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Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum
Department of Medicine, Division of Diabetes, , Helsinki, Finland; Minerva Medical Research Institute, Helsinki, Finland.
VTT Technical Research Centre of Finland, Espoo, Finland.
Department of Medicine, Division of Diabetes, , Helsinki, Finland.
Department of Surgery, University of Helsinki, Helsinki, Finland.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Obesity, ISSN 1930-7381, E-ISSN 1930-739X, Vol. 18, nr 5, s. 937-944Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Ceramides may mediate saturated fat-induced insulin resistance, but there are no data comparing ceramide concentrations between human tissues. We therefore performed lipidomic analysis of human subcutaneous (SCfat) and intra-abdominal (IAfat) adipose tissue, the liver, and serum in eight subjects. The liver contained (nmol/mg tissue) significantly more ceramides (1.5-3-fold), sphingomyelins (7-8-fold), phosphatidylethanolamines (10-11-fold), lysophosphatidylcholines (7-12-fold), less ether-linked phosphatidylcholines (2-2.5-fold) but similar amounts of diacylglycerols as compared to SCfat and IAfat. The amounts of ceramides and their synthetic precursors, such as palmitic (16:0) free fatty acids and sphingomyelins, differed considerably between the tissues. The liver contained proportionally more palmitic, stearic (18:0), and long polyunsaturated fatty acids than adipose tissues. Stearoyl-CoA desaturase 1 (SCD1) activity reflected by serum, estimated from the 16:1/16:0-ratio, was closely related to that in the liver (r = 0.86, P = 0.024) but not adipose tissues. This was also true for estimated elongase (18:1/16:1, r = 0.89, P = 0.01), and Delta5 (20:4/20:3, r = 0.89, P = 0.012) and Delta6 (18:3[n-6]/18:2, r = 1.0, P < 0.001) desaturase activities. We conclude that the human liver contains higher concentrations of ceramides and saturated free fatty acids than either SCfat or IAfat.

sted, utgiver, år, opplag, sider
Wiley-Blackwell Publishing Inc., 2010. Vol. 18, nr 5, s. 937-944
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Identifikatorer
URN: urn:nbn:se:oru:diva-63623DOI: 10.1038/oby.2009.326ISI: 000277234800015PubMedID: 19798063Scopus ID: 2-s2.0-77951665499OAI: oai:DiVA.org:oru-63623DiVA, id: diva2:1169189
Merknad

Funding agencies:

Academy of Finland

Sigrid Juselius Foundation

Finnish Diabetes Research Foundation

Biomedicum Helsinki Foundation

Novo Nordisk Foundation

European Commission

LSHM-CT-2005-018734

Tilgjengelig fra: 2017-12-22 Laget: 2017-12-22 Sist oppdatert: 2018-05-02bibliografisk kontrollert

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