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Memedi, Mevludin, PhDORCID iD iconorcid.org/0000-0002-2372-4226
Publications (10 of 43) Show all publications
Aghanavesi, S., Bergquist, F., Nyholm, D., Senek, M. & Memedi, M. (2019). Motion sensor-based assessment of Parkinson's disease motor symptoms during leg agility tests: results from levodopa challenge. IEEE journal of biomedical and health informatics
Open this publication in new window or tab >>Motion sensor-based assessment of Parkinson's disease motor symptoms during leg agility tests: results from levodopa challenge
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2019 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208Article in journal (Refereed) Epub ahead of print
Abstract [en]

Parkinson's disease (PD) is a degenerative, progressive disorder of the central nervous system that mainly affects motor control. The aim of this study was to develop data-driven methods and test their clinimetric properties to detect and quantify PD motor states using motion sensor data from leg agility tests. Nineteen PD patients were recruited in a levodopa single dose challenge study. PD patients performed leg agility tasks while wearing motion sensors on their lower extremities. Clinical evaluation of video recordings was performed by three movement disorder specialists who used four items from the motor section of the Unified PD Rating Scale (UPDRS), the treatment response scale (TRS) and a dyskinesia score. Using the sensor data, spatiotemporal features were calculated and relevant features were selected by feature selection. Machine learning methods like support vector machines (SVM), decision trees and linear regression, using 10-fold cross validation were trained to predict motor states of the patients. SVM showed the best convergence validity with correlation coefficients of 0.81 to TRS, 0.83 to UPDRS #31 (body bradykinesia and hypokinesia), 0.78 to SUMUPDRS (the sum of the UPDRS items: #26-leg agility, #27-arising from chair and #29-gait), and 0.67 to dyskinesia. Additionally, the SVM-based scores had similar test-retest reliability in relation to clinical ratings. The SVM-based scores were less responsive to treatment effects than the clinical scores, particularly with regards to dyskinesia. In conclusion, the results from this study indicate that using motion sensors during leg agility tests may lead to valid and reliable objective measures of PD motor symptoms.

Place, publisher, year, edition, pages
IEEE Computer Society, 2019
Keywords
Leg agility, Parkinson's disease, support vector machines, stepwise regression, predictive models
National Category
Computer and Information Sciences Neurology
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-72361 (URN)10.1109/JBHI.2019.2898332 (DOI)
Funder
Knowledge Foundation
Available from: 2019-02-09 Created: 2019-02-09 Last updated: 2019-02-11Bibliographically approved
Thomas, I., Alam, M., Bergquist, F., Johansson, D., Memedi, M., Nyholm, D. & Westin, J. (2019). Sensor-based algorithmic dosing suggestions for oral administration of levodopa/carbidopa microtablets for Parkinson’s disease: a first experience. Journal of Neurology, 266(3), 651-658
Open this publication in new window or tab >>Sensor-based algorithmic dosing suggestions for oral administration of levodopa/carbidopa microtablets for Parkinson’s disease: a first experience
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2019 (English)In: Journal of Neurology, ISSN 0340-5354, E-ISSN 1432-1459, Vol. 266, no 3, p. 651-658Article in journal (Refereed) Published
Abstract [en]

Objective: Dosing schedules for oral levodopa in advanced stages of Parkinson’s disease (PD) require careful tailoring to fit the needs of each patient. This study proposes a dosing algorithm for oral administration of levodopa and evaluates its integration into a sensor-based dosing system (SBDS).

Materials and methods: In collaboration with two movement disorder experts a knowledge-driven, simulation based algorithm was designed and integrated into a SBDS. The SBDS uses data from wearable sensors to fit individual patient models, which are then used as input to the dosing algorithm. To access the feasibility of using the SBDS in clinical practice its performance was evaluated during a clinical experiment where dosing optimization of oral levodopa was explored. The supervising neurologist made dosing adjustments based on data from the Parkinson’s KinetiGraph™ (PKG) that the patients wore for a week in a free living setting. The dosing suggestions of the SBDS were compared with the PKG-guided adjustments.

Results: The SBDS maintenance and morning dosing suggestions had a Pearson’s correlation of 0.80 and 0.95 (with mean relative errors of 21% and 12.5%), to the PKG-guided dosing adjustments. Paired t test indicated no statistical differences between the algorithmic suggestions and the clinician’s adjustments.

Conclusion: This study shows that it is possible to use algorithmic sensor-based dosing adjustments to optimize treatment with oral medication for PD patients.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2019
Keywords
Levodopa, Parkinson’s disease, Algorithmic suggestions, Sensor data, Oral medication
National Category
Computer and Information Sciences Neurology
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-71616 (URN)10.1007/s00415-019-09183-6 (DOI)000459203400013 ()30659356 (PubMedID)2-s2.0-85060256040 (Scopus ID)
Funder
Knowledge FoundationVINNOVA
Note

Funding Agencies:

Acreo (Sweden)  

Cenvigo (Sweden)  

Sensidose (Sweden)  

Uppsala University (Sweden)  

Gothenburg University (Sweden)  

Dalarna University (Sweden) 

Available from: 2019-01-21 Created: 2019-01-21 Last updated: 2019-03-13Bibliographically approved
Thomas, I., Memedi, M., Westin, J. & Nyholm, D. (2019). The effect of continuous levodopa treatment during the afternoon hours. Acta Neurologica Scandinavica, 139(1), 70-75
Open this publication in new window or tab >>The effect of continuous levodopa treatment during the afternoon hours
2019 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 139, no 1, p. 70-75Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this retrospective study was to investigate if patients with PD, who are treated with levodopa‐carbidopa intestinal gel (LCIG), clinically worsen during the afternoon hours and if so, to evaluate whether this occurs in all LCIG‐treated patients or in a sub‐group of patients.

Methods: Three published studies were identified and included in the analysis. All studies provided individual response data assessed on the treatment response scale (TRS) and patients were treated with continuous LCIG. Ninety‐eight patients from the three studies fulfilled the criteria. T‐tests were performed to find differences on the TRS values between the morning and the afternoon hours, linear mixed effect models were fitted on the afternoon hours’ evaluations to find trends of wearing‐off, and patients were classified into three TRS categories (meaningful increase in TRS, meaningful decrease in TRS, non ‐meaningful increase or decrease).

Results: In all three studies significant statistical differences were found between the morning TRS values and the afternoon TRS values (p‐value <= 0.001 in all studies). The linear mixed effect models had significant negative coefficients for time in two studies, and 48 out of 98 patients (49%) showed a meaningful decrease of TRS during the afternoon hours.

Conclusion: The results from all studies were consistent, both in the proportion of patients in the three groups and the value of TRS decrease in the afternoon hours. Based on these findings there seems to be a group of patients with predictable “off” behavior in the later parts of the day.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
diurnal motor fluctuation, infusion pumps, levodopa, Parkinson disease
National Category
Neurology Computer and Information Sciences
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-68788 (URN)10.1111/ane.13020 (DOI)000452067700007 ()30180267 (PubMedID)2-s2.0-85053714059 (Scopus ID)
Note

Funding Agencies:

Dalarna University  

Uppsala University  

Örebro University 

Available from: 2018-09-07 Created: 2018-09-07 Last updated: 2019-01-07Bibliographically approved
Javed, F., Thomas, I. & Memedi, M. (2018). A comparison of feature selection methods when using motion sensors data: a case study in Parkinson’s disease. In: : . Paper presented at 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'18), Honolulu, Hawaii, USA, July 17-21, 2018. IEEE
Open this publication in new window or tab >>A comparison of feature selection methods when using motion sensors data: a case study in Parkinson’s disease
2018 (English)Conference paper, Published paper (Refereed)
Abstract [en]

The objective of this study is to investigate the effects of feature selection methods on the performance of machine learning methods for quantifying motor symptoms of Parkinson’s disease (PD) patients. Different feature selection methods including step-wise regression, Lasso regression and Principal Component Analysis (PCA) were applied on 88 spatiotemporal features that were extracted from motion sensors during hand rotation tests. The selected features were then used in support vector machines (SVM), decision trees (DT), linear regression, and random forests models to calculate a so-called treatment-response index (TRIS). The validity, testretest reliability and sensitivity to treatment were assessed for each combination (feature selection method plus machine learning method). There were improvements in correlation coefficients and root mean squared error (RMSE) for all the machine learning methods, except DTs, when using the selected features from step-wise regression inputs. Using step-wise regression and SVM was found to have better sensitivity to treatment and higher correlation to clinical ratings on the Unified PD Rating Scale as compared to the combination of PCA and SVM. When assessing the ability of the machine learning methods to discriminate between tests performed by PD patients and healthy controls the results were mixed. These results suggest that the choice of feature selection methods is crucial when working with data-driven modelling. Based on our findings the step-wise regression can be considered as the method with the best performance.

Place, publisher, year, edition, pages
IEEE, 2018
Keywords
Feature extraction, Support vector machines, Principal component analysis, Correlation, Machine learning, Predictive models, Sensors
National Category
Computer and Information Sciences
Research subject
Informatics; Statistics
Identifiers
urn:nbn:se:oru:diva-69954 (URN)10.1109/EMBC.2018.8513683 (DOI)
Conference
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'18), Honolulu, Hawaii, USA, July 17-21, 2018
Funder
Knowledge Foundation
Available from: 2018-10-30 Created: 2018-10-30 Last updated: 2018-10-31Bibliographically approved
Memedi, M., Lindqvist, J., Tunedal, T. & Duvåker, A. (2018). A study on pre-adoption of a self-management application by Parkinson’s disease patients. In: : . Paper presented at 39th International Conference on Information Systems(ICIS 2018), San Francisco, California, USA, December 13-16, 2018. Association for Information Systems
Open this publication in new window or tab >>A study on pre-adoption of a self-management application by Parkinson’s disease patients
2018 (English)Conference paper, Published paper (Refereed)
Abstract [en]

The aim of this paper is to provide an overview of factors influencing the acceptance by Parkinson's disease (PD) patients of a self-management application for an Internet of Things system. Unified Theory of Acceptance and Use of Technology (UTAUT) factors including performance expectancy, effort expectancy, and social influence were tested along with sociodemographic (age and gender) and technology-associated (experience with modern technology) factors to determine their contributions for predicting behavioral intention to use the application. Fifty respondents completed the survey. The results show that the UTAUT-based factors, sociodemographic and technology-associated factors account for 82.9% of the variability in PD patients' behavioralintention to use the application. We found that women were significantly more positive than men (p<0.001) in their intention to use the application. If offered the application in the future, 70% of the respondents would use it. Respondents with lower level of experience with technology had less intention to use the application. Performance expectancy and social influence were the only factors that positively predicted intention to use the application. The results showed high scores related to intention to use the application, suggesting high acceptance of the application by the PD patients. Based on qualitative results, the application was seen by PD patients as a useful tool for providing them a better overview of their health status. Finally, the acceptance of the application can be increased by showing its benefits to the PD patients and by developing social strategies to encourage them to stimulate each other to use the application.

Place, publisher, year, edition, pages
Association for Information Systems, 2018
Keywords
Technology acceptance, Internet of Things, patient interface, self-management, Parkinson’s disease, sensor technology
National Category
Human Aspects of ICT
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-70769 (URN)
Conference
39th International Conference on Information Systems(ICIS 2018), San Francisco, California, USA, December 13-16, 2018
Projects
EMPARK
Funder
Knowledge Foundation
Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2018-12-18Bibliographically approved
Thomas, I., Westin, J., Alam, M., Bergquist, F., Nyholm, D., Senek, M. & Memedi, M. (2018). A treatment–response index from wearable sensors for quantifying Parkinson's disease motor states. IEEE journal of biomedical and health informatics, 22(5), 1341-1349, Article ID 8119948.
Open this publication in new window or tab >>A treatment–response index from wearable sensors for quantifying Parkinson's disease motor states
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2018 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 22, no 5, p. 1341-1349, article id 8119948Article in journal (Refereed) Published
Abstract [en]

The goal of this study was to develop an algorithm that automatically quantifies motor states (off,on,dyskinesia) in Parkinson's disease (PD), based on accelerometry during a hand pronation-supination test. Clinician's ratings using the Treatment Response Scale (TRS), ranging from -3 (very Off) to 0 (On) to +3 (very dyskinetic), was used as target. For that purpose, 19 participants with advanced PD and 22 healthy persons were recruited in a single center open label clinical trial in Uppsala, Sweden. The trial consisted of single levodopa dose experiments for the people with PD (PwP), where participants were asked to perform standardized wrist rotation tests, using each hand, before and at pre-specified time points after the dose. The participants used wrist sensors containing a 3D accelerometer and gyroscope. Features to quantify the level, variation and asymmetry of the sensor signals, three-level Discrete Wavelet Transform features and approximate entropy measures were extracted from the sensors data. At the time of the tests, the PwP were video recorded. Three movement disorder specialists rated the participants’ state on the TRS scale. A Treatment Response Index from Sensors (TRIS) was constructed to quantify the motor states based on the wrist rotation tests. Different machine learning algorithms were evaluated to map the features derived from the sensor data to the ratings provided by the three specialists. Results from cross validation, both in 10-fold and a leave-one-individual out setting, showed good predictive power of a support vector machine model and high correlation to the TRS scale. Values at the end tails of the TRS scale were under and over predicted due to the lack of observations at those values but the model managed to accurately capture the dose - effect profiles of the patients. In addition, the TRIS had good test-retest reliability on the baseline levels of the PD participants (Intraclass correlation coefficient of 0.83) and reasonable sensitivity to levodopa treatment (0.33 for the TRIS). For a series of test occasions the proposed algorithms provided dose - effect time profiles for participants with PD, which could be useful during therapy individualization of people suffering from advanced PD.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2018
Keywords
Machine learning, Levodopa response, Signal processing, Parkinson’s disease, Accelerometry, Wearable sensors, Pattern recognition
National Category
Other Medical Engineering Computer Sciences
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-62864 (URN)10.1109/JBHI.2017.2777926 (DOI)000441795800002 ()29989996 (PubMedID)2-s2.0-85035809095 (Scopus ID)
Funder
Knowledge FoundationVINNOVA
Note

Funding Agencies:

Acreo (Sweden)  

Cenvigo (Sweden)  

Sensidose (Sweden)  

Uppsala University (Sweden)  

Dalarna University (Sweden) 

Available from: 2017-11-28 Created: 2017-11-28 Last updated: 2018-08-31Bibliographically approved
Kolkowska, E., Scandurra, I., Avatare Nöu, A., Sjölinder, M. & Memedi, M. (2018). A user-centered ethical assessment of welfare technology for elderly. In: Jia Zhou, Gavriel Salvendy (Ed.), Human Aspects of IT for the Aged Population. Applications in Health, Assistance, and Entertainment: . Paper presented at 4th International Conference on Human Aspects of IT for the Aged Population (ITAP 2018), Held as Part of HCI International 2018, Las Vegas, United States, July 15-20, 2018 (pp. 59-73). Springer
Open this publication in new window or tab >>A user-centered ethical assessment of welfare technology for elderly
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2018 (English)In: Human Aspects of IT for the Aged Population. Applications in Health, Assistance, and Entertainment / [ed] Jia Zhou, Gavriel Salvendy, Springer, 2018, p. 59-73Conference paper, Published paper (Refereed)
Abstract [en]

Welfare technology (WT) is often developed with a technical perspective, and little consideration is taken regarding the involvement of important ethical considerations and different values that come up during the development and implementation of WT. Safety, security and privacy are significant, as well as the usability and overall benefit of the tool, but to date assessments often lack a holistic picture of the WT as seen by the users. This paper suggests a user-centered ethical assessment (UCEA) framework for WT to be able to evaluate ethical consequences as a part of the user-centered aspects. Building on established methodologies from research on ethical considerations, as well as the research domain of human-computer interaction, this assessment framework joins knowledge of ethical consequences with aspects affecting the “digitalization with the individual in the center”, e.g. privacy, safety, well-being, dignity, empowerment and usability. The framework was applied during development of an interface for providing symptom information to Parkinson patients. The results showed that the UCEA framework directs the attention to values emphasized by the patients. Thus, functionality of the system was evaluated in the light of values and expected results of the patients, thereby facilitating follow-up of a user-centered assessment. The framework may be further developed and tested, but in this study it served as a working tool for assessing ethical consequences of WT as a part of user-centered aspects.

Place, publisher, year, edition, pages
Springer, 2018
Series
Lecture Notes in Computer Science, ISSN 0302-9743, E-ISSN 1611-3349 ; 10927
Keywords
Ethical evaluation, Elderly, Welfare technology, Assistive technology, Ambient-assisted living, Health-enabling technology, Framework, User-centered, Assessment
National Category
Human Computer Interaction
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-68527 (URN)10.1007/978-3-319-92037-5_6 (DOI)2-s2.0-85050586674 (Scopus ID)978-3-319-92036-8 (ISBN)978-3-319-92037-5 (ISBN)
Conference
4th International Conference on Human Aspects of IT for the Aged Population (ITAP 2018), Held as Part of HCI International 2018, Las Vegas, United States, July 15-20, 2018
Projects
EMPARK
Funder
Knowledge Foundation
Available from: 2018-08-20 Created: 2018-08-20 Last updated: 2018-08-22Bibliographically approved
Memedi, M., Tshering, G., Fogelberg, M., Jusufi, I., Kolkowska, E. & Klein, G. O. (2018). An interface for IoT: feeding back health-related data to Parkinson's disease patients. Journal of Sensor and Actuator Networks, 7(1), Article ID 14.
Open this publication in new window or tab >>An interface for IoT: feeding back health-related data to Parkinson's disease patients
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2018 (English)In: Journal of Sensor and Actuator Networks, E-ISSN 2224-2708, Vol. 7, no 1, article id 14Article in journal (Refereed) Published
Abstract [en]

This paper presents a user-centered design (UCD) process of an interface for Parkinson’s disease (PD) patients for helping them to better manage their symptoms. The interface is designed to visualize symptom and medication information, collected by an Internet of Things (IoT)-based system, which will consist of a smartphone, electronic dosing device, wrist sensor and a bed sensor. In our work, the focus is on measuring data related to some of the main health-related quality of life aspects such as motor function, sleep, medication compliance, meal intake timing in relation to medication intake, and physical exercise. A mock-up demonstrator for the interface was developed using UCD methodology in collaboration with PD patients. The research work was performed as an iterative design and evaluation process based on interviews and observations with 11 PD patients. Additional usability evaluations were conducted with three information visualization experts. Contributions include a list of requirements for the interface, results evaluating the performance of the patients when using the demonstrator during task-based evaluation sessions as well as opinions of the experts. The list of requirements included ability of the patients to track an ideal day, so they could repeat certain activities in the future as well as determine how the scores are related to each other. The patients found the visualizations as clear and easy to understand and could successfully perform the tasks. The evaluation with experts showed that the visualizations are in line with the current standards and guidelines for the intended group of users. In conclusion, the results from this work indicate that the proposed system can be considered as a tool for assisting patients in better management of the disease by giving them insights on their own aggregated symptom and medication information. However, the actual effects of providing such feedback to patients on their health-related quality of life should be investigated in a clinical trial.

Place, publisher, year, edition, pages
Multidisciplinary Digital Publishing Institute (MDPI), 2018
Keywords
Information visualization; user-centered design; internet of things; sensor technology; Parkinson’s disease; patient empowerment; quality of life
National Category
Human Computer Interaction
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-65675 (URN)10.3390/jsan7010014 (DOI)000428559500013 ()2-s2.0-85044327671 (Scopus ID)
Projects
EMPARK
Funder
Knowledge Foundation, 20160176
Note

Funding Agencies:

Sensidose AB  

Cenvigo AB  

Nethouse Sverige AB  

Swedish Institute 

Available from: 2018-03-12 Created: 2018-03-12 Last updated: 2018-12-19Bibliographically approved
Karni, L., Memedi, M., Kolkowska, E. & Klein, G. O. (2018). EMPARK: Internet of Things for Empowerment and Improved Treatment of Patients with Parkinson's Disease. In: : . Paper presented at International Congress of Parkinson´s Disease and Movement Disorders, Hong Kong, People's Republic of China, 5-9 October, 2018. John Wiley & Sons
Open this publication in new window or tab >>EMPARK: Internet of Things for Empowerment and Improved Treatment of Patients with Parkinson's Disease
2018 (English)Conference paper, Poster (with or without abstract) (Other (popular science, discussion, etc.))
Abstract [en]

Objective: This study aims to assess the effects of patient-directed feedback from remote symptom, medication, and disease activity monitoring on patient empowerment and treatment in Parkinson’s disease (PD).

Background: There is a need to empower patients with PD to be able to understand better and control their disease using prescribed medication and following recommendations on lifestyle. The research project EMPARK will develop an Internet of Things system of sensors, mobile devices to deliver real-time, 24/7 patient symptom information with the primary goal to support PD patients empowerment and better understanding of their disease. The system will be deployed in patient homes to continuously measure movements, time-in-bed and drug delivery from a micro-dose levodopa system. Subjective symptom scoring, time of meals and physical activities will be reported by the patients via a smartphone application. Interfaces for patients and clinicians are being developed based on the user center design methodology to ensure maximal user acceptance. 

Methods: This is a randomized controlled trial where 30 PD patients from 2 university clinics in Sweden will be randomized to receive (intervention group) or not (control group) continuous feedback from the results of the EMPARK home monitoring for 2 weeks. Disease-specific (UPDRS, PDQ-39), Quality of Life (QoL) (modified EuroQoL EQ-5D) and empowerment questionnaires will be collected prior and after the intervention. The correlation of technology-based objective and patient-reported subjective parameters will be assessed in both groups. Interviews will be conducted with the clinicians and observations will be made about the patient-clinician interaction to assess the potential treatment benefits of the intervention.

Results: Preliminary results from workshops with patients and clinicians show potential to improve patient empowerment and disease control among patients. Completion of the trial will show the degree of patient empowerment, individualized treatment, and patientclinician interactions.

Conclusions: Raising patients’ awareness about disease activity and home medication is possible among PD patients by providing them with feedback from the results of a home monitoring system. This randomized, controlled trial aims to provide evidence that this approach leads to improved patient empowerment and treatment results.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018
National Category
Computer and Information Sciences
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-69955 (URN)
Conference
International Congress of Parkinson´s Disease and Movement Disorders, Hong Kong, People's Republic of China, 5-9 October, 2018
Funder
Knowledge Foundation
Available from: 2018-10-30 Created: 2018-10-30 Last updated: 2018-11-14Bibliographically approved
Aghanavesi, S., Filip, B., Nyholm, D., Senek, M. & Memedi, M. (2018). Feasibility of a multi-sensor data fusion method for assessment of Parkinson’s disease motor symptoms. In: : . Paper presented at International Congress of Parkinson’s Disease and Movement Disorders (MDS), Hong Kong, Dept. of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden, 5-9 October, 2018.
Open this publication in new window or tab >>Feasibility of a multi-sensor data fusion method for assessment of Parkinson’s disease motor symptoms
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2018 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Title: Feasibility of a multi-sensor data fusion method for assessment of Parkinson’s disease motor symptoms

Objective: To assess the feasibility of measuring Parkinson’s disease (PD) motor symptoms with a multi-sensor data fusion method. More specifically, the aim is to assess validity, reliability and sensitivity to treatment of the methods.

Background: Data from 19 advanced PD patients (Gender: 14 males and 5 females, mean age: 71.4, mean years with PD: 9.7, mean years with levodopa: 9.5) were collected in a single center, open label, single dose clinical trial in Sweden [1].

Methods: The patients performed leg agility and 2-5 meter straight walking tests while wearing motion sensors on their limbs. They performed the tests at baseline, at the time they received the morning dose, and at pre-specified time points until the medication wore off. While performing the tests the patients were video recorded. The videos were observed by three movement disorder specialists who rated the symptoms using a treatment response scale (TRS), ranging from -3 (very off) to 3 (very dyskinetic). The sensor data consisted of lower limb data during leg agility, upper limb data during walking, and lower limb data during walking. Time series analysis was performed on the raw sensor data extracted from 17 patients to derive a set of quantitative measures, which were then used during machine learning to be mapped to mean ratings of the three raters on the TRS scale. Combinations of data were tested during the machine learning procedure.

Results: Using data from both tests, the Support Vector Machines (SVM) could predict the motor states of the patients on the TRS scale with a good agreement in relation to the mean ratings of the three raters (correlation coefficient = 0.92, root mean square error = 0.42, p<0.001). Additionally, there was good test-retest reliability of the SVM scores during baseline and second tests with intraclass-correlation coefficient of 0.84. Sensitivity to treatment for SVM was good (Figure 1), indicating its ability to detect changes in motor symptoms. The upper limb data during walking was more informative than lower limb data during walking since SVMs had higher correlation coefficient to mean ratings.  

Conclusions: The methodology demonstrates good validity, reliability, and sensitivity to treatment. This indicates that it could be useful for individualized optimization of treatments among PD patients, leading to an improvement in health-related quality of life.

National Category
Computer and Information Sciences Physiology
Research subject
Informatics
Identifiers
urn:nbn:se:oru:diva-69855 (URN)
Conference
International Congress of Parkinson’s Disease and Movement Disorders (MDS), Hong Kong, Dept. of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden, 5-9 October, 2018
Available from: 2018-10-25 Created: 2018-10-25 Last updated: 2018-10-29Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-2372-4226

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