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Publications (10 of 234) Show all publications
McQueen, K., Oodit, R., Derbew, M., Banguti, P. & Ljungqvist, O. (2018). Authors' Reply: Enhanced Recovery After Surgery for Low and Middle-Income Countries [Letter to the editor]. World Journal of Surgery
Open this publication in new window or tab >>Authors' Reply: Enhanced Recovery After Surgery for Low and Middle-Income Countries
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2018 (English)In: World Journal of Surgery, ISSN 0364-2313, E-ISSN 1432-2323Article in journal, Letter (Refereed) Epub ahead of print
Place, publisher, year, edition, pages
Taylor & Francis, 2018
National Category
Social Sciences Interdisciplinary
Identifiers
urn:nbn:se:oru:diva-67024 (URN)10.1007/s00268-018-4652-4 (DOI)29717348 (PubMedID)
Available from: 2018-05-18 Created: 2018-05-18 Last updated: 2018-05-18Bibliographically approved
Francis, N. K., Walker, T., Carter, F., Hübner, M., Balfour, A., Jakobsen, D. H., . . . Ljungqvist, O. (2018). Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study. World Journal of Surgery
Open this publication in new window or tab >>Consensus on Training and Implementation of Enhanced Recovery After Surgery: A Delphi Study
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2018 (English)In: World Journal of Surgery, ISSN 0364-2313, E-ISSN 1432-2323Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Enhanced Recovery After Surgery (ERAS) is widely accepted in current surgical practice due to its positive impact on patient outcomes. The successful implementation of ERAS is challenging and compliance with protocols varies widely. Continual staff education is essential for successful ERAS programmes. Teaching modalities exist, but there remains no agreement regarding the optimal training curriculum or how its effectiveness is assessed. We aimed to draw consensus from an expert panel regarding the successful training and implementation of ERAS.

METHODS: A modified Delphi technique was used; three rounds of questionnaires were sent to 58 selected international experts from 11 countries across multiple ERAS specialities and multidisciplinary teams (MDT) between January 2016 and February 2017. We interrogated opinion regarding four topics: (1) the components of a training curriculum and the structure of training courses; (2) the optimal framework for successful implementation and audit of ERAS including a guide for data collection; (3) a framework to assess the effectiveness of training; (4) criteria to define ERAS training centres of excellence.

RESULTS: An ERAS training course must cover the evidence-based principles of ERAS with team-oriented training. Successful implementation requires strong leadership, an ERAS facilitator and an effective MDT. Effectiveness of training can be measured by improved compliance. A training centre of excellence should show a willingness to teach and demonstrable team working.

CONCLUSIONS: We propose an international expert consensus providing an ERAS training curriculum, a framework for successful implementation, methods for assessing effectiveness of training and a definition of ERAS training centres of excellence.

Place, publisher, year, edition, pages
Springer, 2018
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:oru:diva-64040 (URN)10.1007/s00268-017-4436-2 (DOI)29302724 (PubMedID)
Available from: 2018-01-12 Created: 2018-01-12 Last updated: 2018-01-12Bibliographically approved
Blixt, C., Ahlstedt, C., Ljungqvist, O., Isaksson, B., Kalman, S. & Rooyackers, O. (2018). Corrigendum to ‘The effect of perioperative glucose control on postoperative insulin resistance’ [Clin Nutr 31 (5) (2012) 676–681]. Clinical Nutrition, 37(3), 1091-1091
Open this publication in new window or tab >>Corrigendum to ‘The effect of perioperative glucose control on postoperative insulin resistance’ [Clin Nutr 31 (5) (2012) 676–681]
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2018 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 37, no 3, p. 1091-1091Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-67204 (URN)10.1016/j.clnu.2018.03.007 (DOI)000432879800054 ()29599083 (PubMedID)2-s2.0-85044278044 (Scopus ID)
Available from: 2018-06-11 Created: 2018-06-11 Last updated: 2018-06-11Bibliographically approved
McQueen, K., Oodit, R., Derbew, M., Banguti, P. & Ljungqvist, O. (2018). Enhanced Recovery After Surgery for Low- and Middle-Income Countries. World Journal of Surgery, 42(4), 950-952
Open this publication in new window or tab >>Enhanced Recovery After Surgery for Low- and Middle-Income Countries
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2018 (English)In: World Journal of Surgery, ISSN 0364-2313, E-ISSN 1432-2323, Vol. 42, no 4, p. 950-952Article in journal, Editorial material (Refereed) Published
Place, publisher, year, edition, pages
Springer, 2018
National Category
Surgery
Identifiers
urn:nbn:se:oru:diva-64847 (URN)10.1007/s00268-018-4481-5 (DOI)000427050900006 ()29383424 (PubMedID)2-s2.0-85041176141 (Scopus ID)
Available from: 2018-02-07 Created: 2018-02-07 Last updated: 2018-04-03Bibliographically approved
Ljungqvist, O. & Hubner, M. (2018). Enhanced recovery after surgery-ERAS-principles, practice and feasibility in the elderly. Aging Clinical and Experimental Research, 30(3), 249-252
Open this publication in new window or tab >>Enhanced recovery after surgery-ERAS-principles, practice and feasibility in the elderly
2018 (English)In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319, Vol. 30, no 3, p. 249-252Article, review/survey (Refereed) Published
Abstract [en]

This is a short overview of the principles of a novel development in surgery called enhanced recovery after surgery (ERAS) programs. This is an evidence-based approach to perioperative care that has shown to reduce complications and recovery time by 30-50%. The main mechanism is reduction of the stress reactions to the operation. These principles have been shown to be particularly well suited for the compromised patient and hence very good for the elderly people who often have co-morbidities and run a higher risk of complications.

Place, publisher, year, edition, pages
Springer, 2018
Keywords
Surgery; Stress; Recovery; Elderly
National Category
Geriatrics
Identifiers
urn:nbn:se:oru:diva-65196 (URN)10.1007/s40520-018-0905-1 (DOI)000427751600006 ()29453605 (PubMedID)
Note

Funding Agency:

Nyckelfonden, Örebro, Sweden

Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-04-09Bibliographically approved
Frauche, P., Hübner, M. & Ljungqvist, O. (2018). Fast-track and ERAS programs i Geriatric Surgery (1ed.). In: G. Bettelli (Ed.), Perioperative Care of the Elderly: Clinical and Organizational Aspects (pp. 226-232). Cambridge, United Kingdom: Cambridge University Press
Open this publication in new window or tab >>Fast-track and ERAS programs i Geriatric Surgery
2018 (English)In: Perioperative Care of the Elderly: Clinical and Organizational Aspects / [ed] G. Bettelli, Cambridge, United Kingdom: Cambridge University Press, 2018, 1, p. 226-232Chapter in book (Refereed)
Place, publisher, year, edition, pages
Cambridge, United Kingdom: Cambridge University Press, 2018 Edition: 1
National Category
Medical and Health Sciences Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:oru:diva-64365 (URN)978-1-107-13934-3 (ISBN)
Available from: 2018-01-17 Created: 2018-01-17 Last updated: 2018-02-21Bibliographically approved
Wijk, L., Nilsson, K. & Ljungqvist, O. (2018). Metabolic and inflammatory responses and subsequent recovery in robotic versus abdominal hysterectomy: A randomised controlled study. Clinical Nutrition, 37(1), 99-106
Open this publication in new window or tab >>Metabolic and inflammatory responses and subsequent recovery in robotic versus abdominal hysterectomy: A randomised controlled study
2018 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 37, no 1, p. 99-106Article in journal (Refereed) Published
Abstract [en]

BACKGROUND & AIMS: Surgery causes inflammatory and metabolic responses in the body. The aim of the study was to investigate whether robotic-assisted total laparoscopic hysterectomy induces less insulin resistance than abdominal hysterectomy, and to compare inflammatory response and clinical recovery between the two techniques.

METHODS: A randomised controlled study at the Department of Obstetrics and Gynaecology, Örebro University Hospital, Sweden. Twenty women scheduled for a planned total hysterectomy with or without salpingo-oophorectomy between October 2014 and May 2015, were randomly allocated to robotic-assisted total laparoscopic hysterectomy or abdominal hysterectomy. Insulin resistance after surgery was measured by the hyperinsulinemic normoglycaemic clamp method, inflammatory response measured in blood samples, and clinical recovery outcomes registered.

RESULTS: There were no differences in development of insulin resistance between the robotic group and the abdominal group (mean ± SD: 39% ± 22 vs. 40% ± 19; p = 0.948). The robotic group had a significantly shorter hospital stay (median 1 vs. 2 days; p = 0.005). Inflammatory reaction differed; in comparison to the robotic group, the abdominal group showed significantly higher increases in serum interleukin 6 levels, white blood cell count and cortisol from preoperative values to postoperative peak values.

CONCLUSIONS: Robotic laparoscopic surgery reduced inflammatory responses and recovery time, but these changes were not accompanied by decreased insulin resistance.

CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov Identifier no NCT02291406.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Robotic-assisted hysterectomy; Insulin resistance; Hysterectomy; Inflammatory response
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
urn:nbn:se:oru:diva-58062 (URN)10.1016/j.clnu.2016.12.015 (DOI)000425564200010 ()28043722 (PubMedID)
Note

Funding Agencies:

Research Committee of Örebro County Council

Nyckelfonden

Stiftelsen Gynekologisk Onkologi

Lisa och Göran Grönbergs Stiftelse

Available from: 2017-06-16 Created: 2017-06-16 Last updated: 2018-03-12Bibliographically approved
Martin, D., Roulin, D., Grass, F., Addor, V., Ljungqvist, O., Demartines, N. & Hübner, M. (2017). A multicentre qualitative study assessing implementation of an Enhanced Recovery After Surgery program. Clinical Nutrition
Open this publication in new window or tab >>A multicentre qualitative study assessing implementation of an Enhanced Recovery After Surgery program
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2017 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND & AIMS: The existence of enhanced recovery specific guidelines (ERAS) is not enough to change patient management practice since many barriers exist to successful ERAS implementation. The present survey aimed to analyse motivations for implementation as well as encountered difficulties and challenges. Further, relevance and importance of perioperative care items and postoperative recovery targets were assessed.

METHODS: A multicentre qualitative study was conducted between August and December 2016 among surgeons, anaesthesiologists and nurses from implemented ERAS centres in Switzerland (n = 16) and Sweden (n = 14). An online survey (31 closed questions) was sent by email, with reminders at 4, 8 and 12 weeks.

RESULTS: Seventy-seven out of 146 experts completed the survey (response rate 52.7%). Main motivations to implement ERAS were the expectation to reduce complications (91%), higher patient satisfaction (73%) and shorter hospital stay (62%). The application of ERAS program represented major changes in clinical practice for 57% of participants without significant differences between various specialities (surgeons: 63%, nurses: 63%, anaesthesiologists: 36%, p = 0.185). The most important barriers for straightforward implementation were time restraints (69%), opposing colleagues (68%) and logistical reasons (66%). The 3 most frequently cited patient-related barriers to adopt ERAS were opposing personality (52%), co-morbidities (49%) and language barriers (31%).

CONCLUSIONS: Implementing ERAS care into practice was challenging and required important changes in clinical practice for all involved specialities. Main reasons for implementation were the expectation to reduce complications and hospital stay with improved patients' satisfaction. Main barriers were time restraints, reluctance to change and logistics.

Place, publisher, year, edition, pages
Churchill Livingstone, 2017
Keywords
Enhanced recovery after surgery, implementation, qualitative study
National Category
Medical and Health Sciences Nursing Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:oru:diva-64350 (URN)10.1016/j.clnu.2017.10.017 (DOI)29129637 (PubMedID)
Available from: 2018-01-17 Created: 2018-01-17 Last updated: 2018-01-19Bibliographically approved
Barazzoni, R., Deutz, N. E., Biolo, G., Bischoff, S., Boirie, Y., Cederholm, T., . . . Calder, P. C. (2017). Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group. Clinical Nutrition, 36(2), 355-363
Open this publication in new window or tab >>Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group
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2017 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 36, no 2, p. 355-363Article, review/survey (Refereed) Published
Abstract [en]

Growing evidence underscores the important role of glycemic control in health and recovery from illness. Carbohydrate ingestion in the diet or administration in nutritional support is mandatory, but carbohydrate intake can adversely affect major body organs and tissues if resulting plasma glucose becomes too high, too low, or highly variable. Plasma glucose control is especially important for patients with conditions such as diabetes or metabolic stress resulting from critical illness or surgery. These patients are particularly in need of glycemic management to help lessen glycemic variability and its negative health consequences when nutritional support is administered. Here we report on recent findings and emerging trends in the field based on an ESPEN workshop held in Venice, Italy, 8-9 November 2015. Evidence was discussed on pathophysiology, clinical impact, and nutritional recommendations for carbohydrate utilization and management in nutritional support. The main conclusions were: a) excess glucose and fructose availability may exacerbate metabolic complications in skeletal muscle, adipose tissue, and liver and can result in negative clinical impact; b) low-glycemic index and high-fiber diets, including specialty products for nutritional support, may provide metabolic and clinical benefits in individuals with obesity, insulin resistance, and diabetes; c) in acute conditions such as surgery and critical illness, insulin resistance and elevated circulating glucose levels have a negative impact on patient outcomes and should be prevented through nutritional and/or pharmacological intervention. In such acute settings, efforts should be implemented towards defining optimal plasma glucose targets, avoiding excessive plasma glucose variability, and optimizing glucose control relative to nutritional support. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.

Place, publisher, year, edition, pages
Churchill Livingstone, 2017
Keywords
Clinical nutrition, Carbohydrates, Insulin resistance
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-57777 (URN)10.1016/j.clnu.2016.09.010 (DOI)000399624700003 ()27686693 (PubMedID)2-s2.0-84998911197 (Scopus ID)
Available from: 2017-05-23 Created: 2017-05-23 Last updated: 2017-10-18Bibliographically approved
Temple-Oberle, C., Shea-Budgell, M. A., Tan, M., Semple, J. L., Schrag, C., Barreto, M., . . . Ljungqvist, O. (2017). Consensus Review of Optimal Perioperative Care in Breast Reconstruction: Enhanced Recovery after Surgery (ERAS) Society Recommendations. Plastic and reconstructive surgery (1963), 139(5), 1056E-1071E
Open this publication in new window or tab >>Consensus Review of Optimal Perioperative Care in Breast Reconstruction: Enhanced Recovery after Surgery (ERAS) Society Recommendations
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2017 (English)In: Plastic and reconstructive surgery (1963), ISSN 0032-1052, E-ISSN 1529-4242, Vol. 139, no 5, p. 1056E-1071EArticle, review/survey (Refereed) Published
Abstract [en]

Background: Enhanced recovery following surgery can be achieved through the introduction of evidence-based perioperative maneuvers. This review aims to present a consensus for optimal perioperative management of patients undergoing breast reconstructive surgery and to provide evidence-based recommendations for an enhanced perioperative protocol.

Methods: A systematic review of meta-analyses, randomized controlled trials, and large prospective cohorts was conducted for each protocol element. Smaller prospective cohorts and retrospective cohorts were considered only when higher level evidence was unavailable. The available literature was graded by an international panel of experts in breast reconstructive surgery and used to form consensus recommendations for each topic. Each recommendation was graded following a consensus discussion among the expert panel. Development of these recommendations was endorsed by the Enhanced Recovery after Surgery Society.

Results: High-quality randomized controlled trial data in patients undergoing breast reconstruction informed some of the recommendations; however, for most items, data from lower level studies in the population of interest were considered along with extrapolated data from high-quality studies in non-breast reconstruction populations. Recommendations were developed for a total of 18 unique enhanced recovery after surgery items and are discussed in the article. Key recommendations support use of opioid-sparing perioperative medications, minimal preoperative fasting and early feeding, use of anesthetic techniques that decrease postoperative nausea and vomiting and pain, use of measures to prevent intraoperative hypothermia, and support of early mobilization after surgery.

Conclusion: Based on the best available evidence for each topic, a consensus review of optimal perioperative care for patients undergoing breast reconstruction is presented.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017
National Category
Surgery
Identifiers
urn:nbn:se:oru:diva-58960 (URN)10.1097/PRS.0000000000003242 (DOI)000404678400008 ()28445352 (PubMedID)2-s2.0-85020314040 (Scopus ID)
Note

Funding Agency:

Nyckelfonden, Örebro, Sweden

Available from: 2017-08-18 Created: 2017-08-18 Last updated: 2017-09-18Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-2636-4745

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