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Title [sv]
Longitudinell kartläggning av kognition i relation till hjärnans volym, funktion och neurokemi
Title [en]
Cognition, brain, and aging (COBRA): A longitudinal multimodal imaging study
Abstract [sv]
Cognitive impairments in aging compromise the well-being of individuals and make independent living difficult. Such impairments come with major individual and societal costs. Hence, developing means of preserving functioning in old age is of great importance. However, current knowledge of the brain mechanisms underlying age-related cognitive decline is insufficient to inform design of effective intervention programs. Few studies have comprehensively integrated age-related brain changes as measured by different in vivo imaging modalities and linked such changes to cognitive decline, and hardly any previous multi-modal imaging studies used a longitudinal design. This is a noteworthy omission as inferences of change from cross-sectional comparisons may significantly deviate from inferences based on actually measured longitudinal change. We will follow a large representative cohort of 63-67 year-old healthy individuals over one decade, and at multiple measurement points assess dopamine availability, structural integrity of white and grey matter, functional brain integrity, cognitive performance, and engagement in relevant life-style activities. Thereby, we will yield crucial and novel information on brain mechanisms of cognitive decline in aging as well as on how life-style choices may induce protective effects on brain functions and related cognitive operations. This information will pave the road for successful design and implementation of intervention and prevention programs.
Principal InvestigatorNyberg, Lars
Coordinating organisation
Umeå University
Funder
Period
2012-01-01 － 2017-12-31
National Category
NeurosciencesRadiology, Nuclear Medicine and Medical ImagingPsychology (excluding Applied Psychology)
Identifiers
DiVA, id: project:1225Project, id: 2012-00648_VR
v. 2.46.0
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