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2019 (English)In: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 28, no 10, p. 1329-1340Article in journal (Refereed) Published
Abstract [en]
The importance of Vesicular Glutamate Transporter 2 (VGLUT2)-mediated neurotransmission has been highlighted in studies on addiction-related phenotypes. The single nucleotide polymorphism rs2290045 in VGLUT2 has been associated with alcohol dependence, but it is unknown whether or how this association is affected by environmental factors. The present study determined whether the association of alcohol-related problems with the rs2290045 in the VGLUT2 gene was modified by negative and positive environmental factors. Three samples were included: a clinical sample of 131 adolescents followed from age 17 to 22; a general population sample of 1794 young adults; and a general population sample of 1687 adolescents followed from age 14 to 17. DNA was extracted from saliva and the rs2290045 (T/C) was genotyped. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test. Stressful life events (SLE) and parenting were assessed by questionnaires. Gene-environment interactions were investigated using a dual statistical approach. In all samples (effect sizes 0.6-6.2%), and consistent with the differential susceptibility framework, T carriers exposed to SLE reported more alcohol-related problems if they had experienced poor parenting, and lower alcohol-related problems if they had received supportive parenting. T carriers not exposed to SLE reported higher alcohol-related problems if they had received supportive parenting and lower alcohol-related problems if they had received poor parenting. Among CC carriers, alcohol-related problems did not vary as a function of negative and positive environmental factors. In conclusion, in three samples of youths, alcohol-related problems were associated with an interaction of VGLUT2 rs2290045, SLE, and parenting.
Place, publisher, year, edition, pages
Springer, 2019
Keywords
Adolescents, Alcohol, Gene, Glutamate, Stress, VGLUT2
National Category
Psychiatry Substance Abuse
Identifiers
urn:nbn:se:oru:diva-72879 (URN)10.1007/s00787-019-01293-w (DOI)000489301800006 ()30805764 (PubMedID)2-s2.0-85062073264 (Scopus ID)
Funder
Fredrik och Ingrid Thurings StiftelseThe Swedish Brain Foundation, PS2013-0052Forte, Swedish Research Council for Health, Working Life and Welfare, 2015-00897Stiftelsen Söderström - Königska sjukhemmet, SLS-559921Swedish National Board of Health and WelfareÅke Wiberg FoundationSwedish Research Council, 2013-4657 2014-3804 VR: 2015-00495
Note
Funding Agencies:
Alcohol Research Council of the Swedish Alcohol Retailing Monopoly
Lars Hierta's Minne foundation
Lundberg's and Karlsson's foundation
Uppsala and Örebro Regional Research Council
County Council of Västmanland
Swedish Psychiatric Foundation
Research Foundations of Bertil Hallsten and Ahlen
European Union (EU)
INCA 600398 SciLifeLab
2019-03-042019-03-042019-11-12Bibliographically approved