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Publications (9 of 9) Show all publications
Koch, A., Aro, R., Wang, T. & Yeung, L. W. Y. (2020). Towards a comprehensive analytical workflow for the chemical characterisation of organofluorine in consumer products and environmental samples. TrAC. Trends in analytical chemistry, 123, Article ID 115423.
Open this publication in new window or tab >>Towards a comprehensive analytical workflow for the chemical characterisation of organofluorine in consumer products and environmental samples
2020 (English)In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 123, article id 115423Article, review/survey (Refereed) Published
Abstract [en]

This review summarizes and discusses eight analytical methods for organofluorine (OF) analysis, which offer detection limits suitable for consumer products and environmental samples. Direct sample analysis of OF only applies to some techniques on consumer products, whereas others require sample pretreatment or concentration before measurements. Comparison between methods for OF analysis were found to be difficult because of different selectivity (between OF and fluoride), sensitivity and type of samples (bulk, extract, surface) analysed. Neither inter-laboratory comparison on OF analysis nor suitable certified reference materials have been used for method validation, which makes data comparability between studies challenging. A top down approach for the comprehensive assessment of OF is proposed, where OF/extractable OF is first measured, followed by target analysis to obtain unquantifiable OF concentrations using the mass balance approach. For further identification of unquantifiable OF, approaches such as total oxidizable precursor assay, suspect and non-target screening are briefly discussed.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Fluorine mass balance, Extractable organofluorine (EOF), Per- and polyfluoroalkyl substances (PFASs), Combustion ion chromatography (CIC), Particle-induced gamma-ray emission spectrometry (PIGE), Inductively coupled plasma MS/MS (ICP-MS/MS)
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-80250 (URN)10.1016/j.trac.2019.02.024 (DOI)000512979800001 ()2-s2.0-85062809595 (Scopus ID)
Funder
Swedish Research Council, 2015-00320Swedish Research Council Formas, 2016-01158Knowledge Foundation, 20160019
Available from: 2020-02-28 Created: 2020-02-28 Last updated: 2020-02-28Bibliographically approved
Kärrman, A., Wang, T., Kallenborn, R., Langseter, A. M., Grønhovd, S. M., Ræder, E. M., . . . Fredriksson, F. (2019). PFASs in the Nordic environment: Screening of Poly- and Perfluoroalkyl Substances (PFASs) and Extractable Organic Fluorine (EOF) in the Nordic Environment. Copenhagen: Nordisk Ministerråd
Open this publication in new window or tab >>PFASs in the Nordic environment: Screening of Poly- and Perfluoroalkyl Substances (PFASs) and Extractable Organic Fluorine (EOF) in the Nordic Environment
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2019 (English)Report (Refereed)
Abstract [en]

This report describes a screening study of in all ninety-nine conventional and emerging per- and polyfluoroalkyl substances (PFASs) in the Nordic environment. In addition, extractable organic fluorine (EOF) was analysed. The latter can provide the amount, but not identity, of organofluorine in the samples, which in turn can be used to assess the mass balance between known and unknown PFASs. The study was initiated by the Nordic Screening Group and funded by these and the Nordic Council of Ministers through the Chemicals Group. A total of 102 samples were analyzed in this study, including bird eggs, fish, marine mammals, terrestrial mammals, surface water, WWTP effluents and sludge, and air. Samples were collected by institutes from the participating countries and self-governing areas; Denmark, Faroe Islands, Finland, Greenland, Iceland, Norway, and Sweden.

Place, publisher, year, edition, pages
Copenhagen: Nordisk Ministerråd, 2019. p. 153
Series
TemaNord, ISSN 0908-6692 ; 2019:515
National Category
Environmental Management
Research subject
Environment and Climate; Chemicals
Identifiers
urn:nbn:se:oru:diva-81431 (URN)10.6027/TN2019-515 (DOI)978-92-893-6061-6 (ISBN)978-92-893-6062-3 (ISBN)978-92-893-6063-0 (ISBN)
Funder
Nordic Council of Ministers
Note

The study was conducted on behalf of the Nordic Screening group (www.nor-dicscreening.org) which commissioned and funded the work with financial support gra-ciously provided by the Nordic Council of Ministers Chemicals Group, and the partici-pating agencies and institutes.

Available from: 2020-04-30 Created: 2020-04-30 Last updated: 2020-04-30
Ben Ayoub, M. W., Aro, R., Georgin, E., Rochas, J. F. & Sabouroux, P. (2018). Quantification of free and bound water in selected materials using dielectric and thermo-coulometric measurement methods. JOURNAL OF PHYSICS COMMUNICATIONS, 2(3), Article ID UNSP 035040.
Open this publication in new window or tab >>Quantification of free and bound water in selected materials using dielectric and thermo-coulometric measurement methods
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2018 (English)In: JOURNAL OF PHYSICS COMMUNICATIONS, ISSN 2399-6528, Vol. 2, no 3, article id UNSP 035040Article in journal (Refereed) Published
Abstract [en]

Broadband electromagnetic characterization offers useful tools for the quantitative estimation of water content in a insulating solid materials. However, the correlation between electromagnetic characteristics and the amount of water in solids needs to be characterized using precise direct measurement methods. In this study, a two-port coaxial transmission cell has been characterized for water content estimation based on a study with the thermo-coulometric water detection method. The latter allows us to determine the proportions of the different water bonding forms that can exist in the material. The purpose of this paper is to provide a dielectric relaxation behavior study of the kaolinite clay from 10 MHz to 1.5 GHz, which was preceded by an experimental analysis of alpha-D-lactose monohydrate and the calcium oxalate monohydrate, which have stable water content under various humidity conditions.

Keywords
kaolinite clay; alpha-D-lactose monohydrate; calcium oxalate monohydrate; water bonding forms; thermo-coulometric water detection; electromagnetic characteristics
National Category
Water Engineering
Identifiers
urn:nbn:se:oru:diva-82308 (URN)10.1088/2399-6528/aab5d5 (DOI)000434996900045 ()
Available from: 2020-06-02 Created: 2020-06-02 Last updated: 2020-06-02
Ben Ayoub, M. W., Georgin, E., Rochas, J. F., Hubert, S., Aro, R., Neves, L. & Sabouroux, P. (2018). Quantitative determination of bound water in cardboard by measurement of dielectric permittivity. Measurement science and technology, 29(2), Article ID 024001.
Open this publication in new window or tab >>Quantitative determination of bound water in cardboard by measurement of dielectric permittivity
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2018 (English)In: Measurement science and technology, ISSN 0957-0233, E-ISSN 1361-6501, Vol. 29, no 2, article id 024001Article in journal (Refereed) Published
Abstract [en]

In this study we investigated the complex dielectric permittivity of cardboard with different water contents using a coaxial transmission/reflection technique from 10 MHz to 1.5 GHz. A relaxation process was analyzed to identify the bonding forms that exist in cardboard; this analysis was accompanied by a selective direct thermo-coulometric method. Two different types of bonding of water are found in cardboard (free and bound water) and both can be eliminated at 105 degrees C. The novelty of this work is the experimental correlation between the relaxation frequency situated in the radio-frequency band and the fraction of bound water in cardboard with a low water content.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2018
National Category
Physical Chemistry
Identifiers
urn:nbn:se:oru:diva-82298 (URN)10.1088/1361-6501/aa9908 (DOI)000423020300001 ()
Available from: 2020-06-02 Created: 2020-06-02 Last updated: 2020-06-02
Veigure, R., Aro, R., Metsvaht, T., Standing, J. F., Lutsar, I., Herodes, K. & Kipper, K. (2017). A highly sensitive method for the simultaneous UHPLC?MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive. Journal of chromatography. B, 1052, 150-157
Open this publication in new window or tab >>A highly sensitive method for the simultaneous UHPLC?MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive
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2017 (English)In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 1052, p. 150-157Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
UHPLC-MS/MS; Chromatographic separation; Morphine; Clonidine; Midazolam; Hexafluoroisopropanol
National Category
Analytical Chemistry
Research subject
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-61886 (URN)10.1016/j.jchromb.2017.03.007 (DOI)000402218900019 ()28388512 (PubMedID)2-s2.0-85016777948 (Scopus ID)
Note

Funding Agencies:

European Union's Seventh Framework Programme  602453 

People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme under REA  608765 

Estonian Research Council  PUTJD 22 

Ministry of Education and Research of Estonia  IUT20-14 (TLOKT140141) 

United Kingdom Medical Research Council Fellowships  G1002305  M008665 

National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust  

University College London 

Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2018-08-07Bibliographically approved
Haiba, E., Nei, L., Kutti, S., Lillenberg, M., Herodes, K., Ivask, M., . . . Laaniste, A. (2017). Degradation of diclofenac and triclosan residues in sewage sludge compost. Agronomy Research, 15(2), 395-405
Open this publication in new window or tab >>Degradation of diclofenac and triclosan residues in sewage sludge compost
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2017 (English)In: Agronomy Research, ISSN 1406-894X, Vol. 15, no 2, p. 395-405Article in journal (Refereed) Published
Abstract [en]

Land application of sewage sludge compost is an important and efficient tool in the remediation of industrial landscapes and agricultural soils in Estonia. A number of studies have shown that, as a rule, pharmaceuticals and personal care products (PPCPs) are neither completely removed by sewage treatment, nor completely degraded in the environment. In this study, degradation rates of diclofenac sodium (DFC) and triclosan (TCS) were determined during sewage sludge composting. Anaerobically digested and dewatered sewage sludge was mixed with sawdust at two different ratios (1:2 and 1:3 sludge/sawdust, v:v). Then aerobic composting was carried out. These ratios were chosen on the basis of previous studies on sewage sludge composting with different bulking agents. The initial concentration of DFC and TCS was 2 mg kg-1 in relation to dry weight (dw). Low quantities of the studied pharmaceuticals were present in sewage sludge that was used for preparing the compost mixtures used in our experiments. The background concentrations of DFC and TCS were never equal to zero. The results showed that the difference between sewage sludge and bulking agent ratios (1:2 vs 1:3) in compost samples did not significantly affect temperature profiles during the experiment. The degradation of pharmaceuticals was more complete in the compost samples where the ratio of bulking agent was higher (1:3 by volume). The average degradation level (in all compost mixtures) was 95% for DFC and 68% for TCS. Pharmaceuticals entering into the soil may affect microbial activity, plant growth and development, and may have adverse effects on living organisms.

Place, publisher, year, edition, pages
Eesti Pollumajandusulikool, 2017
Keywords
sewage sludge compost, sawdust, fertilizers, diclofenac, triclosan
National Category
Analytical Chemistry
Research subject
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-61887 (URN)2-s2.0-85019607901 (Scopus ID)
Note

Funding Agency:

Environmental Investment Centre of Estonia

Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2017-10-20Bibliographically approved
Takkis, K., Aro, R., Kõrgvee, L.-T., Varendi, H., Lass, J., Herodes, K. & Kipper, K. (2017). Signal Enhancement in the HPLC-ESI-MS/MS analysis of spironolactone and its metabolites using HFIP and NH4F as eluent additives. Analytical and Bioanalytical Chemistry, 409(12), 3145-3151
Open this publication in new window or tab >>Signal Enhancement in the HPLC-ESI-MS/MS analysis of spironolactone and its metabolites using HFIP and NH4F as eluent additives
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2017 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 409, no 12, p. 3145-3151Article in journal (Refereed) Published
Abstract [en]

This paper describes an LC-MS/MS method to determine the concentration of spironolactone and its metabolites 7-alpha-methylthiospironolactone and canrenone in blood plasma samples. The resulting assay is simple (using protein precipitation for sample preparation) and sensitive (the lower limit of quantification is close to 0.5 ng/ml) while requiring only 50 mu l of plasma, making it especially suitable for analyzing samples obtained from pediatric and neonatal patients where sample sizes are limited. The sensitivity is achieved by using ammonium fluoride as an eluent additive, which in our case amplifies the signal from our analytes in the plasma solution on average about 70 times. The method is fully validated according to the European Medicines Agency's guideline and used for the measurement of pediatric patients' samples in clinical trials for evaluating oral spironolactone's and its metabolites' pharmacokinetics in children up to 2 years of age.

Place, publisher, year, edition, pages
Springer, 2017
Keywords
Spironolactone; Ammonium fluoride; Signal enhancement; Liquid chromatography-mass spectrometry; Ionization efficiency; Hexafluoroisopropanol
National Category
Analytical Chemistry
Research subject
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-61888 (URN)10.1007/s00216-017-0255-4 (DOI)000399700700009 ()28224249 (PubMedID)2-s2.0-85013466865 (Scopus ID)
Note

Funding Agencies:

ERANet PRIOMEDCHILD program by the Estonian Science Foundation  18/2011 

People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7)  608765 

PUTJD 22 from the Estonian Research Council  

Ministry of Education and Research of Estonia  IUT20-14 (TLOKT14014I) 

Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2018-08-07Bibliographically approved
Hecht, M., Evard, H., Takkis, K., Veigure, R., Aro, R., Lohmus, R., . . . Kipper, K. (2017). Sponge Spray-Reaching New Dimensions of Direct Sampling and Analysis by MS. Analytical Chemistry, 89(21), 11592-11597
Open this publication in new window or tab >>Sponge Spray-Reaching New Dimensions of Direct Sampling and Analysis by MS
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2017 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 89, no 21, p. 11592-11597Article in journal (Refereed) Published
Abstract [en]

Sample preparation for the analysis of clinical samples with the mass spectrometer (MS) can be extensive and expensive. Simplifying and speeding up the process would be very beneficial. This paper reports sponge spray-a novel sampling and direct MS analysis approach-attempting exactly that. It enables direct analysis without any sample preparation from dried blood, plasma, and urine. The tip of a volumetric absorptive microsampling device is used to collect an exact amount of sample and from that same tip an electrospray can be directed into a mass spectrometer. We demonstrate here that, although with significant matrix effects, quantitation of penicillin G, a common antimicrobial, is, possible in plasma and in urine, with essentially no sample preparation.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017
Keywords
IONIZATION MASS-SPECTROMETRY; PAPER-SPRAY; QUANTITATIVE-ANALYSIS; THERAPEUTIC DRUGS; WHOLE-BLOOD; RAPID MEASUREMENT; SUBSTRATE; CHALLENGES; BIOFLUIDS; ISSUES
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:oru:diva-82314 (URN)10.1021/acs.analchem.7b02957 (DOI)000414887000061 ()29028329 (PubMedID)
Available from: 2020-06-02 Created: 2020-06-02 Last updated: 2020-06-02
Bell, S., Aro, R., Arpino, F., Aytekin, S., Cortellessa, G., Dell'Isola, M., . . . Vachova, T. (2015). METefnet: Developments in metrology for moisture in materials. In: Bernard Larquier (Ed.), 17th International Congress of Metrology, CIM 2015: . Paper presented at 17th International Congress of Metrology (CIM 2015), Paris, France, September 21-24, 2015. EDP Sciences, Article ID 15003.
Open this publication in new window or tab >>METefnet: Developments in metrology for moisture in materials
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2015 (English)In: 17th International Congress of Metrology, CIM 2015 / [ed] Bernard Larquier, EDP Sciences , 2015, article id 15003Conference paper, Published paper (Refereed)
Abstract [fr]

Bien que les mesures de teneur en eau soient largement utilisées dans l'industrie, les considérations métrologiques quant à cette mesure ne sont pas complètement abouties de sorte à fournir des mesures fiables et traçables au SI. Afin de remédier à ceci, le projet de recherche conjoint, Joint Research Project SIB64 “METefnet – Metrology for moisture in materials”, est actuellement en cours, et contribue au programme européen de recherche en métrologie European Metrology Research Programme. Le projet METefnet a pour objectifs de développer et d'améliorer l'approche métrologique de ce sujet. Ceci inclus notamment: le travail sur de nouvelles méthodes de référence pour évaluer la fraction massique en eau, l'amélioration des mesures mettant en œuvre la méthode primaire de type titration Karl Fischer, le développement de nouveaux matériaux de référence certifiés présentant une très bonne stabilité et permettant une traçabilité au SI, le développement de nouveaux étalons de transfert, la réalisation d'études visant à quantifier et réduire les effets liés à la prise d'échantillon, son transport et sa manipulation, le développement d'une nouvelle méthode pour étalonner les instruments mesurant l'humidité de surface, et l'amélioration des méthodes d'estimation d'incertitudes de ces mesures. Ce travail, réalisé dans le domaine de la métrologie de l'humidité au sein des matériaux, couvre à la fois le mesurande décrit comme étant spécifiquement la teneur en eau, seule, dans les matériaux, mais également un mesurande plus large pouvant inclure l'eau ainsi que d'autres liquides ou composés organiques volatiles; ceci afin de bien mettre en exergue la différence qui peut être observée entre ces deux mesurandes. Le projet global a pour objectif de soutenir une action de dissémination et de traçabilité au système SI des mesures de teneur en eau dans les matériaux avec une exactitude optimale et de développer une infrastructure métrologique cohérente pour ce type de mesures. Le travail technique ainsi que les dernières avancées vous sont ainsi présentées.

Place, publisher, year, edition, pages
EDP Sciences, 2015
National Category
Meteorology and Atmospheric Sciences
Identifiers
urn:nbn:se:oru:diva-61884 (URN)10.1051/metrology/20150015003 (DOI)2-s2.0-84980332130 (Scopus ID)
Conference
17th International Congress of Metrology (CIM 2015), Paris, France, September 21-24, 2015
Note

note: CEMIS-Oulu is a multidisciplinary research unit at the University of Oulu established by fusing laboratories of biotechnology and measurement technology.

Available from: 2017-10-19 Created: 2017-10-19 Last updated: 2018-07-09Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-5360-2326

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