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Brus, Ole
Publications (10 of 21) Show all publications
Sönnerqvist, C., Brus, O. & Olivecrona, M. (2020). Validation of the scandinavian guidelines for initial management of minor and moderate head trauma in children. European Journal of Trauma and Emergency Surgery
Open this publication in new window or tab >>Validation of the scandinavian guidelines for initial management of minor and moderate head trauma in children
2020 (English)In: European Journal of Trauma and Emergency Surgery, ISSN 1863-9933, E-ISSN 1863-9941Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Head trauma in children is common, with a low rate of clinically important traumatic brain injury. CT scan is the reference standard for diagnosis of traumatic brain injury, of which the increasing use is alarming because of the risk of induction of lethal malignancies. Recently, the Scandinavian Neurotrauma Committee derived new guidelines for the initial management of minor and moderate head trauma. Our aim was to validate these guidelines.

METHODS: We applied the guidelines to a population consisting of children with mild and moderate head trauma, enrolled in the study: "Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study" by Kuppermann et al. (Lancet 374(9696):1160-1170, https://doi.org/10.1016/S0140-6736(09)61558-0, 2009). We calculated the negative predictive values of the guidelines to assess their ability to distinguish children without clinically-important traumatic brain injuries and traumatic brain injuries on CT scans, for whom CT could be omitted.

RESULTS: We analysed a population of 43,025 children. For clinically-important brain injuries among children with minimal head injuries, the negative predictive value was 99.8% and the rate was 0.15%. For traumatic findings on CT, the negative predictive value was 96.9%. Traumatic finding on CT was detected in 3.1% of children with minimal head injuries who underwent a CT examination, which accounts for 0.45% of all children in this group.

CONCLUSION: Children with minimal head injuries can be safely discharged with oral and written instructions. Use of the SNC-G will potentially reduce the use of CT.

Place, publisher, year, edition, pages
Urban und Vogel Medien und Medizin Verlagsgesellsc, 2020
Keywords
CT, Children, Guidelines, Traumatic brain injury, Validation
National Category
Pediatrics
Identifiers
urn:nbn:se:oru:diva-78969 (URN)10.1007/s00068-019-01288-x (DOI)31907552 (PubMedID)
Available from: 2020-01-14 Created: 2020-01-14 Last updated: 2020-01-14Bibliographically approved
Popiolek, K., Bejerot, S., Brus, O., Hammar, Å., Landén, M., Lundberg, J., . . . Nordenskjöld, A. (2019). Electroconvulsive therapy in bipolar depression: effectiveness and prognostic factors. Acta Psychiatrica Scandinavica, 140(3), 196-204
Open this publication in new window or tab >>Electroconvulsive therapy in bipolar depression: effectiveness and prognostic factors
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2019 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 140, no 3, p. 196-204Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Electroconvulsive therapy (ECT) is used in patients with severe forms of bipolar depression. ECT is effective but not all patients respond. The aim of this study was to determine prognostic factors for response to ECT in patients hospitalized for bipolar depression.

METHODS: Data were obtained from several national Swedish registers. All patients with bipolar depression treated with ECT in any hospital in Sweden between 2011 and 2016 for whom information about ECT response was available were included (n = 1251). Response was defined as a score on the Clinical Global Impression - Improvement scale of one or two. Univariate and multivariate logistic regression were conducted to investigate associations between socio-demographic and clinical factors and response.

RESULTS: Response was achieved in 80.2% patients. Older age was associated with higher response rate to ECT. Patients with comorbid obsessive-compulsive disorder or personality disorder, and patients previously treated with lamotrigine had lower response rate.

CONCLUSION: ECT for bipolar depression was associated with very high response rates. The strongest prognostic factors were higher age, absence of comorbid obsessive-compulsive disorder or personality disorder, and less prior pharmacologic treatment.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2019
Keywords
Bipolar disorders, bipolar depression, electroconvulsive therapy, prognosis
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-75577 (URN)10.1111/acps.13075 (DOI)000480263900003 ()31334829 (PubMedID)2-s2.0-85070454601 (Scopus ID)
Available from: 2019-08-09 Created: 2019-08-09 Last updated: 2019-11-15Bibliographically approved
Brus, O., Cao, Y., Hammar, Å., Landén, M., Lundberg, J., Nordanskog, P. & Nordenskjöld, A. (2019). Lithium for suicide and readmission prevention after electroconvulsive therapy for unipolar depression: population-based register study. BJPsych Open, 5(3), Article ID e46.
Open this publication in new window or tab >>Lithium for suicide and readmission prevention after electroconvulsive therapy for unipolar depression: population-based register study
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2019 (English)In: BJPsych Open, E-ISSN 2056-4724, Vol. 5, no 3, article id e46Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Electroconvulsive therapy (ECT) is effective for unipolar depression but relapse and suicide are significant challenges. Lithium could potentially lower these risks, but is used only in a minority of patients.AimsThis study quantifies the effect of lithium on risk of suicide and readmission and identifies factors that are associate with readmission and suicide.

METHOD: This population-based register study used data from the Swedish National Quality Register for ECT and other Swedish national registers. Patients who have received ECT for unipolar depression as in-patients between 2011 and 2016 were followed until death, readmission to hospital or the termination of the study at the end of 2016. Cox regression was used to estimate hazard ratios (HR) of readmission and suicide in adjusted models.

RESULTS: Out of 7350 patients, 56 died by suicide and 4203 were readmitted. Lithium was prescribed to 638 (9%) patients. Mean follow-up was 1.4 years. Lithium was significantly associated with lower risk of suicide (P = 0.014) and readmission (HR 0.84 95% CI 0.75-0.93). The number needed to be treated with lithium to prevent one readmission was 16. In addition, the following factors were statistically associated with suicide: male gender, being a widow, substance use disorder and a history of suicide attempts. Readmission was associated with young age, being divorced or unemployed, comorbid anxiety disorder, nonpsychotic depression, more severe symptoms before ECT, no improvement with ECT, not receiving continuation ECT or antidepressants, usage of antipsychotics, anxiolytics or benzodiazepines, severity of medication resistance and number of previous admissions.

CONCLUSIONS: More patients could benefit from lithium treatment.

Place, publisher, year, edition, pages
Royal College of Psychiatrists, 2019
Keywords
Depressive disorders, antidepressants, electroconvulsive therapy, inpatient treatment, lithium, suicide
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-75090 (URN)10.1192/bjo.2019.37 (DOI)000514364500014 ()31189487 (PubMedID)
Available from: 2019-07-11 Created: 2019-07-11 Last updated: 2020-03-17Bibliographically approved
Rönnqvist, I., Brus, O., Hammar, Å., Landén, M., Lundberg, J., Nordanskog, P. & Nordenskjöld, A. (2019). Rehospitalization of Postpartum Depression and Psychosis After Electroconvulsive Therapy: A Population-Based Study With a Matched Control Group. Journal of ECT, 35(4), 264-271
Open this publication in new window or tab >>Rehospitalization of Postpartum Depression and Psychosis After Electroconvulsive Therapy: A Population-Based Study With a Matched Control Group
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2019 (English)In: Journal of ECT, ISSN 1095-0680, E-ISSN 1533-4112, Vol. 35, no 4, p. 264-271Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Electroconvulsive therapy (ECT) is used in some cases of postpartum depression (PPD) and postpartum psychosis (PPP). The risk of relapse for PPD and PPP after ECT is unknown. This study compared the relapse rate after ECT between women who had been treated for PPD and/or PPP and women who had been treated for depression and/or psychosis outside the postpartum period.

METHODS: The Swedish National Quality Register for ECT and the Swedish National Patient Register were used to identify women with PPD and/or PPP who had been treated with ECT within 6 months after delivery. For each case, a control (treated with ECT but not postpartum) patient was also selected. A Kaplan-Meier estimator was used to calculate the relapse rate (defined as rehospitalization or suicide) after ECT. Cox regression was used to identify variables associated with relapse.

RESULTS: A total of 180 patients were included in each group. The proportions of patients who suffered relapse after 6 months, 1 year, and 2 years were 28%, 31%, and 40% for the postpartum group and 39%, 50%, and 55% for the nonpostpartum group. Treatment with benzodiazepines, several previous psychiatric admissions, and the absence of improvement after ECT were associated with relapse.

CONCLUSIONS: The risk of relapse after ECT is lower for patients with PPD and/or PPP than for patients outside the postpartum period, but the risk is nonetheless substantial in both groups.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019
Keywords
Postpartum disorders, postpartum depression, postpartum psychosis, electroconvulsive therapy, relapse
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-75089 (URN)10.1097/YCT.0000000000000578 (DOI)000501820500015 ()30807499 (PubMedID)2-s2.0-85075540293 (Scopus ID)
Note

Funding Agency:

Region Örebro County

Available from: 2019-07-11 Created: 2019-07-11 Last updated: 2020-01-14Bibliographically approved
Rundgren, S., Brus, O., Båve, U., Landén, M., Lundberg, J., Nordanskog, P. & Nordenskjöld, A. (2018). Improvement of postpartum depression and psychosis after electroconvulsive therapy: A population-based study with a matched comparison group. Journal of Affective Disorders, 235, 258-264
Open this publication in new window or tab >>Improvement of postpartum depression and psychosis after electroconvulsive therapy: A population-based study with a matched comparison group
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2018 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 235, p. 258-264Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Electroconvulsive therapy (ECT) is used to treat postpartum depression and psychosis based on clinical experience and small observational studies.

AIMS: The primary aim was to test the hypothesis that the response rate to ECT for depression and psychosis is higher during the postpartum period than outside this period. The secondary aim was to identify predictors of a response to ECT during the postpartum period.

MATERIALS AND METHODS: Cases with postpartum depression and/or psychosis received ECT within 6 months of delivery. A matched comparison group with depression and/or psychosis (not within the postpartum period) was identified from the Swedish National Quality Register for ECT. The improvement 1 week after ECT was classified according to the Clinical Global Impressions Scale - Improvement scale (CGI-I) as responder (CGI-I score 1-2) or non-responder (CGI-I score 3-7).

RESULTS: 185 cases and 185 comparison group subjects were included (46% with psychosis in each groups). More cases (87.0%) than comparison group subjects (73.5%) responded to ECT (p = 0.001). Adjusted binary regression analysis revealed that more severe symptoms prior to treatment were the only statistically significant predictor of response.

LIMITATIONS: There was no control group without ECT treatment.

CONCLUSION: The response rate of those with postpartum depression and/or psychosis to ECT was high. The response rate of patients with psychosis or depression was higher during the postpartum period than outside it. This study supports the use of ECT for severe forms of postpartum depression and/or psychosis.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Puerperal disorders, Postpartum depression, Postpartum psychosis, Electroconvulsive therapy treatment outcome
National Category
Psychiatry Neurology
Identifiers
urn:nbn:se:oru:diva-66965 (URN)10.1016/j.jad.2018.04.043 (DOI)000432686900040 ()29660641 (PubMedID)2-s2.0-85045276002 (Scopus ID)
Note

Funding Agency:

Region Örebro County

Available from: 2018-05-17 Created: 2018-05-17 Last updated: 2018-09-18Bibliographically approved
Eriksson, C., Henriksson, I., Brus, O., Zhulina, Y., Nyhlin, N., Tysk, C., . . . Halfvarson, J. (2018). Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease: a population-based cohort study. Alimentary Pharmacology and Therapeutics, 48(6), 638-645
Open this publication in new window or tab >>Incidence, prevalence and clinical outcome of anaemia in inflammatory bowel disease: a population-based cohort study
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2018 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 48, no 6, p. 638-645Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The incidence and short-term outcome of anaemia in inflammatory bowel disease (IBD) are largely unknown.

AIM: To determine the incidence, prevalence and clinical outcome of anaemia in terms of resolution of anaemia within 12 months. We also planned to assess risk factors for anaemia in IBD.

METHODS: A random sample of 342 patients was obtained from the population-based IBD cohort of Örebro University Hospital, Sweden, consisting of 1405 patients diagnosed between 1963 and 2010. Haemoglobin measurements recorded from 1 January 2011 to 31 December 2013 were extracted from the Clinical Chemistry data system.

RESULTS: In Crohn's disease, the incidence rate of anaemia was 19.3 (95% CI: 15.4-23.7) per 100 person-years and the prevalence was 28.7% (CI: 22.0-36.2), compared with 12.9 (CI: 9.8-16.5) and 16.5% (CI: 11.2-22.9) for ulcerative colitis. Crohn's disease was associated with an increased incidence (OR = 1.60; CI: 1.02-2.51) and prevalence of anaemia (OR = 2.04; CI: 1.20-3.46) compared to ulcerative colitis. Stricturing disease phenotype in Crohn's disease (HR = 2.59; CI: 1.00-6.79) and extensive disease in ulcerative colitis (HR = 2.40; CI: 1.10-5.36) were associated with an increased risk of anaemia. Despite a higher probability of receiving specific therapy within 3 months from the diagnosis of anaemia, Crohn's disease patients had a worse outcome in terms of resolution of anaemia within 12 months (56% vs 75%; P = 0.03).

CONCLUSIONS: Anaemia is a common manifestation of IBD even beyond the first years after the diagnosis of IBD. Crohn's disease is associated with both an increased risk and a worse outcome.

Place, publisher, year, edition, pages
Blackwell Science Ltd., 2018
National Category
Gastroenterology and Hepatology General Practice
Identifiers
urn:nbn:se:oru:diva-68681 (URN)10.1111/apt.14920 (DOI)000442338900006 ()30069892 (PubMedID)2-s2.0-85051863489 (Scopus ID)
Note

Funding agency:

Swedish government's Agreement on Medical Training and Research

Available from: 2018-09-03 Created: 2018-09-03 Last updated: 2018-09-06Bibliographically approved
Popiolek, K., Brus, O., Elvin, T., Landen, M., Lundberg, J., Nordanskog, P. & Nordenskjöld, A. (2018). Rehospitalization and suicide following electroconvulsive therapy for bipolar depression: A population-based register study. Journal of Affective Disorders, 226, 146-154
Open this publication in new window or tab >>Rehospitalization and suicide following electroconvulsive therapy for bipolar depression: A population-based register study
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2018 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 226, p. 146-154Article in journal (Refereed) Published
Abstract [en]

Background: Electroconvulsive therapy (ECT) is effective in bipolar depression, but relapse is common. The aim of the study was (i) to identify prognostic factors (ii) and to determine the impact of pharmacological approaches on the risk for rehospitalization or suicide.

Methods: This register study analyzed data from individuals treated with inpatient ECT for bipolar depression. Subjects were identified using the Swedish National Patient Register between 2011 and 2014 and the Swedish National Quality Register for ECT. Other national registers provided data on psychopharmacotherapy, socio-demographic factors, and causes of death. The endpoint was the composite of rehospitalization for any psychiatric disorder, suicide attempt or completed suicide (RoS). Cox regression was used to calculate hazard ratios in univariate and multivariate models.

Results: Data from 1255 patients were analyzed. The mean period of follow-up was 346 days.

A total of 29%, 41%, and 52% of patients reached RoS at 3, 6, and 12 months post-discharge. A history of multiple psychiatric admissions, lower age, and post-discharge treatment with antipsychotics or benzodiazepines was associated with RoS.

Limitations: Indication bias may have affected the results.

Conclusions: A history of multiple hospital admissions and lower age are key predictors of the composite of rehospitalization or suicide in patients treated with ECT for bipolar depression. Lithium might be effective. By contrast, antipsychotics and benzodiazepines were associated with increased risk, but possibly this finding was influenced by indication bias.

Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Neurology Psychiatry
Identifiers
urn:nbn:se:oru:diva-62810 (URN)10.1016/j.jad.2017.09.030 (DOI)000414329000020 ()28982047 (PubMedID)2-s2.0-85030308357 (Scopus ID)
Note

Funding Agency:

Region Örebro County 

Available from: 2017-11-24 Created: 2017-11-24 Last updated: 2018-08-16Bibliographically approved
Fischer, P., Sagerfors, M., Brus, O. & Pettersson, K. (2018). Revision Arthroplasty of the Wrist in Patients With Rheumatoid Arthritis, Mean Follow-Up 6.6 Years. Journal of Hand Surgery-American Volume, 43(5), 489.e1-489.e7
Open this publication in new window or tab >>Revision Arthroplasty of the Wrist in Patients With Rheumatoid Arthritis, Mean Follow-Up 6.6 Years
2018 (English)In: Journal of Hand Surgery-American Volume, ISSN 0363-5023, E-ISSN 1531-6564, Vol. 43, no 5, p. 489.e1-489.e7Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Management of failed total wrist arthroplasty (TWA) can be challenging; surgical treatment options include salvage arthrodesis, revision arthroplasty, and resection arthroplasty. There are few studies regarding salvage arthrodesis, and revision arthroplasty has been infrequently investigated. The aim of the study was to report the outcome after revision arthroplasty of the wrist.

METHODS: A retrospective cohort of 16 revision TWAs was evaluated between 2003 and 2016. Data were collected before surgery and 1 and 5 years after surgery. The indication for revision arthroplasty was failed TWA. The primary end point was implant survival. Secondary outcome measures included visual analog scale (VAS) pain scores, range of motion, handgrip strength, and functional scoring with the Canadian Occupational Performance Measure (COPM), Patient-Rated Wrist Evaluation (PRWE), and Disabilities of the Arm, Shoulder, and Hand (DASH).

RESULTS: Mean follow-up was 6.6 years. Synthetic bone graft was used in 9 cases, allograft corticocancellous bone graft in 1 case, and cement in 6 cases. Of the 16 revision TWAs, 4 were re-revised, 1 because of infection, and 3 cases underwent total wrist arthrodesis. In the non-re-revised cases, range of motion and grip strength was preserved compared with preoperative results. The VAS pain score in activity improved, but not significantly, at 1 (median, 1; range, 0-4.5) and 5 years after surgery (median, 0) compared with before surgery (median, 5). The COPM performance and satisfaction as well as PRWE scores improved significantly at 1 year (median COPM performance, 4.8; COPM satisfaction, 5.6; and PRWE, 24) and improved, but not significantly, at the 5-year follow (median COPM performance, 4.8; COPM satisfaction, 5.0; and PRWE, 37) in the non-re-revised cases.

CONCLUSIONS: Revision arthroplasty of the wrist is a valid motion-preserving option to wrist arthrodesis in the management of failed TWA. However, the outcome is uncertain and as many as 25% require additional surgery.

TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Total wrist arthroplasty, osteoarthritis, rheumatoid arthritis
National Category
Orthopaedics Surgery
Identifiers
urn:nbn:se:oru:diva-67046 (URN)10.1016/j.jhsa.2017.10.038 (DOI)000432437100018 ()29224946 (PubMedID)2-s2.0-85044505797 (Scopus ID)
Note

Funding Agency:

Örebro County Council Research Committee

Available from: 2018-05-18 Created: 2018-05-18 Last updated: 2019-10-18Bibliographically approved
Sönnerqvist, C., Brus, O. & Olivecrona, M. (2018). Validation of the Scandinavian Guidelines for the Initial Management of Minor and Moderate Head Injury in Children. Paper presented at 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, Canada, August 11-16, 2018. Journal of Neurotrauma, 35(16), A248-A248
Open this publication in new window or tab >>Validation of the Scandinavian Guidelines for the Initial Management of Minor and Moderate Head Injury in Children
2018 (English)In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 35, no 16, p. A248-A248Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Head trauma in children is common, with a low rate of clinically-important traumatic brain injury (ciTBI). CT scan is the reference standard for diagnosis of traumatic brain injury, of which the increasing use is alarming because of the risk of induction of lethal malignancies. Recently, the Scandinavian Neurotrauma Committee (SNC) derived new guidelines for the initial management of minor and moderate head trauma (GCS 9-15) in children. Our aim was to validate the SNC guidelines by assessing the risk of a child being discharged with a ciTBI. A secondary aim was to assess the risk of a child being discharged with a TBI on CT.

Methods: We applied the SNC guidelines to a population consisting of children with mild and moderate head trauma, enrolled in the dataset ‘‘Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study’’ (Kuppermanns et al 2009). We calculated the SNC guidelines negative predictive values to assess their ability to distinguish children without ciTBI and traumatic brain injuries on CT scans, for whom CT would be unnecessary.

Results: We enrolled and analysed 43 025 children (mean age 7.0 years, range 0-17, 62.3% males). The prevalence of ciTBI were statistically significant lower in the group of minimal head injury as compared to the mild low-risk head injury group (p<0.001). The rate of ciTBI in the minimal head injury group was 0,15% and the negative predictive value was 99.8% for ciTBI (minimal vs mild-moderate head injury groups). Traumatic finding on CT was detected in 3.1% of the children in the minimal group who underwent a CT examination, which accounts for 0.45% of all children in the minimal head injury group. The negative predictive value was 96.9% for traumatic finding on CT.

Conclusion: It is safe to discharge children with oral and written instructions and, according to the SNC guidelines, minimal head injury. Use of the SNC guidelines will potentially reduce the use of CT.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2018
Keywords
Concussion / mTBI, Pediatric
National Category
Neurology
Identifiers
urn:nbn:se:oru:diva-68774 (URN)000441527400663 ()
Conference
3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, Canada, August 11-16, 2018
Available from: 2018-09-06 Created: 2018-09-06 Last updated: 2018-10-05Bibliographically approved
Brus, O., Cao, Y., Gustafsson, E., Hultén, M., Landén, M., Lundberg, J., . . . Nordenskjöld, A. (2017). Self-assessed remission rates after electroconvulsive therapy of depressive disorders. European psychiatry, 45, 154-160, Article ID S0924-9338(17)32917-6.
Open this publication in new window or tab >>Self-assessed remission rates after electroconvulsive therapy of depressive disorders
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2017 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 45, p. 154-160, article id S0924-9338(17)32917-6Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Electroconvulsive therapy (ECT) effectively treats severe depression, but not all patients remit. The aim of the study was to identify clinical factors that associate with ECT-induced remission in a community setting.

METHODS: Depressed patients who underwent ECT in 2011-2014 were identified from the Swedish National Quality Register for ECT. Remission was defined as self-rated Montgomery-Åsberg Depression Rating Scale scores of 0-10 after ECT. Other registers provided data on previous antidepressant use, comorbidities, and demographics.

RESULTS: Of 1671 patients fulfilling the inclusion criteria, 42.8% achieved remission. Older age, education length over 9 years, psychotic symptoms, shorter duration of preceding antidepressant use, pulse width stimulus≥0.50ms, absence of substance use disorders, anxiety diagnosis, lamotrigine, and benzodiazepines, were associated with remission.

CONCLUSIONS: This study shows that psychotic subtype of depression and older age are clinically relevant predictors of a beneficial ECT effect. Additionally, ECT outcomes can be further improved by optimizing the treatment technique and concomitant medication.

Place, publisher, year, edition, pages
Elsevier Masson, 2017
Keywords
Mania and bipolar disorder; Unipolar depression; ECT
National Category
Psychiatry
Identifiers
urn:nbn:se:oru:diva-61681 (URN)10.1016/j.eurpsy.2017.06.015 (DOI)000414461300021 ()28865389 (PubMedID)2-s2.0-85028504905 (Scopus ID)
Funder
Swedish Research Council, 523-2013-2982Swedish Foundation for Strategic Research , KF10-0039
Note

Funding Agency:

Region Örebro county

Available from: 2017-11-14 Created: 2017-11-14 Last updated: 2018-08-10Bibliographically approved
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