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Physical Activity Alters Inflammation in Older Adults by Different Intensity Levels
Örebro University, School of Health Sciences.ORCID iD: 0000-0003-3793-335X
Örebro University, School of Health Sciences.
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-9831-0896
2018 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 50, no 7, p. 1502-1507Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To examine the influence of reallocating time spent at different objectively measured physical activity (PA) behaviours on markers of systemic inflammation in older women with different levels of metabolic risk.

METHODS: Accelerometer-based monitoring of PA was conducted in a population of community-dwelling older women (n = 111; age = 65-70 yr) for determination of daily sedentary time, time in light (LPA) and moderate-to-vigorous physical activity (MVPA). Blood samples were collected for the assessment of the systemic inflammatory markers CRP, fibrinogen and adiponectin. Metabolic risk was assessed by standardized procedures based on definitions for the metabolic syndrome. Data were analysed by linear regression models based on isotemporal substitution analysis.

RESULTS: Reallocating 30 minutes of sedentary time with either time in LPA (β = -0.47; p<0.05) or MVPA (β = -0.42; p<0.05) was related to reduced fibrinogen level, whereas no corresponding effect was evident when shifting time in LPA with time in MVPA, while holding sedentary time constant. In contrast, reallocating a 30-minute time period in sedentary (β = -0.70; p<0.01) or LPA (β = -0.71; p<0.01) with MVPA was associated with a significant reduction in CRP level, while no impact on CRP was observed when a time period of sedentary behavior was replaced with LPA. Importantly, all significant influences on fibrinogen and CRP by displacement of different PA behaviours remained after adjustment for metabolic risk status among participants. No significant associations with adiponectin were observed.

CONCLUSION: Altogether, this work supports the existence of different intensity thresholds mediating beneficial effects of PA on important clinical markers of systemic inflammation in older women across different stages of disease prevention.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018. Vol. 50, no 7, p. 1502-1507
Keywords [en]
EXERCISE TRAINING, ELDERLY, ISOTEMPORAL, SEDENTARY BEHAVIOR, METABOLIC RISK, ACUTE PHASE PROTEIN
National Category
Occupational Health and Environmental Health Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:oru:diva-65195DOI: 10.1249/MSS.0000000000001582ISI: 000435348900020PubMedID: 29462102Scopus ID: 2-s2.0-85045633896OAI: oai:DiVA.org:oru-65195DiVA, id: diva2:1185274
Note

Funding Agency:

Swedish National Centre for Research  P2012/102  P2014-117  P2015-120

Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2019-09-20Bibliographically approved

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Nilsson, AndreasBergens, OscarKadi, Fawzi

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