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Publications (4 of 4) Show all publications
Karefylakis, C., Särnblad, S., Ariander, A., Ehlersson, G., Rask, E. & Rask, P. (2018). Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men: a randomized controlled trial. Endocrine (Basingstoke), 61(3), 388-397
Open this publication in new window or tab >>Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men: a randomized controlled trial
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2018 (English)In: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100, Vol. 61, no 3, p. 388-397Article in journal (Refereed) Published
Abstract [en]

Purpose: Several observational studies have shown an association between vitamin D deficiency and non-skeletal major health issues including impaired cardiorespiratory fitness and adiposity. Only a few studies have examined the impact of vitamin D supplementation on these conditions and the results are ambiguous. The aim of this study was to examine the effect of vitamin D supplementation on body composition and cardiorespiratory fitness in overweight/obese men with vitamin D deficiency.

Methods: This study was a prospective, placebo controlled, double blinded, randomized trial with a study period of 6 months. Forty overweight/obese men (BMI > 25 kg/m2) with vitamin D deficiency (25(OH)D ≤ 55 nmol/L) were randomized to receive either 2000 IU Cholecalciferol drops or the equivalent amount of drops of placebo. At baseline and follow up body composition and cardiorespiratory fitness were measured and blood samples were obtained. Body composition was measured using bioelectrical impedance analysis (BIA) and cardiorespiratory fitness using cardiopulmonary exercise test (CPET). The primary outcomes were changes in percentage body fat and in maximum oxygen uptake (VO2max).

Results: No statistically significant difference between the placebo and the intervention group regarding changes in percentage body fat (p = 0.54) and VO2max (p = 0.90) was observed. Moreover, there was no statistically significant difference between the groups concerning changes in BMI (p = 0.26), maximum load (p = 0.89) and oxygen uptake at anaerobic threshold (AT) (p = 0.14).

Conclusions: We conclude that treatment with 2000 IU/d vitamin D for 6 months does not impact body composition or maximum oxygen uptake in overweight/obese men with vitamin D deficiency.

Place, publisher, year, edition, pages
Humana Press, 2018
Keywords
Bioelectrical impedance analysis, Body composition, Cardiopulmonary exercise test, Cardiorespiratory fitness, Vitamin D
National Category
Nutrition and Dietetics Endocrinology and Diabetes
Identifiers
urn:nbn:se:oru:diva-68368 (URN)10.1007/s12020-018-1665-6 (DOI)000442234600005 ()29978375 (PubMedID)2-s2.0-85049582617 (Scopus ID)
Note

Funding Agencies:

Nyckelfonden OLL-404451

Örebro University ALF 2016:1 OLL-615521

Available from: 2018-08-13 Created: 2018-08-13 Last updated: 2019-03-26Bibliographically approved
Lidén, M., Wodecki, M., Thunberg, P. & Rask, P. (2017). Impact of Heart Rate on Flow Measurements in Aortic Regurgitation. Journal of Heart Valve Disease, 26(5), 502-508, Article ID 4562.
Open this publication in new window or tab >>Impact of Heart Rate on Flow Measurements in Aortic Regurgitation
2017 (English)In: Journal of Heart Valve Disease, ISSN 0966-8519, E-ISSN 2053-2644, Vol. 26, no 5, p. 502-508, article id 4562Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Flow measurements using cardiac magnetic resonance imaging (CMRI) enable quantification of the stroke volume, regurgitant volume (RV) and regurgitant fraction (RF) in patients with aortic regurgitation (AR). These variables are used to assess the severity of the valve disease and for the timing of surgery. The aim of the study was to investigate the impact of an increased heart rate on measurement of the RV and RF in patients with AR.

METHODS: Among 13 patients with known moderate or severe AR, regurgitant flow measurements, using phase-contrast cine magnetic resonance imaging, were obtained in the ascending aorta. Flow measurements were obtained at rest and at increased heart rates after intravenous administration of atropine.

RESULTS: The mean heart rate was 61 beats per min at rest and 91 beats per min after atropine administration. The RV and RF were 52 ml and 35% at rest, respectively, and 34 ml (p <0.001) and 30% (p = 0.065) at increased heart rate, respectively.

CONCLUSIONS: An increased heart rate leads to a decreased RV. The RF is more stable and may therefore be preferable for severity grading in AR.

Place, publisher, year, edition, pages
I C R Publishers Ltd., 2017
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:oru:diva-67603 (URN)29762918 (PubMedID)
Available from: 2018-06-28 Created: 2018-06-28 Last updated: 2019-03-26Bibliographically approved
Kiotsekoglou, A., Moggridge, J. C., Child, A. H. & Rask, P. (2017). The role of advanced echocardiography and cardiovascular magnetic resonance in the assessment of myocardial function in Marfan syndrome-An update. Echocardiography, 34(5), 760-767
Open this publication in new window or tab >>The role of advanced echocardiography and cardiovascular magnetic resonance in the assessment of myocardial function in Marfan syndrome-An update
2017 (English)In: Echocardiography, ISSN 0742-2822, E-ISSN 1540-8175, Vol. 34, no 5, p. 760-767Article in journal (Refereed) Published
Abstract [en]

Cardiovascular assessment of patients with Marfan syndrome has normally focused on the aortic root and vascular manifestations of the disease due to the high risk of aortic dissection. Although primary myocardial impairment has long been suspected in these patients, the evidence has been controversial. Advanced echocardiography and cardiovascular magnetic resonance imaging have proven to be effective, accurate, and more sensitive in the detection of subtle cardiac dysfunction. The application of these techniques to Marfan syndrome over the last 10 years has made significant progress in demonstrating the presence of primary myocardial impairment in these patients, but further work is still required to obtain confirmatory molecular, pathophysiological, and prognostic clinical data. Phenotypic expression of the disease has prognostic value, also suggesting potential effective medical therapy.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
cardiac magnetic resonance imaging; echocardiography; left atrium; left ventricular function; Marfan syndrome; right atrium; right ventricular function
National Category
Cardiac and Cardiovascular Systems
Research subject
Cardiology
Identifiers
urn:nbn:se:oru:diva-57371 (URN)10.1111/echo.13517 (DOI)000400027800016 ()28317279 (PubMedID)2-s2.0-85016312293 (Scopus ID)
Available from: 2017-05-21 Created: 2017-05-21 Last updated: 2019-03-26Bibliographically approved
Karefylakis, C., Särnblad, S., Ariander, A., Ehlersson, G., Rask, E. & Rask, P.Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men: A randomized controlled trial.
Open this publication in new window or tab >>Effect of Vitamin D supplementation on body composition and cardiorespiratory fitness in overweight men: A randomized controlled trial
Show others...
(English)Manuscript (preprint) (Other academic)
National Category
General Practice
Identifiers
urn:nbn:se:oru:diva-66214 (URN)
Available from: 2018-03-28 Created: 2018-03-28 Last updated: 2019-03-26Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-8982-4572

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