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ENT COBRA ONTOLOGY: the covariates classification system proposed by the Head & Neck and Skin GEC-ESTRO Working Group for interdisciplinary standardized data collection in head and neck patient cohorts treated with interventional radiotherapy (brachytherapy)
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Tata Memorial Centre, Mumbai, India.
Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.
Clìnica Universidad de Navarra, Navarra, Spain.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Journal of Contemporary Brachytherapy, ISSN 1689-832X, E-ISSN 2081-2841, Vol. 10, nr 3, s. 260-266Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Purpose: Clinical data collecting is expensive in terms of time and human resources. Data can be collected in different ways; therefore, performing multicentric research based on previously stored data is often difficult. The primary objective of the ENT COBRA (COnsortium for BRachytherapy data Analysis) ontology is to define a specific terminological system to standardized data collection for head and neck (H&N) cancer patients treated with interventional radiotherapy.

Material and methods: ENT-COBRA is a consortium for standardized data collection for H&N patients treated with interventional radiotherapy. It is linked to H&N and Skin GEC-ESTRO Working Group and includes 11 centers from 6 countries. Its ontology was firstly defined by a multicentric working group, then evaluated by the consortium followed by a multi-professional technical commission involving a mathematician, an engineer, a physician with experience in data storage, a programmer, and a software expert.

Results: Two hundred and forty variables were defined on 13 input forms. There are 3 levels, each offering a specific type of analysis: 1. Registry level (epidemiology analysis); 2. Procedures level (standard oncology analysis); 3. Research level (radiomics analysis). The ontology was approved by the consortium and technical commission; an ad-hoc software architecture ("broker") remaps the data present in already existing storage systems of the various centers according to the shared terminology system. The first data sharing was successfully performed using COBRA software and the ENT COBRA Ontology, automatically collecting data directly from 3 different hospital databases (Lubeck, Navarra, and Rome) in November 2017.

Conclusions: The COBRA Ontology is a good response to the multi-dimensional criticalities of data collection, retrieval, and usability. It allows to create a software for large multicentric databases with implementation of specific remapping functions wherever necessary. This approach is well-received by all involved parties, primarily because it does not change a single center's storing technologies, procedures, and habits.

sted, utgiver, år, opplag, sider
Termedia Publishing , 2018. Vol. 10, nr 3, s. 260-266
Emneord [en]
data collection, ENT-COBRA, head and neck cancer, GEC-ESTRO, personalized medicine
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-68257DOI: 10.5114/jcb.2018.76982ISI: 000438333100011PubMedID: 30038647OAI: oai:DiVA.org:oru-68257DiVA, id: diva2:1235732
Tilgjengelig fra: 2018-07-27 Laget: 2018-07-27 Sist oppdatert: 2018-09-12bibliografisk kontrollert

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