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Bergens, Oscar
Publications (3 of 3) Show all publications
Bergens, O., Nilsson, A. & Kadi, F. (2019). Cardiorespiratory Fitness Does Not Offset Adiposity-Related Systemic Inflammation in Physically Active Older Women. Journal of Clinical Endocrinology and Metabolism, 104(9), 4119-4126
Open this publication in new window or tab >>Cardiorespiratory Fitness Does Not Offset Adiposity-Related Systemic Inflammation in Physically Active Older Women
2019 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 104, no 9, p. 4119-4126Article in journal (Refereed) Published
Abstract [en]

CONTEXT: Chronic inflammation increases diabetes risk and may be exacerbated by excess adipose tissue. Whether cardiovascular fitness can offset chronic inflammation associated with excess adipose tissue in older adults is unclear.

OBJECTIVE: The study aimed to examine the influence of cardiorespiratory fitness on links between adiposity and pro- and anti-inflammatory biomarkers related to metabolic risk in physically active older women.

DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study comprising older community-dwelling women (n = 109; age, 65-70 yr).

MAIN OUTCOME: Cardiorespiratory fitness was assessed using a standardized submaximal test and participants were categorized into high and low adiposity-related metabolic risk (body mass index, waist-to-hip ratio (WHR) and total fat mass). The inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, IL-18, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein (MIP-1α) were analyzed.

RESULTS: Regardless of adiposity measure, women in the metabolic high-risk group had significantly (P<0.05) elevated CRP and lower adiponectin levels. Levels of IL-6 and MIP1-α were significantly elevated in the high-risk group defined by WHR and total fat mass. IL-18 level was significantly elevated in the high-risk group based on WHR only. Importantly, a high cardiorespiratory fitness level did not attenuate the detrimental links between adiposity measures and inflammation.

CONCLUSIONS: Altogether, cardiorespiratory fitness does not offset the detrimental links between adiposity and several inflammatory biomarkers related to metabolic risk in physically active older women. Reducing abdominal adipose tissue in older adults should be emphasized in efforts aiming to attenuate age-related systemic inflammation and metabolic risk regardless of cardiorespiratory fitness.

Place, publisher, year, edition, pages
Williams & Wilkins Co., 2019
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:oru:diva-74240 (URN)10.1210/jc.2019-00067 (DOI)000484208900057 ()31058998 (PubMedID)
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-09-20Bibliographically approved
Nilsson, A., Bergens, O. & Kadi, F. (2018). Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels. Medicine & Science in Sports & Exercise, 50(7), 1502-1507
Open this publication in new window or tab >>Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels
2018 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 50, no 7, p. 1502-1507Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To examine the influence of reallocating time spent at different objectively measured physical activity (PA) behaviours on markers of systemic inflammation in older women with different levels of metabolic risk.

METHODS: Accelerometer-based monitoring of PA was conducted in a population of community-dwelling older women (n = 111; age = 65-70 yr) for determination of daily sedentary time, time in light (LPA) and moderate-to-vigorous physical activity (MVPA). Blood samples were collected for the assessment of the systemic inflammatory markers CRP, fibrinogen and adiponectin. Metabolic risk was assessed by standardized procedures based on definitions for the metabolic syndrome. Data were analysed by linear regression models based on isotemporal substitution analysis.

RESULTS: Reallocating 30 minutes of sedentary time with either time in LPA (β = -0.47; p<0.05) or MVPA (β = -0.42; p<0.05) was related to reduced fibrinogen level, whereas no corresponding effect was evident when shifting time in LPA with time in MVPA, while holding sedentary time constant. In contrast, reallocating a 30-minute time period in sedentary (β = -0.70; p<0.01) or LPA (β = -0.71; p<0.01) with MVPA was associated with a significant reduction in CRP level, while no impact on CRP was observed when a time period of sedentary behavior was replaced with LPA. Importantly, all significant influences on fibrinogen and CRP by displacement of different PA behaviours remained after adjustment for metabolic risk status among participants. No significant associations with adiponectin were observed.

CONCLUSION: Altogether, this work supports the existence of different intensity thresholds mediating beneficial effects of PA on important clinical markers of systemic inflammation in older women across different stages of disease prevention.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018
Keywords
EXERCISE TRAINING, ELDERLY, ISOTEMPORAL, SEDENTARY BEHAVIOR, METABOLIC RISK, ACUTE PHASE PROTEIN
National Category
Occupational Health and Environmental Health Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-65195 (URN)10.1249/MSS.0000000000001582 (DOI)000435348900020 ()29462102 (PubMedID)2-s2.0-85045633896 (Scopus ID)
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2019-09-20Bibliographically approved
Kadi, F., Nilsson, A., Wåhlin-Larsson, B. & Bergens, O. (2017). Chronic Systemic Inflammation, Physical Activity and Skeletal Muscle in Elderly. Paper presented at Annual Meeting of the American-College-of-Sports-Medicine (ACSM 2017), Denver, CO, USA, May 30 - June 3, 2017. Medicine & Science in Sports & Exercise, 49(5), 234-234
Open this publication in new window or tab >>Chronic Systemic Inflammation, Physical Activity and Skeletal Muscle in Elderly
2017 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 49, no 5, p. 234-234Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

PURPOSE: It t is hypothesized that chronic systemic inflammation is influenced by physical activity level and is involved in the age-related decline in muscle function. The impact of physical activity behaviours on the level of C-reactive protein (CRP) and tumour necrosis factor alpha (TNF-α) in elderly women is investigated. The impact of chronic systemic inflammation on muscle mass and the cellular and molecular mechanisms behind the putative inflammation-mediated action on human muscle cells are explored.

METHODS: Total amount of sedentary time, 30-minute periods of sedentary time and breaks in sedentary behaviour and time spent in moderate-to-vigorous physical activity (MVPA) were assessed using accelerometry in a cohort of 89 elderly women. Serum HsCRP and TNF-α are were measured. The proliferative and metabolic capacity of human muscle cells obtained from vastus lateralis and exposed to CRP are assessed.

RESULTS: No variables of sedentary behaviour were significantly associated with the level of CRP or TNF-α. In contrast, time spent in MVPA was inversely associated with the level of CRP, independently of sedentary behaviour and waist circumference, but not TNF-α. Serum CRP levels were inversely associated to skeletal muscle mass. Elevated serum CRP levels were associated to reduced proliferative rate of human muscle cells and changes in the regulation of the size muscle cells.

CONCLUSIONS: Elevation in the inflammatory status in elderly is influenced by the amount of time spent in MVPA and exerts detrimental effects on skeletal muscle mass.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017
National Category
Geriatrics Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-62913 (URN)10.1249/01.mss.0000517490.55576.6c (DOI)000413842900639 ()
Conference
Annual Meeting of the American-College-of-Sports-Medicine (ACSM 2017), Denver, CO, USA, May 30 - June 3, 2017
Available from: 2017-12-01 Created: 2017-12-01 Last updated: 2019-09-20Bibliographically approved
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