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Cao, Yang, Associate ProfessorORCID iD iconorcid.org/0000-0002-3552-9153
Publications (10 of 68) Show all publications
Cao, Y., Fang, X., Ottosson, J., Näslund, E. & Stenberg, E. (2019). A Comparative Study of Machine Learning Algorithms in Predicting Severe Complications after Bariatric Surgery. Journal of Clinical Medicine, 8(5), Article ID 668.
Open this publication in new window or tab >>A Comparative Study of Machine Learning Algorithms in Predicting Severe Complications after Bariatric Surgery
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2019 (English)In: Journal of Clinical Medicine, ISSN 2077-0383, Vol. 8, no 5, article id 668Article in journal (Refereed) Published
Abstract [en]

Background: Severe obesity is a global public health threat of growing proportions. Accurate models to predict severe postoperative complications could be of value in the preoperative assessment of potential candidates for bariatric surgery. So far, traditional statistical methods have failed to produce high accuracy. We aimed to find a useful machine learning (ML) algorithm to predict the risk for severe complication after bariatric surgery.

Methods: We trained and compared 29 supervised ML algorithms using information from 37,811 patients that operated with a bariatric surgical procedure between 2010 and 2014 in Sweden. The algorithms were then tested on 6250 patients operated in 2015. We performed the synthetic minority oversampling technique tackling the issue that only 3% of patients experienced severe complications.

Results: Most of the ML algorithms showed high accuracy (>90%) and specificity (>90%) in both the training and test data. However, none of the algorithms achieved an acceptable sensitivity in the test data. We also tried to tune the hyperparameters of the algorithms to maximize sensitivity, but did not yet identify one with a high enough sensitivity that can be used in clinical praxis in bariatric surgery. However, a minor, but perceptible, improvement in deep neural network (NN) ML was found.

Conclusion: In predicting the severe postoperative complication among the bariatric surgery patients, ensemble algorithms outperform base algorithms. When compared to other ML algorithms, deep NN has the potential to improve the accuracy and it deserves further investigation. The oversampling technique should be considered in the context of imbalanced data where the number of the interested outcome is relatively small.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
machine learning, bariatric surgery, severe complication, prediction, comparative study
National Category
Surgery General Practice
Identifiers
urn:nbn:se:oru:diva-75270 (URN)10.3390/jcm8050668 (DOI)000470992500103 ()31083643 (PubMedID)
Funder
Stockholm County CouncilNovo Nordisk
Note

Funding Agencies:

Örebro Region County Council  

Örebro University 

SRP Diabetes

Available from: 2019-07-24 Created: 2019-07-24 Last updated: 2019-07-24Bibliographically approved
Leepe, K. A., Li, M., Fang, X., Hiyoshi, A. & Cao, Y. (2019). Acute effect of daily fine particulate matter pollution on cerebrovascular mortality in Shanghai, China: a population-based time series study. Environmental science and pollution research international, 26(25), 25491-25499
Open this publication in new window or tab >>Acute effect of daily fine particulate matter pollution on cerebrovascular mortality in Shanghai, China: a population-based time series study
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2019 (English)In: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 26, no 25, p. 25491-25499Article in journal (Refereed) Published
Abstract [en]

Numerous studies have investigated the impacts of ambient fine particulate matter (PM2.5) on human health. In this study, we examined the association of daily PM2.5 concentrations with the number of deaths for the cerebrovascular disease on the same day, using the generalized additive model (GAM) controlling for temporal trend and meteorological variables. We used the data between 2012 and 2014 from Shanghai, China, where the adverse health effects of PM2.5 have been of particular concern. Three different approaches (principal component analysis, shrinkage smoothers, and the least absolute shrinkage and selection operator regularization) were used in GAM to handle multicollinear meteorological variables. Our results indicate that the average daily concentration of PM2.5 in Shanghai was high, 55 μg/m3, with an average daily death for cerebrovascular disease (CVD) of 62. There was 1.7% raised cerebrovascular disease deaths per 10 μg/m3 increase in PM2.5 concentration in the unadjusted model. However, PM2.5 concentration was no longer associated with CVD deaths after controlling for meteorological variables. The results were consistent in the three modelling techniques that we used. As a large number of people are exposed to air pollution, further investigation with longer time period including individual-level information is needed to examine the association.

Place, publisher, year, edition, pages
Springer, 2019
Keywords
Cerebrovascular mortality, Fine particulate matter, Generalized additive model, Least absolute shrinkage and selection operator, Multicollinearity, Principal component analysis, Shrinkage smoother
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:oru:diva-75607 (URN)10.1007/s11356-019-05689-8 (DOI)000483698500009 ()31264151 (PubMedID)2-s2.0-85068737714 (Scopus ID)
Note

Funding Agencies:

Karolinska Institutet, Sweden  C62400032 

Junior Faculty Grant of the Institute of Environmental Medicine, Karolinska Institutet  C62412022 

Joint China-Sweden Mobility Grant of the Swedish Foundation for International Cooperation Research and Education  CH2015-6145 

Available from: 2019-08-20 Created: 2019-08-20 Last updated: 2019-09-20Bibliographically approved
Skogsdal, Y. R., Fadl, H., Cao, Y., Karlsson, J. & Tydén, T. (2019). An intervention in contraceptive counseling increased the knowledge about fertility and awareness of preconception health-a randomized controlled trial. Upsala Journal of Medical Sciences, 1-10
Open this publication in new window or tab >>An intervention in contraceptive counseling increased the knowledge about fertility and awareness of preconception health-a randomized controlled trial
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2019 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, p. 1-10Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background: Reproductive life plan counseling (RLPC) is a tool to encourage women and men to reflect upon their reproduction, to avoid unintended pregnancies and negative health behavior that can threaten reproduction. The aim was to evaluate the effect of RLPC among women attending contraceptive counseling. Outcomes were knowledge about fertility and awareness of preconception health, use of contraception, and women's experience of RLPC.

Material and methods: Swedish-speaking women, aged 20-40 years, were randomized to intervention group (IG) or control group (CG). Participants (n = 1,946) answered a questionnaire before and two months after (n = 1,198, 62%) the consultation. All women received standard contraceptive counseling, and the IG also received the RLPC, i.e. questions on reproductive intentions, information about fertility, and preconception health.

Results: Women in the IG increased their knowledge about fertility: age and fertility, chances of getting pregnant, fecundity of an ovum, and chances of having a child with help of IVF. They also increased their awareness of factors affecting preconception health, such as to stop using tobacco, to refrain from alcohol, to be of normal weight, and to start with folic acid before a pregnancy. The most commonly used contraceptive method was combined oral contraceptives, followed by long-acting reversible contraception. Three out of four women (76%) in the IG stated that the RLPC should be part of the routine in contraceptive counseling.

Conclusions: Knowledge about fertility and awareness of preconception health increased after the intervention. The RLPC can be recommended as a tool in contraceptive counseling.

Place, publisher, year, edition, pages
Taylor & Francis, 2019
Keywords
Contraceptive counseling, fertility, lifestyle factors, preconception care, preconception health, pregnancy, reproductive life plan
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:oru:diva-76430 (URN)10.1080/03009734.2019.1653407 (DOI)31495254 (PubMedID)
Available from: 2019-09-16 Created: 2019-09-16 Last updated: 2019-09-16Bibliographically approved
Guo, J., Wu, C., Zhang, J., Jiang, S., Lv, S., Lu, D., . . . Zhou, Z. (2019). Anthropometric measures at age 3 years in associations with prenatal and postnatal exposures to chlorophenols. Chemosphere, 228, 204-211
Open this publication in new window or tab >>Anthropometric measures at age 3 years in associations with prenatal and postnatal exposures to chlorophenols
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2019 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 228, p. 204-211Article in journal (Refereed) Published
Abstract [en]

Background: Chlorophenols (CPs), suspected as endocrine disrupting chemicals, exposure during early life may contribute to body size. However, limited human data with inconsistent findings have examined the developmental effects of CPs exposure.

Objective: To explore associations between prenatal and postnatal CPs exposure and anthropometric parameters in children aged 3 years.

Methods: A subset of 377 mother-child pairs with urinary five CP concentrations were enrolled from a prospective birth cohort. Generalized linear models were conducted to evaluate associations of CPs exposure with children's anthropometric measures.

Results: Maternal urinary 2,4,6-trichlorophenol (2,4,6-TCP) concentrations were significantly negatively associated with weight z scores [regression coefficient (beta)=-0.51, 95% confidence interval (Cl): -0.96, -0.05; p = 0.01], weight for height z scores (beta = -0.54, 95% Cl:-1.02, -0.06; p= 0.01) and body mass index (BMI) z scores (beta = -0.53, 95% CI;-1.03, 0.03; p = 0.01) of children aged 3 years, after adjustment for potential confounders and postnatal CPs exposure. In the sex-stratified analyses, these inverse associations remained among boys, while in girls, positive associations of prenatal 2,4,6-TCP exposure with weight for height z scores and BMI z scores were observed. Postnatal exposure to 2,5-diclorophenol (2,5-DCP) was positively associated with weight z scores (beta = 0.26, 95% CI: 0.02, 0.50; p = 0.04), after controlling for possible confounders and maternal CPs exposure during pregnancy. Considering potential sex-specific effects, these associations were only observed in girls.

Conclusions: Our findings indicate that prenatal 2,4,6-TCP exposure and postnatal 2,5-DCP exposure may have adverse and sex-specific effects on children's physical development.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Chlorophenols, Prenatal exposure, Childhood exposure, Anthropometric measures, Prospective birth cohort
National Category
Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-75201 (URN)10.1016/j.chemosphere.2019.04.127 (DOI)000471084700023 ()31029966 (PubMedID)2-s2.0-85064663097 (Scopus ID)
Note

Funding Agencies:

National Natural Science Foundation of China  NSFC-STINT 81611130087 

Natural Science Foundation of Shanghai, China  18ZR1404200 

Shanghai Municipal Health Commission  201640037 

Shanghai "3-Year Action" Project  GWIV-27.3 

Available from: 2019-07-26 Created: 2019-07-26 Last updated: 2019-07-26Bibliographically approved
Guo, J., Zhang, J., Wu, C., Lv, S., Lu, D., Qi, X., . . . Zhou, Z. (2019). Associations of prenatal and childhood chlorpyrifos exposure with Neurodevelopment of 3-year-old children. Environmental Pollution, 251, 538-546
Open this publication in new window or tab >>Associations of prenatal and childhood chlorpyrifos exposure with Neurodevelopment of 3-year-old children
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2019 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 251, p. 538-546Article in journal (Refereed) Published
Abstract [en]

Chlorpyrifos (CPF), an organophosphate insecticide, has been linked to adverse neurodevelopmental effects in animal studies. However, little is known about long-term neurotoxicity of early-life CPF exposure in humans. We aimed to evaluate the associations of both prenatal and early childhood CPF exposure with neurodevelopment of children. In this observational study based on Sheyang Mini Birth Cohort, pregnant women were recruited from an agricultural region between June 2009 and January 2010, and their children were followed up from birth to age three. Urinary 3,5,6-Trichloro-2-pyridinol (TCPy), a specific metabolite of CPF, was quantified using large-volume-injection gas chromatography tandem mass spectrometry. Developmental quotients (DQs) of children in motor, adaptive, language, and social areas were assessed by trained pediatricians. Data from 377 mother-child pairs were used in the current study. Associations between CPF exposure and neurodevelopmental indicators were estimated using generalized linear models with adjustment for potential confounders. The median concentrations of TCPy in maternal and children's urine were 5.39 mu g/L and 5.34 mu g/L, respectively. No statistically significant association was found between maternal urinary TCPy concentrations and children neurodevelopment. While for postnatal exposure, we found lower motor area DQ score 0.61 [95% confidence interval (CI): -1.13, -0.09; p = 0.02] and social area DQ score 0.55 (95% CI: -1.07, -0.03; p = 0.04) per one-unit increase in the In-transformed childhood urinary TCPy concentrations. Further stratification by sex indicated that the inverse associations were only observed in boys, but not in girls. Our findings suggest that adverse neurodevelopmental effects were associated with early childhood CPF exposure, but not prenatal exposure. Additional longitudinal studies are needed to replicate these results and to further understand the toxicological mechanisms of CPF.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Chlorpyrifos, 3, 5, 6-Trichloro-2-pyridinol, Prenatal exposure, Childhood exposure, Neurodevelopment
National Category
Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-75364 (URN)10.1016/j.envpol.2019.05.040 (DOI)000474329700059 ()31108286 (PubMedID)2-s2.0-85066093562 (Scopus ID)
Note

Funding Agencies:

National Natural Science Foundation of China  NSFC-STINT 81611130087 

Shanghai "3-Year Action" Project  GWIV-27.3 

Available from: 2019-07-29 Created: 2019-07-29 Last updated: 2019-07-29Bibliographically approved
Pettersson-Pablo, P., Nilsson, T. K., Cao, Y., Breimer, L. & Hurtig-Wennlöf, A. (2019). Cluster Analysis And Risk Score Calculation Of Surrogate Markers Of Vascular Health, And Their Association With Cardiometabolic Risk Factors In A Healthy Young Adults. Paper presented at 87th Congress of the European-Atherosclerosis-Society (EAS), Maastricht, Netherlands, May 26-29, 2019. Atherosclerosis, 287, E191-E191
Open this publication in new window or tab >>Cluster Analysis And Risk Score Calculation Of Surrogate Markers Of Vascular Health, And Their Association With Cardiometabolic Risk Factors In A Healthy Young Adults
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2019 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 287, p. E191-E191Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Elsevier, 2019
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-76189 (URN)10.1016/j.atherosclerosis.2019.06.578 (DOI)000482110800576 ()
Conference
87th Congress of the European-Atherosclerosis-Society (EAS), Maastricht, Netherlands, May 26-29, 2019
Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-10Bibliographically approved
Fang, X., Fang, B., Wang, C., Xia, T., Bottai, M., Fang, F. & Cao, Y. (2019). Comparison of Frequentist and Bayesian Generalized Additive Models for Assessing the Association between Daily Exposure to Fine Particles and Respiratory Mortality: A Simulation Study. International Journal of Environmental Research and Public Health, 16(5), Article ID 746.
Open this publication in new window or tab >>Comparison of Frequentist and Bayesian Generalized Additive Models for Assessing the Association between Daily Exposure to Fine Particles and Respiratory Mortality: A Simulation Study
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2019 (English)In: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 16, no 5, article id 746Article in journal (Refereed) Published
Abstract [en]

Objective: To compare the performance of frequentist and Bayesian generalized additive models (GAMs) in terms of accuracy and precision for assessing the association between daily exposure to fine particles and respiratory mortality using simulated data based on a real time-series study.

Methods: In our study, we examined the estimates from a fully Bayesian GAM using simulated data based on a genuine time-series study on fine particles with a diameter of 2.5 m or less (PM2.5) and respiratory deaths conducted in Shanghai, China. The simulation was performed by multiplying the observed daily death with a random error. The underlying priors for Bayesian analysis are estimated using the real world time-series data. We also examined the sensitivity of Bayesian GAM to the choice of priors and to true parameter.

Results: The frequentist GAM and Bayesian GAM show similar means and variances of the estimates of the parameters of interest. However, the estimates from Bayesian GAM show relatively more fluctuation, which to some extent reflects the uncertainty inherent in Bayesian estimation.

Conclusions: Although computationally intensive, Bayesian GAM would be a better solution to avoid potentially over-confident inferences. With the increasing computing power of computers and statistical packages available, fully Bayesian methods for decision making may become more widely applied in the future.

Place, publisher, year, edition, pages
Basel, Switzerland: MDPI, 2019
Keywords
Bayesian statistics, generalized additive model, time-series analysis, fine particulate matter, respiratory mortality
National Category
Public Health, Global Health, Social Medicine and Epidemiology Environmental Sciences
Identifiers
urn:nbn:se:oru:diva-73605 (URN)10.3390/ijerph16050746 (DOI)000462664200071 ()30832258 (PubMedID)2-s2.0-85062397293 (Scopus ID)
Note

Funding Agencies:

Karolinska Institutet Strategic Grant  C62400032 

Junior Faculty Grant of the Institute of Environmental Medicine, Karolinska Institutet  C62412022 

Joint China-Sweden Mobility Grant of the Swedish Foundation for International Cooperation Research and Education  CH2015-6145 

Available from: 2019-04-10 Created: 2019-04-10 Last updated: 2019-04-10Bibliographically approved
Ahl, R., Matthiessen, P., Fang, X., Cao, Y., Sjölin, G., Lindgren, R., . . . Mohseni, S. (2019). Effect of beta-blocker therapy on early mortality after emergency colonic cancer surgery. British Journal of Surgery, 106(4), 477-483
Open this publication in new window or tab >>Effect of beta-blocker therapy on early mortality after emergency colonic cancer surgery
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2019 (English)In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 106, no 4, p. 477-483Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Emergency colorectal cancer surgery is associated with significant mortality. Induced adrenergic hyperactivity is thought to be an important contributor. Downregulating the effects of circulating catecholamines may reduce the risk of adverse outcomes. This study assessed whether regular preoperative beta-blockade reduced mortality after emergency colonic cancer surgery.

METHODS: This cohort study used the prospectively collected Swedish Colorectal Cancer Registry to recruit all adult patients requiring emergency colonic cancer surgery between 2011 and 2016. Patients were subdivided into those receiving regular beta-blocker therapy before surgery and those who were not (control). Demographics and clinical outcomes were compared. Risk factors for 30-day mortality were evaluated using Poisson regression analysis.

RESULTS: A total of 3187 patients were included, of whom 685 (21·5 per cent) used regular beta-blocker therapy before surgery. The overall 30-day mortality rate was significantly reduced in the beta-blocker group compared with controls: 3·1 (95 per cent c.i. 1·9 to 4·7) versus 8·6 (7·6 to 9·8) per cent respectively (P < 0·001). Beta-blocker therapy was the only modifiable protective factor identified in multivariable analysis of 30-day all-cause mortality (incidence rate ratio 0·31, 95 per cent c.i. 0·20 to 0·47; P < 0·001) and was associated with a significant reduction in death of cardiovascular, respiratory, sepsis and multiple organ failure origin.

CONCLUSION: Preoperative beta-blocker therapy may be associated with a reduction in 30-day mortality following emergency colonic cancer surgery.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
National Category
Surgery Cancer and Oncology
Identifiers
urn:nbn:se:oru:diva-69119 (URN)10.1002/bjs.10988 (DOI)000459801800023 ()30259967 (PubMedID)
Available from: 2018-10-01 Created: 2018-10-01 Last updated: 2019-05-13Bibliographically approved
Zhang, J., Guo, J., Wu, C., Qi, X., Jiang, S., Lu, D., . . . Zhou, Z. (2019). Exposure to carbamate and neurodevelopment in children: Evidence from the SMBCS cohort in China. Environmental Research, 177, Article ID 108590.
Open this publication in new window or tab >>Exposure to carbamate and neurodevelopment in children: Evidence from the SMBCS cohort in China
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2019 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 177, article id 108590Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Carbamate pesticides exposure have been linked with adverse health effects during developmental period. Based on 377 mother-child pairs from Sheyang Mini Birth Cohort Study, the present study aimed to assess carbofuranphenol exposure of three-year-old children and explore the associations between prenatal or postnatal carbofuranphenol exposures and neurodevelopmental indicators.

METHODS: Urinary carbofuranphenol concentrations were measured by gas chromatography-tandem mass spectrometry. Neural developmental quotient (DQ) of children was evaluated using Gesell Developmental Schedules. Generalized linear models were used to examine the associations between carbofuranphenol concentrations and neurodevelopment.

RESULTS: Geometric mean, geometric standard deviation, median, inter quartile range of postnatal urinary carbofuranphenol concentrations were 0.653 μg/L, 9.345 μg/L, 0.413 μg/L, 0.150-1.675 μg/L, respectively. Postnatal carbofuranphenol level showed negatively significant trend in language DQ [beta (β) = -0.121; 95% confidence interval (95% CI): 0.212, -0.031; p value (p) = 0.008] and total average DQ (β = -0.059, 95% CI: 0.115, -0.003; p = 0.035). Prenatal carbofuranphenol level showed negative correlations with children's adaptive DQ (β = -0.755; 95% CI: 1.257, -0.254; p = 0.003), social DQ (β = -0.341; 95% CI: 0.656, -0.027; p = 0.032) and total average DQ (β = -0.349; 95% CI: 0.693, -0.005; p = 0.047).

CONCLUSION: The results of the present study supposed children in agricultural region of China are widely exposed to carbamate pesticides, and both prenatal and postnatal exposure to carbamate pesticides may lead to neurodevelopmental effect.

Place, publisher, year, edition, pages
Academic Press, 2019
Keywords
Carbamate pesticide, Carbofuranphenol, Neurodevelopment, Postnatal exposure, Prenatal exposure
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:oru:diva-75568 (URN)10.1016/j.envres.2019.108590 (DOI)31352300 (PubMedID)
Available from: 2019-08-09 Created: 2019-08-09 Last updated: 2019-08-09Bibliographically approved
Allbrand, M., Åman, J., Nilsson, K., Cao, Y. & Lodefalk, M. (2019). Expression of genes involved in inflammation and growth: does sampling site in human full-term placenta matter?. Journal of Perinatal Medicine, 47(5), 539-546
Open this publication in new window or tab >>Expression of genes involved in inflammation and growth: does sampling site in human full-term placenta matter?
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2019 (English)In: Journal of Perinatal Medicine, ISSN 0300-5577, E-ISSN 1619-3997, Vol. 47, no 5, p. 539-546Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the placental gene expression of substances in the inflammatory cascade and growth factors at nine different well-defined sampling sites in full-term placentas from 12 normal weight healthy non-smoking women with an uncomplicated singleton pregnancy.

Methods: All placentas (six girls and six boys) were delivered vaginally. Quantitative real-time polymerase chain reaction was used to analyze toll receptor-2 and -4, interleukin-6 and -8, tumor necrosis factor-α, leptin, ghrelin, insulin-like growth factor-1 and -2, hepatocyte growth factor, hepatocyte growth factor receptor and insulin receptor (IR).

Results: The leptin gene and the IR gene showed higher expression in lateral regions near the chorionic plate compared to central regions near the basal plate (P = 0.028 and P = 0.041, respectively).

Conclusion: Our results suggest that the sampling site may influence the gene expression for leptin and IR in placental tissue obtained from full-term normal pregnancies. We speculate that this may be due to differences in placental structure and perfusion and may be important when future studies are designed.

Place, publisher, year, edition, pages
Walter de Gruyter, 2019
Keywords
Cytokines, gene expression, growth factors, placenta, sampling
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:oru:diva-73427 (URN)10.1515/jpm-2018-0290 (DOI)000473532900008 ()30920955 (PubMedID)2-s2.0-85063721684 (Scopus ID)
Note

Funding Agencies:

Research Committee of Region Örebro County  

Nyckelfonden, Örebro University Hospital  

Available from: 2019-04-04 Created: 2019-04-04 Last updated: 2019-08-08Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-3552-9153

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