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Lipidomes in health and disease: Analytical strategies and considerations
Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, Hubei, PR China.
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Örebro universitet, Institutionen för medicinska vetenskaper. Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, Hubei, PR China; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID-id: 0000-0002-2856-9165
Örebro universitet, Institutionen för naturvetenskap och teknik.ORCID-id: 0000-0002-4382-4355
2019 (engelsk)Inngår i: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 120, artikkel-id 115664Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Lipidomics is a rapidly-growing field which focuses on global characterization of lipids at molecular and systems levels. As small changes in the concentrations of lipids may have important physiological consequences, much attention in the field has recently been paid to more accurate quantitation and identification of lipids. Community-wide efforts have been initiated, aiming to develop best practices for lipidomic analyses and reporting of lipidomic data. Nevertheless, current approaches for comprehensive analysis of lipidomes have some inherent challenges and limitations. Additionally, there is, currently, limited knowledge concerning the impacts of various external and internal exposures on lipid levels. In this review, we discuss the recent progress in lipidomics analysis, with a primary focus on analytical approaches, as well as on the different sources of variation in quantifying lipid levels, both technical and biological.

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 120, artikkel-id 115664
Emneord [en]
Biomarkers, Lipid identification, Lipidomics, Mass spectrometry, Metabolomics, Quantification
HSV kategori
Identifikatorer
URN: urn:nbn:se:oru:diva-77194DOI: 10.1016/j.trac.2019.115664ISI: 000501783700017Scopus ID: 2-s2.0-85072601123OAI: oai:DiVA.org:oru-77194DiVA, id: diva2:1360099
Forskningsfinansiär
EU, Horizon 2020, 634413Tilgjengelig fra: 2019-10-11 Laget: 2019-10-11 Sist oppdatert: 2020-01-14bibliografisk kontrollert

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