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Effects of Di-Isononyl Phthalate on Neuropeptide Y Expression in Differentiating Human Neuronal Cells
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Public Health Science, Department of Health Sciences, Faculty of Health, Science and Technology, Karlstad University, Karlstad, Sweden; Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID-id: 0000-0003-0417-1686
Biomedical Sciences, Karlstad University, Karlstad, Sweden.ORCID-id: 0000-0001-9302-2396
Vise andre og tillknytning
2017 (engelsk)Inngår i: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 120, nr 3, s. 218-323Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Neuropeptide Y (NPY) is an abundant neuropeptide in the mammalian brain important for behavioural consequences of stress and energy metabolism. We have addressed possible effects of the phthalate DiNP on NPY expression in human SH‐SY5Y cells, a neuronal in vitro differentiation model. Pico‐ to nanomolar doses of DiNP and its metabolite MiNP resulted in decreased NPY mRNA and peptide expression in retinoid‐differentiated cells. Thus, dys‐regulated NPY may be an adverse outcome for exposure to low doses of DiNP in human beings.

sted, utgiver, år, opplag, sider
Blackwell Publishing, 2017. Vol. 120, nr 3, s. 218-323
Emneord [en]
phthlate, DiNP, MiNP, NPY, SH-SY5Y neuroblastoma cells
HSV kategori
Forskningsprogram
Biomedicinsk vetenskap; Biomedicinsk vetenskap
Identifikatorer
URN: urn:nbn:se:oru:diva-79055DOI: 10.1111/bcpt.12670ISI: 000394538600016PubMedID: 27625336Scopus ID: 2-s2.0-85009476073OAI: oai:DiVA.org:oru-79055DiVA, id: diva2:1386269
Merknad

This work was financially supported by The County Council of Värmland.

Retraction

The above article, published online on 13 September 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Kim Brøsen, the Nordic Association for the Publication of BCPT and John Wiley & Sons Ltd. The retraction has been agreed following an investigation into the accuracy of the data acquisition conducted by Karlstad University into the accuracy of the data acquisition, which concluded that manipulation had taken place during tests performed on an ELISA equipment in order to achieve a preferred result.

Tilgjengelig fra: 2016-09-05 Laget: 2020-01-17 Sist oppdatert: 2020-02-03bibliografisk kontrollert

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