marker of Inflammation in Late Adolescence With Premature Mortality
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2019 (English)In: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211Article in journal (Refereed) Epub ahead of print
Place, publisher, year, edition, pages
American Medical Association, 2019
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:oru:diva-76166 (URN)10.1001/jamapediatrics.2019.2835 (DOI)31479147 (PubMedID)
Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-10Bibliographically approved
Udumyan, R., Montgomery, S., Fang, F., Valdimarsdóttir, U., Hardardottir, H., Ekbom, A., . . . Fall, K. (2019). Beta-blocker use and lung cancer mortality in a nationwide cohort study of patients with primary non-small cell lung cancer. Cancer Epidemiology, Biomarkers and Prevention, Article ID cebp.0710.2019.
Open this publication in new window or tab >>Beta-blocker use and lung cancer mortality in a nationwide cohort study of patients with primary non-small cell lung cancer
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2019 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, article id cebp.0710.2019Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Beta-adrenergic receptor blockers have been associated with improved survival among patients with different types of malignancies, but available data for non-small cell lung cancer (NSCLC) patients is contradictory and limited to small hospital-based studies. We therefore aimed to investigate if β-blocker use at the time of cancer diagnosis is associated with lung cancer mortality in the largest general population-based cohort of patients with NSCLC to date.

PATIENTS AND METHODS: For this retrospectively defined nationwide cohort study, we used prospectively collected data from Swedish population and health registers. Through the Swedish Cancer Register, we identified 18,429 patients diagnosed with a primary NSCLC between 2006 and 2014 with follow-up to 2015. Cox regression was used to estimate the association between beta-blocker use at time of cancer diagnosis ascertained from the Prescribed Drug Register and cancer-specific mortality identified from the Cause of Death Register.

RESULTS: Over a median follow-up of 10.2 months, 14,994 patients died (including 13,398 from lung cancer). Compared with non-use, beta-blocker use (predominantly prevalent use, 93%) was not associated with lung cancer mortality [hazard ratio (95% confidence interval): 1.01 (0.97-1.06)]. However, the possibility that diverging associations for specific beta-blockers and some histopathological subtypes exist cannot be excluded.

CONCLUSION: In this nationwide cohort of NSCLC patients, beta-blocker use was not associated with lung cancer mortality when assessed in aggregate in the total cohort, but evidence for some beta-blockers is less conclusive.

IMPACT: Our results do not indicate that beta-blocker use at lung cancer diagnosis reduces the cancer-specific mortality rate in NSCLC patients.

Place, publisher, year, edition, pages
Prevention American Association for Cancer Research, 2019
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-77618 (URN)10.1158/1055-9965.EPI-19-0710 (DOI)31641010 (PubMedID)
Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2019-10-25Bibliographically approved
Petyaev, I. M., Dovgalevsky, P. Y., Klochkov, V. A., Chalyk, N. E., Pristensky, D. V., Chernyshova, M. P., . . . Bashmakov, Y. K. (2019). Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease (vol 6, pg 1770, 2018). Food Science & Nutrition, 7(4), 1551-1551
Open this publication in new window or tab >>Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease (vol 6, pg 1770, 2018)
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2019 (English)In: Food Science & Nutrition, E-ISSN 2048-7177, Vol. 7, no 4, p. 1551-1551Article in journal (Refereed) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2019
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-74643 (URN)10.1002/fsn3.1027 (DOI)000468649700039 ()2-s2.0-85064840912 (Scopus ID)
Available from: 2019-06-10 Created: 2019-06-10 Last updated: 2019-06-10Bibliographically approved
Sundin, P.-O., Udumyan, R., Fall, K. & Montgomery, S. (2019). Grip strength modifies the association between estimated glomerular filtration rate and all-cause mortality [Letter to the editor]. Nephrology, Dialysis and Transplantation, 34(10), 1799-1801
Open this publication in new window or tab >>Grip strength modifies the association between estimated glomerular filtration rate and all-cause mortality
2019 (English)In: Nephrology, Dialysis and Transplantation, ISSN 0931-0509, E-ISSN 1460-2385, Vol. 34, no 10, p. 1799-1801Article in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Oxford University Press, 2019
National Category
Urology and Nephrology
Identifiers
urn:nbn:se:oru:diva-75586 (URN)10.1093/ndt/gfz140 (DOI)000491254500024 ()31317193 (PubMedID)2-s2.0-85072904607 (Scopus ID)
Note

Funding Agencies:

Economic & Social Research Council (ESRC) RES-596-28-0001 ES/JO19119/1

Swedish county councils, Agreement on Medical Education and Research (ALF)  OLL-685971

Swedish government  OLL-685971

Available from: 2019-08-16 Created: 2019-08-16 Last updated: 2019-11-15Bibliographically approved
Wijk, L., Udumyan, R., Pache, B., Altman, A. D., Williams, L. L., Elias, K. M., . . . Nelson, G. (2019). International validation of Enhanced Recovery After Surgery Society guidelines on enhanced recovery for gynecologic surgery. American Journal of Obstetrics and Gynecology, 221(3), 237.e1-237.e11
Open this publication in new window or tab >>International validation of Enhanced Recovery After Surgery Society guidelines on enhanced recovery for gynecologic surgery
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2019 (English)In: American Journal of Obstetrics and Gynecology, ISSN 0002-9378, E-ISSN 1097-6868, Vol. 221, no 3, p. 237.e1-237.e11Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The Enhanced Recovery After Surgery (ERAS) Society publishes guidelines on perioperative care, but these guidelines should be validated prospectively.

OBJECTIVES: To evaluate the association between compliance to ERAS Gynecologic/Oncology guideline elements and postoperative outcomes in an international cohort.

STUDY DESIGN: The study was comprised of 2,101 patients undergoing elective gynecologic/oncology surgery between January 2011 - November 2017 in 10 hospitals across Canada, the United States and Europe. Patient demographics, surgical/anesthesia details and ERAS protocol compliance elements (pre-, intra- and post-operative phases) were entered into the ERAS Interactive Audit System. Surgical complexity was stratified according to the Aletti scoring system (low versus medium/high). The following covariates were accounted for in the analysis: age, Body Mass Index, smoking status, presence of diabetes, American Society of Anesthesiologists class, International Federation of Gynecology and Obstetrics stage, preoperative chemotherapy, radiotherapy, operating time, surgical approach (open versus minimally invasive), intra-operative blood loss, hospital and ERAS implementation status. The primary end-points were primary hospital length of stay and complications. Negative binomial regression was used to model length of stay, and logistic regression to model complications, as a function of compliance score and covariates.

RESULTS: Patient demographics: median age 56 years, 35.5% obese,15% smokers, 26.7% American Society of Anesthesiologists Class III-IV. Final diagnosis was malignant in 49% of patients. Laparotomy was used in 75.9% of cases, and the remainder minimally invasive surgery. The majority of cases (86%) were of low complexity (Aletti score ≤ 3). In patients with ovarian cancer, 69.5% had a medium/high complexity surgery (Aletti score 4-11). Median length of stay was 2 days in the low- and 5 days in the medium/high-complexity group. Every unit increase in ERAS guideline score was associated with 8% (IRR: 0.92 (95% CI: 0.90 - 0.95; p<0.001)) decrease in days in hospital among low-complexity, and 12% (IRR: 0.88 (95% CI: 0.82 - 0.93; p<0.001) decrease among patients with medium/high complexity scores. For every unit increase in ERAS guideline score, the odds of total complications were estimated to be 12% lower (p<0.05) among low-complexity patients.

CONCLUSION: Audit of surgical practices demonstrates that improved compliance with ERAS Gynecologic/Oncology guidelines is associated with an improvement in clinical outcomes, including length of stay, highlighting the importance of ERAS implementation.

Place, publisher, year, edition, pages
Harcourt International Publishers, 2019
Keywords
ERAS, compliance, gynecologic oncology, gynecologic surgery, length of stay, perioperative care
National Category
Obstetrics, Gynecology and Reproductive Medicine Surgery
Identifiers
urn:nbn:se:oru:diva-74194 (URN)10.1016/j.ajog.2019.04.028 (DOI)000484395000012 ()31051119 (PubMedID)2-s2.0-85067447508 (Scopus ID)
Note

Funding Agencies:

Research Committee of Örebro County Council  

Reproductive Scientist Development Program  NICHD K12HD00849

Available from: 2019-05-13 Created: 2019-05-13 Last updated: 2019-11-13Bibliographically approved
Udumyan, R., Montgomery, S., Fang, F., Valdimarsdóttir, U. & Fall, K. (2019). Stress resilience in late adolescence and survival among cancer patients: a Swedish register-based cohort study. Cancer Epidemiology, Biomarkers and Prevention, 28(2), 400-408
Open this publication in new window or tab >>Stress resilience in late adolescence and survival among cancer patients: a Swedish register-based cohort study
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2019 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 28, no 2, p. 400-408Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Chronic stress has been suggested to play a role in cancer progression, but few studies have so far examined the potential influence of stress susceptibility. This national register-based cohort study utilizes a unique data source to investigate whether a stress resilience measure is associated with survival in cancer patients.

METHODS: The cohort includes 9,318 Swedish male cancer patients born during 1952-1956 who had their stress resilience evaluated at a semi-structured interview with a psychologist during mandatory conscription examination in late adolescence.

RESULTS: Over a median of 3 years of follow-up from cancer diagnosis, a total of 2,541 patients died (2,322 from cancer). Overall, low (23%) compared with high (25%) stress resilience was associated with increased mortality (adjusted hazard ratio estimated by Cox regression 1.45; 95% confidence interval 1.28-1.65), particularly among men with carcinomas of the oropharynx (2.62, 1.24-5.56), upper respiratory tract (4.64, 1.05-20.41), and prostate (2.20, 1.04-4.62), as well as with Hodgkin's lymphoma (3.52, 1.40-8.86). An association was evident both for cancer types associated with smoking (1.35, 1.10-1.66) and malignancies without an established smoking aetiology (1.32, 1.12-1.56). The association between low stress resilience and mortality could partly be explained by tumour stage, marital status, and psychiatric comorbidity at cancer diagnosis.

CONCLUSIONS: We observed an association between low stress resilience and mortality among men diagnosed with cancer, particularly, oropharyngeal cancer, upper respiratory tract cancers, prostate cancer and Hodgkin's lymphoma.

IMPACT: These results suggest that individual variation in stress resilience may influence survival among men with some cancer types.

Place, publisher, year, edition, pages
American Association for Cancer Research, 2019
National Category
Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:oru:diva-69907 (URN)10.1158/1055-9965.EPI-18-0451 (DOI)000465321600019 ()30333220 (PubMedID)2-s2.0-85061062199 (Scopus ID)
Funder
Swedish Cancer Society, CAN 2013/650
Note

Funding Agency:

UK Economic and Social Research Council (ESRC)  RES-596-28-0001

Available from: 2018-11-06 Created: 2018-11-06 Last updated: 2019-05-03Bibliographically approved
Ugge, H., Udumyan, R., Carlsson, J., Andrén, O., Montgomery, S., Davidsson, S. & Fall, K. (2018). Acne in late adolescence and risk of prostate cancer. International Journal of Cancer, 1580-1585
Open this publication in new window or tab >>Acne in late adolescence and risk of prostate cancer
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2018 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, p. 1580-1585Article in journal (Refereed) Published
Abstract [en]

Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n= 243,187). Test information along with health data including medical diagnoses at time of conscription was available through the Swedish Military Conscription Register and the National Patient Register. The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31st 2009. We used Cox regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between acne in adolescence and prostate cancer risk. A total of 1,633 men were diagnosed with prostate cancer during a median follow-up of 36.7 years. A diagnosis of acne was associated with a statistically significant increased risk for prostate cancer (adjusted HR: 1.43 95%; CI: 1.06-1.92), particularly for advanced stage disease (HR: 2.37 95%; CI 1.19-4.73). A diagnosis of acne classified as severe conferred a 6-fold increased risk of prostate cancer (HR: 5.70 95% CI 1.42-22.85). Data from this large prospective population-based cohort add new evidence supporting a role of P acnes infection in prostate cancer.

Place, publisher, year, edition, pages
Hoboken, NJ, USA: John Wiley & Sons, 2018
Keywords
Propionibacterium acnes; prostate cancer; acne vulgaris; inflammation; acne vulgaris
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-63302 (URN)10.1002/ijc.31192 (DOI)000425184800009 ()29205339 (PubMedID)2-s2.0-85037982996 (Scopus ID)
Note

Funding Agency:

UK Economic and Social Research Council (ESRC)  RES-596-28-0001  ES/JO19119/1

Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2019-04-09Bibliographically approved
Ugge, H., Udumyan, R., Carlsson, J., Davidsson, S., Andrén, O., Montgomery, S. & Fall, K. (2018). Appendicitis before age 20 years is associated with an increased risk of later prostate cancer. Cancer Epidemiology, Biomarkers and Prevention, 27(6), 660-664
Open this publication in new window or tab >>Appendicitis before age 20 years is associated with an increased risk of later prostate cancer
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2018 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 27, no 6, p. 660-664Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Appendicitis before age 20 years has been observed to influence the risk of several inflammatory conditions, possibly through underlying immunological mechanisms. Inflammation has further been suggested to be involved in prostate cancer development. We therefore hypothesized that immunological characteristics signaled by appendicitis before late adolescence might influence the risk of later prostate cancer, and aimed to evaluate this association in a population-based study.

METHODS: We identified a large cohort of Swedish men who underwent assessment for military conscription around the age of 18 years (n= 242,573). Medical diagnoses at time of conscription were available through the Swedish Military Conscription Register. The Swedish Cancer Register was used to identify diagnoses of prostate cancer. Multivariable adjusted Cox regression analyses were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between appendicitis and prostate cancer.

RESULTS: During a median of 36.7 years of follow-up, 1,684 diagnoses of prostate cancer occurred. We found a statistically significant association between appendicitis and overall prostate cancer (adjusted HR: 1.70; 95% CI: 1.08-2.67). The risk was notably increased for advanced (HR: 4.42; 95% CI: 1.74-11.22) and lethal (HR: 8.95; 95% CI: 2.98-26.91) prostate cancer.

CONCLUSION: These results suggest that a diagnosis of appendicitis before adulthood potentially signals underlying immune characteristics and a pattern of inflammatory response relevant to prostate cancer risk.

IMPACT: The study lends support to the proposed role of inflammation in prostate carcinogenesis, and adds another area of investigation potentially relevant to prostate cancer development.

Place, publisher, year, edition, pages
American Association for Cancer Research, 2018
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-66449 (URN)10.1158/1055-9965.EPI-17-1204 (DOI)000433945800006 ()29588305 (PubMedID)2-s2.0-85047896683 (Scopus ID)
Note

Funding Agency:

UK Economic and Social Research Council (ESRC)  RES-596-28-0001  ES/JO19119/1

Available from: 2018-04-13 Created: 2018-04-13 Last updated: 2019-04-09Bibliographically approved
Eriksson, C., Bergemalm, D., Vigren, L., Nilsson, L., Visuri, I., Hjortswang, H., . . . Halfvarson, J. (2018). Clinical effectiveness of golimumab: Interim analysis of the observational study of patients with ulcerative colitis on golimumab in the Swedish National Quality Registry for IBD-GO-SWIBREG. Paper presented at 13th Congress of ECCO – European Crohn’s and Colitis Organisation, Vienna, Austria, February 14-17, 2018. Journal of Crohn's & Colitis, 12(Suppl. 1), S409-S410
Open this publication in new window or tab >>Clinical effectiveness of golimumab: Interim analysis of the observational study of patients with ulcerative colitis on golimumab in the Swedish National Quality Registry for IBD-GO-SWIBREG
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2018 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S409-S410Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Oxford University Press, 2018
National Category
Gastroenterology and Hepatology
Identifiers
urn:nbn:se:oru:diva-66750 (URN)000427318901372 ()
Conference
13th Congress of ECCO – European Crohn’s and Colitis Organisation, Vienna, Austria, February 14-17, 2018
Note

Funding Agency:

MSD

Available from: 2018-04-26 Created: 2018-04-26 Last updated: 2018-08-31Bibliographically approved
Eriksson, C., Rundquist, S., Lykiardopoulos, V., Karlen, P., Grip, O., Söderman, C., . . . Halfvarson, J. (2018). Clinical effectiveness of vedolizumab: Interim analysis of the Swedish observational study on vedolizumab assessing effectiveness and healthcare resource utilisation in patients with Crohn's disease (SVEAH CD). Journal of Crohn's & Colitis, 12(Suppl. 1), S494-S495
Open this publication in new window or tab >>Clinical effectiveness of vedolizumab: Interim analysis of the Swedish observational study on vedolizumab assessing effectiveness and healthcare resource utilisation in patients with Crohn's disease (SVEAH CD)
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2018 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S494-S495Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Oxford University Press, 2018
National Category
Gastroenterology and Hepatology
Identifiers
urn:nbn:se:oru:diva-66751 (URN)000427318902141 ()
Available from: 2018-04-26 Created: 2018-04-26 Last updated: 2018-08-30Bibliographically approved
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