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Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease
Lycotec Ltd, Cambridge, UK.
Institute of Cardiology, Saratov, Russia.
Institute of Cardiology, Saratov, Russia.
Institute of Cardiology, Saratov, Russia.
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2018 (English)In: Food Science & Nutrition, E-ISSN 2048-7177, Vol. 6, no 6, p. 1770-1777Article in journal (Refereed) Published
Abstract [en]

Oxidative stress and antioxidant deficiency play a pivotal role in initiation, development, and outcomes of cardiovascular disease. Pharmacokinetic parameters as well as the impact of highly bioavailable lycopene on cardiovascular variables, markers of inflammation and oxidation were investigated during a 30-day clinical trial in patients with coronary vascular disease. The patients were randomized into two major groups and were supplemented with a single 7mg daily dose of lycopene ingested either in the form of lactolycopene (68 patients) or in the form of lycosome-formulated GA lycopene (74 patients). The endpoints included cardiovascular function parameters, serum lipids, and four markers of oxidative stress and inflammation. Ingestion of lycosome-formulated lycopene increased serum lycopene levels by 2.9- and 4.3-fold, respectively, after 2 and 4weeks of the trial, whereas supplementation with lactolycopene upregulated serum lycopene by half-fold only after 4weeks of ingestion. Lycosome formulation of lycopene resulted by the end of the trial in a threefold reduction in Chlamydia pneumoniae IgG and reduction to the same degree of the inflammatory oxidative damage marker. The decrease in oxidized LDL caused by lycosome-formulated lycopene was fivefold. Moreover, supplementation with lycosome-formulated lycopene was accompanied by a significant increase in tissue oxygenation and flow-mediated dilation by the end of the observational period. In contrast, lactolycopene did not cause any significant changes in the parameters studied. Therefore, enhanced bioavailability of lycopene promotes its antioxidant and anti-inflammatory functions and endorses a positive effect of lycopene on cardiovascular system.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 6, no 6, p. 1770-1777
Keywords [en]
cardiovascular disease, formulation, inflammation, lycopene, lycosome
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-69721DOI: 10.1002/fsn3.734ISI: 000446166200049PubMedID: 30258622Scopus ID: 2-s2.0-85052684648OAI: oai:DiVA.org:oru-69721DiVA, id: diva2:1257726
Available from: 2018-10-22 Created: 2018-10-22 Last updated: 2018-10-22Bibliographically approved

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Udumyan, Ruzan

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