oru.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Edebol-Carlman, HannaORCID iD iconorcid.org/0000-0001-8451-6263
Alternative names
Publications (10 of 16) Show all publications
Edebol-Carlman, H., Rode, J., König, J., Hutchinson, A., Repsilber, D., Kiselev, A., . . . Brummer, R. J. (2019). Evaluating the effects of probiotic intake on brain activity during an emotional attention task and blood markers related to stress in healthy subjects. In: : . Paper presented at Mind, Mood & Microbes, 2nd International Conference on Microbiota-Gut-Brain Axis, Amsterdam, The Netherlands, 17-18 January, 2019.
Open this publication in new window or tab >>Evaluating the effects of probiotic intake on brain activity during an emotional attention task and blood markers related to stress in healthy subjects
Show others...
2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:oru:diva-73848 (URN)
Conference
Mind, Mood & Microbes, 2nd International Conference on Microbiota-Gut-Brain Axis, Amsterdam, The Netherlands, 17-18 January, 2019
Available from: 2019-04-17 Created: 2019-04-17 Last updated: 2019-04-17Bibliographically approved
Edebol-Carlman, H., Schrooten, M. G. S., Ljóttson, B., Boersma, K., Linton, S. J. & Brummer, R. J. (2018). Cognitive behavioral therapy for irritable bowel syndrome: the effects on state and trait anxiety and the autonomic nervous system during induced rectal distensions - An uncontrolled trial. Scandinavian Journal of Pain, 18, 81-91
Open this publication in new window or tab >>Cognitive behavioral therapy for irritable bowel syndrome: the effects on state and trait anxiety and the autonomic nervous system during induced rectal distensions - An uncontrolled trial
Show others...
2018 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 18, p. 81-91Article in journal (Refereed) Published
Abstract [en]

Background and aims: Irritable bowel syndrome (IBS), is a common multifactorial gastrointestinal disorder linked to disturbances in the microbe gut-brain axis. Cognitive behavioral therapy (CBT), in face-to-face format has showed promising results on IBS and its associated psychological symptoms. The present study explored for the first time if CBT for IBS affects the autonomic nervous system (ANS) during experimentally induced visceral pain and cognitive stress, respectively. The levels of state and trait anxiety, current and perceived stress were also evaluated.

Methods: In this uncontrolled trial, individual CBT was performed in face-to-face format for 12 weeks in 18 subjects with IBS. Heart rate variability and skin conductance were measured during experimentally induced visceral pain and during a cognitive task (Stroop color-word test), before and after intervention. The levels of state and trait anxiety as well as self-rated current and perceived stress were also measured before and after the intervention.

Results: CBT did not affect ANS activity during experimentally induced visceral pain and cognitive stress. The sympathetic activity was high, typical for IBS and triggered during both visceral pain and cognitive stress. The levels of state and trait anxiety significantly decreased after the intervention. No significant changes in self-rated current or perceived stress were found.

Conclusions: Results suggest that face-to-face CBT for IBS improved anxiety- a key psychological mechanism for the IBS pathophysiology, rather than the autonomic stress response to experimentally induced visceral pain and cognitive stress, respectively.

Place, publisher, year, edition, pages
Walter de Gruyter, 2018
Keywords
irritable bowel syndrome; cognitive behavioral therapy; state anxiety; trait anxiety; stress; autonomic nervous system; visceral hypersensitivity
National Category
Neurology
Identifiers
urn:nbn:se:oru:diva-64294 (URN)10.1515/sjpain-2017-0153 (DOI)000426817200009 ()2-s2.0-85043578532 (Scopus ID)
Available from: 2018-01-16 Created: 2018-01-16 Last updated: 2018-03-27Bibliographically approved
Wall, R., Marques, T., Edebol-Carlman, H., Sundin, J., Vumma, R., Rangel, I. & Brummer, R. J. (2017). Altered expression of membrane transporters in colonic mucosa of patients with Irritable Bowel Syndrome (IBS) and Post-infectious (PI)-IBS compared to healthy subjects. Neurogastroenterology and Motility, 29(Suppl. 2), 107-108
Open this publication in new window or tab >>Altered expression of membrane transporters in colonic mucosa of patients with Irritable Bowel Syndrome (IBS) and Post-infectious (PI)-IBS compared to healthy subjects
Show others...
2017 (English)In: Neurogastroenterology and Motility, ISSN 1350-1925, E-ISSN 1365-2982, Vol. 29, no Suppl. 2, p. 107-108Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Irritable bowel syndrome (IBS) affects 5%- 15% of adults in the general population, and is characterized by chronic recurrent abdominal pain and discomfort and associated with altered bowel habits. The pathophysiology of IBS is complex and not fully under-stood. Hence, treatment is often based on symptomatology rather than underlying physiological aberrancies.

Objective: To compare the expression of membrane transporters in mucosal biopsies of healthy subjects, IBS patients and post- infectious (PI)- IBS patients.

Methods: Mucosal biopsies were obtained from the unprepared sigmoid colon in 18 IBS patients, 9 PI- IBS patients and 10 healthy subjects. Total RNA was isolated and prepared for gene expression analyses using quantitative reverse- transcription polymerase chain reaction (qRT- PCR). We compared the expression of genes encoding membrane- spanning transporters, using GAPDH as a reference gene, and by using the comparative 2- ΔΔCt method.

Results: Colonic expression of SCL7A5 and SLC3A2 (together com-prising the amino acid transporter LAT1+4F2hc) was significantly lower in IBS patients, but not in PI- IBS patients, compared to healthy controls (P<.001). The expression of SLC7A8 (LAT2) tended to be lower in IBS patients compared to controls (P=.06). Mucosal gene ex-pression of the short chain fatty acid transporter SMCT1 (SLC5A8) was lower in both IBS- patients and PI- IBS patients compared to healthy subjects (P<.01).

Conclusions: The amino acid transporters LAT1 and LAT2 appeared to be affected in IBS patients, but not in PI- IBS patients, compared to healthy subjects, suggesting a possible alteration in amino acids transport in this patient group. Furthermore, our results suggest a lower uptake of short chain fatty acids in both IBS- and PI- IBS pa-tients. Altered expression of these transporters may be involved in the pathophysiology of IBS as well as being a potential biomarker of this aberration, and therefore deserves further study in IBS.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
National Category
Gastroenterology and Hepatology Neurology
Identifiers
urn:nbn:se:oru:diva-60601 (URN)10.1111/nmo.13180 (DOI)000407643600220 ()
Available from: 2017-09-05 Created: 2017-09-05 Last updated: 2019-04-24Bibliographically approved
Boersma, K., Ljótsson, B., Edebol-Carlman, H., Schrooten, M., Linton, S. J. & Brummer, R. J. (2016). Exposure-based cognitive behavioral therapy for irritable bowel syndrome: A single-case experimental design across 13 subjects. Cognitive Behaviour Therapy, 45(6), 415-430
Open this publication in new window or tab >>Exposure-based cognitive behavioral therapy for irritable bowel syndrome: A single-case experimental design across 13 subjects
Show others...
2016 (English)In: Cognitive Behaviour Therapy, ISSN 1650-6073, E-ISSN 1651-2316, Vol. 45, no 6, p. 415-430Article in journal (Refereed) Published
Abstract [en]

Irritable bowel syndrome (IBS) is a highly prevalent disorder with a significant impact on quality of life. The presence of psychological symptoms in IBS patients such as catastrophic worry and behavioral avoidance suggests the possible efficacy of cognitive behavioral interventions. Exposure-based cognitive behavioral therapy (CBT) has proven to be a promising approach but has only been investigated in a few studies and mainly via the Internet. Therefore, the aims of this study were to extend and replicate previous findings and to evaluate whether an individual, face-to-face, exposure-based CBT leads to improvement in gastrointestinal symptoms, pain catastrophizing, avoidance behavior and quality of life in IBS patients. Thirteen patients with IBS according to Rome III criteria participated in a single-case experimental study using a five-week baseline and a subsequent twelve-session intervention phase focusing on psycho-education, mindfulness and in vivo exposure. Standardized measurement of gastrointestinal symptoms, pain catastrophizing, avoidance behavior and quality of life was conducted weekly during baseline as well as intervention phase and at six-month follow-up. Results showed that over 70% of patients improved significantly on gastrointestinal symptoms, pain catastrophizing, and quality of life. Effects on avoidance behavior were modest. These results strengthen and extend earlier findings and provide further support for the efficacy of exposure-based strategies for IBS.

Place, publisher, year, edition, pages
Oxon, United Kingdom: Routledge, 2016
Keywords
Irritable bowel syndrome, exposure treatment, singlecase experimental design, behavioral medicine
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:oru:diva-50864 (URN)10.1080/16506073.2016.1194455 (DOI)000389240600001 ()27285475 (PubMedID)2-s2.0-84982085450 (Scopus ID)
Available from: 2016-06-15 Created: 2016-06-15 Last updated: 2018-07-13Bibliographically approved
König, J., Ganda-Mall, J.-P., Rangel, I., Edebol-Carlman, H. & Brummer, R. J. (2015). The Role of the Gut Microbiota in Brain Function. In: Koen Venema & Ana Paula do Carmo (Ed.), Probiotics and Prebiotics: Current Research and Future Trends. Poole, UK: Caister Academic Press
Open this publication in new window or tab >>The Role of the Gut Microbiota in Brain Function
Show others...
2015 (English)In: Probiotics and Prebiotics: Current Research and Future Trends / [ed] Koen Venema & Ana Paula do Carmo, Poole, UK: Caister Academic Press, 2015Chapter in book (Refereed)
Place, publisher, year, edition, pages
Poole, UK: Caister Academic Press, 2015
National Category
Medical and Health Sciences Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:oru:diva-39860 (URN)978-1-910190-09-8 (ISBN)
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2019-03-26Bibliographically approved
Edebol-Carlman, H., Nordén, T. & Norlander, T. (2013). Behavior change and pain relief in chronic whiplash associated disorder Grade IV using flotation restricted environmental stimulation technique: A case report. Psychology and Behavioral Sciences, 2, 202-216
Open this publication in new window or tab >>Behavior change and pain relief in chronic whiplash associated disorder Grade IV using flotation restricted environmental stimulation technique: A case report
2013 (English)In: Psychology and Behavioral Sciences, ISSN 2328-7837, E-ISSN 2328-7845, Vol. 2, p. 202-216Article in journal (Refereed) Published
Abstract [en]

Pain is a major public health problem and the needs for more differentiated and flexible treatment options are obvious. The purpose of the present study was to examine, for the first time, experiences from long-term flotation Restricted Environmental Stimulation Technique (REST) made by a patient with chronic Whiplash Associated Disorder (WAD), grade IV. The patient of the present study was a middle aged native-born Caucasian male from Sweden who had been diagnosed with chronic WAD IV by a licensed physician. The patient performed regular flotation during one and a half year and wrote about his experiences in a diary. A semi-structured interview was conducted at the end of therapy. Both the diary and the interviews were analyzed with help of the empirical phenomenological psychological method and results describe experiences of relaxation, pain relief, sleep and deep rest, mental coping, increased energy, wellbeing and behavioral changes as a result of flotation. A model describes the rehabilitative circuit of chronic whiplash during flotation and is in line with the potential role of a stress response system for development and management of chronic whiplash. The study provides qualitative insights into the experiences of flotation as a pain- and stress- management system for chronic whiplash. Results are encouraging for future research and even suggest that interested clinics may use flotation-REST in order to relieve chronic pain and enhance the quality of life for a more comprehensive group of patients with whiplash associated disorders.

Keywords
Chronic WAD, Whiplash, Stress, Pain, Flotation, Phenomenology
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:oru:diva-39859 (URN)10.11648/j.pbs.20130206.12 (DOI)
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2018-08-27Bibliographically approved
Edebol, H., Helldin, L. & Norlander, T. (2013). Measuring adult attention deficit hyperactivity disorder using the Quantified Behavior Test Plus. PsyCh Journal, 2(1), 48-62
Open this publication in new window or tab >>Measuring adult attention deficit hyperactivity disorder using the Quantified Behavior Test Plus
2013 (English)In: PsyCh Journal, ISSN 2046-0252, E-ISSN 2046-0260, Vol. 2, no 1, p. 48-62Article in journal (Refereed) Published
Abstract [en]

Attention Deficit Hyperactivity Disorder (ADHD) occurs in approximately 5% of the adult population and includes cardinal symptoms of hyperactivity, inattention, and impulsivity that may be difficult to identify with clinical routine methods. Continuous performance tests are objective measures of inattention and impulsivity that, combined with objective measures of motor activity, facilitate identification of ADHD among adults. The aim of the present study was to examine the sensitivity, specificity, and a composite measure of ADHD using objective measures of the ADHD-cardinal symptoms in adult participants with ADHD and non-ADHD normative participants. Cardinal symptoms were measured in 55 participants having ADHD, 202 non-ADHD normative participants, as well as 84 ADHD normative participants using the Quantified Behavior Test Plus. This test measures inattention and impulsivity using a continuous performance test, and hyperactivity using a motion-tracking system. A predictive variable for the detection of ADHD called Prediction of ADHD yielded 86% sensitivity and 83% specificity. A composite measure of ADHD cardinal symptoms was developed using a Weighed Core Symptoms scale that indicated the total amount of ADHD symptoms on a numeric scale from 0 to 100. The total amount of ADHD symptoms was measured on a scale and predicted with the categorical variable in a majority of the cases in the present study. Further studies are needed in order to confirm the results with regard to additional clinical and normative samples. Careful consideration of potential sex and diagnostic subtype differences are noteworthy aspects for future examinations of the new instruments.

Place, publisher, year, edition, pages
John Wiley & Sons, 2013
Keywords
adults, Attention Deficit Hyperactivity Disorder, psychometrics, objective measures
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:oru:diva-39856 (URN)10.1002/pchj.17 (DOI)24294490 (PubMedID)
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2018-05-22Bibliographically approved
Edebol-Carlman, H. & Norlander, T. (2013). Perspektiv på utredning och diagnos vid ADHD. Socialmedicinsk Tidskrift, 90(3), 319-327
Open this publication in new window or tab >>Perspektiv på utredning och diagnos vid ADHD
2013 (Swedish)In: Socialmedicinsk Tidskrift, ISSN 0037-833X, Vol. 90, no 3, p. 319-327Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [sv]

Attention Deficit Hyperactivity Disorder, ADHD, är en erkänd och väl etablerad klinisk diagnos som används inom psykiatrin för att beteckna en samling beteenden som återfinns hos både barn och vuxna och som orsakar problem i vardagen. Diagnosen har hög klinisk validitet vilket innebär att ADHD hänger ihop rent statistiskt, uppvisas av barn och vuxna som har funktionsnedsättning och behöver hjälp, svarar på behandling samt korrelerar med andra meningsfulla markörer på grupp-nivå t ex olika biologiska och genetiska markörer samt via långtidsuppföljningar. I likhet med de flesta andra psykiatriska diagnoser (förutom vissa typer av mental retardation) har diagnosen inte uppnått etiologisk validitet eftersom vi då skulle behöva förklara orsakerna till ADHD i varje enskilt fall. Mycket forskning är idag inriktad på orsaksmekanismer inom ramen för multifaktoriella teorier.

De sociala och medicinska konsekvenserna av ADHD är många och allvarliga och hänger samman med att ADHD hos de flesta, i synnerhet vuxna, idag är en odiagnostiserad funktionsnedsättning. Långsiktig behandling och positiva resultat är ofta avhängig kvaliteten på utredningarna, och här ser vi att vetenskapligt utprovade och tillförlitliga metoder är nödvändiga och utslagsgivande. Vi valde att med utgångspunkt från ett befintligt test (Quantified Behavior Test Plus) utveckla två mått som kan användas vid klinisk utredning av ADHD hos vuxna personer. PADHD är ett kategoriskt mått (ja/nej) som predicerar sannolikheten för ADHD med goda testresultat i avseende på sensitivitet och specificitet. WCS är ett mått på graden av ADHD från 0 till 100 som visat sig i stor utsträckning kunna skilja personer med ADHD från personer utan psykiatriska diagnoser samt skilja ADHD från andra liknande psykiatriska diagnoser. En studie antyder också att WCS kan indikera respons och remission vid behandling med centralstimulerande läkemedel.

ADHD diagnosen innebär en rad metodologiska utmaningar samt medför särskilt i obehandlad form allvarliga socialmedicinska konsekvenser för individen och samhället. Diagnosens exakta utformning kommer sannolikt att förändras en del under den närmaste tiden vilket kan påverka utredningsarbetet. Målet är dock detsamma, att på ett systematiskt, empirinära och konstruktivt sätt undersöka, beskriva och göra allt som det enskilda fallet kräver för att uppnå och bibehålla remission samt förmedla att det finns god behandling och hopp att få.

Keywords
ADHD, diagnostik, objektiva mått, WCS, PADHD
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:oru:diva-39862 (URN)
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2018-05-22Bibliographically approved
Kjellgren, A., Edebol-Carlman, H., Nordén, T. & Norlander, T. (2013). Quality of Life with Flotation Therapy for a Person diagnosed with Attention Deficit Disorder, Atypical autism, PTSD, Anxiety and Depression. Open Journal of Medical Psychology, 2, 134-138
Open this publication in new window or tab >>Quality of Life with Flotation Therapy for a Person diagnosed with Attention Deficit Disorder, Atypical autism, PTSD, Anxiety and Depression
2013 (English)In: Open Journal of Medical Psychology, ISSN 2165-9370, Vol. 2, p. 134-138Article in journal (Refereed) Published
Abstract [en]

The aim of this single-subject study was to report experiences from one and a half years of regular floating as described by a person with neuropsychiatric and mental health disorders. Floating, or Flotation Restricted Environmental Stimulation Technique, involves relaxation and sensory deprivation by means of resting in a tank with highly salted and body-tempered water. The subject, a 24-year-old woman diagnosed with attention deficit hyperactivity disorder, atypical autism, posttraumatic stress disorder, anxiety and depression floated regularly for one and a half years. Interviews regarding her experiences were analyzed and the main findings involved a subjective sense of improved quality of life, wellbeing and healthy behavior. There were no negative effects from treatment. Results suggest that floating may have beneficial therapeutic effects on mental health. Further studies that evaluate the efficacy and possible effects of floating with regard to mental health are needed.

Place, publisher, year, edition, pages
Scientific Research Publishing, 2013
Keywords
Flotation, Relaxation, Mental Health, Neuropsychiatric Disorders
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:oru:diva-39857 (URN)10.4236/ojmp.2013.23020 (DOI)
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2018-05-22Bibliographically approved
Edebol-Carlman, H. & Norlander, T. (2013). Robust mätmetod för ADHD hos vuxna.. Best Practice, 4(14), 18-21
Open this publication in new window or tab >>Robust mätmetod för ADHD hos vuxna.
2013 (Swedish)In: Best Practice, ISSN 1329-1874, Vol. 4, no 14, p. 18-21Article in journal (Other (popular science, discussion, etc.)) Published
National Category
Psychology
Research subject
Psychology
Identifiers
urn:nbn:se:oru:diva-39861 (URN)
Available from: 2014-12-17 Created: 2014-12-17 Last updated: 2018-05-22Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-8451-6263

Search in DiVA

Show all publications