To Örebro University

oru.seÖrebro University Publications
Change search
Link to record
Permanent link

Direct link
Alternative names
Publications (10 of 70) Show all publications
Nilsagård, Y., Smith, D. R., Söderqvist, F., Nilsing Strid, E. & Wallin, L. (2025). Achieving health-promotion practice in primary care using a multifaceted implementation strategy: a non-randomized parallel group study. Implementation Science Communications, 6(1), Article ID 36.
Open this publication in new window or tab >>Achieving health-promotion practice in primary care using a multifaceted implementation strategy: a non-randomized parallel group study
Show others...
2025 (English)In: Implementation Science Communications, E-ISSN 2662-2211, Vol. 6, no 1, article id 36Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Evidence-based healthcare recommendations exist for tobacco use, harmful alcohol consumption, low physical activity, and poor diet. However, the uptake of these recommendations in Swedish primary healthcare is poor, and the potential benefits for patients are not fully realized. Our aim was to evaluate the effect (i.e. the uptake) of a 12-month multifaceted implementation strategy to achieve a more health-promoting practice. We hypothesized that primary healthcare centers receiving this strategy would increase and sustain their health-promotion practices to a significantly greater extent than control centers, from baseline to the 6-month follow-up.

METHODS: In a non-randomized parallel group study, 5 intervention centers and 5 matched control centers were compared regarding health-promotion activities delivered in relation to visits to each center. The intervention centers received a multifaceted implementation strategy over at least 12 months based on established strategies, the Astrakan model of leading change, and findings from pre-implementation studies. The main strategies were: using external and internal facilitators to combine bottom-up and top-down perspectives, and emphasizing leadership responsibility for change. Medical record data on health-promotion activities, including prescribed physical activity and use of lifestyle screening forms, were collected monthly for 2 years: 6 months before and after implementation, and during the implementation phase. The implementation strategy effect was estimated using generalized linear mixed models.

RESULTS: During the 12-month implementation phase, the intervention and control sites had 135 002 and 160 987 healthcare visits, respectively; conducted 8839 and 6171 health-promotion activities, respectively; and administered 2423 and 282 lifestyle screening forms, respectively. A statistically significant higher relative uptake rate of health-promotion activities was found in intervention sites compared to control sites after the implementation period compared to before. The effect increased during the active phase, with the intervention sites having on average 1.07 and 2.0 times the uptake rate of the control sites at 1 and 12 months, respectively; this effect was largely maintained during the 6-month post-intervention phase. A significant absolute effect, in terms of difference in predicted uptake per 1000 visits, was evident 7 months into the implementation phase.

CONCLUSION: This multi-faceted implementation strategy was successful in achieving a more health-promoting practice.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2025
Keywords
Change Management, Clinical Practice Guidelines, Health Promotion, Healthy Lifestyle, Implementation Science, Primary Health Care
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:oru:diva-120446 (URN)10.1186/s43058-025-00723-y (DOI)001463755400001 ()40197376 (PubMedID)2-s2.0-105002896929 (Scopus ID)
Funder
Örebro UniversityRegion Örebro County, OLL-96956
Available from: 2025-04-09 Created: 2025-04-09 Last updated: 2025-04-28Bibliographically approved
Svedjebrant, M., Bråndal, A. & Nilsagård, Y. (2025). Experiences of participation in cardiorespiratory training among people with post-stroke fatigue: a qualitative study. Journal of Rehabilitation Medicine, 57, Article ID jrm42282.
Open this publication in new window or tab >>Experiences of participation in cardiorespiratory training among people with post-stroke fatigue: a qualitative study
2025 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 57, article id jrm42282Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To explore the experiences of 8-week thrice-weekly supervised intense cardiorespiratory interval training at home in people with post-stroke fatigue. DESIGN: Qualitative, using semi-structured individual interviews.

METHODS: Eleven people with post-stroke fatigue were recruited from a study investigating the effects of supervised intense cardiorespiratory interval training. The interviews were conducted 1-2 weeks after the intervention period and analysed inductively with qualitative content analysis.

RESULTS: The theme "Supervised cardiorespiratory interval training at home was perceived as feasible and safe, reducing fatigue and contributing to enhanced self-efficacy in both exercise and everyday life" was based on 4 main categories: "Experiences of performing the intervention and testing, "Perceived impact of the intervention on fatigue", "Perceived impact of the intervention on self-efficacy", and "The reinforcing experiences of exercise transfer to everyday life". The informants reported that participating in the intervention made them feel physically and mentally stronger and no longer restricted by a lack of confidence in performing activities that increased their heart rate.

CONCLUSIONS: Participating in supervised intense cardiorespiratory interval training provided a model on how to train, which was transferable to other contexts in everyday life. The training improved exercise self-efficacy and gave the informants the confidence to challenge themselves in everyday life.

Place, publisher, year, edition, pages
Foundation of Rehabilitation Medicine, 2025
Keywords
cerebrovascular disorders, post-stroke fatigue, cardiorespiratory training, qualitative study, physiotherapy
National Category
Rehabilitation Medicine
Identifiers
urn:nbn:se:oru:diva-120659 (URN)10.2340/jrm.v57.42282 (DOI)001480994500001 ()40237418 (PubMedID)
Available from: 2025-04-17 Created: 2025-04-17 Last updated: 2025-05-15Bibliographically approved
Hälleberg Nyman, M., Nilsagård, Y., Nilsing Strid, E. & Fjordkvist, E. (2025). One fracture is enough!: Support for implementation of a new care process. In: : . Paper presented at European Implementation Event 2025 (EIE 2025), Newcastle upon Tyne, June 4-6, 2025.
Open this publication in new window or tab >>One fracture is enough!: Support for implementation of a new care process
2025 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Nursing
Identifiers
urn:nbn:se:oru:diva-120414 (URN)
Conference
European Implementation Event 2025 (EIE 2025), Newcastle upon Tyne, June 4-6, 2025
Funder
Nyckelfonden, 999960
Available from: 2025-04-04 Created: 2025-04-04 Last updated: 2025-04-23Bibliographically approved
Määttä, S., Petersson, C., Andersson Gäre, B., Henriks, G., Ånfors, H., Lundberg, C. & Nilsagård, Y. (2024). Experiences of co-producing person-centred and cohesive clinical pathways in the national system for knowledge-based management in Swedish healthcare: a qualitative study. Research Involvement and Engagement, 10, Article ID 55.
Open this publication in new window or tab >>Experiences of co-producing person-centred and cohesive clinical pathways in the national system for knowledge-based management in Swedish healthcare: a qualitative study
Show others...
2024 (English)In: Research Involvement and Engagement, E-ISSN 2056-7529, Vol. 10, article id 55Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: When the 21 Swedish county councils decided to collaborate in the creation of a national system for knowledge-based management, patient participation was mandatory. Patient and next-of-kin representatives (PR) co-produced person-centred and cohesive clinical pathways together with healthcare professionals (HPR). Research on co-production in healthcare at the national level is scarce. The aim of this study is to explore experiences of patient participation from the perspectives of both PRs and HPRs when co-producing clinical pathways within the Swedish nationwide healthcare system for knowledge-based management.

METHODS: A qualitative study was conducted. A strategic sample of nine PRs and eight HPRs were interviewed individually between August 2022 and January 2023 using a semi-structured interview guide. We analysed data using an inductive content analysis.

RESULTS: Three main categories were identified: (1) Finding appropriate patient representativeness; (2) Working methods that facilitate a patient perspective; and (3) Influence of the patient perspective in the clinical pathways.

CONCLUSIONS: The study demonstrates the importance of patient and next-of-kin participation in the construction of clinical pathways at the national level. The results provide a platform for further research on patient participation on the national level and add to studies on if and how patient participation on this level has an impact on how the clinical pathways are put into practice at the micro level, and the support provided at the meso level. The study contributes to the growing body of literature studying patient participation and co-production.

TRIAL REGISTRATION: Region Örebro County ID 276,940. An advisory opinion was obtained from the Swedish Ethical Review Authority (2021-05899-01).

Keywords
Clinical pathways, Co-production, Experiences, Healthcare, Healthcare system, Macro level, Management, Patient participation
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:oru:diva-114117 (URN)10.1186/s40900-024-00565-3 (DOI)38849932 (PubMedID)2-s2.0-85195592840 (Scopus ID)
Funder
Region Örebro County, OLL-977423
Available from: 2024-06-10 Created: 2024-06-10 Last updated: 2025-01-20Bibliographically approved
Nilsing Strid, E., Wallin, L. & Nilsagård, Y. (2024). Exploring expectations and readiness for healthy lifestyle promotion in Swedish primary health care: a qualitative analysis of managers, facilitators, and professionals. Scandinavian Journal of Primary Health Care, 42(1), 201-213
Open this publication in new window or tab >>Exploring expectations and readiness for healthy lifestyle promotion in Swedish primary health care: a qualitative analysis of managers, facilitators, and professionals
2024 (English)In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 42, no 1, p. 201-213Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Prior to a multifaceted implementation strategy for a healthy lifestyle-promoting practice the expectations of primary health care managers, appointed internal facilitators and health care professionals on supporting change was explored.

DESIGN: This study had an explorative qualitative design using data gathered from individual interviews and focus groups. Qualitative content analysis with a deductive category development was applied using the Consolidated Framework for Implementation Research.

SETTING AND PARTICIPANTS: The study was conducted in a primary care setting in central Sweden as a part of the Act in Time research project. Prior to a multifaceted implementation strategy, we held 16 individual interviews with managers and appointed facilitators and five focus groups with 26 health care professionals.

RESULTS: Managers, facilitators, and professionals held similar expectations, where their expressed need for support corresponded to three constructs: Readiness for implementation, Implementation climate, and Engaging. Our findings indicate the need for strong leadership engagement to focus on how the healthy lifestyle-promoting practice can be anchored among the professionals. Managers at all levels should communicate the vision and goals, enable facilitators and professionals to improve their competencies, build inter-professional teams, and jointly plan the new practice.

CONCLUSION: To change to a healthy lifestyle promoting practice professionals request support from their managers, who in turn need support from the middle and top managers. The requested support includes helping to prioritise health promotion and enabling the primary care centres to build competence and take ownership of the implementation.

TRIAL REGISTRATION: ClinicalTrials.gov NCT04799860.

Place, publisher, year, edition, pages
Taylor & Francis, 2024
Keywords
Qualitative research, health personnel, healthy lifestyle, implementation science, leadership, practice guidelines, primary health care
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:oru:diva-111025 (URN)10.1080/02813432.2023.2301556 (DOI)001145189500001 ()38241166 (PubMedID)2-s2.0-85182677608 (Scopus ID)
Funder
Region Örebro County, OLL-969561
Available from: 2024-01-30 Created: 2024-01-30 Last updated: 2024-03-22Bibliographically approved
Wäneskog, A. H., Forsberg, A. & Nilsagård, Y. (2024). Exploring the Complexity of Falls in People With Multiple Sclerosis: A Qualitative Study. International Journal of MS Care, 26(Q4), 308-314
Open this publication in new window or tab >>Exploring the Complexity of Falls in People With Multiple Sclerosis: A Qualitative Study
2024 (English)In: International Journal of MS Care, ISSN 1537-2073, E-ISSN 2834-5398, Vol. 26, no Q4, p. 308-314Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The complexity of falls in people with multiple sclerosis (MS) needs further exploration to develop strategies to reduce fall risk. The aim of this study is to explore and describe factors contributing to falls and the complexity of fall situations in people with MS.

METHODS: This longitudinal study used individual interviews shortly after prospective reporting of falls. Manifest analysis was used to describe frequency, place, and time of falls. The International Classification of Functioning, Disability and Health (ICF) was used for deductive content analyses to describe fall-inducing factors. Participants were adults with MS (N = 33) who had experienced falls during the past year and who did not use walking aids.

RESULTS: The 25 participants who fell during the study period reported 94 falls, mainly during the day (61%) and outdoors (56%). Fall situations were complex, with interaction between triggering and circumstantial factors related to all domains in the ICF, the impact of preceding factors, and fluctuating symptoms.

CONCLUSIONS: The complexity of fall situations can be more clearly understood and managed by considering the preceding activities and circumstances in addition to describing single risk factors. This may facilitate discussions of fall risk between health care professionals and people with MS. Individualized fall risk assessments and interventions that strengthen self-management are recommended.

Place, publisher, year, edition, pages
Delaware Media Group, 2024
Keywords
Accidents, complexity, fall risk, falls
National Category
Physiotherapy
Identifiers
urn:nbn:se:oru:diva-117244 (URN)10.7224/1537-2073.2024-020 (DOI)39502367 (PubMedID)2-s2.0-85209905552 (Scopus ID)
Funder
Nyckelfonden
Available from: 2024-11-07 Created: 2024-11-07 Last updated: 2025-02-11Bibliographically approved
Nilsing Strid, E., Wallin, L. & Nilsagård, Y. (2023). Expectations on implementation of a health promotion practice using individually targeted lifestyle interventions in primary health care: a qualitative study. BMC Primary Care, 24(1), Article ID 122.
Open this publication in new window or tab >>Expectations on implementation of a health promotion practice using individually targeted lifestyle interventions in primary health care: a qualitative study
2023 (English)In: BMC Primary Care, E-ISSN 2731-4553, Vol. 24, no 1, article id 122Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: There is moderate to strong evidence of the effectiveness of health-promotion interventions, but implementation in routine primary health care (PHC) has been slow. In the Act in Time project implementation support is provided for a health promotion practice using individually targeted lifestyle interventions in a PHC setting. Identifying health care professionals' (HCPs') perceptions of barriers and facilitators helps adapt implementation activities and achieve a more successful implementation. This study aimed, at a pre-implementation stage, to describe the expectations of managers, appointed internal facilitators (IFs) and HCPs on implementing a healthy lifestyle-promoting practice in PHC.

METHODS: In this qualitative study five focus group discussions with 27 HCPs and 16 individual interviews with managers and appointed IFs were conducted at five PHC centres in central Sweden. The PHC centres are participating in the Act in Time project, evaluating the process and outcomes of a multifaceted implementation strategy for a healthy lifestyle-promoting practice. A deductive qualitative content analysis based on the Consolidated Framework for Implementation Research (CFIR) was followed using inductive analysis.

RESULTS: Twelve constructs from four of five CFIR domains were derived: Innovation characteristics, Outer setting, Inner setting, and Characteristics of individuals. These domains are related to the expectations of HCPs to implement a healthy lifestyle-promoting practice, which includes facilitating factors and barriers. The inductive analysis showed that the HCPs perceived a need for a health-promotion approach to PHC. It serves the needs of the patients and the expectations of the HCPs, but lifestyle interventions must be co-produced with the patient. The HCPs expected that changing routine practice into a healthy lifestyle-promoting practice would be challenging, requiring sustainability, improved structures, cooperation in inter-professional teams, and a common purpose. A collective understanding of the purpose of changing practice was vital to successful implementation.

CONCLUSIONS: The HCPs valued implementing a healthy lifestyle-promoting practice in a PHC setting. However, changing routine methods was challenging, implying that the implementation strategy should address obstacles and facilitating factors identified by the HCPs.

TRIAL REGISTRATION: This study is part of the Act in Time project, registered in ClinicalTrials.gov with the number NCT04799860. Registered 03 March 2021.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2023
Keywords
Change Management, Clinical Practice Guidelines, Health Personnel, Healthy Lifestyle, Implementation Science, Primary Health Care, Qualitative Research
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:oru:diva-106397 (URN)10.1186/s12875-023-02079-5 (DOI)001012438000003 ()37328813 (PubMedID)2-s2.0-85162070185 (Scopus ID)
Funder
Örebro UniversityRegion Örebro County, OLL-969561
Available from: 2023-06-26 Created: 2023-06-26 Last updated: 2024-04-05Bibliographically approved
Anens, E., Ahlström, I., Emtner, M., Zetterberg, L., Nilsagård, Y. & Hellström, K. (2023). Validity and reliability of physical activity measures in multiple sclerosis. Physiotherapy Theory and Practice, 39(1), 137-153
Open this publication in new window or tab >>Validity and reliability of physical activity measures in multiple sclerosis
Show others...
2023 (English)In: Physiotherapy Theory and Practice, ISSN 0959-3985, E-ISSN 1532-5040, Vol. 39, no 1, p. 137-153Article in journal (Refereed) Published
Abstract [en]

PURPOSE: The purpose was to evaluate the psychometric properties of physical activity measures in persons with multiple sclerosis (PwMS).

METHODS: Adults with multiple sclerosis were recruited, n = 30 (validation) and n = 57 (test-retest). Steps measured with PiezoRX, Yamax SW200 and ActiGraph GT9X Link (AGlink) and time in different positions measured with AGlink were validated against data from video analysis. Psychometric properties of the Physical Activity and Disability Survey - Revised Swedish version (PADS-R(Sw)) was evaluated.

RESULTS: The most valid measures were AGlink using the low-frequency extension filter, and PiezoRX with median absolute percentage errors (MeAPEs) of 0.9-3.1% and 1.3-3.3%. The MeAPEs were higher for Yamax SW200 (2.9-21.0%), AGlink display (3.6-44.8%) and AGlink normal filter (8.9-48.9%), indicating low validity. AGlink was not valid in measurements of sitting (MeAPE 12.0-12.5%) or lying (MeAPE 31.0-41.7%). The correlation between PADS-R(Sw) and AGlink steps was r = 0.492 (p = .009). The relative reliability of PADS-R(Sw) was ICC2,1 0.85 (CI 0.76-0.91), and absolute reliability was SEM 0.54.

CONCLUSION: AGlink and PiezoRX were valid measures of steps in PwMS. The questionnaire PADS-R(Sw) was valid, with high relative reliability, but its absolute reliability was unsatisfactory.

Place, publisher, year, edition, pages
Taylor & Francis, 2023
Keywords
Exercise, multiple sclerosis, physical activity, reproducibility of results, validation studies
National Category
Physiotherapy
Identifiers
urn:nbn:se:oru:diva-95328 (URN)10.1080/09593985.2021.1996498 (DOI)000714815700001 ()34738486 (PubMedID)2-s2.0-85118577741 (Scopus ID)
Funder
Norrbacka-Eugenia FoundationP.O. Zetterling Foundation
Available from: 2021-11-08 Created: 2021-11-08 Last updated: 2025-02-11Bibliographically approved
Nilsing Strid, E., Wallin, L. & Nilsagård, Y. (2022). Implementation of a Health Promotion Practice Using Individually Targeted Lifestyle Interventions in Primary Health Care: Protocol for the "Act in Time" Mixed Methods Process Evaluation Study. JMIR Research Protocols, 11(8), Article ID e37634.
Open this publication in new window or tab >>Implementation of a Health Promotion Practice Using Individually Targeted Lifestyle Interventions in Primary Health Care: Protocol for the "Act in Time" Mixed Methods Process Evaluation Study
2022 (English)In: JMIR Research Protocols, E-ISSN 1929-0748, Vol. 11, no 8, article id e37634Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: There is growing evidence that noncommunicable diseases (NCDs) can be attributable to unhealthy lifestyle habits. However, there has been little application of this knowledge in primary health care (PHC).

OBJECTIVE: This study aims to evaluate the process and outcomes of a multifaceted implementation strategy for a healthy lifestyle-promoting practice in a PHC setting. This practice is based on national guidelines targeting unhealthy lifestyle habits with a potential risk for NCDs.

METHODS: A pre-post implementation study design with a control group is used in a PHC setting in central Sweden. The Medical Research Council guidelines for process evaluation of complex interventions will be applied. The implementation process and outcomes will be assessed using a mix of qualitative and quantitative methods. A strategic sample of up to 6 PHC centers will be included as intervention centers, which will receive a 12-month multifaceted implementation strategy. Up to 6 matched PHC centers will serve as controls. Core components in the implementation strategy are external and internal facilitators in line with the integrated-Promoting Action on Research Implementation in Health Services (i-PARIHS) framework and the Astrakan change leadership model. Data will be collected at baseline, during the implementation phase, and 4-6 months after the implementation strategy. Questionnaires will be sent to roughly 500 patients in every PHC center and 200 health care professionals (HCPs) before and after implementation. In addition, purposeful sampling will be used for interviews and focus group discussions with managers, HCPs, patient representatives, and internal and external facilitators. Use of data from medical records and activity logs will be an additional data source.

RESULTS: Recruitment of PHC centers began in March 2021 and ended in Spring 2022. Based on the planned timeline with the 12-month implementation strategy and 4-6-month follow-up, we expect to collect the final data in Summer 2023.

CONCLUSIONS: This study will explain implementation process and outcomes using a multifaceted implementation strategy for a healthy lifestyle-promoting practice in a real-world PHC context. The study is expected to provide new knowledge about the role of facilitators and their contribution to implementation outcomes. These findings can guide policy makers, managers, and PHC staff to integrate health promotion and disease prevention in PHC and provide methodological support to facilitators.

TRIAL REGISTRATION: ClinicalTrials.gov NCT04799860; https://clinicaltrials.gov/ct2/show/NCT04799860.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/37634.

Place, publisher, year, edition, pages
JMIR Publications, Inc., 2022
Keywords
Facilitation, health personnel, health promotion, implementation science, lifestyle, practice guideline, primary health care, qualitative research, quality improvement
National Category
Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:oru:diva-100730 (URN)10.2196/37634 (DOI)001096112800003 ()35984700 (PubMedID)2-s2.0-85136670571 (Scopus ID)
Available from: 2022-08-22 Created: 2022-08-22 Last updated: 2025-02-20Bibliographically approved
Westerdahl, E., Gunnarsson, M., Wittrin, A. & Nilsagård, Y. (2021). Pulmonary Function and Respiratory Muscle Strength in Patients with Multiple Sclerosis. Multiple Sclerosis International, 2021, Article ID 5532776.
Open this publication in new window or tab >>Pulmonary Function and Respiratory Muscle Strength in Patients with Multiple Sclerosis
2021 (English)In: Multiple Sclerosis International, ISSN 2090-2654, E-ISSN 2090-2662, Vol. 2021, article id 5532776Article in journal (Refereed) Published
Abstract [en]

Background: In patients with multiple sclerosis (MS), there is a decline in muscle strength and physical capacity due to demyelination and axonal loss in the central nervous system. In patients with advanced MS or in a later stage of the disease, also respiratory impairment may occur. The degree of pulmonary dysfunction in the earlier stages of MS has not been thoroughly described. Therefore, the primary aims of this study are to describe pulmonary function and respiratory muscle strength in patients with a moderate disease course and to identify associations between respiratory muscle strength and functional capacity.

Methods: A sample of 48 patients with a diagnosis of MS and mean age 56 +/- 11 years was studied using a descriptive cross-sectional design. The patients had a disease duration of 24 +/- 11 years and a median Expanded Disability Status Scale (EDSS) score of 4.5 (interquartile range 4.0-6.5). Pulmonary function assessed by spirometry, respiratory muscle strength, peak cough flow and peripheral oxygen saturation, subjective breathing and coughing ability, and physical capacity measured using the 6MWT were evaluated.

Results: The patients had normal pulmonary function with no significant abnormalities in dynamic spirometry (vital capacity 103 +/- 16% predicted, forced expiratory volume in 1 second 95 +/- 15% predicted). Peak expiratory flow rate 89 +/- 17% predicted was in the lower limit of normal. Respiratory muscle strength, determined by maximal inspiratory (MIP) and expiratory (MEP) static pressures, was normal but with large differences between individuals. MIP ranged from 26 to 143 cmH(2)O (98 +/- 31% predicted); the MEP values ranged from 43 to 166 cmH(2)O (104 +/- 29% predicted), with two patients having values below the lower limit of normal. Significant positive associations between MIP as well as MEP were found in several pulmonary function variables. A significant negative association was found between EDSS score and MEP (r=-0.312, p=0.031). Mean peak cough flow was 389 +/- 70 L/min, which is comparable with the values reported for healthy adults. The patients did not experience a severely decreased ability to take deep breaths or cough. There was a moderate correlation between MEP and physical capacity, as assessed by the 6MWT (r=0.399, p=0.010) and between peak expiratory flow (PEF) and the 6MWT (r=0.311, p=0.048).

Conclusion: Respiratory muscle strength, pulmonary function assessed by spirometry, and peak cough flow were normal in patients with mild to moderate MS; however, there were large individual differences demonstrating low respiratory muscle strength in some patients. Significant associations between MEP and functional capacity and between MEP and disease severity were found, indicating that patients with impaired respiratory muscle strength have lower functional capacity and more severe disease.

Place, publisher, year, edition, pages
Hindawi Limited, 2021
National Category
Neurology
Identifiers
urn:nbn:se:oru:diva-93240 (URN)10.1155/2021/5532776 (DOI)000669928900001 ()34221507 (PubMedID)
Available from: 2021-07-29 Created: 2021-07-29 Last updated: 2021-07-29Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9760-3785

Search in DiVA

Show all publications