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Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease
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2012 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 11, article id e49138Article in journal (Refereed) Published
Abstract [en]

Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures of CD in stool samples from six twin pairs that were either healthy, or that had CD in the ileum (ICD) or colon (CCD). Integration of these omics approaches revealed several genes, proteins, and pathways that primarily differentiated ICD from healthy subjects, including depletion of many proteins in ICD. In addition, the ICD phenotype was associated with alterations in bacterial carbohydrate metabolism, bacterial-host interactions, as well as human host-secreted enzymes. This eco-systems biology approach underscores the link between the gut microbiota and functional alterations in the pathophysiology of Crohn's disease and aids in identification of novel diagnostic targets and disease specific biomarkers.

Place, publisher, year, edition, pages
San Francisco: Public Library Science , 2012. Vol. 7, no 11, article id e49138
National Category
Clinical Medicine
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-27418DOI: 10.1371/journal.pone.0049138ISI: 000312601700009PubMedID: 23209564Scopus ID: 2-s2.0-84870322666OAI: oai:DiVA.org:oru-27418DiVA, id: diva2:603691
Note

Funding Agency:

UH2DK83991

Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2017-12-06Bibliographically approved

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Halfvarson, JonasTysk, Curt

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School of Health and Medical Sciences, Örebro University, Sweden
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