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Plantaricins markedly enhance the effects of traditional antibiotics against Staphylococcus epidermidis
Faculty of Medicine & Health, School of Medical Sciences, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper.
Örebro universitet, Institutionen för medicinska vetenskaper.
Division of Molecular Physics, Department of Physics, Chemistry & Biology (IFM), Linköping University, Linköping, Sweden.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Future microbiology, ISSN 1746-0913, Vol. 14, nr 3, s. 195-206Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIM: Bacteriocins are considered as promising alternatives to antibiotics against infections. In this study, the plantaricins (Pln) A, E, F, J and K were investigated for their antimicrobial activity against Staphylococcus epidermidis.

MATERIALS & METHODS: The effects on membrane integrity were studied using liposomes and viable bacteria, respectively.

RESULTS: We show that PlnEF and PlnJK caused rapid and significant lysis of S. epidermidis, and induced lysis of liposomes. The PlnEF and PlnJK displayed similar mechanisms by targeting and disrupting the bacterial cell membrane. Interestingly, Pln enhanced the effects of different antibiotics by 30- to 500-fold.

CONCLUSION: This study shows that Pln in combination with low concentrations of antibiotics is efficient against S. epidermidis and may be developed as potential treatment of infections.

sted, utgiver, år, opplag, sider
Future Medicine , 2019. Vol. 14, nr 3, s. 195-206
Emneord [en]
Pln, antibiotic, combination therapy, liposome, membrane lysis, plantaricin, synergy
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-71656DOI: 10.2217/fmb-2018-0285ISI: 000460352400005PubMedID: 30648887Scopus ID: 2-s2.0-85062167749OAI: oai:DiVA.org:oru-71656DiVA, id: diva2:1281412
Forskningsfinansiär
Magnus Bergvall Foundation, 2015-00823Knowledge Foundation, 20150244 20150086Swedish Research Council, 2016-04874Tilgjengelig fra: 2019-01-22 Laget: 2019-01-22 Sist oppdatert: 2019-03-19bibliografisk kontrollert

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