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Expression of genes involved in inflammation and growth: does sampling site in human full-term placenta matter?
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Obstetrics and Gynecology.
Department of Pediatrics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Obstetrics and Gynecology.
Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (Clinical Epidemiology and Biostatistics)ORCID-id: 0000-0002-3552-9153
Vise andre og tillknytning
2019 (engelsk)Inngår i: Journal of Perinatal Medicine, ISSN 0300-5577, E-ISSN 1619-3997, Vol. 47, nr 5, s. 539-546Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: To investigate the placental gene expression of substances in the inflammatory cascade and growth factors at nine different well-defined sampling sites in full-term placentas from 12 normal weight healthy non-smoking women with an uncomplicated singleton pregnancy.

Methods: All placentas (six girls and six boys) were delivered vaginally. Quantitative real-time polymerase chain reaction was used to analyze toll receptor-2 and -4, interleukin-6 and -8, tumor necrosis factor-α, leptin, ghrelin, insulin-like growth factor-1 and -2, hepatocyte growth factor, hepatocyte growth factor receptor and insulin receptor (IR).

Results: The leptin gene and the IR gene showed higher expression in lateral regions near the chorionic plate compared to central regions near the basal plate (P = 0.028 and P = 0.041, respectively).

Conclusion: Our results suggest that the sampling site may influence the gene expression for leptin and IR in placental tissue obtained from full-term normal pregnancies. We speculate that this may be due to differences in placental structure and perfusion and may be important when future studies are designed.

sted, utgiver, år, opplag, sider
Walter de Gruyter, 2019. Vol. 47, nr 5, s. 539-546
Emneord [en]
Cytokines, gene expression, growth factors, placenta, sampling
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-73427DOI: 10.1515/jpm-2018-0290ISI: 000473532900008PubMedID: 30920955Scopus ID: 2-s2.0-85063721684OAI: oai:DiVA.org:oru-73427DiVA, id: diva2:1302410
Merknad

Funding Agencies:

Research Committee of Region Örebro County  

Nyckelfonden, Örebro University Hospital  

Tilgjengelig fra: 2019-04-04 Laget: 2019-04-04 Sist oppdatert: 2019-08-08bibliografisk kontrollert

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Allbrand, MarianneNilsson, KerstinCao, YangLodefalk, Maria

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