oru.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Fiedler, Heidelore, Dr.ORCID iD iconorcid.org/0000-0003-1496-9245
Publications (10 of 94) Show all publications
Sun, Z., Yang, X., Liu, Q. S., Li, C., Zhou, Q., Fiedler, H., . . . Jiang, G. (2019). Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells. Journal of Hazardous Materials, 379, Article ID UNSP 120794.
Open this publication in new window or tab >>Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells
Show others...
2019 (English)In: Journal of Hazardous Materials, ISSN 0304-3894, E-ISSN 1873-3336, Vol. 379, article id UNSP 120794Article in journal (Refereed) Published
Abstract [en]

Butylated hydroxyanisole (BHA) isomers, as the widely used anthropogenic antioxidants in food, have been revealed to induce endocrine disrupting effects, while the mechanism how BHA isomers regulate the lipogenic differentiation remains to be elucidated. Using 3T3-L1 differentiation model, the effects of BHA isomers, including 2-tert-butyl-4-hydroxyanisole (2-BHA), 3-tert-butyl-4-hydroxyanisole (3-BHA) and their mixture (BHA), on adipogenesis were tested. The results showed that 3-BHA and BHA promoted adipocyte differentiation and enhanced the cellular lipid accumulation through the regulation of the transcriptional and protein levels of the adipogenetic biomarkers, while 2-BHA had no effect. The effective window for 3-BHA induced lipogenesis was the first four days during 3T3-L1 differentiation. BHA isomers showed no binding affinities for peroxisome proliferator activated receptor gamma (PPAR gamma). Instead, the upstream of PPAR gamma signaling pathway, i.e. the phosphorylation of cAMP-response element binding protein (CREB), upregulation of CAAT/enhancer-binding proteins beta (C/EBP beta) and elevated cell proliferation during postconfluent mitosis stage were induced by 3-BHA exposure. Altogether, this study revealed the adipogenic effect of 3-BHA through interference with the upstream events of the PPAR gamma signaling pathway. The authorized usage of BHA as food additives and its occurrence in human sera can potentially contribute to the incidence of obesity, which is of high concern.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Butylated hydroxyanisole (BHA) isomers, 3T3-L1 cells, Adipogenesis, Lipogenesis, Obesity
National Category
Cell Biology
Identifiers
urn:nbn:se:oru:diva-77431 (URN)10.1016/j.jhazmat.2019.120794 (DOI)000488419700010 ()31238218 (PubMedID)2-s2.0-85067595649 (Scopus ID)
Note

Funding Agencies:

Major International (Regional) Joint Project 21461142001

National Natural Science Foundation of China 21876195 21621064

Chinese Academy of Sciences 14040302 QYZDJ-SSW-DQC017

Sanming Project of Medicine in Shenzhen  SZSM201811070

Available from: 2019-10-18 Created: 2019-10-18 Last updated: 2019-10-18Bibliographically approved
Zhang, T., Hu, L., Zhang, M., Jiang, M., Fiedler, H., Bai, W., . . . Li, Z. (2019). Cr(VI) removal from soils and groundwater using an integrated adsorption and microbial fuel cell (A-MFC) technology. Environmental Pollution, 252(Pt B), 1399-1405
Open this publication in new window or tab >>Cr(VI) removal from soils and groundwater using an integrated adsorption and microbial fuel cell (A-MFC) technology
Show others...
2019 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 252, no Pt B, p. 1399-1405Article in journal (Refereed) Published
Abstract [en]

Remediation of hexavalent chromium [Cr(VI)] has been widely studied for its high mobility and toxicity. As Cr(VI) migrates in natural environment, both soils and groundwater are contaminated simultaneously. In the present study, a novel reactor combining adsorption and microbial fuel cell (A-MFC) using Platanus acerifolia leaves was developed for removing Cr(VI) from groundwater and soils. When initial Cr(VI) concentration was 50 mg/L, the adsorption efficiency of A-MFC achieved 98% after 16 h. Afterwards, the leaves were used for fabricating an MFC-integrated leaching reactor. The A-MFC significantly improved the overall Cr(VI) removal efficiency through leaching and 40% of Cr(VI) in the soil column was removed. The electrical voltage and current of A-MFC reactor achieved averagely 343 mV and 141 μA to maintain the system operation without extra energy supply. This novel A-MFC reactor is an environmentally friendly technology which achieved efficient Cr(VI) removal from groundwater and soils using natural materials, proving the concept that integrated self-remediation of Cr(VI) in contaminated soil and groundwater with natural material and energy.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Biosorbent, Chromium(VI), Electricity generation, Integrated remediation, Microbial fuel cell (MFC)
National Category
Other Environmental Engineering Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-76113 (URN)10.1016/j.envpol.2019.06.051 (DOI)000483405400049 ()31260939 (PubMedID)2-s2.0-85067854411 (Scopus ID)
Note

Funding Agencies:

National Natural Science Foundation of China  41807133 

Special fund of State Key Joint Laboratory of Environment Simulation and Pollution Control  18K05ESPCT 

China Postdoctoral Science Foundation  2018M631314 

Fundamental Research Funds for the Central Universities  PT1905 

Open Research Fund Program of Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry 

Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-20Bibliographically approved
Guan, Q., Tan, H., Yang, L., Liu, X., Fiedler, H., Li, X. & Chen, D. (2019). Isopropylated and tert-butylated triarylphosphate isomers in house dust from South China and Midwestern United States. Science of the Total Environment, 686, 1113-1119
Open this publication in new window or tab >>Isopropylated and tert-butylated triarylphosphate isomers in house dust from South China and Midwestern United States
Show others...
2019 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 686, p. 1113-1119Article in journal (Refereed) Published
Abstract [en]

In the present study we determined the concentrations and compositions of a suite of isopropylated and tert-butylated triarylphosphate ester (ITP and TBPP) isomers in house dust from the city of Guangzhou located in South China and the city of Carbondale in Midwestern United States. These two groups of organophosphate esters (OPE) are structurally analogous to triphenyl phosphate (TPHP), but have rarely been investigated for environmental occurrences and human exposure risks. The majority of target ITP and TBPP isomers were 100% detected in house dust from the two locations. Median concentrations of Sigma ITPs (including all ITP isomers) and Sigma TBPPs (including all TBPP isomers) were 63.4 ng/g (range: 16.0-500 ng/g) and 35.4 ng/g (8.1-198 ng/g) in South China house dust, respectively, compared with 476 ng/g (140-1610 ng/g) for Sigma ITPs and 81.3 ng/g (352-800 ng/g) for Sigma TBPPs in Midwestern US. dust. The profiles of ITP or TBPP isomers were similar between the two locations and were dominated by 2-isopropylphenyl diphenyl phosphate (2IPPDPP) and 4-tertbutylphenyl diphenyl phosphate (4tBPDPP), respectively. Although the levels of Sigma ITPs and Sigma TBPPs were generally one order of magnitude lower than those of TPHP in the same dust samples, the broad occurrences of most of these isomers in house dust from the two locations likely suggest their wide applications in household consumer products. Estimated intakes of Sigma ITPs and Sigma ITBPPs via dust ingestion were generally three orders of magnitude lower than the reference dose proposed for TPHP. However, these emerging OPE chemicals merit continuous environmental surveillance, given their possible applications as specific commercial mixtures or as components/impurities in other flame retardant/plasticizer mixtures. (C) 2019 Published by Elsevier B.V.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Isopropylated triarylphosphate esters, tert-butylated triarylphosphate esters, Organophosphate esters, House dust, Daily intake
National Category
Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-75944 (URN)10.1016/j.scitotenv.2019.06.055 (DOI)000479029700100 ()31412507 (PubMedID)2-s2.0-85067026936 (Scopus ID)
Note

Funding Agencies:

Guangdong Innovative and Entrepreneurial Research Team Program  2016ZT06N258 

National Natural Science Foundation of China  21777059 

China Postdoctoral Science Foundation  2018M633281 

Available from: 2019-08-30 Created: 2019-08-30 Last updated: 2019-08-30Bibliographically approved
Chen, P., Gong, W., Yu, G. & Fiedler, H. (2019). Preliminary release inventories of unintentionally generated dl-PCB and HCB from sources in China: Base year 2015. Chemosphere, 219, 875-881
Open this publication in new window or tab >>Preliminary release inventories of unintentionally generated dl-PCB and HCB from sources in China: Base year 2015
2019 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 219, p. 875-881Article in journal (Refereed) Published
Abstract [en]

This research presents release inventories of unintentionally generated dioxin-like polychlorinated biphenyls (dl-PCB) and hexachlorobenzene (HCB), which so far have not been developed or assessed. For the inventory development, the amended Toolkit methodology as developed for reporting under the Stockholm Convention on Persistent Organic Pollutants, has been applied. Based on the activity rate (AR) obtained from various statistical yearbooks, reports, or scientific literature, and the emission factors (EFs) suited to each technology level, we estimated the preliminary release inventories of unintentionally produced dl-PCB and HCB from 36 source categories in China for the reference year 2015. The result showed that in 2015, 656 g TEQ of unintentionally produced dl-PCB and 2,145,504 g (or 2146 kg) of unintentionally generated HCB were released in China from these 36 source categories. Most of dl-PCB and HCB was released to air, 71% or 60%, respectively. For comparison and for the sources which could be estimated for all three unintentional POPs the total releases of PCDD/PCDF were 5695 g TEQ per year. Of these, 78% were released to air. For dl-PCB and HCB, the vast majority of the releases from the source group 7 Production and use of consumer goods - is found in the products and not in air. With respect to source attribution and releases to air, the source groups SG3 - Heat and power generation and SG2 - Ferrous and non-ferrous metal production dominate the air emission inventory. Due to the lack of EFs, the calculated releases to the water and land were not well covered, which overall results in an underestimation of the total releases for all unintentional POPs.

For comparison, the release inventories from Japan and from several other countries that were developed using methodologies other than the UNEP Toolkit are presented as well.

Place, publisher, year, edition, pages
Pergamon Press, 2019
Keywords
Dioxin-like polychlorinated biphenyls, Hexachlorobenzene, Release inventory for China, Toolkit methodology under the Stockholm, convention on persistent organic pollutants
National Category
Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-72523 (URN)10.1016/j.chemosphere.2018.12.098 (DOI)000457511700093 ()30572237 (PubMedID)2-s2.0-85059329379 (Scopus ID)
Note

Funding Agencies:

NSFC-UNEP Joint Research Project  21561142001 

Program for Changjiang Scholars and Innovative Research Team in University  1RT1261 

Collaborative Innovation Center for Regional Environmental Quality of Tsinghua University 

Available from: 2019-02-19 Created: 2019-02-19 Last updated: 2019-02-19Bibliographically approved
Henry, B. J., Carlin, J. P., Hammerschmidt, J. A., Buck, R. C., Buxton, L. W., Fiedler, H., . . . Hernandez, O. (2018). A critical review of the application of polymer of low concern and regulatory criteria to fluoropolymers. Integrated Environmental Assessment and Management, 14(3), 316-334
Open this publication in new window or tab >>A critical review of the application of polymer of low concern and regulatory criteria to fluoropolymers
Show others...
2018 (English)In: Integrated Environmental Assessment and Management, ISSN 1551-3777, E-ISSN 1551-3793, Vol. 14, no 3, p. 316-334Article, review/survey (Refereed) Published
Abstract [en]

Per- and poly-fluoroalkyl substances (PFAS) are a group of fluorinated substances that are in the focus of researchers and regulators due to widespread presence in the environment and biota, including humans, of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). Fluoropolymers, high molecular weight polymers within the PFAS group, have unique properties that constitute a distinct class within the PFAS group. Fluoropolymers have thermal, chemical, photochemical, hydrolytic, oxidative and biological stability. They have negligible residual monomer and oligomer content and low to no leachables. Fluoropolymers are practically insoluble in water and not subject to long-range transport. With a molecular weight well over 100,000 Da, fluoropolymers cannot cross the cell membrane. Fluoropolymers are not bioavailable or bioaccumulative, as evidenced by toxicology studies on PTFE: acute and subchronic systemic toxicity, irritation, sensitization, local toxicity on implantation, cytotoxicity, in vitro and in vivo genotoxicity, hemolysis, complement activation, and thrombogenicity. Clinical studies of patients receiving permanently implanted PTFE cardiovascular medical devices demonstrate no chronic toxicity or carcinogenicity, reproductive or developmental or endocrine toxicity. This paper brings together fluoropolymer toxicity data, human clinical data, and physical-chemical-thermal-biological data for review and assessment to show that fluoropolymers satisfy widely accepted assessment criteria to be considered as "Polymers of Low Concern". This review concludes that fluoropolymers are distinctly different from other polymeric and non-polymeric per- and poly-fluoroalkyl substances and should be separated from them for hazard assessment or regulatory purposes. Grouping fluoropolymers with all classes of PFAS for "read across" or structure activity relationship assessment is not scientifically appropriate.

Place, publisher, year, edition, pages
Society of Environmental Toxicology and Chemistry (SETAC), 2018
Keywords
Fluoropolymer; International regulation; Polytetrafluoroethylene; Polymer of low concern; PFAS
National Category
Pharmacology and Toxicology Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-64981 (URN)10.1002/ieam.4035 (DOI)000430059200002 ()29424474 (PubMedID)2-s2.0-85044537689 (Scopus ID)
Available from: 2018-02-12 Created: 2018-02-12 Last updated: 2018-08-30Bibliographically approved
Liu, X., Fiedler, H., Gong, W., Wang, B. & Yu, G. (2018). Potential sources of unintentionally produced PCB, HCB, and PeCBz in China: A preliminary overview. Frontiers of Environmental Science and Engineering, 12(6), Article ID 1.
Open this publication in new window or tab >>Potential sources of unintentionally produced PCB, HCB, and PeCBz in China: A preliminary overview
Show others...
2018 (English)In: Frontiers of Environmental Science and Engineering, ISSN 2095-2201, E-ISSN 2095-221X, Vol. 12, no 6, article id 1Article in journal (Refereed) Published
Abstract [en]

Under the Stockholm Convention on Persistent Organic Pollutants (POPs), China is required not only to reduce polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/PCDF) but also unintentionally produced polychlorinated biphenyls (PCB), hexachlorobenzene (HCB) and pentachlorobenzene (PeCBz). A baseline of the sources in China that generate these unintentional POPs is needed for both research and regulation purposes. In this paper, we have compiled production data of potential sources in China and assessed them in five-year intervals from 2000 to 2015. Most of these activities experienced changes from rapid growth to slow growth. Measured data for PCB, HCB and PeCBz in samples collected from potential sources in China were reviewed. Most information was associated to thermal processes with high potential of emission, including waste incineration and ferrous and non-ferrous metal production. In addition, high levels of PCB, HCB and PeCBz were found as impurities in a few chlorinated products or as by-products in solvent production, which suggested organochlorine industry might be important sources. Finally, based on the studies reviewed, recommendations for future actions in research and policy as well as a few regulatory issues in China are discussed.

Place, publisher, year, edition, pages
Higher Education Press, 2018
Keywords
Unintentionally produced POPs, Polychlorinated biphenyls, Hexachlorobenzene, Pentachlorobenzene, sources of releases, Annual production activities
National Category
Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-68032 (URN)10.1007/s11783-018-1036-9 (DOI)000436049600006 ()2-s2.0-85046546978 (Scopus ID)
Note

Funding Agencies:

National High Technology Research and Development Program of China  2013AA06A305 

Program for Changjiang Scholars and Innovative Research Team in University  

Collaborative Innovation Center for Regional Environmental Quality project NSFC/UNEP  B07  21561142001 

Available from: 2018-07-25 Created: 2018-07-25 Last updated: 2018-07-25Bibliographically approved
Elgazali, A. A. S., Gajdosechova, Z., Abbas, Z., Lombi, E., Scheckel, K. G., Donner, E., . . . Krupp, E. M. (2018). Reactive gaseous mercury is generated from chloralkali factories resulting in extreme concentrations of mercury in hair of workers. Scientific Reports, 8(1), Article ID 3675.
Open this publication in new window or tab >>Reactive gaseous mercury is generated from chloralkali factories resulting in extreme concentrations of mercury in hair of workers
Show others...
2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, no 1, article id 3675Article in journal (Refereed) Published
Abstract [en]

Occupational exposure of chloralkali workers to highly concentrated mercury (Hg) vapour has been linked to an increased risk of renal dysfunction and behavioural changes. It is generally believed that these workers are exposed to elemental Hg, which is used in abundance during the production process however, the lack in analytical techniques that would allow for identification of gaseous Hg species poses a challenge, which needs to be addressed in order to reach a consensus. Here, we present the results from simulated exposure studies, which provide sound evidence of higher adsorption rate of HgCl2 than Hg-0 and its irreversible bonding on the surface of hair. We found that chloralkali workers were exposed to HgCl2, which accumulated in extremely high concentrations on the hair surface, more than 1,000 times higher than expected from unexposed subjects and was positively correlated with Hg levels in the finger- and toenails.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:oru:diva-65447 (URN)10.1038/s41598-018-20544-5 (DOI)000426151800008 ()29487292 (PubMedID)2-s2.0-85042714707 (Scopus ID)
Note

Funding Agency:

UNEP Chemicals

Available from: 2018-03-02 Created: 2018-03-02 Last updated: 2018-09-12Bibliographically approved
Fiedler, H., van der Veen, I. & de Boer, J. (2017). Bi-ennial Global Interlaboratory Assessment on Persistent Organic Pollutants: Third Round 2016/2017, Dioxin-like POPs and Perfluorinated Alkyl Substances. Organohalogen Compounds, 79, 237-240
Open this publication in new window or tab >>Bi-ennial Global Interlaboratory Assessment on Persistent Organic Pollutants: Third Round 2016/2017, Dioxin-like POPs and Perfluorinated Alkyl Substances
2017 (English)In: Organohalogen Compounds, Vol. 79, p. 237-240Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Dioxin20XX, 2017
Keywords
Proficiency test, dioxins/furans, PFAS, interlaboratory
National Category
Natural Sciences
Research subject
Environmental Chemistry
Identifiers
urn:nbn:se:oru:diva-72014 (URN)
Projects
UNEP GMP2 project
Available from: 2019-02-01 Created: 2019-02-01 Last updated: 2019-02-14Bibliographically approved
van der Veen, I., Fiedler, H. & de Boer, J. (2017). Bi-ennial Global Interlaboratory Assessment on Persistent Organic Pollutants – Third Round 2016/2017, Organochlorine Pesticides, PCBs and Brominated Flame Retardants. Organohalogen Compounds, 79, 575-578
Open this publication in new window or tab >>Bi-ennial Global Interlaboratory Assessment on Persistent Organic Pollutants – Third Round 2016/2017, Organochlorine Pesticides, PCBs and Brominated Flame Retardants
2017 (English)In: Organohalogen Compounds, Vol. 79, p. 575-578Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Dioxin201XX, 2017
Keywords
Proficiency test, organochlorine pesticides, broinated flame retardants, PCB
National Category
Organic Chemistry
Research subject
Environmental Chemistry
Identifiers
urn:nbn:se:oru:diva-72015 (URN)
Projects
UNEP GMP2
Available from: 2019-02-01 Created: 2019-02-01 Last updated: 2019-02-14Bibliographically approved
Jin, R., Liu, G., Zheng, M., Fiedler, H., Jiang, X., Yang, L., . . . Xu, Y. (2017). Congener-specific determination of ultratrace levels of chlorinated and brominated polycyclic aromatic hydrocarbons in atmosphere and industrial stack gas by isotopic dilution gas chromatography/high resolution mass spectrometry method. Journal of Chromatography A, 1509, 114-122
Open this publication in new window or tab >>Congener-specific determination of ultratrace levels of chlorinated and brominated polycyclic aromatic hydrocarbons in atmosphere and industrial stack gas by isotopic dilution gas chromatography/high resolution mass spectrometry method
Show others...
2017 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1509, p. 114-122Article in journal (Refereed) Published
Abstract [en]

Isotopic dilution gas chromatography combined with high resolution mass spectrometry (GC/HRMS) has overwhelming advantages with respect to the accuracy of congener-specific ultratrace analysis of complex persistent organic pollutants (POPs) in environmental matrices. However, an isotopic dilution GC/HRMS method for analysis of chlorinated and brominated polycyclic aromatic hydrocarbons (Cl-PAHs and Br-PAHs) using 13C-labelled congeners as internal standards has not been established. In this study, a method for identification and quantification of 38 congeners of Cl-PAHs and Br-PAHs in atmosphere and stack gas samples from waste incinerators was developed using the isotopic dilution GC/HRMS technique. The instrumental detection limits of the GC/HRMS method ranged from 0.2pg to 1.8pg for Cl-PAH congeners, and 0.7pg to 2.7pg for Br-PAH congeners, which were about three orders of magnitude lower than those of the GC/quadrupole MS method. This new method developed was also the first to enable determination of Cl-PAH and Br-PAH homologs comprising congeners with the same molecular skeleton and chlorine or bromine substitution numbers. Among the detected congeners, seven Cl-PAH congeners and thirteen Br-PAH congeners that were abundant in the atmosphere and stack gases released from waste incinerators were firstly detected in real samples and reported using the established isotopic dilution GC/HRMS method. The developed isotopic dilution GC/HRMS is significant and needed for better studying the environmental behavior and health risk of Cl-PAHs and Br-PAHs.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
Isotopic dilution method; 13C labelled compounds; Chlorinated PAHs; Brominated PAHs; Atmosphere; Stack gas
National Category
Environmental Sciences Analytical Chemistry
Research subject
Environmental Chemistry
Identifiers
urn:nbn:se:oru:diva-58623 (URN)10.1016/j.chroma.2017.06.022 (DOI)000407868800013 ()28622970 (PubMedID)2-s2.0-85020458767 (Scopus ID)
Note

Funding Agencies:

Chinese National 973 Program  2015CB453100 

National Natural Science Foundation of China  91543108  21477147  21361140359 

United Nations Environment Programme  21361140359 

Strategic Priority Research Program of the Chinese Academy of Sciences  XDB14020102 

Youth Innovation Promotion Association of the Chinese Academy of Sciences  2016038 

Available from: 2017-07-09 Created: 2017-07-09 Last updated: 2018-02-05Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-1496-9245

Search in DiVA

Show all publications