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Development of atopic disease and disturbed sleep in childhood and adolescence: a longitudinal population-based study
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden; OsherCenter for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.
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2013 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 43, no 5, p. 552-9Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Both atopic diseases and sleep disturbances have increased during recent decades, especially in children. Sleep is important for many aspects of immune regulation relevant in allergic diseases, and sleep disturbances are common in patients with such diseases. A connection between sleep disturbances and fatigue, and atopic disease is well established. However, the time course and putative causal relationships between these factors are obscure.

OBJECTIVE: We aimed at investigating the developmental relationships between subjectively reported sleep disturbances and symptoms of atopic disease, from childhood to adolescence.

METHODS: This longitudinal study used parent-report questionnaire data on symptoms of atopic disease, and sleep disturbances, from the Twin Study of Child and Adolescent Development (TCHAD). Overall, 1480 twin pairs born in Sweden were approached first when children were 8-9 years old, and again later at 13-14 years old. Response rates were 75% and 72%. Data from the TCHAD questionnaires were linked to the Swedish Medical Birth Register based on personal identification numbers.

RESULTS: Being overtired at age 8 increased the risk [OR; 95% CI (2.59; 1.31-5.11)] to develop rhinitis symptoms at age 13, even when controlling for gender, previous rhinitis, Socio-economic status, birth weight and other sleep disturbances at age 8. Likewise, symptoms of asthma at age 8 was an independent risk factor for being overtired at age 13 [OR; 95% CI (2.64; 1.44-4.84)], controlling for similar confounders.

CONCLUSION & CLINICAL RELEVANCE: The findings from this study are consonant with the proposition that atopic disease and disturbed sleep are more than passively interrelated. Future research needs to delineate whether causal relationships between these problems are at hand and, if so, at what periods in development this applies. These results point to a need for clinicians to investigate sleep difficulties and treat impaired sleep in paediatric patients with atopic disease.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2013. Vol. 43, no 5, p. 552-9
Keywords [en]
Atopic disease, epidemiology, longitudinal, paediatrics, sleep
National Category
Medical and Health Sciences Respiratory Medicine and Allergy Immunology
Identifiers
URN: urn:nbn:se:oru:diva-66284DOI: 10.1111/cea.12087ISI: 000318110400010PubMedID: 23600546Scopus ID: 2-s2.0-84876725701OAI: oai:DiVA.org:oru-66284DiVA, id: diva2:1194435
Funder
Stockholm County CouncilThe Karolinska Institutet's Research FoundationSwedish Research Council, 80748301
Note

Funding Agencies:

Karolinska Institutet Center of Neurodevelopmental Disorders

Stockholm Stress Center 

Strategic Research Program in Epidemiology at Karolinska Institutet 

Available from: 2018-04-03 Created: 2018-04-03 Last updated: 2018-05-29Bibliographically approved

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