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Nilsson, Torbjörn, K.
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Publications (10 of 63) Show all publications
Isaksson, H. S., Farkas, S. A., Müller, P., Gustafsson, D. & Nilsson, T. K. (2018). Whole genome microarray expression analysis in blood leucocytes identifies pathways linked to signs and symptoms of a patient with hypercalprotectinaemia and hyperzincaemia. Clinical and Experimental Immunology, 191(2), 240-251
Open this publication in new window or tab >>Whole genome microarray expression analysis in blood leucocytes identifies pathways linked to signs and symptoms of a patient with hypercalprotectinaemia and hyperzincaemia
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2018 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 191, no 2, p. 240-251Article in journal (Refereed) Published
Abstract [en]

A child, 2 years with the "hypercalprotectinemia with hyperzincemia" clinical syndrome presented with atypical symptoms and signs, notably persistent fever of around 38°C, thrombocythaemia of >700 x 10(9) /L, and a predominance of persistent intestinal symptoms. In an effort to find a cure by identifying the dysregulated pathways we analyzed whole-genome mRNA expression by the Affymetrix HG U133 PLUS 2.0 array on three occasions 3 to 5 months apart. Major upregulation was demonstrated for the JAK/STAT pathway including in particular CD177, S100A8, S100A9, and S100A12, accounting for the thrombocytosis; a large number of interleukins, their receptors, and activators, accounting for the febrile apathic state; and the HMBG1 gene, possibly accounting for part of the intestinal symptoms. These results show that gene expression array technology may assist the clinician in the diagnostic workup of individual patients with suspected syndromal states of unknown origin, and the expression data can guide the selection of optimal treatment directed at the identified target pathways.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2018
Keywords
expression array, fever, hypercalprotectinaemia, hyperzincaemia, thrombocytaemia
National Category
Medical Genetics Immunology in the medical area
Identifiers
urn:nbn:se:oru:diva-61444 (URN)10.1111/cei.13064 (DOI)000419624200012 ()28984903 (PubMedID)
Available from: 2017-11-02 Created: 2017-11-02 Last updated: 2018-01-19Bibliographically approved
Makdoumi, K., Nilsson, T. K. & Crafoord, S. (2017). Levels of beta-trace protein in optic disc pit with macular detachment. Acta Ophthalmologica, 95(8), 815-819
Open this publication in new window or tab >>Levels of beta-trace protein in optic disc pit with macular detachment
2017 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 95, no 8, p. 815-819Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: To report beta-trace protein (βTP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP).

METHODS: Four patients with a serous retinal detachment involving the macula was operated by pars plana vitrectomy (PPV) with C2 F6 gas tamponade and peeling of internal limiting membrane (ILM). Patients with a follow-up period exceeding one year postoperatively were included in the study. The SRF was drained using a fine cannula without laser photocoagulation, and the samples were analysed using particle-enhancing nephelometry. The levels of βTP were compared to 20 routine cerebrospinal fluid (CSF) samples.

RESULTS: In four of the five samples from SRF had relatively low βTP levels, with a mean concentration of 6.6 mg/l (range 2.0 to 23.1 mg/l) compared to 16.0 mg/l (range 6.3-26.8 mg/l) in CSF. The only SRF sample within the range corresponding to normal CSF was the first sample from patient 4, and the analysis of the renewed aspirate during the second operation was 2.8 mg/l. Postoperatively, the regression of SRF was slow, but regression of SRF in the foveal region took place in all cases; however, visual acuity (VA) was improved in only half of the patients.

CONCLUSION: The results from the analysed SRF regarding βTP concentration in these patients indicate that the SRF in ODP is not identical to CSF, as the concentrations of βTP differ.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2017
Keywords
beta trace, beta-trace protein, optic disc pit, β-trace protein
National Category
Ophthalmology
Identifiers
urn:nbn:se:oru:diva-62465 (URN)10.1111/aos.13527 (DOI)000417645900036 ()28926186 (PubMedID)2-s2.0-85030124493 (Scopus ID)
Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2018-08-11Bibliographically approved
Farkas, S. A., Vymetalkova, V., Vodickova, L., Vodicka, P. & Nilsson, T. K. (2014). DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes. Epigenomics, 6(2), 179-191
Open this publication in new window or tab >>DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes
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2014 (English)In: Epigenomics, ISSN 1750-1911, Vol. 6, no 2, p. 179-191Article in journal (Refereed) Published
Abstract [en]

Aim: The onset and progression of colorectal cancer (CRC) involves a cascade of genetic and/or epigenetic events. The aim of the present study was to address the DNA methylation status of genes relevant in colorectal carcinogenesis and its progression, such as genes frequently mutated in CRC, genes involved in the DNA repair and Wnt signaling pathway.

Material & methods: We analyzed methylation status in totally 160 genes in 12 paired colorectal tumors and adjacent healthy mucosal tissues using the Illumina Infinium Human Methylation 450 BeadChip.

Results: We found significantly aberrant methylation in 23 genes (NEIL1, NEIL3, DCLRE1C, NHEJ1, GTF2H5, CCNH, CTNNB1, DKK2, DKK3, FZD5 LRP5, TLE3, WNT2, WNT3A, WNT6, TCF7L1, CASP8, EDNRB1, GPC6, KIAA1804, MYO1B, SMAD2 and TTN). External validation by mRNA expression showed a good agreement between hypermethylation in cancer and down-regulated mRNA expression of the genes EDNRB1, GPC6 and SMAD2, and between hypomethylation and up-regulated mRNA expression of the CASP8 and DCLRE1C genes.

Conclusion: Aberrant methylation of the DCLRE1C and GPC6 genes are presented here for the first time and are therefore of special interest for further validation as novel candidate biomarker genes in CRC, and merit further validation with specific assays.

Place, publisher, year, edition, pages
Future Medicine, 2014
Keywords
CpG, DNA repair genes, Infinium Human Methylation 450 BeadChip, methylation status, sporadic colorectal cancer, Wnt/beta-catenin signaling pathway
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Medical Genetics
Research subject
Biomedicine
Identifiers
urn:nbn:se:oru:diva-35867 (URN)10.2217/EPI.14.7 (DOI)000335684900015 ()24811787 (PubMedID)2-s2.0-84900412412 (Scopus ID)
Note

Funding agencies:

CZ:GA CR GA Grant numbers: P304/11/P715 P304/12/1585

IGA:NT Grant number: 14329

Lions Cancer Foundation

Nyckelfonden

Örebro läns landsting 

Available from: 2014-08-07 Created: 2014-08-07 Last updated: 2018-06-07Bibliographically approved
Murto, T., Skoog Svanberg, A., Yngve, A., Nilsson, T. K., Altmäe, S., Wånggren, K., . . . Stavreus-Evers, A. (2014). Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility. Reproductive Biomedicine Online, 28(6), 766-772
Open this publication in new window or tab >>Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility
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2014 (English)In: Reproductive Biomedicine Online, ISSN 1472-6483, E-ISSN 1472-6491, Vol. 28, no 6, p. 766-772Article in journal (Refereed) Published
Abstract [en]

Folic acid supplements are commonly used by infertile women and lead to a positive folate status. However, the effect of folic acid supplements on pregnancy outcome in women with unexplained infertility has not been well investigated. This study evaluated folic acid supplement use and folate status in women with unexplained infertility in relation to pregnancy outcome. In addition, use of folic acid supplements and folate status were compared between women with unexplained infertility and fertile, nonpregnant control women. Women with unexplained infertility used significantly more folic acid supplements and had higher median total folic acid intake from supplements compared with fertile control women (both P < 0.001). Women with unexplained infertility also had significantly higher median plasma folate and lower median plasma homocysteine concentrations than fertile women (both P < 0.001), but folic acid supplementation or folate status were not related to pregnancy outcome in women with unexplained infertility. In conclusion, folic acid supplementation or good folate status did not have a positive effect on pregnancy outcome following infertility treatment in women with unexplained infertility.

Place, publisher, year, edition, pages
Elsevier, 2014
Keywords
dietary supplement, folate, homocysteine, infertility, pregnancy
National Category
Social Sciences
Research subject
Culinary Arts and Meal Science
Identifiers
urn:nbn:se:oru:diva-34682 (URN)10.1016/j.rbmo.2014.01.017 (DOI)000338862000014 ()24745837 (PubMedID)2-s2.0-84901938999 (Scopus ID)
Funder
EU, FP7, Seventh Framework Programme, EU41564EU, FP7, Seventh Framework Programme, SARM, EU324509
Note

Funding Agencies:

Family Planning Foundation

Födelsefonden, Uppsala, Sweden

Regional Research Foundation, Örebro, Sweden

Pampers Scholarship, Sweden

Praktikertjänst, Stockholm, Sweden

Marie Curie postdoctoral fellowship 329812

Available from: 2014-04-09 Created: 2014-04-09 Last updated: 2018-06-05Bibliographically approved
Murto, T., Kallak, T. K., Hoas, A., Altmäe, S., Salumets, A., Nilsson, T. K., . . . Stavreus-Evers, A. (2014). Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to IVF pregnancy outcome. Acta Obstetricia et Gynecologica Scandinavica, 94(1), 65-71
Open this publication in new window or tab >>Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to IVF pregnancy outcome
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2014 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 94, no 1, p. 65-71Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677C>T, 1298A>C and 1793G>A polymorphisms. Also the use of folic acid supplements, folate status and the frequency of different gene variations were studied in women undergoing infertility treatment and fertile women.

DESIGN: Observational study.

SETTING: University hospital.

POPULATION: Women undergoing infertility treatment and healthy, fertile, non-pregnant women.

METHODS: A questionnaire was used to assess general background data and use of dietary supplements. Blood samples were taken to determine plasma folate and homocysteine levels, and for genomic DNA extraction. A comparison of four studies was performed to assess pregnancy outcome in relation to MTHFR 677 TT vs. CC, and 1298 CC vs. AA polymorphisms.

MAIN OUTCOME MEASURES: Folic acid supplement intake, and plasma folate, homocysteine and genomic assays.

RESULTS: Women in the infertility group used significantly more folic acid supplements and had better folate status than fertile women, but pregnancy outcome after fertility treatment was not dependent on folic acid intake, folate status or MTHFR gene variations.

CONCLUSION: High folic acid intakes and MTHFR gene variations seem not associated with helping women to achieve pregnancy during or after fertility treatment.

Keywords
Folate, folic acid, homocysteine, infertility, methylenetetrahydrofolate reductase, pregnancy outcome
National Category
Nutrition and Dietetics
Research subject
Nutrition
Identifiers
urn:nbn:se:oru:diva-38300 (URN)10.1111/aogs.12522 (DOI)000346704100012 ()25283235 (PubMedID)2-s2.0-84919360179 (Scopus ID)
Note

Funding Agencies:

Family Planning Foundation and Fodelsefonden, Uppsala, Sweden

Regional Research Foundation, Örebro, Sweden

Pampers Scholarship, Sweden

R&D grants from Praktikertjanst AB, Stockholm, Sweden

Available from: 2014-10-31 Created: 2014-10-31 Last updated: 2018-06-11Bibliographically approved
Olsson, L. A., Hagnelius, N.-O. & Nilsson, T. K. (2014). Renal function is a determinant of subjective well-being in active seniors but not in patients with subjective memory complaints. BMC Research Notes, 7(1), Article ID 647.
Open this publication in new window or tab >>Renal function is a determinant of subjective well-being in active seniors but not in patients with subjective memory complaints
2014 (English)In: BMC Research Notes, ISSN 1756-0500, E-ISSN 1756-0500, Vol. 7, no 1, article id 647Article in journal (Refereed) Published
Abstract [en]

Results: There were no significant differences in cystatin C and eGFR values between the two cohorts: cystatin C medians 0.88 vs 0.86 mg/L and eGFR 73 vs 80 mL/min/1.73 m2(AS vs DGM). In the AS cohort cystatin C was negatively related to PGWB index in women (P &lt; 0.001, R 2≈ 5%), and the covariates age and BMI did not improve the models. The renal biomarkers were unrelated to the PGWB index in the DGM cohort. Cystatin C in the AS cohort was adversely related to the PGWB subdimensions anxiety, depressed mood, positive well-being, and vitality in women, but in men only to depressed mood (P &lt; 0.006; R 2≈ 6%). In the DGM cohort, depressed mood in men was also significantly related to cystatin C (P = 0.050), but not in women.

Background: During our whole life span, factors influencing health and functioning are accumulated. In chronic kidney disease, quality of life is adversely affected. We hypothesized that biomarkers of renal function could also be determinants of subjective well-being (SWB) in Swedish elderly subjects. SWB was assessed by the Psychological General Well-Being index (PGWB index) in two study groups: Active seniors (AS) consisted of community-dwelling elderly Swedes leading an active life (n = 389), and the DGM cohort (n = 300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics for memory problems, Serum creatinine, cystatin C, and eGFR (CKD-EPI) were used as biomarkers of renal function.

Conclusions: Renal function even within the normal range, measured by serum cystatin C concentration, has significant and sex specific associations with subjective well-being and its subdimensions in healthy elderly subjects. Maintenance of good renal function in aging may be of importance in maintaining a high subjective well-being.

Place, publisher, year, edition, pages
BioMed Central, 2014
Keywords
Biomarkers; Creatinine; Cystatin C; Elderly; Renal function; Subjective well-being
National Category
Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:oru:diva-43262 (URN)10.1186/1756-0500-7-647 (DOI)25219531 (PubMedID)2-s2.0-84907579308 (Scopus ID)
Available from: 2015-03-03 Created: 2015-03-03 Last updated: 2018-06-18Bibliographically approved
Olsson, L. A., Hurtig-Wennlöf, A. & Nilsson, T. K. (2014). Subjective well-being in Swedish active seniors and its relationship with physical activity and commonly available biomarkers. Clinical Interventions in Aging, 9, 233-239
Open this publication in new window or tab >>Subjective well-being in Swedish active seniors and its relationship with physical activity and commonly available biomarkers
2014 (English)In: Clinical Interventions in Aging, ISSN 1176-9092, E-ISSN 1178-1998, Vol. 9, p. 233-239Article in journal (Refereed) Published
Abstract [en]

Background: Physical activity is claimed to be related to well-being and to a lower risk of cardiovascular disease. Therefore, the possible associations of well-being with physical activity and biomarkers of somatic health were studied in a sample of Swedish active seniors to determine the strength of these associations.

Methods: Three hundred and eighty-nine community-dwelling senior citizens (127 men and 262 women) of mean age 74 +/- 5 years were recruited for this cross-sectional population study. Serum samples were analyzed for lipoproteins and markers of inflammation. The Psychological General Well-Being (PGWB) index was used to measure subjective well-being. Physical activity was assessed by the International Physical Activity Questionnaire modified for the elderly.

Results: More than 50% of men and women rated their physical activity as high; in the women, there was a significant difference between the age groups (younger and older than the median age [median =74.1 years], respectively). The mean PGWB index indicates a high degree of subjective well-being in this group of Swedish seniors. Of the PGWB subdimensions, general health had the strongest positive relationship with physical activity (r(2)=5.4%). for the subdimensions of depressed mood, positive well-being, vitality, and PGWB index, physical activity had an r(2)<= 4%, while the contributions of sex, age, and biomarkers were minor.

Conclusion: We have estimated the contribution of physical activity to the variance of subjective well-being in active seniors. Physical activity appears to play a greater role as a determinant of subjective well-being than do biomarkers of somatic health, especially in females, but most of the variance remained unaccounted for by the studied variables.

Place, publisher, year, edition, pages
Dove Medical Press, 2014
Keywords
subjective well-being, physical activity, biomarkers
National Category
Geriatrics
Research subject
Geriatrics
Identifiers
urn:nbn:se:oru:diva-36184 (URN)10.2147/CIA.S63198 (DOI)000339920600001 ()2-s2.0-84905227461 (Scopus ID)
Note

Funding Agency:

Research Committee of Örebro County Council and Nyckelfonden, Örebro, Sweden

Available from: 2014-09-02 Created: 2014-08-28 Last updated: 2018-06-09Bibliographically approved
Lindqvist, B. M., Wingren, S., Motlagh, P. B. & Nilsson, T. K. (2014). Whole genome DNA methylation signature of HER2-positive breast cancer. Epigenetics, 9(8), 1149-1162
Open this publication in new window or tab >>Whole genome DNA methylation signature of HER2-positive breast cancer
2014 (English)In: Epigenetics, ISSN 1559-2294, E-ISSN 1559-2308, Vol. 9, no 8, p. 1149-1162Article in journal (Refereed) Published
Abstract [en]

In order to obtain a comprehensive DNA methylation signature of HER2-positive breast cancer (HER2+ breast cancer), we performed a genome-wide methylation analysis on 17 HER2+ breast cancer and compared with ten normal breast tissue samples using the Illumina Infinium HumanMethylation450 BeadChip (450K). In HER2+ breast cancer, we found altered DNA methylation in genes involved in multicellular development, differentiation and transcription. Within these genes, we observed an overrepresentation of homeobox family genes, including several genes that have not been previously reported in relation to cancer (DBX1, NKX2-6, SIX6). Other affected genes included several belonging to the PI3K and Wnt signaling pathways. Notably, HER2, AKT3, HK1, and PFKP, genes for which altered methylation has not been previously reported, were also identified in this analysis. In total, we report 69 candidate biomarker genes with maximum differential methylation in HER2+ breast cancer. External validation of gene expression in a selected group of these genes (n = 13) revealed lowered mean gene expression in HER2+ breast cancer. We analyzed DNA methylation in six top candidate genes (AKR1B1, INA, FOXC2, NEUROD1, CDKL2, IRF4) using EpiTect Methyl II Custom PCR Array and confirmed the 450K array findings. Future clinical studies focusing on these genes, as well as on homeobox-containing genes and HER2, AKT3, HK1, and PFKP, are warranted which could provide further insights into the biology of HER2+ breast cancer.

Place, publisher, year, edition, pages
Austin, USA: Landes Bioscience, 2014
Keywords
DNA methylation, HER2-positive breast cancer, Illumina Infinium HumanMethylation450 BeadChip
National Category
Medical and Health Sciences Cancer and Oncology
Research subject
Biomedicine
Identifiers
urn:nbn:se:oru:diva-37169 (URN)10.4161/epi.29632 (DOI)000341360600010 ()25089541 (PubMedID)2-s2.0-84905672549 (Scopus ID)
Note

Funding Agencies:

Swedish Cancer Society

Örebro County Council

Lions Cancer Foundation, Uppsala

Nyckelfonden, Örebro

Available from: 2014-09-25 Created: 2014-09-25 Last updated: 2017-12-05Bibliographically approved
Isaksson, H. S., Sorbe, B. & Nilsson, T. K. (2014). Whole genome expression profiling of blood cells in ovarian cancer patients: prognostic impact of the CYP1B1, MTSS1, NCALD, and NOP14 genes. OncoTarget, 5(12), 4040-4049
Open this publication in new window or tab >>Whole genome expression profiling of blood cells in ovarian cancer patients: prognostic impact of the CYP1B1, MTSS1, NCALD, and NOP14 genes
2014 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 5, no 12, p. 4040-4049Article in journal (Refereed) Published
Abstract [en]

Ovarian cancer patients with different tumor stages and cell differentiation might be distinguished from each other by gene expression profiles in whole blood cell mRNA by the Affymetrix Human Gene 1.0 ST Array. We also examined if there is any association with other clinical variables, response to therapy, and residual tumor burden after surgery. Patients were divided into two groups, one with poor prognosis, advanced stage and poorly differentiated tumors (n = 22), and one group with good prognosis, early stage and well-to medium differentiated tumors (n = 11). Six genes were found to be differentially expressed: the PDIA3, LYAR, NOP14, NCALD and MTSS1 genes were down-regulated and the CYP1B1 gene expression was up-regulated in the poor prognosis group, all with p value <0.05, adjusted for mass comparison. In survival analyses, CYP1B1, MTSS1, NCALD and NOP14 remained significantly different (p<0.05). Patient groups did not differ in any transcript related to acute phase or immune responses. This minimal gene expression signature of prognostic ovarian cancer-related genes opens up an avenue for more practicable monitoring of ovarian cancer patients by simple peripheral blood tests, which may evolve into a tool to guide selection of curative and postoperative supportive therapies.

Place, publisher, year, edition, pages
Impact press, 2014
Keywords
ovarian cancer, whole genome profiling, prognosis, mRNA, NCALD, MTSS1, PDA3, CYP1B1, NOP14, LYAR
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
urn:nbn:se:oru:diva-36179 (URN)000339055200007 ()24961659 (PubMedID)2-s2.0-84905090787 (Scopus ID)
Note

Funding Agencies:

Research Committee of Örebro County Council

Foundation for Gynecological Oncology, Örebro

Lions' Cancer Research Foundation, Uppsala-Örebro

Available from: 2014-09-02 Created: 2014-08-28 Last updated: 2018-06-09Bibliographically approved
Nilsson, T. K., Lof-Ohlin, Z. M. & Sun, X.-F. (2013). DNA methylation of the p14(ARF), RASSF1A and APC1A genes as an independent prognostic factor in colorectal cancer patients. International Journal of Oncology, 42(1), 127-133
Open this publication in new window or tab >>DNA methylation of the p14(ARF), RASSF1A and APC1A genes as an independent prognostic factor in colorectal cancer patients
2013 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 42, no 1, p. 127-133Article in journal (Refereed) Published
Abstract [en]

We quantitated the methylated fraction of CpG sites in the promoter regions of O-6-MGMT, p14(ARF), p16(INK4a), RASSF1A and APC1A in tumor tissue from patients with colorectal cancer (CRC) in order to determine if promoter hypermethylation of any of these genes predicts survival. DNA was isolated from 111 primary CRC and 46 matched normal colorectal mucosa samples from the same patients, obtained at primary surgery and DNA methylation was examined by Pyrosequencing (R). Follow-up time was up to 20 years. Patients showed partial promoter methylation in the following frequencies: O-6-MGMT, 34%; p14(ARF), 29%; p16(INK4a), 28%; RASSF1A, 14%; and APC1A, 27%. Normal mucosa was always unmethylated. CRC patients with methylated p14(ARF). gene promoter had significantly worse prognosis (p=0.036), whereas those with methylated O-6-MGMT had significantly better prognosis through the first 60 months post-treatment (RR 0.36; p=0.023). Methylation of one or more of the genes from the set p14(ARF), RASSF1A and APC1A, was significantly (p=0.021) associated with worse prognosis even adjusting for tumor stage and differentiation (RR 2.2, p=0.037). Thus, DNA methylation of the p14(ARF), RASSF1A and APC1A genes, diagnosed by Pyrosequencing, defines a poor prognosis subset of CRC patients independently of both tumor stage and differentiation. O-6-MGMT methylation may play a protective role.

National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-26933 (URN)10.3892/ijo.2012.1682 (DOI)000312566900014 ()
Available from: 2013-01-21 Created: 2013-01-18 Last updated: 2017-12-06Bibliographically approved
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