Open this publication in new window or tab >>Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy.
Department of Environmental Engineering,Technical University of Denmark, Kgs Lyngby, Denmark.
Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
Faculty of Science, RECETOX, Masaryk University, Brno, Czech Republic.
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France.
Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy.
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France.
Analytical and Environmental Sciences Division, King's College, London, UK.
European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Ispra, Italy.
Marine Biology Station Piran, National Institute of Biology, Ljubljana, Slovenia.
University of Natural Resources and Life Sciences, Vienna, Austria.
University of Natural Resources and Life Sciences, Vienna, Austria.
Diabetes and Nutritional Sciences Division, King's College London, London, UK.
Faculty of Science, RECETOX, Masaryk University, Brno, Czech Republic.
Örebro University, School of Science and Technology.
European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Ispra, Italy.
National Institute of Nutrition and Seafood Research, Bergen, Norway.
Örebro University, School of Science and Technology. Life Science Center, Örebro University, Örebro, Sweden.
Örebro University, School of Science and Technology. Life Science Center, Örebro University, Örebro, Sweden.
University of Natural Resources and Life Sciences, Vienna, Austria.
Analytical and Environmental Sciences Division, King's College, London, UK.
Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy.
National Institute for Industrial Environment and Risks, Verneuil en Halatte, France.
Swiss Centre for Applied Ecotoxicology, Eawag-EPFL, Dübendorf, Switzerland.
Swiss Centre for Applied Ecotoxicology, Eawag-EPFL, Dübendorf, Switzerland.
Department of Environmental and Life Sciences, Universita del Piemonte Orientale Vercelli Novara Alessandria, Alessandria, Italy.
Analytical and Environmental Sciences Division, King's College, London, UK.
National Institute of Nutrition and Seafood Research, Bergen, Norway.
Marine Biology Station Piran, National Institute of Biology, Ljubljana, Slovenia.
Department of Environmental and Life Sciences, Università del Piemonte Orientale Vercelli Novara Alessandria, Alessandria, Italy.
Swiss Centre for Applied Ecotoxicology, Swiss Federal Institute of Aquatic Science and Technology ( Eawag-EPFL), Dübendorf, Switzerland.
Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
Faculty of Science, RECETOX, Masaryk University, Brno, Czech Republic.
European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Rome, Italy.
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2014 (English)In: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 141, no 1, p. 218-233Article in journal (Refereed) Published
Abstract [en]
The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.
Keywords
bioassays, effects, mixtures, ecotoxicology, biomarkers
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
urn:nbn:se:oru:diva-38654 (URN)10.1093/toxsci/kfu118 (DOI)000342990200026 ()24958932 (PubMedID)2-s2.0-84913611065 (Scopus ID)
Note
Funding Agencies:
RADAR 265721
French Office Water and Aquatic Environment
French Ministry for Ecology and Sustainable Development P181 DRC50
2014-11-172014-11-172023-12-08Bibliographically approved