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Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
Biotechnology for Health and Well-being, VTT Technical Research Centre of Finland Espoo, Espoo, Finland.
German Breast Group, GBG-Forschungs GmbH, Neu-Isenburg, Germany.
Örebro universitet, Institutionen för naturvetenskap och teknik. Biotechnology for Health and Well-being, VTT Technical Research Centre of Finland Espoo, Espoo, Finland.ORCID-id: 0000-0002-4382-4355
German Breast Group, GBG-Forschungs GmbH, Neu-Isenburg, Germany.
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2014 (engelsk)Inngår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 134, nr 7, s. 1725-1733Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic lipid metabolism. The objective of this study was to perform comprehensive analysis of lipids in breast cancer patient serum samples. Lipidomic profiling using an established analytical platform was performed in two cohorts of breast cancer patients receiving neoadjuvant chemotherapy. The analyses were performed for 142 patients before and after neoadjuvant chemotherapy, and the results before chemotherapy were validated in an independent cohort of 194 patients. The analyses revealed that in general the tumor characteristics are not reflected in the serum samples. However, there was an association of specific triacylglycerols (TGs) in patients' response to chemotherapy. These TGs containing mainly oleic acid (C18:1) were found in lower levels in those patients showing pathologic complete response before receiving chemotherapy. Some of these TGs were also associated with estrogen receptor status and overall or disease-free survival of the patients. The results suggest that the altered serum levels of oleic acid in breast cancer patients are associated with their response to chemotherapy.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2014. Vol. 134, nr 7, s. 1725-1733
Emneord [en]
breast cancer, lipidomics, oleic acid, pathologic complete response rate, stearoyl-CoA desaturase (SCD)
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-63691DOI: 10.1002/ijc.28491ISI: 000329579500020PubMedID: 24114462Scopus ID: 2-s2.0-84892599003OAI: oai:DiVA.org:oru-63691DiVA, id: diva2:1169256
Forskningsfinansiär
EU, FP7, Seventh Framework Programme, HEALTH-F2-2008-200327
Merknad

Funding agencies:

Academy of Finland Postdoctoral Researcher's Fellowship 138201 

Tilgjengelig fra: 2017-12-22 Laget: 2017-12-22 Sist oppdatert: 2019-03-04bibliografisk kontrollert

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