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ADHD-originating in the gut?: The emergence of a new explanatory model
School of Medical Sciences, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper.ORCID-id: 0000-0002-0362-0008
2018 (engelsk)Inngår i: Medical Hypotheses, ISSN 0306-9877, E-ISSN 1532-2777, Vol. 120, s. 135-145Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The microbiome-gut-brain axis paradigm explains that alterations in the central nervous system and behavior may be secondary to functional changes in the gut in general and more specifically the enteric nervous system. An unfavorable development of the intestinal microbial ecosystem, leading to e.g. a diminished microbial diversity, may play a central role. This paper outlines, and describes the theoretical basis of, a novel integrative model explaining the etiology and pathogenesis of ADHD in a microbiota-gut-brain context, taking into account the complexity of the bi-directional signaling between the gut and the brain.

sted, utgiver, år, opplag, sider
Elsevier, 2018. Vol. 120, s. 135-145
Emneord [en]
ADHD, Enteric nervous system, Autonomic nervous system, Microbiome-gut-brain axis, Explanatory model
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-69969DOI: 10.1016/j.mehy.2018.08.022ISI: 000447100300024PubMedID: 30220333OAI: oai:DiVA.org:oru-69969DiVA, id: diva2:1260133
Tilgjengelig fra: 2018-11-01 Laget: 2018-11-01 Sist oppdatert: 2019-02-11bibliografisk kontrollert

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