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Zelic, R., Zugna, D., Bottai, M., Andrén, O., Fridfeldt, J., Carlsson, J., . . . Akre, O. (2019). Estimation of Relative and Absolute Risks in a Competing-Risks Setting Using a Nested Case-Control Study Design: Example From the ProMort Study. American Journal of Epidemiology, 188(6), 1165-1173
Open this publication in new window or tab >>Estimation of Relative and Absolute Risks in a Competing-Risks Setting Using a Nested Case-Control Study Design: Example From the ProMort Study
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2019 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 188, no 6, p. 1165-1173Article in journal (Refereed) Published
Abstract [en]

In this paper, we describe the Prognostic Factors for Mortality in Prostate Cancer (ProMort) study and use it to demonstrate how the weighted likelihood method can be used in nested case-control studies to estimate both relative and absolute risks in the competing-risks setting. ProMort is a case-control study nested within the National Prostate Cancer Register (NPCR) of Sweden, comprising 1,710 men diagnosed with low- or intermediate-risk prostate cancer between 1998 and 2011 who died from prostate cancer (cases) and 1,710 matched controls. Cause-specific hazard ratios and cumulative incidence functions (CIFs) for prostate cancer death were estimated in ProMort using weighted flexible parametric models and compared with the corresponding estimates from the NPCR cohort. We further drew 1,500 random nested case-control subsamples of the NPCR cohort and quantified the bias in the hazard ratio and CIF estimates. Finally, we compared the ProMort estimates with those obtained by augmenting competing-risks cases and by augmenting both competing-risks cases and controls. The hazard ratios for prostate cancer death estimated in ProMort were comparable to those in the NPCR. The hazard ratios for dying from other causes were biased, which introduced bias in the CIFs estimated in the competing-risks setting. When augmenting both competing-risks cases and controls, the bias was reduced.

Place, publisher, year, edition, pages
Oxford University Press, 2019
Keywords
absolute risk, competing risks, cumulative incidence function, flexible parametric survival model, inverse probability weighting, nested case-control studies, weighted likelihood
National Category
Cancer and Oncology Urology and Nephrology
Identifiers
urn:nbn:se:oru:diva-75236 (URN)10.1093/aje/kwz026 (DOI)000473760200020 ()30976789 (PubMedID)2-s2.0-85067089473 (Scopus ID)
Funder
Swedish Cancer Society
Available from: 2019-07-25 Created: 2019-07-25 Last updated: 2019-07-25Bibliographically approved
Erlandsson, A., Carlsson, J., Lundholm, M., Fält, A., Andersson, S.-O., Andrén, O. & Davidsson, S. (2019). M2 macrophages and regulatory T cells in lethal prostate cancer. The Prostate, 79(4), 363-369
Open this publication in new window or tab >>M2 macrophages and regulatory T cells in lethal prostate cancer
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2019 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 79, no 4, p. 363-369Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Prostate cancer (PCa) is one of the most frequently diagnosed cancers in the world. Emerging evidence suggests that inflammatory cells such as M2 macrophages and regulatory T cells (Tregs) can contribute to cancer progression by suppressing the anti‐tumor immune response. This study investigated the number of CD163‐positive M2 macrophages in PCa tissue. It also investigated the correlation and interaction of M2 macrophages and Tregs.

METHODS: were assessed using Spearman's rank-order correlation and a likelihood test, respectively. Logistic regression was used to estimate odds ratios (ORs) for lethal PCa and macrophage counts.

RESULTS: showed a significant correlation (P < 0.001) but no interactions. The OR for lethal PCa was 1.93 (95%CI: 1.23-3.03) for men with high numbers of M2 macrophages. Also for cases with uncertain outcome (GS categories 3 + 4 and 4 + 3) high numbers of M2 macrophages does predict a poorer prognosis.

CONCLUSIONS: Our data showed that men with high numbers of M2 macrophages in the prostate tumor environment had increased odds of dying of PCa. It is possible that M2 macrophages, together with other suppressor cells such as Tregs , promote an immunosuppressive environment.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
CD163, FOXP3, TAMs, Tregs
National Category
Urology and Nephrology Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-70404 (URN)10.1002/pros.23742 (DOI)000456214000004 ()30500076 (PubMedID)2-s2.0-85057833977 (Scopus ID)
Available from: 2018-12-03 Created: 2018-12-03 Last updated: 2019-02-05Bibliographically approved
Ugge, H., Udumyan, R., Carlsson, J., Andrén, O., Montgomery, S., Davidsson, S. & Fall, K. (2018). Acne in late adolescence and risk of prostate cancer. International Journal of Cancer, 1580-1585
Open this publication in new window or tab >>Acne in late adolescence and risk of prostate cancer
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2018 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, p. 1580-1585Article in journal (Refereed) Published
Abstract [en]

Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n= 243,187). Test information along with health data including medical diagnoses at time of conscription was available through the Swedish Military Conscription Register and the National Patient Register. The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31st 2009. We used Cox regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between acne in adolescence and prostate cancer risk. A total of 1,633 men were diagnosed with prostate cancer during a median follow-up of 36.7 years. A diagnosis of acne was associated with a statistically significant increased risk for prostate cancer (adjusted HR: 1.43 95%; CI: 1.06-1.92), particularly for advanced stage disease (HR: 2.37 95%; CI 1.19-4.73). A diagnosis of acne classified as severe conferred a 6-fold increased risk of prostate cancer (HR: 5.70 95% CI 1.42-22.85). Data from this large prospective population-based cohort add new evidence supporting a role of P acnes infection in prostate cancer.

Place, publisher, year, edition, pages
Hoboken, NJ, USA: John Wiley & Sons, 2018
Keywords
Propionibacterium acnes; prostate cancer; acne vulgaris; inflammation; acne vulgaris
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-63302 (URN)10.1002/ijc.31192 (DOI)000425184800009 ()29205339 (PubMedID)2-s2.0-85037982996 (Scopus ID)
Note

Funding Agency:

UK Economic and Social Research Council (ESRC)  RES-596-28-0001  ES/JO19119/1

Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2019-04-09Bibliographically approved
Ugge, H., Udumyan, R., Carlsson, J., Davidsson, S., Andrén, O., Montgomery, S. & Fall, K. (2018). Appendicitis before age 20 years is associated with an increased risk of later prostate cancer. Cancer Epidemiology, Biomarkers and Prevention, 27(6), 660-664
Open this publication in new window or tab >>Appendicitis before age 20 years is associated with an increased risk of later prostate cancer
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2018 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 27, no 6, p. 660-664Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Appendicitis before age 20 years has been observed to influence the risk of several inflammatory conditions, possibly through underlying immunological mechanisms. Inflammation has further been suggested to be involved in prostate cancer development. We therefore hypothesized that immunological characteristics signaled by appendicitis before late adolescence might influence the risk of later prostate cancer, and aimed to evaluate this association in a population-based study.

METHODS: We identified a large cohort of Swedish men who underwent assessment for military conscription around the age of 18 years (n= 242,573). Medical diagnoses at time of conscription were available through the Swedish Military Conscription Register. The Swedish Cancer Register was used to identify diagnoses of prostate cancer. Multivariable adjusted Cox regression analyses were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between appendicitis and prostate cancer.

RESULTS: During a median of 36.7 years of follow-up, 1,684 diagnoses of prostate cancer occurred. We found a statistically significant association between appendicitis and overall prostate cancer (adjusted HR: 1.70; 95% CI: 1.08-2.67). The risk was notably increased for advanced (HR: 4.42; 95% CI: 1.74-11.22) and lethal (HR: 8.95; 95% CI: 2.98-26.91) prostate cancer.

CONCLUSION: These results suggest that a diagnosis of appendicitis before adulthood potentially signals underlying immune characteristics and a pattern of inflammatory response relevant to prostate cancer risk.

IMPACT: The study lends support to the proposed role of inflammation in prostate carcinogenesis, and adds another area of investigation potentially relevant to prostate cancer development.

Place, publisher, year, edition, pages
American Association for Cancer Research, 2018
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-66449 (URN)10.1158/1055-9965.EPI-17-1204 (DOI)000433945800006 ()29588305 (PubMedID)2-s2.0-85047896683 (Scopus ID)
Note

Funding Agency:

UK Economic and Social Research Council (ESRC)  RES-596-28-0001  ES/JO19119/1

Available from: 2018-04-13 Created: 2018-04-13 Last updated: 2019-04-09Bibliographically approved
Davidsson, S., Andrén, O., Ohlson, A.-L., Carlsson, J., Andersson, S.-O., Giunchi, F., . . . Fiorentino, M. (2018). FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer. The Prostate, 78(1), 40-47
Open this publication in new window or tab >>FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer
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2018 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 78, no 1, p. 40-47Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The tumor promoting or counteracting effects of the immune response to cancer development are thought to be mediated to some extent by the infiltration of regulatory T cells (Tregs ). In the present study we evaluated the prevalence of Treg populations in stromal and epithelial compartments of normal, post atrophic hyperplasia (PAH), prostatic intraepithelial neoplasia (PIN), and tumor lesions in men with and without prostate cancer.

METHODS: Study subjects were 102 men consecutively diagnosed with localized prostate cancer undergoing radical prostatectomy and 38 men diagnosed with bladder cancer undergoing cystoprostatectomy without prostate cancer at the pathological examination. Whole mount sections from all patients were evaluated for the epithelial and stromal expression of CD4+ Tregs and CD8+ Tregs in normal, PAH, PIN, and tumor lesions. A Friedmańs test was used to investigate differences in the mean number of Tregs across histological lesions. Logistic regression was used to estimate crude and adjusted odds ratios (OR) for prostate cancer for each histological area.

RESULTS: In men with prostate cancer, similarly high numbers of stromal CD4+ Tregs were identified in PAH and tumor, but CD4+ Tregs were less common in PIN. Greater numbers of epithelial CD4+ Tregs in normal prostatic tissue were positively associated with both Gleason score and pT-stage. We observed a fourfold increased risk of prostate cancer in men with epithelial CD4+ Tregs in the normal prostatic tissue counterpart.

CONCLUSIONS: Our results may suggest a possible pathway through which PAH develops directly into prostate cancer in the presence of CD4+ Tregs and indicate that transformation of the anti-tumor immune response may be initiated even before the primary tumor is established.

Place, publisher, year, edition, pages
Hoboken, USA: John Wiley & Sons, 2018
Keywords
CD4+FOXP3+ Tregs, Lag-3+ Tregs, prostate carcinoma
National Category
Endocrinology and Diabetes Urology and Nephrology
Identifiers
urn:nbn:se:oru:diva-63016 (URN)10.1002/pros.23442 (DOI)000417131400006 ()29105795 (PubMedID)2-s2.0-85037338544 (Scopus ID)
Note

Funding Agencies:

Foundation for Medical Research at Örebro University Hospital  

Lions Cancer Foundation  

Örebro County Council Research Committee 

Available from: 2017-12-07 Created: 2017-12-07 Last updated: 2018-08-31Bibliographically approved
Erlandsson, A., Carlsson, J., Andersson, S.-O., Vyas, C., Wikström, P., Andrén, O., . . . Rider, J. R. (2018). High inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancer. Scandinavian journal of urology, 52(2), 129-133
Open this publication in new window or tab >>High inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancer
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2018 (English)In: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 52, no 2, p. 129-133Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The aim of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in lethal prostate cancer (PCa) by studying the iNOS immunoreactivity in tumor tissue from men diagnosed with localized PCa.

MATERIALS AND METHODS: This study is nested within a cohort of men diagnosed with incidental PCa undergoing transurethral resection of the prostate (the Swedish Watchful Waiting Cohort). To investigate molecular determinants of lethal PCa, men who died from PCa (n = 132) were selected as cases; controls (n = 168) comprised men with PCa who survived for at least 10 years without dying from PCa during follow-up. The immunoreactivity of iNOS in prostate tumor epithelial cells and in cells of the surrounding stroma was scored as low/negative, moderate or high. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for lethal PCa according to iNOS category.

RESULTS: There was no association between iNOS immunoreactivity in stroma and lethal disease. However, when comparing high versus low/negative iNOS immunoreactivity in epithelial cells, the OR for lethal PCa was 3.80 (95% CI 1.45-9.97).

CONCLUSION: Patients with localized PCa have variable outcomes, especially those with moderately differentiated tumors. Identifying factors associated with long-term PCa outcomes can elucidate PCa tumor biology and identify new candidate prognostic markers. These findings support the hypothesis that high iNOS in tumor epithelium of the prostate is associated with lethal disease.

Place, publisher, year, edition, pages
Informa Healthcare, 2018
Keywords
Inducible nitric oxide synthase, iNOS, nitric oxide, prognostic marker, prostate cancer
National Category
Urology and Nephrology Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-64111 (URN)10.1080/21681805.2017.1421261 (DOI)000446242100009 ()29307261 (PubMedID)2-s2.0-85041130976 (Scopus ID)
Note

Funding Agencies:

Örebro County Council Research Committee  

Foundation for Medical Research at Örebro University Hospital, Sweden  OLL-577581  OLL-488741 

Available from: 2018-01-12 Created: 2018-01-12 Last updated: 2018-10-16Bibliographically approved
Davidsson, S. (2018). PD-L1 Expression is Associated with Poor Prognosis in Renal Cell Carcinoma. In: : . Paper presented at 3rd International Cancer study & Therapy Conference, Rome, Italy, May 2-4, 2018.
Open this publication in new window or tab >>PD-L1 Expression is Associated with Poor Prognosis in Renal Cell Carcinoma
2018 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Programmed death ligand 1 (PD-L1) is an immunosuppressive membrane protein which, when interacting with its receptor programmed death 1 (PD-1), acts as a negative regulator of the anti-tumor T cell-mediated immune response. Overexpression of PD-L1 in different malignancies such as melanoma and gastric cancer is associated with poor clinical outcomes. The prognostic value of PD-L1 expression in renal cell carcinoma (RCC) has been controversial to some extent. In this study, the prognostic value of PD-L1 expression in RCC was evaluated by analyzing PD-L1 immunoreactivity in tumor cells and tumor infiltrating immune cells (TIICs) in 358 RCC patients with long term follow-up. Since the discrepancy between previous studies may be due to the lack of standardized methodology for evaluating PD-L1 expression by immunohistochemistry, the agreement between two anti-PD-L1 antibody clones, 28.8 and SP142, was also compared. PD-L1 positivity in tumor cells was associated with higher Fuhrman nuclear grade (p<0.001), recurrence (p=0.006), and death due to RCC (p=0.05). PD-L1 positivity in TIICs was associated with higher Fuhrman grade (p<0.001), higher AJCC-stage (p=0.019), and death due to RCC (p=0.001). A multivariate regression analysis revealed a significant positive association of time to cancer-specific death with both PD-L1 positive tumor cells and TIICs (p= 0.014 and p= 0.004, respectively). To conclude, RCC patients with PD-L1 positive tumor cells and TIICs are at significant risk for cancer progression, and the expression of PD-L1 on those cell types may be used as a complementary prognostic factor in the management of RCC patients.

National Category
Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-68671 (URN)
Conference
3rd International Cancer study & Therapy Conference, Rome, Italy, May 2-4, 2018
Available from: 2018-08-31 Created: 2018-08-31 Last updated: 2018-08-31Bibliographically approved
Carlsson, J., Davidsson, S., Fridfeldt, J., Giunchi, F., Fiano, V., Grasso, C., . . . Akre, O. (2018). Quantity and quality of nucleic acids extracted from archival formalin fixed paraffin embedded prostate biopsies. BMC Medical Research Methodology, 18(1), Article ID 161.
Open this publication in new window or tab >>Quantity and quality of nucleic acids extracted from archival formalin fixed paraffin embedded prostate biopsies
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2018 (English)In: BMC Medical Research Methodology, ISSN 1471-2288, E-ISSN 1471-2288, Vol. 18, no 1, article id 161Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: In Sweden, human tissue samples obtained from diagnostic and surgical procedures have for decades been routinely stored in a formalin-fixed, paraffin-embedded, form. Through linkage with nationwide registers, these samples are available for molecular studies to identify biomarkers predicting mortality even in slow-progressing prostate cancer. However, tissue fixation causes modifications of nucleic acids, making it challenging to extract high-quality nucleic acids from formalin fixated tissues.

METHODS: In this study, the efficiency of five commercial nucleic acid extraction kits was compared on 30 prostate biopsies with normal histology, and the quantity and quality of the products were compared using spectrophotometry and Agilent's BioAnalyzer. Student's t-test's and Bland-Altman analyses were performed in order to investigate differences in nucleic acid quantity and quality between the five kits. The best performing extraction kits were subsequently tested on an additional 84 prostate tumor tissues. A Spearman's correlation test and linear regression analyses were performed in order to investigate the impact of tissue age and amount of tissue on nucleic acid quantity and quality.

RESULTS: Nucleic acids extracted with RNeasy® FFPE and QIAamp® DNA FFPE Tissue kit had the highest quantity and quality, and was used for extraction from 84 tumor tissues. Nucleic acids were successfully extracted from all biopsies, and the amount of tumor (in millimeter) was found to have the strongest association with quantity and quality of nucleic acids.

CONCLUSIONS: To conclude, this study shows that the choice of nucleic acid extraction kit affects the quantity and quality of extracted products. Furthermore, we show that extraction of nucleic acids from archival formalin-fixed prostate biopsies is possible, allowing molecular studies to be performed on this valuable sample collection.

Place, publisher, year, edition, pages
BioMed Central, 2018
Keywords
Archival formalin-fixed paraffin-embedded tissue, Nucleic acid isolation kits, Prostate biopsies, RNA integrity number
National Category
Urology and Nephrology Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-70618 (URN)10.1186/s12874-018-0628-1 (DOI)000452277900002 ()30518332 (PubMedID)2-s2.0-85058594763 (Scopus ID)
Funder
Swedish Cancer Society, CAN 2011/825
Note

Funding Agencies:

Italian Association for Cancer Research (IARC)  

Örebro county council research committee  

Lions cancer research foundation in Uppsala/Örebro 

Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2019-01-07Bibliographically approved
Ugge, H., Carlsson, J., Söderquist, B., Fall, K., Andrén, O. & Davidsson, S. (2018). The influence of prostatic Cutibacterium acnes infection on serum levels of IL6 and CXCL8 in prostate cancer patients. Infectious Agents and Cancer, 13, Article ID 34.
Open this publication in new window or tab >>The influence of prostatic Cutibacterium acnes infection on serum levels of IL6 and CXCL8 in prostate cancer patients
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2018 (English)In: Infectious Agents and Cancer, ISSN 1750-9378, E-ISSN 1750-9378, Vol. 13, article id 34Article in journal (Refereed) Published
Abstract [en]

Background: Chronic prostatic inflammation, caused by Cutibacterium acnes (C. acnes), has been proposed to influence the risk of prostate cancer development. In vitro studies have demonstrated the capacity of C. acnes to induce secretion of Interleukin 6 (IL6) and C-X-C motif chemokine ligand 8 (CXCL8) by prostate epithelial cells. Both these inflammatory mediators have been implicated in prostate cancer pathophysiology. In this cohort study, we aimed to investigate the influence of prostatic C. acnes on serum levels of IL6 and CXCL8.

Methods: We recruited 99 prostate cancer patients who underwent radical prostatectomy at orebro University Hospital. The cultivation of pre-operatively obtained prostate biopsies identified C. acnes in 60 of the 99 patients. Levels of IL6 and CXCL8 in pre-operative serum samples were analyzed using ELISA, and concentrations were compared between prostate cancer patients with and without prostatic C. acnes infection using standard statistical methods.

Results: No statistical differences were observed in serum levels of IL6 and CXCL8 between subjects with and without prostatic C. acnes infection.

Conclusions: Our results indicate that prostatic C. acnes infection may give rise to low-grade inflammation with little effect on systemic levels of IL6 and CXCL8.

Place, publisher, year, edition, pages
BioMed Central, 2018
Keywords
Prostate cancer, Inflammation, Cutibacterium acnes, IL6, CXCL8, Cytokines
National Category
Cancer and Oncology Immunology in the medical area
Identifiers
urn:nbn:se:oru:diva-70366 (URN)10.1186/s13027-018-0204-7 (DOI)000450287500001 ()30473726 (PubMedID)2-s2.0-85056906445 (Scopus ID)
Note

Funding Agency:

Foundation Lions Cancerforskningsfond vid Akademiska sjukhuset i Uppsala 

Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2019-04-08Bibliographically approved
Mushtaq, M., Jensen, L., Davidsson, S., Grygoruk, O. V., Andrén, O., Kashuba, V. & Kashuba, E. (2018). The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells. Scientific Reports, 8(1), Article ID 2268.
Open this publication in new window or tab >>The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, no 1, article id 2268Article in journal (Refereed) Published
Abstract [en]

We have earlier found abnormal expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) in endometrial cancer, compared to the expression in hyperplasia and in normal endometrium. Here we report that expression of S18-2 was increased with disease progression in clinical specimens of prostate cancer (PCa). The level of induction of epithelial to mesenchymal cell transition (EMT) correlated with the expression level of S18-2 in PCa cell lines. Moreover, cells acquired increased ability of migration upon S18-2 overexpression, as was evaluated in zebrafish embryo model and in trans-well assay. We found that this is due to increased CXCR4 cell surface expression. Neutralizing CXCR4 protein or abrogating S18-2 expression in cells significantly reduced their migratory ability directed toward CXCL12. The mRNA expression of TWIST2, encoding one of transcription factors that induce EMT upon CXCR4 increase, positively correlated with the S18-2 protein level. Together, these data suggest that the S18-2 protein induces EMT through the TWIST2/E-cadherin signalling and, consequently, CXCR4-mediated migration of PCa cells.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Cancer and Oncology Urology and Nephrology
Identifiers
urn:nbn:se:oru:diva-64841 (URN)10.1038/s41598-018-20765-8 (DOI)000319588900001 ()29396484 (PubMedID)2-s2.0-85041612784 (Scopus ID)
Available from: 2018-02-07 Created: 2018-02-07 Last updated: 2019-09-20Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-2850-6009

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