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Schollin, Jens
Publications (10 of 28) Show all publications
Schollin, J. & Lindgren, S. (2019). Starten på det yrkeslivslånga lärandet som läkare [A new internationally harmonized Swedish basic medical education]. Läkartidningen, 116(35-36), Article ID FR4S.
Open this publication in new window or tab >>Starten på det yrkeslivslånga lärandet som läkare [A new internationally harmonized Swedish basic medical education]
2019 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 116, no 35-36, article id FR4SArticle in journal (Refereed) Published
Abstract [sv]

The Swedish Parliament and Government has recently sanctioned a new 6 year undergraduate medical degree leading directly to license, followed by a 12 month introduction to work as a certified doctor. The undergraduate education is internationally harmonized and the 23 learning outcomes address competence needs in future Swedish and international health-care. Particular attention is given to professional competence, critical thinking, team-work and health promotion. All 23 learning outcomes must be documented before the University can issue a MD degree. After license, the doctor applies for a 12 month introduction to employment as doctor in the Swedish health-care system. This introduction is mandatory for all, regardless of the country where the license was issued. The introduction comprises clinical service in general medicine, emergency medicine and elective disciplines. Assessment of 10 learning outcomes is carried out in a formative wav by experienced and trained clinicians during the clinical service. After the introduction, the doctor is duly qualified to apply for specialist training.

Place, publisher, year, edition, pages
läkartidningen Förlag AB, 2019
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:oru:diva-76106 (URN)31454058 (PubMedID)
Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-10Bibliographically approved
Björkman, L., Hagberg, J., Schollin, J. & Ohlin, A. (2017). Can the use of isopropanol impregnated caps cause alcohol leakage into intravenous lines?. In: : . Paper presented at Pediatric Academic Societies (PAS) 2017 Meeting, San Francisco, CA, USA, May 6-9, 2017.
Open this publication in new window or tab >>Can the use of isopropanol impregnated caps cause alcohol leakage into intravenous lines?
2017 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:oru:diva-67263 (URN)
Conference
Pediatric Academic Societies (PAS) 2017 Meeting, San Francisco, CA, USA, May 6-9, 2017
Available from: 2018-06-14 Created: 2018-06-14 Last updated: 2018-09-06Bibliographically approved
Ohlin, A., Björkman, L., Serenius, F., Schollin, J. & Källén, K. (2015). Sepsis as a risk factor for neonatal morbidity in extremely preterm infants. Acta Paediatrica, 104(11), 1070-1076
Open this publication in new window or tab >>Sepsis as a risk factor for neonatal morbidity in extremely preterm infants
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 11, p. 1070-1076Article in journal (Refereed) Published
Abstract [en]

Aim: This study evaluated sepsis as a risk factor for neonatal morbidities and investigated the association between specific pathogens and neonatal morbidities.

Methods: This was a nationwide Swedish prospective cohort study, consisting of the 497 extremely premature children, who were born before 27weeks of gestation between 2004 and 2007 and survived their first year of life. Neonatal sepsis was evaluated as a risk factor for neonatal morbidity using multiple logistic linear regression analyses.

Results: We found that 326 (66%) of the infants had at least one sepsis episode and coagulase-negative staphylococci was the most common pathogen. Definite sepsis, with an odds ratio (OR) of 1.6, was associated with severe bronchopulmonary dysplasia, but not clinical sepsis (OR 1.1). Definite sepsis was also associated with a prolonged hospital stay (OR 1.6). Sepsis was not significantly associated with a higher risk of retinopathy of prematurity or intraventricular haemorrhage.

Conclusion: Extremely preterm infants face a great risk of acquiring neonatal sepsis, with coagulase-negative staphylococci being the most common pathogen in this population. Definite sepsis seemed to be a risk factor for severe bronchopulmonary dysplasia and prolonged hospital stay, but the associations were weaker than in previous studies.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015
Keywords
Morbidity, Neonatal, Prematurity, Risk factor, Sepsis
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:oru:diva-46694 (URN)10.1111/apa.13104 (DOI)000363866200018 ()26118325 (PubMedID)2-s2.0-84945493792 (Scopus ID)
Funder
Swedish Research Council, 2006-3858
Note

Funding Agencies:

Lilla Barnets Fond

Evy and Gunnar Sandbergs Foundation

Birgit and Håkan Ohlssons Foundation

Available from: 2015-11-23 Created: 2015-11-23 Last updated: 2018-10-17Bibliographically approved
Ivarsson, M., Schollin, J. & Björkqvist, M. (2013). Staphylococcus epidermidis and Staphylococcus aureus trigger different interleukin-8 and intercellular adhesion molecule-1 in lung cells: implications for inflammatory complications following neonatal sepsis. Acta Paediatrica, 102(10), 1010-1016
Open this publication in new window or tab >>Staphylococcus epidermidis and Staphylococcus aureus trigger different interleukin-8 and intercellular adhesion molecule-1 in lung cells: implications for inflammatory complications following neonatal sepsis
2013 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 102, no 10, p. 1010-1016Article in journal (Refereed) Published
Abstract [en]

Aim: Staphylococci are a major contribution for neonatal sepsis, which is the main risk factor for bronchopulmonary dysplasia. This study investigated the expression of pro-inflammatory mediators in endothelial and respiratory cells from newborns exposed to staphylococci.

Methods: Human vascular endothelial cells and small airway epithelial cells were incubated with neonatal blood isolates of Staphylococcus epidermidis (n = 14) and Staphylococcus aureus (n = 14). The extracellular release of IL-8, IL-10, sICAM-1, ICAM-1 mRNA and the expression of membrane bound ICAM-1 were assessed by ELISA, RT-PCR and immunofluorescence microscopy.

Results: Staphylococcus epidermidis induced higher levels of IL-8 (mean 38.5 ng/mL) and ICAM-1 mRNA (mean ratio 1.037) in the small airway epithelial cells than S. aureus (IL-8 mean 22.2 ng/mL, p < 0.01 and ICAM-1 mRNA mean ratio 0.715, p < 0.01). In the endothelial cells, ICAM-1 remained more integrated in the cell membranes after exposure to S. epidermidis compared with S. aureus, which induced disintegration and release of soluble ICAM-1 into the supernatants.

Conclusion: Staphylococcus epidermidis induced a higher chemoattractive response than S. aureus. A persistent transmigration of granulocytes into the lung tissue in neonatal S. epidermidis sepsis might contribute to the development of bronchopulmonary dysplasia.

Keywords
Bronchopulmonary dysplasia, ICAM-1, Interleukin-8, Neonatal sepsis, Staphylococci
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-31079 (URN)10.1111/apa.12350 (DOI)000323886300030 ()23845107 (PubMedID)
Available from: 2013-10-04 Created: 2013-10-04 Last updated: 2018-05-21Bibliographically approved
Ohlin, A., Bäckman, A., Ewald, U., Schollin, J. & Björkqvist, M. (2012). Diagnosis of neonatal sepsis by broad-range 16S real-time polymerase chain reaction. Neonatology, 101(4), 241-246
Open this publication in new window or tab >>Diagnosis of neonatal sepsis by broad-range 16S real-time polymerase chain reaction
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2012 (English)In: Neonatology, ISSN 1661-7800, E-ISSN 1661-7819, Vol. 101, no 4, p. 241-246Article in journal (Refereed) Published
Abstract [en]

Background: The standard diagnostic test (blood culture) for suspected neonatal sepsis has limitations in sensitivity and specificity, and 16S polymerase chain reaction (PCR) has been suggested as a new diagnostic tool for neonatal sepsis. Objectives: To develop and evaluate a new real-time PCR method for detection of bacterial DNA in blood samples collected from infants with suspected neonatal sepsis. Methods: Immediately after blood culture, a study sample of 0.5–1.0 ml whole blood was collected and used for a novel 16S real-time PCR assay. All positive samples were sequenced. Detailed case studies were performed in all cases with conflicting results, to verify if PCR could detect pathogens in culture negative sepsis. Results: 368 samples from 317 infants were included. When compared with blood culture, the assay yielded a sensitivity of 79%, a specificity of 90%, a positive predictive value of 59%, and a negative predictive value of 96%. Seven of the 31 samples with a positive PCR result and a negative blood culture had definite or suspected bacterial sepsis. In five samples, PCR (but not blood culture) could detect a pathogen that was present in a blood culture collected more than 24 h prior to the PCR sample. Conclusions: This study presents an evaluation of a new real-time PCR technique that can detect culture-positive sepsis, and suggests that PCR has the potential to detect bacteria in culture-negative samples even after the initiation of intravenous antibiotics.

Place, publisher, year, edition, pages
Basel, Switzerland: Karger, 2012
Keywords
Sepsis, Diagnosis, Polymerase chain reaction, Sensitivity and specificity
National Category
Medical and Health Sciences Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:oru:diva-20775 (URN)10.1159/000334655 (DOI)000304894700003 ()22205207 (PubMedID)2-s2.0-84455202156 (Scopus ID)
Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2017-12-08Bibliographically approved
Nahmias, A. J., Schollin, J. & Abramowsky, C. (2011). Evolutionary-developmental perspectives on immune system interactions among the pregnant woman, placenta, and fetus, and responses to sexually transmitted infectious agents. In: André Nahmias, Dan Danielsson, Susa Beckman Nahmias (Ed.), The evolution of infectious agents in relation to sex. Paper presented at Conference on the Evolution of Infectious Agents in Relation to Sex, Björkborn, Karlskoga, Sweden, Oct 21-23, 2010 (pp. 25-47). Oxford: Blackwell Science, 1230
Open this publication in new window or tab >>Evolutionary-developmental perspectives on immune system interactions among the pregnant woman, placenta, and fetus, and responses to sexually transmitted infectious agents
2011 (English)In: The evolution of infectious agents in relation to sex / [ed] André Nahmias, Dan Danielsson, Susa Beckman Nahmias, Oxford: Blackwell Science , 2011, Vol. 1230, p. 25-47Conference paper, Published paper (Other academic)
Abstract [en]

A balance has evolved over deep time between the various immune systems of the "triad" that is linked together for a short period: the pregnant woman, the fetus, and the placenta. This balance is affected by, and helps to determine, the immune responses to maternal infectious agents that may be transmitted to the fetus/infant transplacentally, intrapartum, or via breast milk. This review identifies newer evolutionary concepts and processes related particularly to the human placenta, innate and adaptive immune systems involved in tolerance, and in responses to sexually transmitted infectious (STI) agents that may be pathogenic to the fetus/infant at different gestational periods and in the first year of life. An evolutionary developmental (EVO-DEVO) perspective has been applied to the complexities within, and among, the different actors and their beneficial or deleterious outcomes. Such a phylogenetic and ontogenic approach has helped to stimulate several basic questions and suggested possible explanations and novel practical interventions.

Place, publisher, year, edition, pages
Oxford: Blackwell Science, 2011
Series
Annals of the New York Academy of Sciences, ISSN 0077-8923 ; 1230
Keywords
evolution-development (EVO-DEVO), pregnant woman, placenta, fetus/infant, immune systems, STI agents
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-18798 (URN)10.1111/j.1749-6632.2011.06137.x (DOI)000294181100006 ()978-1-57331-819-8 (ISBN)
Conference
Conference on the Evolution of Infectious Agents in Relation to Sex, Björkborn, Karlskoga, Sweden, Oct 21-23, 2010
Available from: 2011-09-29 Created: 2011-09-29 Last updated: 2017-10-17Bibliographically approved
Ohlin, A., Björkqvist, M., Montgomery, S. M. & Schollin, J. (2010). Clinical signs and CRP values associated with blood culture results in neonates evaluated for suspected sepsis. Acta Paediatrica, 99(11), 1635-1640
Open this publication in new window or tab >>Clinical signs and CRP values associated with blood culture results in neonates evaluated for suspected sepsis
2010 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 99, no 11, p. 1635-1640Article in journal (Refereed) Published
Abstract [en]

Aim: To identify which clinical signs at presentation are most predictive of sepsis subsequently confirmed by blood culture and to investigate whether the predictive power of the clinical signs varies by gestational age.

Methods: Among 401 newborn infants <28 days of age with suspected sepsis, nine signs of sepsis and C-reactive protein (CRP) values were prospectively recorded. Logistic regression assessed the association of these signs and laboratory values with a subsequently confirmed diagnosis of sepsis by positive blood culture. The analysis was stratified by gestational age with mutual simultaneous adjustment for the signs and sex.

Results: Five of the nine clinical signs (feeding intolerance, distended abdomen, blood pressure, bradycardia and apnoea), along with CRP were statistically significantly associated with a positive blood culture. After simultaneous adjustment for all of the signs, apnoea, hypotension and CRP were independently predictive of positive blood culture. When the material was stratified by gestational age, differences in the association with positive blood culture were found for bradycardia, tachypnea and irritability/seizures.

Conclusion: In this selected population of infants with suspected sepsis, apnoea and hypotension are independently predictive of a confirmed diagnosis, while bradycardia is more predictive among preterm infants and tachypnea among term infants.

Place, publisher, year, edition, pages
Malden, USA: Wiley-Blackwell, 2010
Keywords
Diagnosis, logistic regression, neonatal sepsis, neonatology
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-12721 (URN)10.1111/j.1651-2227.2010.01913.x (DOI)000282641600008 ()20560896 (PubMedID)2-s2.0-78649728350 (Scopus ID)
Available from: 2010-12-15 Created: 2010-12-15 Last updated: 2018-07-22Bibliographically approved
Björkqvist, M., Liljedahl, M., Zimmermann, J., Schollin, J. & Söderquist, B. (2010). Colonization pattern of coagulase-negative staphylococci in preterm neonates and the relation to bacteremia. European Journal of Clinical Microbiology and Infectious Diseases, 29(9), 1085-1093
Open this publication in new window or tab >>Colonization pattern of coagulase-negative staphylococci in preterm neonates and the relation to bacteremia
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2010 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 29, no 9, p. 1085-1093Article in journal (Refereed) Published
Abstract [en]

Coagulase-negative staphylococci (CoNS) are the major cause of sepsis in extreme preterm (EPT) newborns, but data on the CoNS colonization in EPT newborns prior to invasive infection are limited. Our aim was to describe the early establishment of the CoNS microflora in EPT newborns and to compare the colonization pattern in neonates with and without positive CoNS blood cultures. From a cohort of 46 EPT neonates, newborns with positive CoNS blood culture were identified (n = 10) and compared with matched controls. Samples for bacterial cultures were obtained repetitively from nares, perineum, and umbilicus. All CoNS isolates were characterized using the PhenePlate system for biochemical fingerprinting. Persistent CoNS strains were found on day 2-3 after delivery in 7/20 newborns, and there was a tendency for earlier colonization in nares than in the perineum or umbilicus. The CoNS blood strains were prevalent in superficial sites prior to positive blood culture (11/14 blood strains), but no single invasive pathway was identified. Most CoNS blood strains (9/14) persisted on superficial sites after antibiotic treatment. We hypothesize that the invasive pathways in neonatal CoNS sepsis are complex and that the colonization of mucosal membranes and umbilical catheters might be of equal importance.

Place, publisher, year, edition, pages
Springer, 2010
National Category
Infectious Medicine Microbiology in the medical area
Identifiers
urn:nbn:se:oru:diva-25348 (URN)10.1007/s10096-010-0966-3 (DOI)000280844500006 ()20517628 (PubMedID)2-s2.0-78349284429 (Scopus ID)
Note

Funding Agency:

Research committee of Örebro county, Sweden

Available from: 2012-08-27 Created: 2012-08-27 Last updated: 2018-01-12Bibliographically approved
Holmlund, U., Amoudruz, P., Johansson, M. A., Haileselassie, Y., Ongoiba, A., Kayentao, K., . . . Sverremark-Ekström, E. (2010). Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring. Clinical and Experimental Immunology, 162(3), 500-509
Open this publication in new window or tab >>Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring
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2010 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 162, no 3, p. 500-509Article in journal (Refereed) Published
Abstract [en]

Breast milk contains pro- and anti-inflammatory cytokines and chemokines with potential to influence immunological maturation in the child. We have shown previously that country of birth is associated with the cytokine/chemokine profile of breast milk. In this study we have investigated how these differences in breast milk affect the cellular response of cord blood mononuclear cells (CBMCs) and intestinal epithelial cells (IECs, cell line HT-29) to microbial challenge. Ninety-five women were included: 30 from Mali in West Africa, 32 Swedish immigrants and 33 native Swedish women. CBMCs or IECs were stimulated in vitro with breast milk, alone or in combination with lipopolysaccharide (LPS) or peptidoglycan (PGN). Breast milk in general abrogated the LPS-induced down-regulation of surface CD14 and Toll-like receptor (TLR)-4 expression on CB monocytes, while inhibiting the PGN-induced TLR-2 up-regulation. However, breast milk from immigrant women together with LPS induced a lower CBMC release of interleukin (IL)-6 (P = 0 center dot 034) and CXCL-8/IL-8 (P = 0 center dot 037) compared with breast milk from Swedish women, while breast milk from Swedish women and Mali women tended to increase the response. The same pattern of CXCL-8/IL-8 release could be seen after stimulation of IECs (HT-29). The lower CBMC and IEC (HT-29) responses to microbial compounds by breast milk from immigrant women could be explained by the fact that breast milk from the immigrant group showed a divergent pro- and anti-inflammatory content for CXCL-8/IL-8, transforming growth factor-beta 1 and soluble CD14, compared to the other two groups of women. This may have implications for maturation of their children's immune responses.

Place, publisher, year, edition, pages
Oxford, Untited Kingdom: Wiley-Blackwell Publishing Inc., 2010
Keywords
Growth-factor-beta, pattern-recognition receptor, inflammatory-bowel-disease, soluble cd14, nonallergic mothers, atopic disease, iga production, secretory iga, ethnic-groups, cytokines
National Category
Medical and Health Sciences Clinical Medicine Pediatrics
Research subject
Pediatrics
Identifiers
urn:nbn:se:oru:diva-13082 (URN)10.1111/j.1365-2249.2010.04275.x (DOI)000284068400012 ()20942805 (PubMedID)2-s2.0-79952472168 (Scopus ID)
Note

Funding Agency: Swedish Research Council,74X-15160-03-2, 57X-15160-05-02. Montgomery S. M. is also affiliated to Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden and Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Dept Primary Care & Social Med, London, England

Available from: 2011-01-10 Created: 2011-01-10 Last updated: 2018-07-22Bibliographically approved
Stenberg, R., Dahle, C., Lindberg, E. & Schollin, J. (2009). Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy. Journal of Pediatric Gastroenterology and Nutrition - JPGN, 49(4), 424-429
Open this publication in new window or tab >>Increased prevalence of anti-gliadin antibodies and anti-tissue transglutaminase antibodies in children with cerebral palsy
2009 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 49, no 4, p. 424-429Article in journal (Refereed) Published
Abstract [en]

AIM AND OBJECTIVE:: The aim of the study was to investigate whether there is any association between cerebral palsy (CP) and celiac disease (CD) in children.

PATIENTS AND METHODS:: Ninety children between 18 months and 18 years of age (median 9 years) with CP were included. Antibodies (IgA and IgG) against gliadin (AGA), endomysium (EMA), and tissue transglutaminase (tTG) were measured. Children with elevated levels of these antibodies were offered a small-bowel biopsy. RESULTS:: Thirty-nine children showed an elevated level of 1 or more of the tested antibodies (43%). None had raised EMA antibodies. Presence of tetraplegia or dyskinesia was associated with increased antibody levels (P = 0.045), as was a more severe functional type of CP (P = 0.008). Children with elevated antibodies had a lower body weight (P = 0.049), height (P = 0.041), and body mass index (BMI) (P = 0.014). Small-bowel biopsies were performed in 27 out of 39 children; 1 had CD and 2 had intraepithelial lymphocytosis.

CONCLUSIONS:: A large number of children with CP had elevated AGA and/or anti-tTG. Because these elevations were associated with lower weight, height, and BMI, it seemed of interest to speculate on how these findings correlated to CP and CD. However, we found no correlation between CP and CD.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2009
National Category
Gastroenterology and Hepatology
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-8042 (URN)10.1097/MPG.0b013e31819a4e52 (DOI)000270473200009 ()19590452 (PubMedID)2-s2.0-70349731943 (Scopus ID)
Available from: 2009-09-30 Created: 2009-09-30 Last updated: 2017-12-13Bibliographically approved
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