oru.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Publications (10 of 28) Show all publications
Nilsson, A., Halvardsson, P. & Kadi, F. (2019). Adherence to DASH-Style Dietary Pattern Impacts on Adiponectin and Clustered Metabolic Risk in Older Women. Nutrients, 11(4), Article ID 805.
Open this publication in new window or tab >>Adherence to DASH-Style Dietary Pattern Impacts on Adiponectin and Clustered Metabolic Risk in Older Women
2019 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, no 4, article id 805Article in journal (Refereed) Published
Abstract [en]

While dietary patterns are related to the age-related progression of chronic diseases, to what extent different dietary patterns influence inflammatory and metabolic risk factors in older adults remains to be elucidated. Additionally, potential moderating effects by physical activity (PA) become important to clarify. Here, we hypothesize that dietary patterns are linked to inflammatory and metabolic biomarkers and that these links are independent of PA. The present study aims to explore links between two dietary constructs and biomarkers of systemic inflammation and metabolic health in older women, while considering time spent in moderate-to-vigorous PA (MVPA). A cross-sectional analysis of a sample of 112 community-dwelling older women (65-70 years old) was performed. Dietary constructs based on the Dietary Approach to Stop Hypertension (DASH) and the dietary inflammatory index (DII) were determined from food records. MVPA was objectively assessed using accelerometry. Metabolic outcomes (waist circumference, systolic/diastolic blood pressures and levels of glucose, triglycerides and high-density lipoprotein (HDL)-cholesterol) and inflammatory biomarkers (C-reactive protein (CRP), fibrinogen and adiponectin) were determined using standardized procedures and a clustered metabolic risk score was derived. Adherence to DASH-style diet was significantly (p < 0.05) associated with a lower clustered metabolic risk, where women in the highest adherence group had a significantly (p < 0.05) lower waist circumference and blood glucose level compared to those in the lowest group. Further, a significantly higher (p < 0.05) adiponectin level was observed in the high DASH adherence group compared to those with low adherence. Notably, adjustment by waist circumference did not alter links with either adiponectin or blood glucose level. Importantly, all observed links remained significant after further adjustment for time in MVPA. Finally, no significant associations were observed when the dietary pattern was defined by the DII. The findings of this study demonstrate that DASH-style diets promote a systemic anti-inflammatory environment, while also mitigating clustered metabolic risk in older women. A key finding is that favourable impacts of the DASH-style diet are independent of time spent in moderate-to-vigorous PA, which further strengthens healthy eating behaviours as a key target for clinical and public health interventions designed to prevent age-related metabolic abnormalities.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
diet, dietary inflammatory index, inflammation, CRP, moderate-to-vigorous physical activity, aging
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-74644 (URN)10.3390/nu11040805 (DOI)000467749800098 ()30970648 (PubMedID)2-s2.0-85064722097 (Scopus ID)
Note

Funding Agency:

Food and Health Initiative at Örebro University

Available from: 2019-06-10 Created: 2019-06-10 Last updated: 2019-06-10Bibliographically approved
Bergens, O., Nilsson, A. & Kadi, F. (2019). Cardiorespiratory Fitness Does Not Offset Adiposity-Related Systemic Inflammation in Physically Active Older Women. Journal of Clinical Endocrinology and Metabolism, Article ID jc.2019-00067.
Open this publication in new window or tab >>Cardiorespiratory Fitness Does Not Offset Adiposity-Related Systemic Inflammation in Physically Active Older Women
2019 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, article id jc.2019-00067Article in journal (Refereed) Epub ahead of print
Abstract [en]

CONTEXT: Chronic inflammation increases diabetes risk and may be exacerbated by excess adipose tissue. Whether cardiovascular fitness can offset chronic inflammation associated with excess adipose tissue in older adults is unclear.

OBJECTIVE: The study aimed to examine the influence of cardiorespiratory fitness on links between adiposity and pro- and anti-inflammatory biomarkers related to metabolic risk in physically active older women.

DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study comprising older community-dwelling women (n = 109; age, 65-70 yr).

MAIN OUTCOME: Cardiorespiratory fitness was assessed using a standardized submaximal test and participants were categorized into high and low adiposity-related metabolic risk (body mass index, waist-to-hip ratio (WHR) and total fat mass). The inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, IL-18, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein (MIP-1α) were analyzed.

RESULTS: Regardless of adiposity measure, women in the metabolic high-risk group had significantly (P<0.05) elevated CRP and lower adiponectin levels. Levels of IL-6 and MIP1-α were significantly elevated in the high-risk group defined by WHR and total fat mass. IL-18 level was significantly elevated in the high-risk group based on WHR only. Importantly, a high cardiorespiratory fitness level did not attenuate the detrimental links between adiposity measures and inflammation.

CONCLUSIONS: Altogether, cardiorespiratory fitness does not offset the detrimental links between adiposity and several inflammatory biomarkers related to metabolic risk in physically active older women. Reducing abdominal adipose tissue in older adults should be emphasized in efforts aiming to attenuate age-related systemic inflammation and metabolic risk regardless of cardiorespiratory fitness.

Place, publisher, year, edition, pages
Williams & Wilkins Co., 2019
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:oru:diva-74240 (URN)10.1210/jc.2019-00067 (DOI)31058998 (PubMedID)
Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-05-14Bibliographically approved
Nilsson, A., Tarum, J. & Kadi, F. (2019). Detrimental Links Between Inflammation and Muscle Mass are Moderated by Physical Activity in Older Adults. Paper presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019. Medicine & Science in Sports & Exercise, 51(6), 215-215
Open this publication in new window or tab >>Detrimental Links Between Inflammation and Muscle Mass are Moderated by Physical Activity in Older Adults
2019 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 51, no 6, p. 215-215Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

While age-related elevations in systemic inflammation may contribute to the accelerated loss of skeletal muscle mass, previous findings have been based on a limited number of biomarkers. Moreover, whether links between inflammation and muscle mass are independent of protein intake and habitual physical activity (PA) remain unknown.

PURPOSE: The aim of the study was to explore links between skeletal muscle mass and inflammatory biomarkers in older women with different metabolic risk status, while accounting for adherence to guidelines on protein intake and PA.

METHODS: Skeletal muscle mass index (SMI) was assessed in 112 women (67±1.5 years) by bioelectrical impedance together with the equation of Janssen et al. (2002) to obtain muscle mass expressed in relation to body weight. Fasting blood samples were obtained following standardized protocols. Acute-phase proteins C-reactive protein (CRP) and fibrinogen were determined, together with the following inflammatory biomarkers: Adiponectin, Oncostatin-M (OSM), Leukemia inhibitory factor-receptor (LIF-R), Interleukin-6 (IL-6), IL-8, IL-12, and IL-18. Protein intake and PA were determined during 6 days by food record and accelerometry, respectively. Classification of metabolic risk status was based on the metabolic syndrome. Multivariate regression models were used to explore links between SMI and inflammatory biomarkers while adjusting for adherence to PA and protein intake guidelines and metabolic risk status.

RESULTS: Variations in SMI were inversely linked to levels of CRP (β-coefficient: -0.47; p< 0.05) and OSM (-0.20 p< 0.05), where the OSM link was attenuated after further adjustment for PA. In contrast, positive links between SMI and adiponectin (0.19 p< 0.05) and LIF-R (0.24 p< 0.05) were observed, which both remained significant in fully adjusted models. Links to other biomarkers were non-significant.

CONCLUSIONS: Several inflammatory markers are linked to skeletal muscle mass in older adults, where detrimental or beneficial actions are indicated depending on the biomarker. While adherence to PA guidelines moderates some of these links, others seem unaffected by either PA and protein intake or metabolic risk status. Further research is needed to elucidate mechanisms underlying these observations.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-76068 (URN)10.1249/01.mss.0000561153.98240.7a (DOI)000481662800608 ()
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019
Available from: 2019-09-05 Created: 2019-09-05 Last updated: 2019-09-05Bibliographically approved
Nilsson, A., Santoro, A., Franceschi, C. & Kadi, F. (2019). Detrimental links between physical inactivity, metabolic risk and N-glycomic biomarkers of aging. Experimental Gerontology, 124, Article ID UNSP 110626.
Open this publication in new window or tab >>Detrimental links between physical inactivity, metabolic risk and N-glycomic biomarkers of aging
2019 (English)In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 124, article id UNSP 110626Article in journal (Refereed) Published
Abstract [en]

Background: N-linked enzymatic glycosylation modulates the function of proteins and contributes to development of age-related metabolic abnormalities. Whether physical activity (PA) is linked to a specific N-glycan profile and can offset detrimental links between N-glycans and metabolic risk profile has never been explored. The aim of the present study is to assess serum N-glycan profile in older women with different PA levels and metabolic risk status.

Materials and methods: Components of the metabolic syndrome (MetS) and serum N-glycans analyzed using DSAFACE technology were assessed in 109 older community-dwelling women (65-70 yrs). Ten peaks, each representing a unique N-glycan structure were detected. Moderate-to-vigorous PA (MVPA) was assessed objectively using accelerometry. All analyses were adjusted by covariates.

Results: Significantly elevated levels of NGA2FB (peak 2) and NA3F (peak 9) and lower level of the alpha(1,6)-arm monogalactosylated (NG1(6)A2F) (peak 3) were demonstrated in women with MetS compared to their healthier peers (p < 0.05). Importantly, women adhering to the PA guideline of time in MVPA had a 10% and a 12% lower level of NA3 (peak 8) and NA4 (peak 10), respectively, compared to those less active even after adjustment by MetS and covariates (p < 0.05). Interestingly, time spent in PA below the MVPA threshold was not linked to N-glycans.

Conclusion: Novel links between PA behaviors and N-glycan profile are demonstrated in older adults, regardless of metabolic risk status. This proposed effect on N-glycans requires engagement in MVPA. This supports public health efforts to promote adherence to PA guidelines in older adults across different stages of disease prevention.

Place, publisher, year, edition, pages
Elsevier, 2019
National Category
Geriatrics
Identifiers
urn:nbn:se:oru:diva-75703 (URN)10.1016/j.exger.2019.05.015 (DOI)000476589500008 ()31158451 (PubMedID)2-s2.0-85066934490 (Scopus ID)
Available from: 2019-08-14 Created: 2019-08-14 Last updated: 2019-08-14Bibliographically approved
Kadi, F., Nilsson, A., Santoro, A. & Franceschi, C. (2019). Impact Of Physical Activity On N-glycan Profile In Older Adults. Paper presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019. Medicine & Science in Sports & Exercise, 51(6), 542-542
Open this publication in new window or tab >>Impact Of Physical Activity On N-glycan Profile In Older Adults
2019 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 51, no 6, p. 542-542Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

The biological mechanisms underlying the beneficial effects of regular physical activity (PA) on prevention of chronic diseases are not fully understood. It is currently suggested that N-linked enzymatic glycosylation, a post-translational modification modulating the biological function of several proteins, may contribute to disease development. Nevertheless, the influence of PA on N-glycans in humans has never been explored.

PURPOSE: To explore serum N-glycan profile in a sample of community-dwelling older women with different objectively assessed PA levels and metabolic risk status.

METHODS: Components of the metabolic syndrome (MetS) and serum N-glycans analyzed using DSA-FACE technology were assessed in 109 older community-dwelling women (65-70 yrs). Ten peaks, each representing a unique N-glycan structure were detected. Adherence to PA guidelines was determined using accelerometry. Participants daily engaged in 30 minutes of MVPA were classified as meeting PA guidelines.

RESULTS: Significant differences in N-glycan peaks were indicated when comparing women adhering to the PA guideline to those less active: when adjusted by MetS, a 12% (p = 0.006) and a 13% (p = 0.004) lower level of NA3 (peak 8) and NA4 (peak 10), respectively, were evident among the physically active women compared to those less active. In contrast to findings based on the MVPA threshold, no differences in N-glycan peaks were observed between PA groups when based on the lower intensity threshold, which may indicate that the influence on N-glycan levels by PA is intensity-sensitive.

CONCLUSIONS: Adherence to PA guidelines is related to a favorable N-glycan profile, regardless of metabolic risk status. This proposed effect on N-glycans only occurs above the moderate PA-intensity threshold. Our findings support the promotion of a physically active lifestyle as a supporting non-pharmacological public health approach.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-76069 (URN)10.1249/01.mss.0000562129.57753.ad (DOI)000481662802132 ()
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM), Orlando, FL, USA, May 28 - June 1, 2019
Available from: 2019-09-05 Created: 2019-09-05 Last updated: 2019-09-05Bibliographically approved
Edholm, P., Nilsson, A. & Kadi, F. (2019). Physical function in older adults: Impacts of past and present physical activity behaviors. Scandinavian Journal of Medicine and Science in Sports, 29(3), 415-421
Open this publication in new window or tab >>Physical function in older adults: Impacts of past and present physical activity behaviors
2019 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 29, no 3, p. 415-421Article in journal (Refereed) Published
Abstract [en]

While physical activity (PA) may counteract age-related functional decline and loss of independence at old age, to what extent physical function is influenced by past or present PA behaviors is currently unclear. Therefore, the aim of the study was to examine relationships between both past and present PA behaviors and components of physical function in older women. A physical function score based on the 6-minute walk test, squat jump, and single-leg-stance balance was aggregated in 60 older women (65-70 years). Present PA behavior was assessed by accelerometry (Actigraph) and past leisure-time PA was self-reported, where times in sports-related activities and in walking were analyzed separately. Analysis of differences in physical function across tertiles of PA behaviors was adjusted by DXA-derived fat mass. Physical activity level at present age and engagements in sports-related activities before retirement age, excluding walking, were both associated (P < 0.05) to physical function. Time spent in PA of at least moderate intensity was associated with physical function (P < 0.05), whereas no corresponding relationships to either sedentary time or time in light intensity PA were observed. In conclusion, PA behaviors at present age and engagement in sports-related activities performed during adulthood are both related to physical function in older women. Being physically active at old age infers beneficial effects on physical function, even in individuals with a past or present sedentary lifestyle, which supports public health efforts aiming at increasing daily time in PA of at least moderate intensity to preserve physical function in older women.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
aerobic capacity, aging, exercise, muscle strength, sedentary
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-72758 (URN)10.1111/sms.13350 (DOI)000458294800011 ()30506596 (PubMedID)2-s2.0-85059033224 (Scopus ID)
Funder
Swedish National Centre for Research in Sports, P2012/102 P2014/117 P2015/120
Available from: 2019-02-25 Created: 2019-02-25 Last updated: 2019-06-14Bibliographically approved
Nilsson, A. & Kadi, F. (2018). Fysisk aktivitet gav positiva effekter på graden av åldersinflammation [Letter to the editor]. Läkartidningen, 115(16), 720-720, Article ID E43F.
Open this publication in new window or tab >>Fysisk aktivitet gav positiva effekter på graden av åldersinflammation
2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, no 16, p. 720-720, article id E43FArticle in journal, Letter (Refereed) Published
Place, publisher, year, edition, pages
Stockholm: Läkartidningen Förlag AB, 2018
National Category
Medical and Health Sciences Gerontology, specialising in Medical and Health Sciences Rheumatology and Autoimmunity
Research subject
Sports Physiology/Medicine
Identifiers
urn:nbn:se:oru:diva-68435 (URN)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-09-14Bibliographically approved
Nilsson, A., Montiel Rojas, D. & Kadi, F. (2018). Impact of Meeting Different Guidelines for Protein Intake on Muscle Mass and Physical Function in Physically Active Older Women. Nutrients, 10(9), Article ID 1156.
Open this publication in new window or tab >>Impact of Meeting Different Guidelines for Protein Intake on Muscle Mass and Physical Function in Physically Active Older Women
2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 9, article id 1156Article in journal (Refereed) Published
Abstract [en]

The role of dietary protein intake on muscle mass and physical function in older adults is important for the prevention of age-related physical limitations. The aim of the present study was to elucidate links between dietary protein intake and muscle mass and physical function in older women meeting current guidelines of objectively assessed physical activity. In 106 women (65 to 70 years old), protein intake was assessed using a 6-day food record and participants were classified into high and low protein intake groups using two Recommended Dietary Allowance (RDA) thresholds (0.8 gkg(-1) bodyweight (BW) and 1.1 gkg(-1) BW). Body composition, aerobic fitness, and quadriceps strength were determined using standardized procedures, and self-reported physical function was assessed using the SF-12 Health Survey. Physical activity was assessed by accelerometry and self-report. Women below the 0.8 gkg(-1) BW threshold had a lower muscle mass (p < 0.05) with no differences in physical function variables. When based on the higher RDA threshold (1.1 gkg(-1) BW), in addition to significant differences in muscle mass, women below the higher threshold had a significantly (p < 0.05) higher likelihood of having physical limitations. In conclusion, the present study supports the RDA threshold of 0.8 gkg(-1) BW of proteins to prevent the loss of muscle mass and emphasizes the importance of the higher RDA threshold of at least 1.1 gkg(-1) BW to infer additional benefits on constructs of physical function. Our study also supports the role of protein intake for healthy ageing, even in older adults meeting guidelines for physical activity.

Place, publisher, year, edition, pages
MDPI, 2018
Keywords
elderly, muscle strength, nutrition, physical activity, physical functioning, Recommended Dietary Allowance (RDA), sarcopenia
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:oru:diva-70225 (URN)10.3390/nu10091156 (DOI)000448659900029 ()30149519 (PubMedID)2-s2.0-85052592694 (Scopus ID)
Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2018-11-20Bibliographically approved
Kadi, F. & Nilsson, A. (2018). Motion mot inflammation: fysisk aktivitet viktigt för äldres hälsa. Idrottsforskning, Article ID 9 jan.
Open this publication in new window or tab >>Motion mot inflammation: fysisk aktivitet viktigt för äldres hälsa
2018 (Swedish)In: Idrottsforskning, ISSN 2002-3944, article id 9 janArticle in journal (Other (popular science, discussion, etc.)) Published
Place, publisher, year, edition, pages
Stockholm: Centrum för Idrottsforskning, 2018
National Category
Medical and Health Sciences Physiotherapy Rheumatology and Autoimmunity
Research subject
Sports Physiology/Medicine
Identifiers
urn:nbn:se:oru:diva-68436 (URN)
Available from: 2018-08-10 Created: 2018-08-10 Last updated: 2018-08-16Bibliographically approved
Nilsson, A., Bergens, O. & Kadi, F. (2018). Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels. Medicine & Science in Sports & Exercise, 50(7), 1502-1507
Open this publication in new window or tab >>Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels
2018 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 50, no 7, p. 1502-1507Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To examine the influence of reallocating time spent at different objectively measured physical activity (PA) behaviours on markers of systemic inflammation in older women with different levels of metabolic risk.

METHODS: Accelerometer-based monitoring of PA was conducted in a population of community-dwelling older women (n = 111; age = 65-70 yr) for determination of daily sedentary time, time in light (LPA) and moderate-to-vigorous physical activity (MVPA). Blood samples were collected for the assessment of the systemic inflammatory markers CRP, fibrinogen and adiponectin. Metabolic risk was assessed by standardized procedures based on definitions for the metabolic syndrome. Data were analysed by linear regression models based on isotemporal substitution analysis.

RESULTS: Reallocating 30 minutes of sedentary time with either time in LPA (β = -0.47; p<0.05) or MVPA (β = -0.42; p<0.05) was related to reduced fibrinogen level, whereas no corresponding effect was evident when shifting time in LPA with time in MVPA, while holding sedentary time constant. In contrast, reallocating a 30-minute time period in sedentary (β = -0.70; p<0.01) or LPA (β = -0.71; p<0.01) with MVPA was associated with a significant reduction in CRP level, while no impact on CRP was observed when a time period of sedentary behavior was replaced with LPA. Importantly, all significant influences on fibrinogen and CRP by displacement of different PA behaviours remained after adjustment for metabolic risk status among participants. No significant associations with adiponectin were observed.

CONCLUSION: Altogether, this work supports the existence of different intensity thresholds mediating beneficial effects of PA on important clinical markers of systemic inflammation in older women across different stages of disease prevention.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018
Keywords
EXERCISE TRAINING, ELDERLY, ISOTEMPORAL, SEDENTARY BEHAVIOR, METABOLIC RISK, ACUTE PHASE PROTEIN
National Category
Occupational Health and Environmental Health Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-65195 (URN)10.1249/MSS.0000000000001582 (DOI)000435348900020 ()29462102 (PubMedID)2-s2.0-85045633896 (Scopus ID)
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-07-25Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-3025-0719

Search in DiVA

Show all publications