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Protection against clinical pertussis induced by whole-cell pertussis vaccination is related to primo-immunisation intervals
Örebro universitet, Hälsoakademin.ORCID-id: 0000-0001-6328-5494
2007 (engelsk)Inngår i: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 25, nr 43, s. 7510-7515Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

AIMS: Information on subjects who had at least three immunisations against pertussis was provided by longitudinal data from the 1970 British Cohort Study (BCS70) and used to assess whether three whole-cell pertussis (wP) immunisations given within less than 5 months confer less effective protection in childhood compared with a schedule with a longer interval.

METHODS: Age at pertussis infection was the dependent variable in a Cox regression analysis, to investigate associations with duration between first and third pertussis immunisation; with third immunisation modelled as a time-dependent covariate. Adjustment was for number of pertussis immunisations (three or four), sex, social class and other potential confounding factors.

RESULTS: A total of 8545 children were included in the analysis and 556 had a history of whooping cough. A duration of over 4 months between first and third pertussis immunisations is statistically significantly associated with a reduced risk of pertussis infection by age 10 years, compared with three immunisations given over a shorter period, producing a statistically significant adjusted hazard ratio of 0.74 (0.62-0.92). A fourth immunisation against pertussis further enhanced the protective effect with a hazard ratio of 0.59 (0.44-0.82).

CONCLUSION: These results were based on a historical UK cohort using wP vaccine, and indicate that a vaccination schedule with an interval between the immunisations greater than 4 months, and also including a fourth immunisation, would be more effective in this population than a three dose schedule within a shorter interval without booster.

sted, utgiver, år, opplag, sider
Guildford: Butterworths , 2007. Vol. 25, nr 43, s. 7510-7515
Emneord [en]
Adult, Child, Child; Preschool, Cohort Studies, Female, Great Britain, Humans, Immunization Schedule, Infant, Infant; Newborn, Male, Pertussis Vaccine/administration & dosage/*immunology, Proportional Hazards Models, Time Factors, Vaccination/*methods/statistics & numerical data, Whooping Cough/*immunology/prevention & control
HSV kategori
Forskningsprogram
immunologi
Identifikatorer
URN: urn:nbn:se:oru:diva-3777PubMedID: 17905483OAI: oai:DiVA.org:oru-3777DiVA, id: diva2:138075
Tilgjengelig fra: 2009-01-05 Laget: 2009-01-05 Sist oppdatert: 2018-01-13bibliografisk kontrollert

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PubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17905483&dopt=Citation

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Montgomery, Scott M.

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