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Autonomic dysfunction is associated with cardiac remodeling in heart failure patients – The HARVEST study
Örebro universitet, Institutionen för hälsovetenskaper.
2017 (engelsk)Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
Abstract [en]

Background: Orthostatic hypotension (OH) is a cardinal sign of autonomic dysfunction, and a common comorbidity in patients with heart failure. The relationship between OH and structural cardiac anomalies has not been sufficiently explored.

Purpose: To assess relations between orthostatic blood pressure (BP) responses during active standing and echocardiographic findings in patients with heart failure.

Methods: 149 patients hospitalized for heart failure (mean age: 74.0 years; mean ejection fraction (EF) 40±16%) were examined with conventional echocardiograms and active-standing test. Associations between left atrial volume, right atrial volume, left ventricular mass, left ventricular diameter and right ventricular diameter and the difference between supine and standing systolic/diastolic BP were examined.

Results: A total of 33 patients met conventional OH criteria i.e. systolic/diastolic BP decrease ≥20/10 mmHg. In linear regression models, decrease in systolic BP upon standing was associated with greater left ventricular mass. Decrease in systolic BP was also borderline significant associated with greater left atrial volume.

Conclusions: Orthostatic decline in systolic BP among older heart failure patients is associated with structural cardiac changes such as increased left ventricular mass, independently of traditional risk factors and LVEF.

sted, utgiver, år, opplag, sider
2017.
Emneord [en]
Orthostatic hypotension, heart failure, left ventricle mass and left atrium.
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-61176OAI: oai:DiVA.org:oru-61176DiVA, id: diva2:1145315
Fag / kurs
Medicine
Tilgjengelig fra: 2017-09-28 Laget: 2017-09-28 Sist oppdatert: 2017-09-28bibliografisk kontrollert

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