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Infectious keratitis treated with corneal crosslinking
Örebro University, School of Health and Medical Sciences.
2010 (English)In: Cornea, ISSN 0277-3740, E-ISSN 1536-4798, Vol. 29, no 12, p. 1353-1358Article in journal (Refereed) Published
Abstract [en]

Purpose: To describe 7 eyes with severe infectious keratitis treated using collagen crosslinking (CXL) with riboflavin. Materials and Methods: Seven eyes of 6 patients with severe infectious keratitis were treated with corneal crosslinking. Three patients were contact lens users. Symptom duration before CXL ranged between 0 and 7 days. Corneal melting was present in all cases. Photodocumentation of the keratitis was carried out and repeated at follow-up. All but 1 patient received topical antibiotic treatment in addition to the CXL treatment. CXL was conducted according to the standardized protocol for keratoconus. Results: In all but 1 eye, patients experienced improvement in symptoms within 24 hours. Two patients reported no symptoms whatsoever at this time. Corneal melting was arrested and complete epithelialization was achieved in all cases. In the 2 eyes with hypopyon, this regressed completely within 2 days after the CXL. Follow-up ranged between 1 and 6 months. Discussion: Our experience based on the above and other cases suggest that CXL could be an effective tool in battling difficult cases of infectious keratitis. This treatment could present many advantages but will need further investigation.

Place, publisher, year, edition, pages
2010. Vol. 29, no 12, p. 1353-1358
Keywords [en]
CXL, crosslinking, riboflavin, keratitis, UV-A, ultraviolet A, corneal melting
National Category
Surgery
Research subject
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-20751DOI: 10.1097/ICO.0b013e3181d2de91ISI: 000284580000003OAI: oai:DiVA.org:oru-20751DiVA, id: diva2:474390
Available from: 2012-01-09 Created: 2012-01-09 Last updated: 2017-12-08Bibliographically approved
In thesis
1. Ultraviolet light A (UVA) photoactivation of riboflavin as a potential therapy for infectious keratitis
Open this publication in new window or tab >>Ultraviolet light A (UVA) photoactivation of riboflavin as a potential therapy for infectious keratitis
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2011. p. 70
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 63
National Category
Medical and Health Sciences Surgery
Research subject
Surgery
Identifiers
urn:nbn:se:oru:diva-20130 (URN)978-91-7668-834-2 (ISBN)
Public defence
2011-12-16, Wilandersalen, Universitetssjukhuset, Örebro, 09:15 (Swedish)
Opponent
Supervisors
Available from: 2011-10-20 Created: 2011-10-20 Last updated: 2017-10-17Bibliographically approved

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Makdoumi, KarimCrafoord, Sven

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