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Wikström, Sverre
Publications (10 of 27) Show all publications
Svensson, K., Gennings, C., Lindh, C., Kiviranta, H., Rantakokko, P., Wikström, S. & Bornehag, C.-G. (2024). EDC mixtures during pregnancy and body fat at 7 years of age in a Swedish cohort, the SELMA study. Environmental Research
Open this publication in new window or tab >>EDC mixtures during pregnancy and body fat at 7 years of age in a Swedish cohort, the SELMA study
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2024 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Some endocrine disrupting chemicals (EDC), are "obesogens" and have been associated with overweight and obesity in children. Daily exposure to different classes of EDCs demands for research with mixtures approach.

OBJECTIVES: This study evaluates the association, considering sex-specific effects, between prenatal exposure to EDC mixture and children's body fat at seven years of age. METHODS: A total of 26 EDCs were assessed in prenatal urine and serum samples from first trimester in pregnancy from 737 mother-child pairs participating in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. An indicator for children's "overall body fat" was calculated, using principal component analysis (PCA), based on BMI, percent body fat, waist, and skinfolds measured at seven years of age. Weighted quantile sum (WQS) regression was used to assess associations between EDC mixture and children's body fat.

RESULTS: Principal component (PC1) represented 83.6 % of the variance, suitable as indicator for children's "overall body fat", with positive loadings of 0.40-0.42 for each body fat measure. A significant interaction term, WQS*sex, confirmed associations in the opposite direction for boys and girls. Higher prenatal exposure to EDC mixture was borderline significant with more "overall body fat" for boys (Mean β = 0.20; 95 % CI: -0.13, 0.53) and less for girls (Mean β = -0.23; 95 % CI: -0.58, 0.13). Also, higher exposure to EDC mixture was borderline significant with more percent body fat (standardized score) for boys (Mean β = 0.09; 95 % CI: -0.04, 0.21) and less for girls (Mean β = -0.10 (-0.26, 0.05). The chemicals of concern included bisphenols, phthalates, PFAS, PAH, and pesticides with different patterns for boys and girls.

DISCUSSION: Borderline significant associations were found between prenatal exposure to a mixture of EDCs and children's body fat. The associations in opposite directions suggests that prenatal exposure to EDCs may present sex-specific effects on children's body fat.

Place, publisher, year, edition, pages
Elsevier, 2024
Keywords
Body fat, Chemical mixtures, Child, Endocrine disrupting chemicals, Pregnancy
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:oru:diva-111230 (URN)10.1016/j.envres.2024.118293 (DOI)38281561 (PubMedID)
Funder
Swedish Research Council FormasEU, Horizon 2020, 634880Landstinget i Värmland
Note

The study was funded by grants from the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (Formas), the EDC-MixRisk European Union's Horizon 2020 Research and Innovation Programme (634880), and the County Council of Värmland. C.G. were supported by Powering Research Through Innovative Methods for Mixtures in Epidemiology (PRIME) Program (R01ES028811-01).

Available from: 2024-02-01 Created: 2024-02-01 Last updated: 2024-02-01Bibliographically approved
Svensson, K., Gennings, C., Lindh, C., Kiviranta, H., Rantakokko, P., Wikström, S. & Bornehag, C.-G. (2023). Prenatal exposures to mixtures of endocrine disrupting chemicals and sex-specific associations with children's BMI and overweight at 5.5 years of age in the SELMA study. Environment International, 179, Article ID 108176.
Open this publication in new window or tab >>Prenatal exposures to mixtures of endocrine disrupting chemicals and sex-specific associations with children's BMI and overweight at 5.5 years of age in the SELMA study
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2023 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 179, article id 108176Article in journal (Refereed) Published
Abstract [en]

Background: Prenatal exposure to mixtures of endocrine disrupting chemicals (EDC) has the potential to disrupt human metabolism. Prenatal periods are especially sensitive as many developmental processes are regulated by hormones. Prenatal exposure to EDCs has inconsistently been associated with children's body mass index (BMI) and obesity. The objective of this study was to investigate if prenatal exposure to a mixture of EDCs was associated with children's BMI and overweight (ISO-BMI ≥ 25) at 5.5 years of age, and if there were sex-specific effects.

Methods: A total of 1,105 mother-child pairs with complete data on prenatal EDCs concentrations (e.g., phthalates, non-phthalate plasticizers, phenols, PAH, pesticides, PFAS, organochlorine pesticides, and PCBs), children's measured height and weight, and selected covariates in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study were included in this analysis. The mixture effect of EDCs with children's BMI and overweight was assessed using WQS regression with 100 repeated holdouts. A positively associated WQS index with higher BMI and odds of overweight was derived. Models with interaction term and stratified weights by sex was applied in order to evaluate sex-specific associations.

Results: A significant WQS*sex interaction term was identified and associations for boys and girls were in opposite directions. Higher prenatal exposure to a mixture of EDCs was associated with lower BMI (Mean β = -0.19, 95%CI: -0.40, 0.01) and lower odds of overweight (Mean OR = 0.72, 95%CI: 0.48, 1.04) among girls with borderline significance. However, the association among boys did not reach statistical significance. Among girls, the possible chemicals of concern were MEP, 2-OHPH, BPF, BPS, DPP and PFNA.

Conclusion: Prenatal exposure to a mixture of EDCs was associated with lower BMI and overweight among girls, and non-significant associations among boys. Chemicals of concern for girls included phthalates, non-phthalate plasticizers, bisphenols, PAHs, and PFAS.

Place, publisher, year, edition, pages
Elsevier, 2023
Keywords
BMI, Child, EDC, Endocrine disrupting chemicals, Overweight, Pregnancy
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:oru:diva-108119 (URN)10.1016/j.envint.2023.108176 (DOI)001078491500001 ()37672941 (PubMedID)2-s2.0-85169918152 (Scopus ID)
Funder
Swedish Research Council FormasEU, Horizon 2020, 634880Region Värmland
Note

The study was funded by grants from the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (Formas), the EDC-MixRisk European Union’s Horizon 2020 Research and Innovation Programme (634880), and the County Council of Värmland. C.G. were supported by Powering Research Through Innovative Methods for Mixtures in Epidemiology (PRIME) Program (R01ES028811-01).

Available from: 2023-09-07 Created: 2023-09-07 Last updated: 2023-10-20Bibliographically approved
Bejerot, S., Eklund, D., Hesser, H., Hietala, M. A., Kariis, T., Lange, N., . . . Humble, M. B. (2023). Study protocol for a randomized controlled trial with rituximab for psychotic disorder in adults (RCT-Rits). BMC Psychiatry, 23(1), Article ID 771.
Open this publication in new window or tab >>Study protocol for a randomized controlled trial with rituximab for psychotic disorder in adults (RCT-Rits)
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2023 (English)In: BMC Psychiatry, E-ISSN 1471-244X, Vol. 23, no 1, article id 771Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The role of inflammation in the aetiology of schizophrenia has gained wide attention and research on the association shows an exponential growth in the last 15 years. Autoimmune diseases and severe infections are risk factors for the later development of schizophrenia, elevated inflammatory markers in childhood or adolescence are associated with a greater risk of schizophrenia in adulthood, individuals with schizophrenia have increased levels of pro-inflammatory cytokines compared to healthy controls, and autoimmune diseases are overrepresented in schizophrenia. However, treatments with anti-inflammatory agents are so far of doubtful clinical relevance. The primary objective of this study is to test whether the monoclonal antibody rituximab, directed against the B-cell antigen CD20 ameliorates psychotic symptoms in adults with schizophrenia or schizoaffective disorder and to examine potential mechanisms. A secondary objective is to examine characteristics of inflammation-associated psychosis and to identify pre-treatment biochemical characteristics of rituximab responders. A third objective is to interview a subset of patients and informants on their experiences of the trial to obtain insights that rating scales may not capture.

METHODS: A proof-of-concept study employing a randomised, parallel-group, double-blind, placebo-controlled design testing the effect of B-cell depletion in patients with psychosis. 120 participants with a diagnosis of schizophrenia spectrum disorders (SSD) (ICD-10 codes F20, F25) will receive either one intravenous infusion of rituximab (1000 mg) or saline. Psychiatric measures and blood samples will be collected at baseline, week 12, and week 24 post-infusion. Brief assessments will also be made in weeks 2 and 7. Neuroimaging and lumbar puncture, both optional, will be performed at baseline and endpoints. Approximately 40 of the patients and their informants will be interviewed for qualitative analyses on the perceived changes in well-being and emotional qualities, in addition to their views on the research.

DISCUSSION: This is the first RCT investigating add-on treatment with rituximab in unselected SSD patients. If the treatment is helpful, it may transform the treatment of patients with psychotic disorders. It may also heighten the awareness of immune-psychiatric disorders and reduce stigma.

TRIAL REGISTRATION: NCT05622201, EudraCT-nr 2022-000220-37 version 2.1. registered 14th of October 2022.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2023
Keywords
Clinical trials, Immunology, Inflammation, Magnetic resonance imaging, Monoclonal antibodies, Schizophrenia & psychotic disorders
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-109377 (URN)10.1186/s12888-023-05250-5 (DOI)001095789000002 ()37872497 (PubMedID)2-s2.0-85174826025 (Scopus ID)
Funder
Örebro UniversitySwedish Research Council, 2022-00288The Swedish Brain Foundation, FO2022-0073Torsten Söderbergs stiftelse, MT4/22
Available from: 2023-10-24 Created: 2023-10-24 Last updated: 2024-01-17Bibliographically approved
Jägetoft, Z., Unenge Hallerbäck, M., Julin, M., Bornehag, C.-G. & Wikström, S. (2022). Anthropometric measures do not explain the 2D: 4D ratio sexual dimorphism in 7-year-old children. American Journal of Human Biology, 34(9), Article ID e23776.
Open this publication in new window or tab >>Anthropometric measures do not explain the 2D: 4D ratio sexual dimorphism in 7-year-old children
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2022 (English)In: American Journal of Human Biology, ISSN 1042-0533, E-ISSN 1520-6300, Vol. 34, no 9, article id e23776Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Digit ratio (2D:4D) might reflect prenatal testosterone exposure and has been used as a putative marker for androgen related outcomes. However, such associations might be inflicted by confounders. Application of 2D:4D in epidemiological research motivate identification of biological background determinants. We examined sex, anthropometric measures, and maternal factors as determinants of 2D:4D in Swedish 7-year-old children.

METHODS: The study was embedded in the Swedish Environmental, Longitudinal, Mother and Child, Asthma and Allergy (SELMA) pregnancy cohort. A total of 870 pre-pubertal children, median 7.5 years of age, were studied. A single assessor performed digit measurements from scanned photocopies using computer software. Child anthropometric measurements investigated were hand size, birthweight, recumbent birth length, standing height, weight, BMI, body fat percentage, and waist/hip circumference. Maternal factors included age, pregnancy length, parity, and education.

RESULTS: We found a significant sexual dimorphism regarding digit lengths and 2D:4D, boys on average presenting a lower 2D:4D than girls also after adjustment for summed finger lengths and body fatness. In crude analyses, maternal age correlated with 2D:4D across the whole population and in females but not in adjusted models. No other study variables were associated with 2D:4D.

CONCLUSION: Digit ratio showed sexual dimorphism at the age of seven and seems to represent a true sex difference rather than an artifact and bias from hand size, body size or body fat content. Among the rest of our investigated variables, we found no determinants constituting important confounders in future research on 2D:4D ratio.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022
National Category
Pediatrics Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:oru:diva-99783 (URN)10.1002/ajhb.23776 (DOI)000815600300001 ()35751545 (PubMedID)2-s2.0-85132575699 (Scopus ID)
Funder
Region Örebro CountySwedish Research Council FormasRegion Värmland
Available from: 2022-06-28 Created: 2022-06-28 Last updated: 2022-09-29Bibliographically approved
Vihlborg, P., Pettersson, H., Makdoumi, K., Wikström, S., Bryngelsson, I.-L., Selander, J. & Graff, P. (2022). Carpal Tunnel Syndrome and Hand-Arm Vibration: A Swedish National Registry Case-Control Study. Journal of Occupational and Environmental Medicine, 64(3), 197-201
Open this publication in new window or tab >>Carpal Tunnel Syndrome and Hand-Arm Vibration: A Swedish National Registry Case-Control Study
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2022 (English)In: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 64, no 3, p. 197-201Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate the increased risk for carpal tunnel syndrome (CTS) in men and women with hand-arm vibration (HAV) exposure.

DESIGN: Case-control study of CTS where 4396 cases was obtained from National Outpatient Register between 2005 through 2016. Cases were matched to controls and exposure was estimated using a job exposure matrix.

RESULTS: Exposure to HAV increased the risk of CTS with an OR of 1.61 (95% CI 1.46-1.77). The risk was highest in men <30 years of age and among women <30 years no increased risk was observed. The risk increased with a mean year exposure above 2.5 m/s2 to OR 1.84 (95% CI 1.38-2.46).

CONCLUSIONS: HAV exposure increase the risk of CTS in both genders, with highest risk increase in younger men. This emphasize identification of HAV exposure in patients with CTS.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2022
Keywords
carpal tunnel syndrome, case-control study, hand-arm vibration, occupational exposure
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:oru:diva-95868 (URN)10.1097/JOM.0000000000002451 (DOI)000764238200018 ()34873137 (PubMedID)2-s2.0-85125682911 (Scopus ID)
Available from: 2021-12-10 Created: 2021-12-10 Last updated: 2024-01-02Bibliographically approved
Savvidou, A., Jennions, E., Wikström, S., Olsson-Engman, M., Sofou, K. & Darin, N. (2022). Drug-induced hyperthermia with rhabdomyolysis in CLN3 disease. European journal of paediatric neurology, 39, 74-78
Open this publication in new window or tab >>Drug-induced hyperthermia with rhabdomyolysis in CLN3 disease
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2022 (English)In: European journal of paediatric neurology, ISSN 1090-3798, E-ISSN 1532-2130, Vol. 39, p. 74-78Article in journal (Refereed) Published
Abstract [en]

CLN3 disease (MIM# 204200), the most prevalent of the neuronal ceroid lipofuscinoses (NCL), is an autosomal recessive disorder with juvenile onset characterized by blindness, epilepsy, dementia, psychiatric manifestations, and motor deterioration. Problems related to behavior, emotions and thought are among the main features. Antidepressant and antipsychotic drugs have been employed with variable results. Neuroleptic malignant syndrome (NMS) has previously been described in two patients with NCL, one with CLN3 disease and one with adult onset NCL of unclear genetic origin. Our aims were to describe the occurrence of drug-induced hyperthermia in pediatric patients with CLN3 disease from West and South Sweden and to delineate the range of associated clinical features. Our study identified four patients presenting with seven episodes of severe drug-induced hyperthermia and either NMS-like or Serotonin syndrome (SS)-like features. Possibly provoking drugs were risperidone, clozapine, olanzapine, haloperidol, quetiapine, and sertraline. The course was atypical, frequently prolonged, associated with rhabdomyolysis and status dystonicus, and resulted in the death of three of the patients. Our study points to a vulnerability to drug-induced hyperthermia in patients with CLN3 disease which we believe could be underreported. Interestingly the proposed pathophysiological mechanisms behind NMS and SS on one hand and CLN3 on the other hand seem to converge in a common mechanism involving dysregulation of the sympathetic nervous system.

Place, publisher, year, edition, pages
Elsevier, 2022
Keywords
CLN3, Juvenile neuronal ceroid lipofuscinosis, Neuroleptic malignant syndrome, Rhabdomyolysis, Serotonin syndrome
National Category
Neurology
Identifiers
urn:nbn:se:oru:diva-99645 (URN)10.1016/j.ejpn.2022.06.007 (DOI)000813006200003 ()35716526 (PubMedID)2-s2.0-85132515985 (Scopus ID)
Note

Funding agency:

Queen Silvia Children's Hospital Research Foundation ALFGBG-718681

Available from: 2022-06-20 Created: 2022-06-20 Last updated: 2022-08-18Bibliographically approved
Delvert, J., Wikström, S., Bornehag, C.-G. & Wadensjö, H. V. (2022). Struggling to Enable Physical Activity for Children with Disabilities: A Narrative Model of Parental Roles. Scandinavian Journal of Disability Research, 24(1), 196-209
Open this publication in new window or tab >>Struggling to Enable Physical Activity for Children with Disabilities: A Narrative Model of Parental Roles
2022 (English)In: Scandinavian Journal of Disability Research, ISSN 1501-7419, E-ISSN 1745-3011, Vol. 24, no 1, p. 196-209Article in journal (Refereed) Published
Abstract [en]

This article presents a narrative model based on in-depth interviews with parents of children 6-12 years old with a variety of disabilities. It is a grounded theory study aiming to explore the parents' experiences of enabling health-promoting physical activity (PA) for their children. The core of the generated theory struggling between roles to facilitate PA describes how the parents, in different contexts and over time, are forced to take on roles as experts, coaches, minesweepers, and activists to facilitate adapted PA for their children. How tiresome this struggle became depended on contextual factors, the extent of effort put into the separate roles, and the interaction between them. The study revealed a complex picture unique for each family but at the same time suitable despite the character of the child's disability. This study adds knowledge to better support parents enabling PA on equal terms for all children.

Place, publisher, year, edition, pages
Stockholm University Press, 2022
Keywords
Child, Disability, Parenting, Physical Activity, Health Promotion, Grounded Theory
National Category
Pediatrics Occupational Health and Environmental Health
Identifiers
urn:nbn:se:oru:diva-100469 (URN)10.16993/sjdr.839 (DOI)000818479500001 ()2-s2.0-85133330020 (Scopus ID)
Funder
Karlstad University
Note

Funding agency:

County of Värmland

Available from: 2022-08-18 Created: 2022-08-18 Last updated: 2022-08-18Bibliographically approved
Vihlborg, P., Makdomi, K., Gavlovská, H., Wikström, S. & Graff, P. (2021). Arterial abnormalities in the hands of workers with vibration white fingers: a magnetic resonance angiography case series. Journal of Occupational Medicine and Toxicology, 16(1), Article ID 27.
Open this publication in new window or tab >>Arterial abnormalities in the hands of workers with vibration white fingers: a magnetic resonance angiography case series
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2021 (English)In: Journal of Occupational Medicine and Toxicology, ISSN 1745-6673, E-ISSN 1745-6673, Vol. 16, no 1, article id 27Article in journal (Refereed) Published
Abstract [en]

Vibration white finger (VWF) is a complication from exposure to hand-arm vibrations. Poor knowledge of the pathophysiology of VWF means that making an accurate prognosis is difficult. Thus, a better understanding of VWF's pathophysiology is of importance.The purpose of this study was to investigate whether there were arterial abnormalities in the hands in patients with VWF and a positive Allen's test, using ultrasound and MRA imaging.This was a case series where arterial abnormalities in the hands were investigated in ten participants with VWF and using prolonged Allen's test (> 5 s). The participants had an average vibration exposure of 22 years and underwent Doppler ultrasound and Magnetic Resonance Angiography (MRA) to check for arterial abnormalities.The participants had VWF classified as 1-3 on the Stockholm workshop scale. Ultrasound and MRA identified vascular abnormalities in all participants, the predominant finding was missing or incomplete superficial arch. Also, stenosis was identified in four participants.This study reveals a high proportion of arterial stenosis and abnormalities in patients with VWF and a prolonged Allen's test.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2021
Keywords
Hand-arm vibration, Raynaud’s syndrome, Vascular abnormalities, Vibration white finger
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:oru:diva-93526 (URN)10.1186/s12995-021-00323-1 (DOI)000679428800002 ()34325708 (PubMedID)2-s2.0-85111565530 (Scopus ID)
Note

Funding Agencies:

Region Örebro County OLL-675781

Örebro University

Correction to: Arterial abnormalities in the hands of workers with vibration white fingers - a magnetic resonance angiography case series. Vihlborg, P., Makdoumi, K., Gavlovská, H. et al.  J Occup Med Toxicol 16, 30 (2021). DOI:10.1186/s12995-021-00323-1. WOS:000684206800001. Scopus:2-s2.0-85112259493

Available from: 2021-08-10 Created: 2021-08-10 Last updated: 2024-01-02Bibliographically approved
Wikström, S., Hussein, G., Lingroth Karlsson, A., Lindh, C. H. & Bornehag, C.-G. (2021). Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage. Scientific Reports, 11(1), Article ID 3568.
Open this publication in new window or tab >>Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
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2021 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 11, no 1, article id 3568Article in journal (Refereed) Published
Abstract [en]

Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester miscarriage were included and 1449 women were available as live birth controls. Eight PFASs were measured in first trimester serum. A doubling of perfluorooctanoic acid (PFOA) exposure, corresponding to an inter-quartile increase, was associated with an odds ratio (95%CI) for miscarriage of 1.48 (1.09-2.01) when adjusting for parity, age and smoking. Analyses per quartiles of PFOA exposure indicated a monotonic dose response association with miscarriage. A similar, but not significant, pattern was observed for perfluorononanoic acid (PFNA). For other PFAS, there were no associations with miscarriage. We have previously shown associations between early pregnancy PFAS exposures and preeclampsia, as well as lower birth weight. Now we report an association between PFOA and miscarriage within the same cohort, which may suggest shared but unknown mechanisms. The study can only represent a period of early placentation and clinical pregnancy loss during the second half of the first trimester.

Place, publisher, year, edition, pages
Nature Publishing Group, 2021
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:oru:diva-89572 (URN)10.1038/s41598-021-82748-6 (DOI)000626725200002 ()33574373 (PubMedID)2-s2.0-85101166708 (Scopus ID)
Funder
Swedish Research Council Formas
Note

Funding Agencies:

Örebro University 

County Council of Värmland  

Available from: 2021-02-15 Created: 2021-02-15 Last updated: 2022-09-15Bibliographically approved
Preece, A.-S., Shu, H., Knutz, M., Krais, A. M., Wikström, S. & Bornehag, C.-G. (2021). Phthalate levels in indoor dust and associations to croup in the SELMA study. Journal of Exposure Science and Environmental Epidemiology, 30, 257-265
Open this publication in new window or tab >>Phthalate levels in indoor dust and associations to croup in the SELMA study
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2021 (English)In: Journal of Exposure Science and Environmental Epidemiology, ISSN 1559-0631, E-ISSN 1559-064X, Vol. 30, p. 257-265Article in journal (Refereed) Published
Abstract [en]

Phthalates are ubiquitous indoor pollutants which have been associated with child airway disease although results are inconclusive. This study examined associations between phthalate levels in residential indoor dust and croup during infancy. Settled indoor dust was collected in 482 homes of 6-month-old infants in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study and analysed for seven phthalates and one phthalate replacement using gas chromatography tandem mass spectrometry. The incidence of parental reported croup at 12 months was 6.4% for girls and 13.4% for boys. Associations between phthalate dust levels and croup were analysed by logistic regression adjusted for potential confounders. We found significant associations between di-ethyl phthalate (DEP) and di-ethyl-hexyl phthalate (DEHP) in residential dust and parental reported croup (adjusted odds ratio (aOR) = 1.71; 95% CI: 1.08-2.73 and 2.07; 1.00-4.30, respectively). Stratified results for boys showed significant associations between DEP and butyl-benzyl phthalate (BBzP) in dust and infant croup (aOR = 1.86; 95% CI: 1.04-3.34 and 2.02; 1.04-3.90, respectively). Results for girls had questionable statistical power due to few cases. Our results suggest that exposure to phthalates in dust is a risk factor for airway inflammatory responses in infant children.

Place, publisher, year, edition, pages
Nature Publishing Group, 2021
Keywords
Croup, Dust, Exposure, Phthalate, SELMA study
National Category
Pediatrics Occupational Health and Environmental Health
Identifiers
urn:nbn:se:oru:diva-85872 (URN)10.1038/s41370-020-00264-7 (DOI)000571372200002 ()32952153 (PubMedID)2-s2.0-85091157156 (Scopus ID)
Funder
Swedish Research Council FormasVårdal FoundationSwedish Asthma and Allergy Association
Note

Funding Agency:

County Council of Värmland

Available from: 2020-09-25 Created: 2020-09-25 Last updated: 2021-03-25Bibliographically approved
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