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Sedation And Analgesia For Neonates In Nicus Across Europe: The Europain Survey
Emergency Department, Hôpital Armand-Trousseau, Paris, France.
Centre for Health Care Sciences, Örebro University Hospital, Örebro, Sweden. (PEARL - Pain in Early Life)ORCID iD: 0000-0002-5996-2584
Emergency Department, Hôpital Armand-Trousseau, Paris, France.
Complexo Hospitalario Universitario de a Coruña, a Coruña, Spain.
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2014 (English)In: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 99, p. A64-A64Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: Pain and stress induced by mechanical ventilation, invasive procedures, or painful diseases supports the use of sedation/analgesia (S/A) in newborns admitted to Neonatal Intensive Care Units (NICUs). To date, these practices have not been studied at a large scale.

Objective: To determine current clinical practices regarding the use of S/A drugs in NICUs across Europe.

Methods: This epidemiological observational study on bedside clinical practices regarding S/A collected data for all neonates in participating NICUs until the infant left the unit (discharge, death, transfer) or for up to 28 days. Data collection occurred via an online database for 1 month at each NICU. All neonates up to 44 weeks gestation were included.

Results: From October 2012 to June 2013, 243 NICUs from 18 European countries collected data on 6680 eligible neonates. Of these, 2142 received tracheal ventilation (TV), 1496 non-invasive ventilation (NIV) and 3042 only spontaneous ventilation (SV). The median (IQR) gestational age of TV, NIV and SV neonates were 32.1 (28.1–37.4), 33.6 (31.0–36.6) and 37.9 (35.0–39.9), respectively (p < 0.001). Overall, more TV neonates [81.5% (n = 1746)] received S/A drugs than NIV neonates [17.8% (n = 266)] and SV neonates [9.3% (n = 282)]; p < 0.001. Fig. shows the rate of S/A use by country; table shows S/A drugs used.

Conclusions: Most ventilated but few non-ventilated neonates (NIV and SV) receive S/A therapy in European NICUs. Wide variations in S/A use, drugs used, and mode of administration (continuous, bolus, or both) exist among countries.

Place, publisher, year, edition, pages
London, United Kingdom: BMJ Group , 2014. Vol. 99, p. A64-A64
Keywords [en]
Newborn, Pain, Sedation
National Category
Pediatrics
Research subject
Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-47043DOI: 10.1136/archdischild-2014-307384.170OAI: oai:DiVA.org:oru-47043DiVA, id: diva2:881653
Conference
The 5th Congress of the European Academy of Paediatric Societies (EAPS), Barcelona, Spain, October 17-21, 2014
Projects
EUROPAIN
Funder
EU, FP7, Seventh Framework Programme, 223767Available from: 2015-12-11 Created: 2015-12-11 Last updated: 2018-06-18Bibliographically approved

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