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Cao, Yang, Associate ProfessorORCID iD iconorcid.org/0000-0002-3552-9153
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Publications (10 of 262) Show all publications
Lind, A., Cao, Y., Hesser, H., Hårdstedt, M., Jansson, S. P. O., Lernmark, Å., . . . Jendle, J. (2024). Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19. Diabetes epidemiology and management, 13, Article ID 100194.
Open this publication in new window or tab >>Anxiety, depression and quality of life in relation to SARS-CoV-2 antibodies in individuals living with diabetes during the second wave of COVID-19
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2024 (English)In: Diabetes epidemiology and management, ISSN 2666-9706, Vol. 13, article id 100194Article in journal (Refereed) Published
Abstract [en]

Aims: The objective was to compare anxiety, depression, and quality of life (QoL) in individuals living with type 1 (T1D) and type 2 (T2D) diabetes with matched controls during the second wave of the COVID-19 pandemic.

Methods: Via randomization, individuals living with diabetes T1D (n = 203) and T2D (n = 413), were identified during February-July 2021 through health-care registers. Population controls (n = 282) were matched for age, gender, and residential area. Questionnaires included self-assessment of anxiety, depression, QoL, and demographics in relation to SARS-CoV-2 exposure. Blood was collected through home-capillary sampling, and SARS-CoV-2 Nucleocapsid (NCP) and Spike antibodies (SC2_S1) were determined by multiplex Antibody Detection by Agglutination-PCR (ADAP) assays.

Results: Younger age and health issues were related to anxiety, depression, and QoL, with no differences between the study groups. Female gender was associated with anxiety, while obesity was associated with lower QoL. The SARS-CoV-2 NCP seroprevalence was higher in T1D (8.9 %) compared to T2D (3.9 %) and controls (4.0 %), while the SARS-CoV-2 SC2_S1 seroprevalence was higher for controls (25.5 %) compared to T1D (16.8 %) and T2D (14.0 %).

Conclusions: A higher SARS-CoV-2 infection rate in T1D may be explained by younger age and higher employment rate, and the associated increased risk for viral exposure.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Diabetes, SARS-CoV-2, COVID-19, Anxiety, Depression, Quality of life, Virus antibodies
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:oru:diva-111559 (URN)10.1016/j.deman.2023.100194 (DOI)001154927400001 ()2-s2.0-85182889973 (Scopus ID)
Funder
Swedish Foundation for Strategic Research, IRC15-0067
Note

This work was supported by NIH SBIR 2R44DK110005-02, Strategic Research Area Exodiab Dnr 2009-1039, and the Swedish Foundation for Strategic Research Dnr IRC15-0067.

Available from: 2024-02-14 Created: 2024-02-14 Last updated: 2024-02-14Bibliographically approved
Zhai, Y., Hu, F., Yuan, L., Ye, X., Shi, W., Yang, R., . . . Xu, F. (2024). Atrial fibrillation increases the risk of all-cause dementia, Alzheimer's disease, and vascular dementia: A cohort study of 373, 415 participants in the UK Biobank. Journal of Affective Disorders
Open this publication in new window or tab >>Atrial fibrillation increases the risk of all-cause dementia, Alzheimer's disease, and vascular dementia: A cohort study of 373, 415 participants in the UK Biobank
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2024 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Accumulated evidence has highlighted the association between atrial fibrillation and the risk of developing dementia.

METHODS: This current cohort study utilized data from the UK Biobank to explore the association between atrial fibrillation (AF) and all-cause dementia (ACD), encompassing its main subtypes (Alzheimer's disease (AD), and vascular dementia (VD)). Cox proportional hazards models were applied to examine the association of AF and dementia with its primary subtypes after adjusting for different sets of covariates. Hazard ratios (HRs) with 95 % confidential intervals (CIs) were estimated to quantify the associated risks. Competing risk model was applied in sensitivity analysis.

RESULTS: After exclusion, 373, 415 participants entered the primary analysis. Among these, 27, 934 (7.48 %) were with a history AF at baseline, while 345, 481 (92.52 %) were without. During a mean follow-up of 13.45 years, ACD was diagnosed in 1215 individuals with AF and 3988 individuals without AF. Participants with AF had higher risks of ACD (1.79 [1.67-1.91]), AD (1.48 [1.32-1.65]), and VD (2.46 [2.17-2.80]) in the fully adjusted Cox regression models. Results of subgroup and sensitivity analyses predominantly aligned with the positive associations in primary analysis.

LIMITATIONS: The applicability of our findings to diverse ethnicities might require careful consideration and the behind biological mechanisms need to be further revealed.

CONCLUSIONS: It indicated that people with atrial fibrillation had an increased future risk of all-cause dementia, Alzheimer's disease, vascular dementia. Atrial fibrillation screening and prevention strategies should take into account to prevent and delay the onset of dementia.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
All-cause dementia, Alzheimer's disease, Atrial fibrillation, Cohort study, UK Biobank, Vascular dementia
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-111232 (URN)10.1016/j.jad.2024.01.224 (DOI)38286227 (PubMedID)
Note

This study was supported by the following funding: The 2021 Shanghai “Science and Technology Innovation Action Plan” (Project Number: 21XD1432900), the Research Project Plan of the Shanghai Municipal Health Commission (Project Number: 202150019), the Project of Hospital Management from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (Project Number: YGA202308), and the 2022 Medical and Health Science and Technology Plan of Zhoushan City, China (Project Number: 2022JYB05).

Available from: 2024-02-01 Created: 2024-02-01 Last updated: 2024-02-01Bibliographically approved
Mohammad Ismail, A., Forssten, M. P., Hildebrand, F., Sarani, B., Ioannidis, I., Cao, Y., . . . Mohseni, S. (2024). Cardiac risk stratification and adverse outcomes in surgically managed patients with isolated traumatic spine injuries. European Journal of Trauma and Emergency Surgery
Open this publication in new window or tab >>Cardiac risk stratification and adverse outcomes in surgically managed patients with isolated traumatic spine injuries
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2024 (English)In: European Journal of Trauma and Emergency Surgery, ISSN 1863-9933, E-ISSN 1863-9941Article in journal (Refereed) Epub ahead of print
Abstract [en]

INTRODUCTION: As the incidence of traumatic spine injuries has been steadily increasing, especially in the elderly, the ability to categorize patients based on their underlying risk for the adverse outcomes could be of great value in clinical decision making. This study aimed to investigate the association between the Revised Cardiac Risk Index (RCRI) and adverse outcomes in patients who have undergone surgery for traumatic spine injuries.

METHODS: All adult patients (18 years or older) in the 2013-2019 TQIP database with isolated spine injuries resulting from blunt force trauma, who underwent spinal surgery, were eligible for inclusion in the study. The association between the RCRI and in-hospital mortality, cardiopulmonary complications, and failure-to-rescue (FTR) was determined using Poisson regression models with robust standard errors to adjust for potential confounding.

RESULTS: A total of 39,391 patients were included for further analysis. In the regression model, an RCRI ≥ 3 was associated with a threefold risk of in-hospital mortality [adjusted IRR (95% CI): 3.19 (2.30-4.43), p < 0.001] and cardiopulmonary complications [adjusted IRR (95% CI): 3.27 (2.46-4.34), p < 0.001], as well as a fourfold risk of FTR [adjusted IRR (95% CI): 4.27 (2.59-7.02), p < 0.001], compared to RCRI 0. The risk of all adverse outcomes increased stepwise along with each RCRI score.

CONCLUSION: The RCRI may be a useful tool for identifying patients with traumatic spine injuries who are at an increased risk of in-hospital mortality, cardiopulmonary complications, and failure-to-rescue after surgery.

Place, publisher, year, edition, pages
Urban und Vogel Medien und Medizin Verlagsgesellsc, 2024
Keywords
Cardiopulmonary complications, Mortality, Revised Cardiac Risk Index, Risk stratification, Traumatic spine injury
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-110622 (URN)10.1007/s00068-023-02413-7 (DOI)001135545400001 ()38170276 (PubMedID)2-s2.0-85181522328 (Scopus ID)
Funder
Örebro University
Available from: 2024-01-09 Created: 2024-01-09 Last updated: 2024-02-05Bibliographically approved
Li, H., Zhang, X., Cao, Y. & Zhang, G. (2024). Effects of Participating in Religious Groups on Mental Health Issues: A Two-Sample Mendelian Randomization Study. The international journal for the psychology of religion, 34(1), 24-36
Open this publication in new window or tab >>Effects of Participating in Religious Groups on Mental Health Issues: A Two-Sample Mendelian Randomization Study
2024 (English)In: The international journal for the psychology of religion, ISSN 1050-8619, E-ISSN 1532-7582, Vol. 34, no 1, p. 24-36Article in journal (Refereed) Published
Abstract [en]

We conducted a Mendelian randomization study to evaluate the potential causal effects of attending religious groups on the prevalence of depression, generalized anxiety disorders, anxiety disorders, and suicide and self-harm. Data from the UK Biobank and the FinnGen project were processed by inverse variance weighting (IVW), weighted median, and MR-Egger regression methods. Despite certain pleiotropic risks, we found that attending religious groups was potentially associated with a reduced risk of anxiety disorders (OR = 0.213, p = .028). The pleiotropies were largely controlled and the effect on anxiety disorders became more significant in our sensitivity analysis (OR = 0.162; p = .006). Additionally, attending religious groups was associated with a reduced risk of suicide and self-harm (OR = 0.231, p = .0006). However, we did not observe any substantial protection against depression. In conclusion, our study adds to the existing literature and sheds light on the potential health benefits of religious activities from a novel perspective.

Place, publisher, year, edition, pages
Routledge, 2024
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-109404 (URN)10.1080/10508619.2023.2267956 (DOI)001080739000001 ()2-s2.0-85173728230 (Scopus ID)
Available from: 2023-10-25 Created: 2023-10-25 Last updated: 2024-01-29Bibliographically approved
Mohseni, S., Forssten, M. P., Mohammad Ismail, A., Cao, Y., Hildebrand, F., Sarani, B. & Ribeiro, M. A. (2024). Investigating the link between frailty and outcomes in geriatric patients with isolated rib fractures. Trauma surgery & acute care open, 9(1), Article ID e001206.
Open this publication in new window or tab >>Investigating the link between frailty and outcomes in geriatric patients with isolated rib fractures
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2024 (English)In: Trauma surgery & acute care open, E-ISSN 2397-5776, Vol. 9, no 1, article id e001206Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Studies have shown an increased risk of morbidity in elderly patients suffering rib fractures from blunt trauma. The association between frailty and rib fractures on adverse outcomes is still ill-defined. In the current investigation, we sought to delineate the association between frailty, measured using the Orthopedic Frailty Score (OFS), and outcomes in geriatric patients with isolated rib fractures.

METHODS: All geriatric (aged 65 years or older) patients registered in the 2013-2019 Trauma Quality Improvement database with a conservatively managed isolated rib fracture were considered for inclusion. An isolated rib fracture was defined as the presence of ≥1 rib fracture, a thorax Abbreviated Injury Scale (AIS) between 1 and 5, an AIS ≤1 in all other regions, as well as the absence of pneumothorax, hemothorax, or pulmonary contusion. Based on patients' OFS, patients were classified as non-frail (OFS 0), pre-frail (OFS 1), or frail (OFS ≥2). The prevalence ratio (PR) of composite complications, in-hospital mortality, failure-to-rescue (FTR), and intensive care unit (ICU) admission between the OFS groups was determined using Poisson regression models to adjust for potential confounding.

RESULTS: A total of 65 375 patients met the study's inclusion criteria of whom 60% were non-frail, 29% were pre-frail, and 11% were frail. There was a stepwise increased risk of complications, in-hospital mortality, and FTR from non-frail to pre-frail and frail. Compared with non-frail patients, frail patients exhibited a 87% increased risk of in-hospital mortality [adjusted PR (95% CI): 1.87 (1.52-2.31), p<0.001], a 44% increased risk of complications [adjusted PR (95% CI): 1.44 (1.23-1.67), p<0.001], a doubling in the risk of FTR [adjusted PR (95% CI): 2.08 (1.45-2.98), p<0.001], and a 17% increased risk of ICU admission [adjusted PR (95% CI): 1.17 (1.11-1.23), p<0.001].

CONCLUSION: There is a strong association between frailty, measured using the OFS, and adverse outcomes in geriatric patients managed conservatively for rib fractures.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2024
Keywords
Frailty, geriatrics, rib fractures
National Category
Geriatrics
Identifiers
urn:nbn:se:oru:diva-111653 (URN)10.1136/tsaco-2023-001206 (DOI)38347893 (PubMedID)2-s2.0-85184814992 (Scopus ID)
Available from: 2024-02-21 Created: 2024-02-21 Last updated: 2024-02-21Bibliographically approved
Brus, O., Cao, Y., Carlborg, A., Engström, I., von Knorring, L. & Nordenskjöld, A. (2024). Long-Term Effect of Maintenance Electroconvulsive Therapy in Patients With Depression-Data From a Small Randomized Controlled Trial. Journal of ECT
Open this publication in new window or tab >>Long-Term Effect of Maintenance Electroconvulsive Therapy in Patients With Depression-Data From a Small Randomized Controlled Trial
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2024 (English)In: Journal of ECT, ISSN 1095-0680, E-ISSN 1533-4112Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVES: This study aimed to compare the long-term effects of maintenance electroconvulsive therapy (M-ECT) with medication and medication only in patients with depression.

METHODS: A randomized controlled trial of 1 year of M-ECT with medication or medication only investigated relapse/recurrence among 56 patients in remission after electroconvulsive therapy (ECT) for depression was conducted. The results of the first year are published already and showed a significant advantage of M-ECT with medication.The current study was a long-term follow-up. When the randomized treatment allocation ended, medication was continued in both groups but M-ECT was terminated. Patients were followed for up to 10 years via Swedish national registers until the study endpoint of a new psychiatric diagnosis as an inpatient, suicide, suspected suicide, or death of another cause. Time to relapse was compared between the M-ECT with medication group and the medication-only group using Kaplan-Meier estimates.

RESULTS: The median follow-up time was 6.5 years for the M-ECT and medication group and 3.1 years for the medication-only group. One year after randomization 22 patients remained in the M-ECT and medication group, and 14 patients remained in the medication-only group. Relapse patterns between the treatment groups after the completion of M-ECT seemed to be similar according to visual inspection.

CONCLUSIONS: This long-term follow-up study suggests that most of the benefit achieved during the treatment period with M-ECT is maintained over several years, but the small sample size, with accompanying large statistical imprecision, makes the results uncertain. More long-term studies of M-ECT are required.Trial registration: ClinicalTrials.gov identifier: NCT00627887.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2024
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-111028 (URN)10.1097/YCT.0000000000000983 (DOI)38232249 (PubMedID)
Funder
Region Örebro County
Note

Uppsala-Örebro Regional Research Council and Research Committee of Örebro County Council, Örebro, Sweden, supported the research

Available from: 2024-01-30 Created: 2024-01-30 Last updated: 2024-01-30Bibliographically approved
Ferrari, G., Geijer, H., Cao, Y., Graf, U., Bojö, L., Carlsson, R., . . . Samano, N. (2024). Long-term results of percutaneous coronary intervention in no-touch vein grafts are significantly better than in conventional vein grafts. Perfusion, Article ID 2676591241230012.
Open this publication in new window or tab >>Long-term results of percutaneous coronary intervention in no-touch vein grafts are significantly better than in conventional vein grafts
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2024 (English)In: Perfusion, ISSN 0267-6591, E-ISSN 1477-111X, article id 2676591241230012Article in journal (Refereed) Epub ahead of print
Abstract [en]

INTRODUCTION: Conventional vein grafts have a high risk of thrombosis and early atherosclerosis. Percutaneous coronary intervention (PCI) in conventional vein grafts is associated with a higher incidence of late adverse cardiac events. The aim of this study was to evaluate the long-term results after PCI in saphenous vein grafts (SVG) harvested with the no-touch technique compared to the conventional technique.

METHODS: This was a single-center, retrospective, cohort study, based on data from the Swedeheart register. The inclusion criterion was individuals who underwent CABG using different vein graft techniques between January 1992 and July 2020, and who required a PCI in SVGs between January 2006 and July 2020. The primary end point was long-term in-stent restenosis. The secondary endpoints were long-term major adverse cardiac events (MACE) and 1-year re-hospitalization rates. The associations between the graft types and the endpoints were evaluated using the Fine and Gray competing-risk regression analysis.

RESULTS: The study included 346 individuals (67 no-touch, 279 conventional). The mean clinical follow-up time was 6.4 years with a standard deviation of 3.7 years. The long-term in-stent restenosis rate for the no-touch grafts was 3.2% compared to 18.7% for the conventional grafts (p < .01), with a subdistribution hazard ratio (SHR) of 0.16 (p = .010). The long-term MACE rate was 27.0% in the no-touch group and 48.3% in the conventional group (p < .01) with a SHR of 0.53 (p = .017). The short-term results were similar in both groups.

CONCLUSIONS: Percutaneous coronary intervention in a no-touch vein graft was associated with statistically significantly fewer in-stent restenoses and MACE at long-term follow-up compared to a conventional SVG.

Place, publisher, year, edition, pages
Sage Publications, 2024
Keywords
coronary artery bypass graft, major adverse cardiac events, no-touch, percutaneous coronary intervention, saphenous vein, stent
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-111036 (URN)10.1177/02676591241230012 (DOI)001147222400001 ()38253348 (PubMedID)2-s2.0-85182996475 (Scopus ID)
Funder
Region Örebro County, OLL-935188Region Uppsala, RFR-55691
Available from: 2024-01-30 Created: 2024-01-30 Last updated: 2024-02-05Bibliographically approved
Sun, S., Stenberg, E., Luo, N., Franklin, K. A., Lindholm, L., Salén, K.-G. & Cao, Y. (2024). SF-6D Normative Values Among Patients Undergoing Bariatric Surgery: Results Based on Real-World Evidence from the Scandinavian Obesity Surgery Registry (SOReg). Obesity Surgery
Open this publication in new window or tab >>SF-6D Normative Values Among Patients Undergoing Bariatric Surgery: Results Based on Real-World Evidence from the Scandinavian Obesity Surgery Registry (SOReg)
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2024 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: The SF-6D index can be used to calculate quality-adjusted life years in economic evaluations, which is required by reimbursement agencies and national advisory bodies, including the Swedish ones. However, despite that SF-36 has been largely applied among patients undergoing bariatric surgery, almost no study has accessed the short form six-dimensions (SF-6D) after bariatric surgery. AIM: To establish normative values for the SF-6D index among patients undergoing bariatric surgery.

MATERIALS AND METHODS: All patients who received bariatric surgery in Sweden between 2011-01-01 and 2019-03-31 were obtained from the Scandinavian Obesity Surgery Registry (SOReg). Information includes patients' sociodemographic characteristics, details regarding the procedure, and postsurgical conditions. The SF-36 is applied at baseline and at follow-up years 1, 2, and 5. The multiple sequential imputation method was applied to handle missingness on SF-6D items. Based on the UK tariff, the SF-6D preference scores were calculated. The normative values for the mean (SD) SF-6D index were reported by timepoint and surgical complications for men and women, respectively. Multivariate analyses were applied to investigate how the SF-6D index is associated with timepoint, controlling for age, sex, BMI, and comorbidities in a stepwise manner.

RESULTS: The SF-6D index increased at 1 year relative to baseline and was roughly maintained at the same level at 2 years. The normative value of the SF-6D index can be used in economic evaluations for bariatric surgery.

Place, publisher, year, edition, pages
Springer, 2024
Keywords
Bariatric surgery, Health preference, Normative value, Quality-adjusted life years, Real-world data, SF-6D
National Category
Surgery
Identifiers
urn:nbn:se:oru:diva-110635 (URN)10.1007/s11695-023-07024-0 (DOI)001137720100005 ()38189900 (PubMedID)2-s2.0-85181716238 (Scopus ID)
Funder
Umeå UniversityForte, Swedish Research Council for Health, Working Life and Welfare, 2018–00896
Available from: 2024-01-09 Created: 2024-01-09 Last updated: 2024-02-05Bibliographically approved
Wang, J., Chang, Y.-S., Wei, X., Cao, Y. & Winkley, K. (2024). The effectiveness of interventions on changing caregivers' feeding practices with preschool children: A systematic review and meta-analysis. Obesity Reviews, Article ID e13688.
Open this publication in new window or tab >>The effectiveness of interventions on changing caregivers' feeding practices with preschool children: A systematic review and meta-analysis
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2024 (English)In: Obesity Reviews, ISSN 1467-7881, E-ISSN 1467-789X, article id e13688Article, review/survey (Refereed) Epub ahead of print
Abstract [en]

Caregivers' feeding practices are critical in shaping preschool children's eating habits and preventing childhood obesity. We conducted a systematic review and meta-analysis to evaluate the effectiveness of existing interventions targeting caregivers of preschool children, which aimed to promote child healthy eating and/or manage child weight and/or prevent child nutrition-related problems and included feeding practices as one of the outcomes. Eighteen studies with 18 intervention programs and 3887 respondents that completed baseline evaluations were eligible for data synthesis. Behavior change techniques (BCTs) frequently used included the following: instruction on how to perform the behavior and demonstration of the behavior. The pooled effects of randomized controlled trials (RCTs) on pressure to eat (pooled standardized mean difference [SMD] = 0.61; 95%CI: -1.16, -0.06), use of food as a reward (pooled SMD = -0.31; 95%CI: -0.61, -0.01), and emotional feeding (pooled SMD = -0.36; 95%CI: -0.66, -0.06) were found statistically significant compared with control groups at post-intervention. However, there were no pooled effects on restrictive feeding and pressure to eat at other follow-ups or on other feeding practices at post-intervention. Interventions may have short-term effects on decreasing the adoption of coercive control. Future interventions should directly and adequately optimize feeding practices, include components of individual support, and contribute to the maintenance of the effects over the long term.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2024
Keywords
Child, feeding practices, interventions, systematic review
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:oru:diva-110633 (URN)10.1111/obr.13688 (DOI)001137467100001 ()38186213 (PubMedID)2-s2.0-85181715221 (Scopus ID)
Available from: 2024-01-09 Created: 2024-01-09 Last updated: 2024-02-05Bibliographically approved
Wu, J., Xiao, Z., Wang, M., Wu, W., Ma, X., Liang, X., . . . Ding, D. (2024). The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study. Alzheimer's Research & Therapy, 16(1), Article ID 32.
Open this publication in new window or tab >>The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study
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2024 (English)In: Alzheimer's Research & Therapy, E-ISSN 1758-9193, Vol. 16, no 1, article id 32Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The blood-based biomarkers are approaching the clinical practice of Alzheimer's disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to characterize the impact of renal function on AD markers.

METHODS: Plasma phospho-tau181 (P-tau181), and neurofilament light (NfL) were assayed via the Simoa HD-X platform in 1189 dementia-free participants from the Shanghai Aging Study (SAS). The estimated glomerular filter rate (eGFR) was calculated. The association between renal function and blood NfL, P-tau181 was analyzed. An analysis of interactions between various demographic and comorbid factors and eGFR was conducted.

RESULTS: The eGFR levels were negatively associated with plasma concentrations of NfL and P-tau181 (B = - 0.19, 95% CI - 0.224 to - 0.156, P < 0.001; B = - 0.009, 95% CI - 0.013 to -0.005, P < 0.001, respectively). After adjusting for demographic characteristics and comorbid diseases, eGFR remained significantly correlated with plasma NfL (B = - 0.010, 95% CI - 0.133 to - 0.068, P < 0.001), but not with P-tau181 (B = - 0.003, 95% CI - 0.007 to 0.001, P = 0.194). A significant interaction between age and eGFR was found for plasma NfL (Pinteraction < 0.001). In participants ≥ 70 years and with eGFR < 60 ml/min/1.73 m2, the correlation between eGFR and plasma NfL was significantly remarkable (B = - 0.790, 95% CI - 1.026 to - 0,554, P < 0.001).

CONCLUSIONS: Considering renal function and age is crucial when interpreting AD biomarkers in the general aging population.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2024
Keywords
Comorbid conditions, Glomerular filter rate, Neurofilament light, Phospho-tau181, Renal function
National Category
Neurosciences
Identifiers
urn:nbn:se:oru:diva-111662 (URN)10.1186/s13195-024-01401-2 (DOI)001161492500001 ()38347655 (PubMedID)
Note

This work was supported by grants from the National Natural Science Foundation of China (82371429, 82071200, 82173599), National Ministry of Science and Technology (SQ2021AAA010157), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01 and ZJ LAB).

Available from: 2024-02-21 Created: 2024-02-21 Last updated: 2024-02-26Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-3552-9153

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